Abstract:
OBJECTIVES:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other possible causes of progressive muscle wasting. However, there are also pathologic changes in nerve conduction studies in ALS patients. METHODS:In this study we analysed the values of distal motor latency (DML), compound muscle action potential (CMAP) and motor nerve conduction velocity (MNCV) in 95 patients with definite ALS. RESULTS:We found slight slowing of MNCV and moderate to strong reduction of CMAP and a prolongation of DML. We found no significant correlation between MNCV and CMAP. DISCUSSION:The main finding of the present work was the negative correlation between DML and CMAP. It is interpreted as a very distal axonal damage as the main reason for prolongation of DML in ALS patients.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Mohammadi B,Krampfl K,Kollewe K,Seyfadini A,Bufler J,Dengler Rdoi
10.1179/016164107X159261subject
Has Abstractpub_date
2007-07-01 00:00:00pages
425-8issue
5eissn
0161-6412issn
1743-1328journal_volume
29pub_type
杂志文章abstract::The selection of drugs to prevent the development of pathology in cerebral infarction remains an important problem. For the selection of effective drugs from among a large number of possible candidates, widely-used test screening techniques are sufficient for obtaining a good understanding of candidate drug effects. T...
journal_title:Neurological research
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journal_title:Neurological research
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journal_title:Neurological research
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journal_title:Neurological research
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journal_title:Neurological research
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journal_title:Neurological research
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journal_title:Neurological research
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journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1998-10-01 00:00:00
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更新日期:2018-12-01 00:00:00
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