Abstract:
:It is being increasingly suggested that the microcirculation, which is known to be in a large part responsible for maintaining an adequate and constant microenvironment for function of the central nervous system, functions as part of a neurovascular unit. The neurovascular unit includes neurons, astrocytes and elements of capillaries. The cerebral circulation exhibits unique functional characteristics and critical elements for the pathogenesis of cerebrovascular disease. For example, the blood-brain barrier formed by epithelial-like high resistance tight junctions within the endothelium is a key feature of microvessels of the central nervous system. Alterations in the microcirculation after ischemia/reperfusion include disruption of the blood-brain barrier, edema and swelling of perivascular astrocyte foot processes, decrease in arteriole endothelium-dependent relaxation and reduced inwardly-rectifying potassium channel function, altered expression of proteases and matrix metalloproteinases, increased inflammatory mediators and inflammation. Experiments studying the microcirculation in ischemia are few compared with those examining neuroprotection, although the two overlap because protection of the microcirculation might achieve some degree of neuroprotection and both processes may be mediated by at least some mechanisms in common.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Takahashi M,Macdonald RLdoi
10.1179/016164104X3815subject
Has Abstractpub_date
2004-12-01 00:00:00pages
862-9issue
8eissn
0161-6412issn
1743-1328journal_volume
26pub_type
杂志文章,评审abstract:OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X323717
更新日期:2008-12-01 00:00:00
abstract:: Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1853988
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:This review article summarizes in vitro, in vivo, and clinical evidence pertaining to temozolomide (TMZ) and bevacizumab (BEV) efficacy and mechanism of action in gliomas. METHODS:Relevant publications published before June 2013 in PubMed database were reviewed. RESULTS:Temozolomide and BEV are current chem...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132814Y.0000000423
更新日期:2015-02-01 00:00:00
abstract::The relationship between the states of spinal impact injuries and magnetically evoked electromyograms (EMGs) were studied in rats. Impact injuries to the spinal cord were induced at a depth of 0.25-2.0 mm by insertion of a cylinder tip measuring 2 mm in diameter into the lumbar vertebrae L1-L2. Magnetically induced el...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740747
更新日期:2000-10-01 00:00:00
abstract::The present study aimed to examine the effects of N omega-nitro-L-arginine (LNA) on the early ischemic neuronal damage (EIND). All the experiments were carried out under general anesthesia, maintaining the blood gases and the body temperature within the physiological ranges. The local CBF, the topographically correspo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740795
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVES:Progesterone modulates dopamine (DA) release in corpus striatum. Our objective was to evaluate the effect of the i.c.v injection of the neurosteroid allopregnanolone (ALL), a progesterone metabolite on dopaminergic activity in the corpus striatum of rats under different gonadal hormonal conditions. METHODS:...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X166281
更新日期:2007-09-01 00:00:00
abstract::According to recent reports, malnutrition may be associated with a worse prognosis in stroke patients. The aim of this study was to determine the nutritional status of stroke patients and its impact on neurological and functional status of patients in the early post-stroke period. Our prospective study included a tota...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1672379
更新日期:2020-01-01 00:00:00
abstract::The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and environmental factors play important roles in its pathogenesis. While demyelination of axons is a hallmark histological feature of MS, axonal and neuronal dysfunction may correlate better with clinical disability. All major immune cell ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X98125
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172167
更新日期:2007-09-01 00:00:00
abstract::We performed proton magnetic resonance spectroscopy (1H-MRS) in three patients with amyotrophic lateral sclerosis (ALS) to evaluate the distribution and extent of cortical neuronal damage as demonstrated by decreased N-acetyl-aspartate (NAA) levels. We examined primary motor (precentral gyrus) and parietal neocortical...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740412
更新日期:1996-06-01 00:00:00
abstract:INTRODUCTION:Alteration of sensorium or an encephalopathy is a common diagnostic dilemma in critically ill patients and can be caused by a number of conditions. Sepsis associated encephalopathy (SAE) is now the most common encephalopathy encountered among intensive care unit (ICU) patients. DEFINITIONS:SAE is an encep...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164107X240233
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:Transient ischemic attack (TIA) with carotid artery disease (CAD) can increase the risk of cognitive decline. However, the neural mechanisms of the disorder remain unclear. The aim of this study was, using diffusion tensor imaging (DTI), to detect microstructural changes in patients with symptomatic CAD pres...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000255
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Our objective was to characterize the heat shock response (HSR) in a model of traumatic brain injury (TBI) and to determine the association of HSR to cell death. METHODS:We used immunofluorescent detection of HSP-70 to characterize HSR and TUNEL labeling to determine the pattern of cell death. RESULTS:HSP-...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X204666
更新日期:2007-06-01 00:00:00
abstract::Brain tumours were induced by intracerebral inoculation of beagle puppies with Avian sarcoma virus (ASV) suspension. The inoculation produced solitary or multiple sarcomas in three dogs and intraventricular anaplastic gliomas in four dogs. At the time of the first tumour positive CT-control Iodine-125 seeds (activity ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1984.11739685
更新日期:1984-12-01 00:00:00
abstract::Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199162
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12700393823651
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of calcification surrounding the odontoid process (odontoid calcification) with crowned dens syndrome (CDS) and without CDS (non-CDS) and investigate factors that may related to the onset of CDS. METHODS:Retrospective review of consecutive patients visited Sir Run Run Shaw Hospital ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1792700
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X191021
更新日期:2007-09-01 00:00:00
abstract::The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739995
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to evaluate whether resveratrol (RSV) modulates membrane lipid composition, as well as on ganglioside profile in ischemia/reperfusion injury. METHODS:Global cerebral ischemia was induced by four-vessel occlusion for 10 minutes. RSV (30 mg/kg) or vehicle was intraperitoneally...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000116
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Late-onset Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder. Associations of the glutathione S-transferases (GSTs) polymorphisms with the risk factors for AD have not been definitely confirmed. We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1390902
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of etomidate, ketamine, phenytoin, and phenytoin/midazolam in a mouse model of acute cocaine toxicity. METHODS:We performed a randomized controlled study consisting of five groups (n = 25 each) of rats that received intraperitoneal injections of normal saline solution, 5 mg/kg ketamin...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000097
更新日期:2012-12-01 00:00:00
abstract::Precocious puberty and amenorrhea have been associated with hydrocephalus, but the pathogenesis has not been determined. Approximately 22 cases of amenorrhea, and a few cases of precocious puberty, have been reported in hydrocephalic patients. Shunt treatment leads to initiation and maintenance of normal reproductive ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2000.11741047
更新日期:2000-01-01 00:00:00
abstract::Endovascular reconstruction of basilar artery (BA) apex aneurysms has been augmented by adjunctive techniques such as balloon and stent assistance. We present three cases of a wide-necked BA apex aneurysm involving the bilateral P1 segments of both posterior cerebral arteries (PCAs) treated by placement of BA to PCA s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225013969
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1564188
更新日期:2019-04-01 00:00:00
abstract::This paper describes a previously unreported clinical onset of carcinomatous meningitis with bilateral deafness. Typical changes in the cerebrospinal fluid aside from positive cytology findings are reviewed. In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased gluc...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200708
更新日期:2002-10-01 00:00:00
abstract::Background Transtemporal Doppler (TTD) with middle cerebral artery (MCA) is widely used for right-to-left shunt (RLS) detection. However, an alternative method for patients without suitable temporal bone windows should be established. The present study prospectively evaluated the effectiveness of transorbital Doppler ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1428276
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X338043
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:It has been suggested that metalloproteinase-9 (MMP-9) could predict the onset of cerebral vasospasm after subarachnoidal haemorrhage (SAH). The aim of this study was to analyse, in patients with SAH, the difference between patients with MRI ischaemic infarcts and patients without, and to investigate the rol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000045
更新日期:2015-08-01 00:00:00
abstract::The objective of this study was to improve the ability to detect cerebrovascular complications in patients undergoing complicated neurosurgical procedures using on-line monitoring of cerebral pH with in vivo microdialysis. We employed on-line pH monitoring in patients with a variety of neurosurgical procedures includi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740497
更新日期:1998-03-01 00:00:00