Abstract：
:Microbes have chemotactic signaling systems that enable them to detect and follow chemical gradients in their environments. The core of these sensory systems consists of chemoreceptor proteins coupled to the CheA kinase via the scaffold or coupler protein CheW. Some bacterial chemotaxis systems replace or augment CheW with a related protein, CheV, which is less well understood. CheV consists of a CheW domain fused to a receiver domain that is capable of being phosphorylated. Our review of the literature, as well as comparisons of the CheV and CheW sequence and structure, suggest that CheV proteins conserve CheW residues that are crucial for coupling. Phosphorylation of the CheV receiver domain might adjust the efficiency of its coupling and thus allow the system to modulate the response to chemical stimuli in an adaptation process.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Alexander RP,Lowenthal AC,Harshey RM,Ottemann KMdoi
10.1016/j.tim.2010.07.004subject
Has Abstractpub_date
2010-11-01 00:00:00pages
494-503issue
11eissn
0966-842Xissn
1878-4380pii
S0966-842X(10)00131-9journal_volume
18pub_type
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