Neurological aspects of tuberous sclerosis in relation to MRI/MR spectroscopy findings in children with epilepsy.

Abstract:

:Our aim was to evaluate the relationship between the neurological outcome of tuberous sclerosis complex (TSC) and the findings obtained from both cranial magnetic resonance imaging (MRI) and single voxel proton spectroscopy (SVPS). MRIs of 13 children who met the diagnostic criteria for TSC were taken. Eleven of these children also underwent a prospective analysis of SVPS. Fisher's exact test and Mann-Whitney U test were used, where applicable, to detect any signs of the imaging data that would indicate poor outcome, or in other words, poor seizure control and/ or high degree of mental retardation. Poor seizure control was seen in eight of the patients and multiple seizure types in seven. Mental retardation was severe in six patients and mild/moderate in seven. MRI revealed multiple bilateral tubers and subependymal nodules (13/13), confluence of tubers (8/13), subcortical linear heterotopias (7/13), gyral cores (3/13) and cortical atrophy (3/13). SVPS findings of tubers were characterized by decreased NAA/Cr (1.43 +/- 0.33, p<0.001), increased Cho/Cr (0.91 +/- 0.082, p< 0.05) and mI/Cr (0.97 +/- 0.19, p<0.01) ratios when compared with those of the control group. Lactate peak was detected in six patients. Unfavorable outcome in TSC can be predicted with the help of the following: multiple seizure types, a number of confluent appearances of the tubers and cortical atrophy. SVPS could be a useful clue to understand the pathophysiologic function of the tubers, especially in children with refractory epilepsy along with TSC.

journal_name

Neurol Res

journal_title

Neurological research

authors

Yapici Z,Dörtcan N,Baykan BB,Okan F,Dinçer A,Baykal C,Eraksoy M,Roach S

doi

10.1179/016164107X163996

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

449-54

issue

5

eissn

0161-6412

issn

1743-1328

journal_volume

29

pub_type

杂志文章
  • CCR7 expression on peripheral blood lymphocytes is up-regulated following treatment of multiple sclerosis with interferon-beta.

    abstract::A prospective study of the expression of the chemokine receptor CCR7 was performed in 11 relapsing-remitting multiple sclerosis (MS) patients during 12 months of interferon-beta (IFNbeta) treatment. The results show increased expression of CCR7 on peripheral blood lymphocytes (PBL) of MS patients receiving IFNbeta tre...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1179/016164107X228633

    authors: Vallittu AM,Saraste M,Airas L

    更新日期:2007-12-01 00:00:00

  • Nitric oxide synthase inhibitor augments post-ischemic leukocyte adhesion in the cerebral microcirculation in vivo.

    abstract::The objective was to examine the effect of the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME) on leukocyte adhesion in the cerebral microcirculation during reperfusion following partial forebrain ischemia in the rat. Intravital fluorescence video-microscopy through a closed cranial win...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740947

    authors: Hudetz AG,Wood JD,Kampine JP

    更新日期:1999-06-01 00:00:00

  • Detection of the bladder volume from the neural afferent activities in dogs: experimental results.

    abstract:OBJECTIVE:We evaluate the bladder volume and pressure through recording the bladder afferent activity in the sacral nerve roots in acute experiments of paraplegic dogs. These measurements are intended to report the status of the bladder and to adjust the stimulation parameters of an implantable electric stimulator. ME...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164108X268250

    authors: Saleh A,Sawan M,Elzayat EA,Corcos J,Elhilali MM

    更新日期:2008-02-01 00:00:00

  • An ultrastructural study on the reactive oligodendrocytes, myeloclasts, and myelophages in transected dog spinal cord.

    abstract::As early as 1 to 3 hr after cord transection, proliferation of many reactive oligodendrocytes was observed. Bundles of microfilaments and microtubules were observed in those cells that sent out long, complex pseudopodlike processes near the area of injury. These reactive oligodendrocytes may be comparable to Vaughn's ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1980.11739566

    authors: Chang LW,Kao CC

    更新日期:1980-01-01 00:00:00

  • Needle-free acupuncture benefits both patients and clinicians.

    abstract:OBJECTIVE:This study examined whether a needle-free acupuncture can be an alternative to conventional needle injection acupuncture. METHODS:Patients (n=101) suffering myofascial shoulder pain were randomly assigned to either needle-free or conventional needle injection acupuncture group. Bee venom was administered int...

    journal_title:Neurological research

    pub_type: 杂志文章,随机对照试验

    doi:10.1179/016164109X12537002793760

    authors: An K,Kim YS,Kim HY,Lee H,Hahm DH,Lee KS,Kang SK

    更新日期:2010-02-01 00:00:00

  • Tissue plasminogen activator and plasminogen activator inhibitor in patients with acute ischemic stroke: relation to stroke etiology.

    abstract::Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events such as stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11741005

    authors: Zunker P,Schick A,Padró T,Kienast J,Phillips A,Ringelstein EB

    更新日期:1999-12-01 00:00:00

  • Protective effect of BAG5 on MPP+-induced apoptosis in PC12 cells.

    abstract:OBJECTIVES:Parkinson's disease (PD) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of PD. The purpose of this study was to assess the role of B-cell lymphoma 2 (Bcl-2)-associated athanogene 5 (BAG5) protein, whic...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000102

    authors: Ma M,Wang X,Ding X,Jing J,Ma Y,Teng J

    更新日期:2012-12-01 00:00:00

  • Measurement of regional cerebrovascular haemoglobin oxygen saturation in cats using optical spectroscopy.

    abstract::We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio--percen...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1991.11739967

    authors: McCormick PW,Stewart M,Ray P,Lewis G,Dujovny M,Ausman JI

    更新日期:1991-03-01 00:00:00

  • CT observations on the natural history of asymptomatic cerebral infarction following transient ischaemic attacks.

    abstract::Two hundred and sixty-one neurologically asymptomatic patients were examined by computed tomography (CT) following a variable number of transient ischaemic attacks (TIAs) experienced over different time intervals. Cerebral infarcts were discovered in 101 patients. Dominant hemisphere infarcts were usually small, of re...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1985.11739720

    authors: Turnbull IW,Bannister CM

    更新日期:1985-12-01 00:00:00

  • Rebleeding of intracranial dissecting aneurysm in the vertebral artery following proximal clipping.

    abstract::We describe a case of rebleeding from an intracranial vertebral dissecting aneurysm following proximal clipping. This case suggests that proximal clipping alone may not be an adequate surgical procedure to prevent rebleeding. Surgical treatment of intracranial dissecting aneurysms in the vertebral artery presenting as...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.1994.11740213

    authors: Kawamata T,Tanikawa T,Takeshita M,Onda H,Takakura K,Toyoda C

    更新日期:1994-04-01 00:00:00

  • Does the siphon effect of cerebrospinal fluid shunting develop in vivo? Report of a case casting doubt on the presence of this phenomenon.

    abstract::A 52-year-old male underwent lumboperitoneal shunting after external decompressive craniectomy. His postoperative course was accompanied by remarkable displacement of the intracranial structures to the opposite side of craniectomy. This phenomenon, probably caused by the siphon effect of cerebrospinal fluid shunting, ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1991.11739979

    authors: Aoki N

    更新日期:1991-06-01 00:00:00

  • Wall characteristics and mechanisms of ischaemic stroke in patients with atherosclerotic middle cerebral artery stenosis: a high-resolution MRI study.

    abstract:OBJECTIVE:To evaluate the characteristics of atherosclerotic middle cerebral artery (MCA) stenosis by high-resolution magnetic resonance imaging (HR-MRI) and determine the relationship between wall characteristics and infarction patterns. METHODS:Thirty-six patients with acute ischaemic stroke due to MCA stenosis unde...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132815Y.0000000088

    authors: Zhao DL,Deng G,Xie B,Gao B,Peng CY,Nie F,Yang M,Ju S,Teng GJ

    更新日期:2016-07-01 00:00:00

  • Combined preoperative onyx embolization and protective internal carotid artery covered stent placement for treatment of glomus vagale tumor: review of literature and illustrative case.

    abstract:OBJECTIVE:Surgical resection of complex glomus vagale tumors can be complicated by extensive blood loss and might require surgical sacrifice of an encased internal carotid artery. METHODS:A young patient presented with mass effect from glomus valage tumor. Computerized tomography angiography showed an encased interna...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/1743132812Y.0000000036

    authors: Alaraj A,Pytynia K,Carlson AP,Krishna PH,Charbel FT,Amin-Hanjani S,Aletich V

    更新日期:2012-07-01 00:00:00

  • The protective effect of adenosine A2A receptor antagonism in cerebral ischemia.

    abstract:OBJECTIVES:We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS:Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS:A(2A) ant...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164105X21913

    authors: Pedata F,Gianfriddo M,Turchi D,Melani A

    更新日期:2005-03-01 00:00:00

  • A rat glioblastoma model with diffuse leptomeningeal gliomatosis induced by intracarotid injection of C6 glioma cells.

    abstract:OBJECTIVE:A reproducible brain tumor model using experimental animals is required to study biological behavior and develop more potent antineoplastic drugs and effective therapeutic modalities. In this work, we attempted to establish diffuse leptomeningeal gliomatosis in the rat by intracarotid injection of C6 glioma c...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X403904

    authors: Wasita B,Kamitani H,Kinoshita Y,Mamun MH,Watanabe T

    更新日期:2009-06-01 00:00:00

  • Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.

    abstract:OBJECTIVES:We attempted to determine whether a functional polymorphism of TRPM6 (rs2274924) is associated with susceptibility to epilepsy following ischemic stroke, and to further explore the effect of this polymorphism on serum levels of Mg2+ in post-stroke patients. METHODS:We carried out a case-control study on 378...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1568755

    authors: Fu CY,Chen SJ,Cai NH,Liu ZH,Zhang M,Wang PC,Zhao JN

    更新日期:2019-04-01 00:00:00

  • Spermine attenuates the preconditioning of diazoxide against transient focal cerebral ischemia in rats.

    abstract::It is known that mitochondrial ATP-sensitive potassium channels (mitoKATP) play a significant role in protecting cerebral function from ischemia-reperfusion injury, which is related with a decrease in the mitochondrial matrix calcium. However, the effect of mitochondrial calcium uniporter (MCU) on diazoxide-induced ce...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000299

    authors: Zhang L,Wang S,Dong H,Li Y,Wang P,Li S,Guo Y,Yao R

    更新日期:2014-07-01 00:00:00

  • Bevacizumab is superior to Temozolomide in causing mitochondrial dysfunction in human brain tumors.

    abstract:OBJECTIVE:Current chemotherapy treatments available for treating high-grade brain tumors, Temozolomide (TMZ) or Bevacizumab (BEV), not only have specific anti-tumor mechanisms, but also have an effect on mitochondria. However, effects of both drugs on mitochondria isolated from human brain tumors have not been thorough...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2015.1114233

    authors: Nanegrungsunk D,Apaijai N,Yarana C,Sripetchwandee J,Limpastan K,Watcharasaksilp W,Vaniyapong T,Chattipakorn N,Chattipakorn SC

    更新日期:2016-04-01 00:00:00

  • Central and peripheral dopamine transporter reduction in Parkinson's disease.

    abstract:OBJECTIVE:Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patient...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X383259

    authors: Buttarelli FR,Capriotti G,Pellicano C,Prosperi D,Circella A,Festa A,Giovannelli M,Tofani A,Pontieri FE,Scopinaro F

    更新日期:2009-09-01 00:00:00

  • Refractory status epilepticus: new insights in presentation, treatment, and outcome.

    abstract::Refractory status epilepticus (RSE), defined as status epilepticus that fails to respond to the acute administration of two antiepileptic medications, occurs in approximately a third of patients with status epilepticus, and is associated with increased hospital length of stay, mortality, and functional disability. Com...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/1743132812Y.0000000128

    authors: Hocker S,Wijdicks EF,Rabinstein AA

    更新日期:2013-03-01 00:00:00

  • Exposure time and frequency of irradiation in brain tumours.

    abstract::The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1987.11739796

    authors: Christensen JC

    更新日期:1987-09-01 00:00:00

  • New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies.

    abstract::Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164105X25225

    authors: Aronowski J,Hall CE

    更新日期:2005-04-01 00:00:00

  • Laterality of seizure onset and the simple reaction time: revamping the Poffenberger's paradigm for seizure surgery.

    abstract:BACKGROUND:Crossed-uncrossed differentials (CUDs) are viewed as surrogates for interhemispheric transfer time (IHTT). Not uncommonly CUDs assume statistically significant negative values (inverted CUDs). This raises doubts of the accepted interpretation of CUDs, i.e. intra- and inter-hemispheric routings of signals in ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164106X115107

    authors: Derakhshan I

    更新日期:2006-10-01 00:00:00

  • Thrombolysis with alteplase for acute ischemic stroke patients with atrial fibrillation.

    abstract:OBJECTIVE:Intravenous administration of recombinant tissue plasminogen activator (rtPA) is known as the only approved treatment for acute ischemic stroke. However, it is still controversial whether acute ischemic stroke patients with atrial fibrillation should receive rtPA therapy. METHODS:We studied 99 patients altog...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12656393665206

    authors: Zhang JB,Ding ZY,Yang Y,Sun W,Hai F,Sui XN,Li XY,Wang HZ,Wang XT,Zheng JL

    更新日期:2010-05-01 00:00:00

  • Ramipril prevents extracellular matrix accumulation in cerebral microvessels.

    abstract:OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X49256

    authors: Liebetrau M,Burggraf D,Büscher C,Linz W,Hamann GF

    更新日期:2005-07-01 00:00:00

  • Protective effect of low molecular weight polyethylene glycol on the repair of experimentally damaged neural membranes in rat's spinal cord.

    abstract:OBJECTIVES:Membrane disruption is one of the main factors that cause axonal damage and functional deficits manifested in spinal cord injury (SCI). In this study, we used polyethylene glycol (PEG) to induce immediate membrane sealing and to promote functional recovery after SCI. METHODS:The effects of PEG (200-2000 Da)...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000133

    authors: Kouhzaei S,Rad I,Mousavidoust S,Mobasheri H

    更新日期:2013-05-01 00:00:00

  • Risk factor profile in patients with stroke at a young age.

    abstract::Background The distribution of risk factors for stroke is related to gender and age. The main objective of study was to determine the type and frequency of stroke risk factors in patients with first-in-life stroke before the age of 50. Methods Our study included patients under the age of 50 with first-in-life stroke. ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1455367

    authors: Lasek-Bal A,Kopyta I,Warsz-Wianecka A,Puz P,Łabuz-Roszak B,Zaręba K

    更新日期:2018-07-01 00:00:00

  • The changes of systemic immune responses during the neuroprotection induced by remote ischemic postconditioning against focal cerebral ischemia in mice.

    abstract::Objective: Remote limb ischemic postconditioning (RIPostC) protects the brain from damage induced by transient focal ischemia/reperfusion. However, the underlying mechanism remains unclear. Methods: RIPostC induced by 10 min of occlusion and another 10 min releasing of blood flow for three cycles in the hind limbs was...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1523037

    authors: Liu C,Yang J,Zhang C,Geng X,Zhao H

    更新日期:2019-01-01 00:00:00

  • Blood-brain barrier restoration following cold injury.

    abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1980.11739556

    authors: Pollay M,Stevens FA

    更新日期:1980-01-01 00:00:00

  • Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle.

    abstract:OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164108X323717

    authors: Oishi A,Tobimatsu S,Ogata K,Taniwaki T,Kinukawa N,Toyoshiba H,Kira J

    更新日期:2008-12-01 00:00:00