An ultrastructural study on the reactive oligodendrocytes, myeloclasts, and myelophages in transected dog spinal cord.

Abstract:

:As early as 1 to 3 hr after cord transection, proliferation of many reactive oligodendrocytes was observed. Bundles of microfilaments and microtubules were observed in those cells that sent out long, complex pseudopodlike processes near the area of injury. These reactive oligodendrocytes may be comparable to Vaughn's multipotential glia cells. Between 1 day and 1 wk, hypertrophy of the oligodendrocytes was observed. These hypertrophied oligodendrocytes also became hyperactive and infiltrated into the axons within the myelin sheath. These infiltrating hyperactive oligodendrocytes had a scanty fibrillary cytoplasm and are believed to correspond to Jakob's "myeloclasts". The infiltration of macrophages into the nerve fibers and myelin sheaths was also observed. These macrophages were found to be very active in phagocytosis and removal of degenerated debris within the nerve fiber and are believed to represent the "myelophages" described by Jakob in 1913.

journal_name

Neurol Res

journal_title

Neurological research

authors

Chang LW,Kao CC

doi

10.1080/01616412.1980.11739566

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

349-67

issue

4

eissn

0161-6412

issn

1743-1328

journal_volume

1

pub_type

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