A brief review of the effects of chronic hydrocephalus on the gonadotropin releasing hormone system: implications for amenorrhea and precocious puberty.

Abstract:

:Precocious puberty and amenorrhea have been associated with hydrocephalus, but the pathogenesis has not been determined. Approximately 22 cases of amenorrhea, and a few cases of precocious puberty, have been reported in hydrocephalic patients. Shunt treatment leads to initiation and maintenance of normal reproductive cycles in most cases. An underlying mechanism responsible for reproductive dysfunction may involve the role of gonadotrophin releasing hormone (GnRH). The exact pathway by which hydrocephalus disrupts the hypothalamic GnRH system is unknown. However, compressive forces, ischemia, and impairment of neurotransmitter feedback loops are likely candidates.

journal_name

Neurol Res

journal_title

Neurological research

authors

Abdolvahabi RM,Mitchell JA,Diaz FG,McAllister JP 2nd

doi

10.1080/01616412.2000.11741047

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

123-6

issue

1

eissn

0161-6412

issn

1743-1328

journal_volume

22

pub_type

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