Diffusion tensor tractography to visualize axonal outgrowth and regeneration in a 4-cm reverse autograft sciatic nerve rabbit injury model.

Abstract:

BACKGROUND:Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical technique. METHODS:Transection injury of unilateral sciatic nerve (4 cm long) was performed in 25 rabbits and repaired using a RA surgical technique. Analysis of the nerve autograft was performed at 3, 6, and 11 weeks postoperatively and compared to normal contralateral sciatic nerve, used as control group. High-resolution DTT from ex vivo sciatic nerves were obtained using 3D diffusion-weighted spin-echo acquisitions at 7-T. Total axons and motor and sensory axons were counted at defined lengths along the graft. RESULTS:At 11 weeks, histologically, the total axon count of the RA group was equivalent to the contralateral uninjured nerve control group. Similarly, by qualitative DTT visualization, the 11-week RA group showed increased fiber tracts compared to the 3 and 6 weeks counterparts. Upon immunohistochemical evaluation, 11-week motor axon counts did not significantly differ between RA and control; but significantly decreased sensory axon counts remained. Nerves explanted at 3 weeks and 6 weeks showed decreased motor and sensory axon counts. DISCUSSION:7-T DTT is an effective imaging modality that may be used qualitatively to visualize axonal outgrowth and regeneration. This has implications for the development of technology that non-invasively monitors peripheral nerve regeneration in a variety of clinical settings.

journal_name

Neurol Res

journal_title

Neurological research

authors

Farinas AF,Pollins AC,Stephanides M,O'Neill D,Al-Kassis S,Esteve IVM,Colazo JM,Keller PR,Rankin T,Wormer BA,Kaoutzanis C,Dortch RD,Thayer WP

doi

10.1080/01616412.2018.1554284

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

257-264

issue

3

eissn

0161-6412

issn

1743-1328

journal_volume

41

pub_type

杂志文章
  • Is fusion the most suitable treatment option for recurrent lumbar disc herniation? A systematic review.

    abstract:OBJECTIVE:Recurrent lumbar disc herniation (rLDH) is a common issue after primary discectomy and can cause severe pain, morbidity, and reoperation. The purpose of this systematic review was to evaluate the surgical management of recurrent lumbar disc herniation. METHODS:A systematic literature search was conducted usi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1787661

    authors: Arif S,Brady Z,Enchev Y,Peev N

    更新日期:2020-12-01 00:00:00

  • An efficient method for fractionated whole rodent brain radiation.

    abstract:OBJECTIVE:In order to test for mechanisms of whole brain radio therapy side effects and possible neuroprotective measures, a rodent model is desirable. In many models, a high single dose of 8-20 Gray (Gy) of whole brain irradiation is used. These experimental radiation protocols do not closely reflect the clinical situ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000143

    authors: Semmler A,Garbe S,Moskau S,Frisch C,Eter N,Schlegel U,Linnebank M

    更新日期:2013-05-01 00:00:00

  • Callosotomy for generalized seizures associated with hypothalamic hamartoma.

    abstract::A case is reported of intractable epilepsy associated with a hypothalamic hamartoma in an 18 year old man. The patient underwent a two-third anterior callsotomy and, subsequently, removal of the hamartoma. Callosotomy did not affect the generalized seizure pattern. The authors believe this to be the first documented c...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740125

    authors: Pallini R,Bozzini V,Colicchio G,Lauretti L,Scerrati M,Rossi GF

    更新日期:1993-04-01 00:00:00

  • Needle-free acupuncture benefits both patients and clinicians.

    abstract:OBJECTIVE:This study examined whether a needle-free acupuncture can be an alternative to conventional needle injection acupuncture. METHODS:Patients (n=101) suffering myofascial shoulder pain were randomly assigned to either needle-free or conventional needle injection acupuncture group. Bee venom was administered int...

    journal_title:Neurological research

    pub_type: 杂志文章,随机对照试验

    doi:10.1179/016164109X12537002793760

    authors: An K,Kim YS,Kim HY,Lee H,Hahm DH,Lee KS,Kang SK

    更新日期:2010-02-01 00:00:00

  • Cerebrospinal fluid flow through an implanted shunt.

    abstract::Although the circulation of cerebrospinal fluid enjoys an apparent simplicity, its underlying basis is amazingly complex. Many factors influence how CSF flows through the human central nervous system. In the presence of hydrocephalus and subsequent shunt placement, this system is further complicated. The challenge bef...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.2000.11741037

    authors: Magram G,Liakos AM

    更新日期:2000-01-01 00:00:00

  • Sonographic and electrophysiological detection in patients with carpal tunnel syndrome.

    abstract:OBJECTIVES:To assess prospectively the significance of sonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome (CTS), to look for proper parameters and cutoff values for the sonographic diagnosis, and to correlate with the electrophysiological findings. MATERIALS AND METHODS:This study ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132811Y.0000000028

    authors: Guan J,Ji F,Chen W,Chu H,Lu Z

    更新日期:2011-11-01 00:00:00

  • Atrial fibrillation as an important clinical condition of cognitive decline; diagnosis, comorbidities and severity of symptoms in patients with dementia.

    abstract::Objective: To determine the time of dementia diagnosis, symptom intensity and to assess the comorbidities.Methods: 110 patients with dementia or mild cognitive impairment were enrolled in this retrospective study. The study group was divided into subgroups: patients with a maximum of three (S ≤ 3 n = 62) and four or m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1738648

    authors: Niedziela N,Nowak MM,Lis M,Blaszkowska M,Kośmider R,Adamczyk-Sowa M

    更新日期:2020-05-01 00:00:00

  • Sphenoorbital meningiomas: surgical management and outcome.

    abstract:OBJECTIVE:Surgical management of sphenoorbital meningiomas ranges among the most complex of intracranial tumors. We report on our experience of surgical technique, outcome, and tumor recurrence in sphenoorbital meningiomas. METHODS:Between 2003 and 2013, surgical resections for sphenoorbital meningioma were performed ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000329

    authors: Forster MT,Daneshvar K,Senft C,Seifert V,Marquardt G

    更新日期:2014-08-01 00:00:00

  • Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow.

    abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1457130

    authors: Tsutsui S,Nanba T,Yoshioka Y,Sasaki M,Fujiwara S,Kobayashi M,Yoshida K,Miyoshi K,Sato S,Ogasawara K

    更新日期:2018-08-01 00:00:00

  • Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model.

    abstract::Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP.Methods: A total of 36 male Sprague-Dawley rats were divi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1685064

    authors: Shen M,Zheng Y,Zhu K,Cai Z,Liu W,Sun X,Liu J,Zhu D

    更新日期:2020-01-01 00:00:00

  • Exercise pre-conditioning reduces brain inflammation in stroke via tumor necrosis factor-alpha, extracellular signal-regulated kinase 1/2 and matrix metalloproteinase-9 activity.

    abstract:OBJECTIVE:We sought to determine whether cerebral inflammation in ischemic rats was reduced by a neuroprotective action of pre-ischemic tumor necrosis factor-alpha up-regulation, which down-regulated matrix metalloproteinase-9 activity via extracellular signal-regulated kinase 1/2 phosphorylation. MATERIAL AND METHODS...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X459101

    authors: Curry A,Guo M,Patel R,Liebelt B,Sprague S,Lai Q,Zwagerman N,Cao FX,Jimenez D,Ding Y

    更新日期:2010-09-01 00:00:00

  • Assessment of anti-amyloidogenic activity of marine red alga G. acerosa against Alzheimer's beta-amyloid peptide 25-35.

    abstract:OBJECTIVE:The amyloid hypothesis stimulates the discovery of compounds, which promotes beta-amyloid peptide (Aβ) clearance, thereby altering the underlying pathophysiology of Alzheimer's disease (AD). Hence, the present study aims at the evaluation of anti-amyloidogenic potential of Gelidiella acerosa. METHODS:Prevent...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000422

    authors: Syad AN,Devi KP

    更新日期:2015-01-01 00:00:00

  • Strategy for the treatment of inaccessible unruptured giant and large aneurysms of the internal carotid artery.

    abstract::Our goal was to clarify the optimum management of the inaccessible unruptured giant and large aneurysms of the internal carotid artery (ICA). Since 1981, we have treated 18 patients with unclippable unruptured giant or large aneurysms of the ICA. Aneurysms were classified as either intracavernous or intradural. We per...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164101101198604

    authors: Kaminogo M,Kitagawa N,Takahata H,Matsuo Y,Hayashi K,Yoshioka T,Shibata S

    更新日期:2001-06-01 00:00:00

  • Regional cerebral blood flow (rCBF) pattern analysis corresponds with albumin extravasation in experimental cerebral ischaemia.

    abstract::The possibility of the evaluation of ischemia solely by the momentary values of regional cerebral blood flow (rCBF) was investigated. Ischaemic damage was evaluated histopathologically and by observing albumin extravasation. Unilateral carotid clippings were performed for 1 h and the gerbils evaluated with regard to t...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1988.11739846

    authors: Kadota E

    更新日期:1988-12-01 00:00:00

  • Thrombin up-regulates vascular endothelial growth factor in experimental gliomas.

    abstract:OBJECTIVE:Vascular endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production. The present study examined if thrombin modulates vascular endoth...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X385699

    authors: Xu Y,Gu Y,Keep RF,Heth J,Muraszko KM,Xi G,Hua Y

    更新日期:2009-09-01 00:00:00

  • A proposed ethical framework for interventional cognitive neuroscience: a consideration of deep brain stimulation in impaired consciousness.

    abstract::Advances in neuromodulation techniques offer the promise of new therapeutic interventions for patients with neuropsychiatric maladies. Several complex social, ethical and policy issues will attend developments in this area. In this paper an ethical framework for clinical research in interventional cognitive neuroscien...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.2000.11740670

    authors: Fins JJ

    更新日期:2000-04-01 00:00:00

  • The role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral gliomas.

    abstract:OBJECTIVE:To study histopathologic changes and the role of the microglia/macrophage cell in the therapeutic effect of I-125 interstitial brachytherapy on the cerebral gliomas. METHODS:Out of a series of 60 cases with cerebral astrocytomas and other brain tumors treated with I-125 interstitial brachytherapy, autopsy ma...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1179/016164107X158875

    authors: Julow J,Szeifert GT,Bálint K,Nyáry I,Nemes Z

    更新日期:2007-04-01 00:00:00

  • Endothelin receptors A and B are expressed in distinct cellular compartments of rat hippocampus following global ischemia: an immunocytochemical study.

    abstract:OBJECTIVES:The syntheses of endothelin receptors A and B were previously shown to be upregulated in rat dorsal hippocampus after traumatic brain injury. Here we characterize endothelin receptor A and endothelin receptor B cellular distribution in hippocampus after permanent global brain ischemia and their possible asso...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164111X12881719352291

    authors: Kreipke CW,Reynolds CA,Schafer PC,Schafer S,Pirooz R,Rafols JA

    更新日期:2011-03-01 00:00:00

  • Central and peripheral dopamine transporter reduction in Parkinson's disease.

    abstract:OBJECTIVE:Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patient...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X383259

    authors: Buttarelli FR,Capriotti G,Pellicano C,Prosperi D,Circella A,Festa A,Giovannelli M,Tofani A,Pontieri FE,Scopinaro F

    更新日期:2009-09-01 00:00:00

  • Serum complement factor H and Tyr402 His gene polymorphism among Egyptians with multiple sclerosis.

    abstract:BACKGROUND AND OBJECTIVES:Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. A contribution from complement has long been suspected. We investigated the association of complement factor H (CFH) Tyr402 His gene polymorphism and serum level in Egyptian patients with MS to examine whet...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132815Y.0000000075

    authors: Abdel Rasol HA,Helmy H,Aziz MA

    更新日期:2015-10-01 00:00:00

  • Regional cerebral blood flow, diaschisis, and steal after stroke.

    abstract::Regional CBF was measured by 133Xe inhalation in unilateral cerebral infarction, carotid TIAs, and normal volunteers. Regional CBF values were bilaterally and symmetrically reduced in patients measured within 3 weeks after stroke. Later, rCBF values returned toward normal in the contralateral hemisphere of patients wi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1979.11739545

    authors: Meyer JS,Naritomi H,Sakai F,Ishihara N,Grant P

    更新日期:1979-01-01 00:00:00

  • Cerebral density and perfusion measured among heart disease patients with and without stroke.

    abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:

    authors: Obara K,Meyer JS,Muramatsu K,Mortel KF

    更新日期:1995-10-01 00:00:00

  • P300 as an index of implicit self-esteem.

    abstract::OBJECTIVE: To explore the neural substrates of implicit self-esteem in university students. METHODS: The subjects comprised four females and six males (aged 20-25 years). They were asked to finish the implicit association test (IAT) for implicit self-esteem while brain electrical activity was recorded at 64 scalp site...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X431138

    authors: Yang J,Zhang Q

    更新日期:2009-07-08 00:00:00

  • Relationship between the states of spinal impact injuries and magnetically evoked EMGs in rats.

    abstract::The relationship between the states of spinal impact injuries and magnetically evoked electromyograms (EMGs) were studied in rats. Impact injuries to the spinal cord were induced at a depth of 0.25-2.0 mm by insertion of a cylinder tip measuring 2 mm in diameter into the lumbar vertebrae L1-L2. Magnetically induced el...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2000.11740747

    authors: Chiba A,Hiruma S,Hashimoto S,Inase M

    更新日期:2000-10-01 00:00:00

  • New device to treat chronic subdural hematoma--hollow screw.

    abstract::Different surgical approaches exist for the treatment of chronic subdural hematoma. None of these approaches is superior to the other, so a minimal-invasive device (a hollow screw) was developed. The system consists of a stable hollow screw of surgical steel with a perforated tip, a hand-drill, screwdriver with guide,...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740897

    authors: Emonds N,Hassler WE

    更新日期:1999-01-01 00:00:00

  • Microsurgical anatomy of the suboccipital segment of the vertebral artery.

    abstract::The craniocervical regions of seven cadavers (14 sides) injected with silicone rubber were dissected under a Zeiss OPMI surgical microscope. The present study provides a detailed description of the suboccipital segment of the vertebral artery, with particular attention to its loops, branches, supporting osteofibrous s...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740507

    authors: Castillo C,Viñas FC,Gutikhonda M,Diaz FG

    更新日期:1998-04-01 00:00:00

  • Albumin ameliorates tissue plasminogen activator-mediated blood-brain barrier permeability and ischemic brain injury in rats.

    abstract:OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METH...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X393898

    authors: Tang J,Li YJ,Mu J,Li Q,Yang DY,Xie P

    更新日期:2009-03-01 00:00:00

  • Rebleeding of intracranial dissecting aneurysm in the vertebral artery following proximal clipping.

    abstract::We describe a case of rebleeding from an intracranial vertebral dissecting aneurysm following proximal clipping. This case suggests that proximal clipping alone may not be an adequate surgical procedure to prevent rebleeding. Surgical treatment of intracranial dissecting aneurysms in the vertebral artery presenting as...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.1994.11740213

    authors: Kawamata T,Tanikawa T,Takeshita M,Onda H,Takakura K,Toyoda C

    更新日期:1994-04-01 00:00:00

  • Combination therapy with U74006F (tirilazad mesylate), MK-801, insulin and diazepam in transient forebrain ischaemia.

    abstract::The mechanism of cerebral ischaemic injury is complex and likely involves more than a single pathophysiologic event. Drugs are available which interfere with numerous harmful biochemical and pharmacologic processes begun by ischaemia. Hence, combination chemotherapy might be useful in cerebral ischaemia. The purpose o...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1995.11740301

    authors: Auer RN

    更新日期:1995-04-01 00:00:00

  • Stent, balloon-assisted coiling and double microcatheter for treating wide-neck aneurysms in anterior cerebral circulation.

    abstract:OBJECTIVE:To investigate the clinical application of adjuvant coiling techniques in treating anterior-circulation wide-necked aneurysms. METHODS:Over 4·5 years, 93 anterior-circulation wide-neck aneurysms in 81 patients were treated with different endovascular techniques: balloon-assisted, stent-assisted, and double-m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000234

    authors: Pan J,Xiao F,Szeder V,Yan M,Fan W,Gu J,He L,Zhan R

    更新日期:2013-12-01 00:00:00