Abstract:
:The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is needed regarding aneurysm rupture and its deleterious effects. This study presents a physiologically-feasible explanation for the development of an enormous haemodynamic stress in the vicinity of the aneurysm in the cerebrovascular bed. Using a computer circulation model, this build-up of pressure was developed by sequentially imposing a series of interventions on the normal system.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Duros J,Clark ME,Kufahl RH,Nadvornik Pdoi
10.1080/01616412.1991.11739995subject
Has Abstractpub_date
1991-12-01 00:00:00pages
217-23issue
4eissn
0161-6412issn
1743-1328journal_volume
13pub_type
杂志文章abstract::We examined the effect of local anaesthesia of the skin on somatosensory evoked potentials (SEPs) and psychophysical magnitude estimates for a constant intensity air-puff stimulation (7 kg.cm-2) in 23 normal subjects. Before and after intradermal injection (0.1 ml of 1% xylocain) to the tip of the right index finger, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740283
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12761752770177
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:4-N-trimethylammonium-3-hydroxybutyric acid (L-carnitine) is an endogenous mitochondrial membrane compound and some studies have reported that L-carnitine could effectively protect various cells against oxidative injury both in vitro and in vivo. In the present study, we used the human neuroblastoma SH-SY5Y ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132810Y.0000000028
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To establish a detailed technical procedure for studying the anatomical correlates of chronic cerebrospinal venous insufficiency in cadavers of multiple sclerosis and control subjects, and to present our findings of the normal anatomic venous structures, with reference to previous descriptions from the liter...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000071
更新日期:2012-10-01 00:00:00
abstract::Objectives: Brain arteriovenous malformations (AVMs) represent high-flow vascular lesions made up of a complex network of feeding arteries and draining veins interposed by a nidus and without a capillary bed. The management of the AVMs represents a challenge, and the optimal treatment should be considered based on the...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1803604
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:To describe the role of neurosurgical techniques in treatment of symptoms of multiple sclerosis (MS). METHODS:A review of the existing world literature searching (using PubMed, August 22, 2005) for key words 'multiple sclerosis' and multiple symptoms associated with MS including trigeminal neuralgia, pain (...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X98224
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132813Y.0000000166
更新日期:2013-04-01 00:00:00
abstract::Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201580
更新日期:2003-06-01 00:00:00
abstract::According to recent reports, malnutrition may be associated with a worse prognosis in stroke patients. The aim of this study was to determine the nutritional status of stroke patients and its impact on neurological and functional status of patients in the early post-stroke period. Our prospective study included a tota...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1672379
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172167
更新日期:2007-09-01 00:00:00
abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740159
更新日期:1993-10-01 00:00:00
abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740394
更新日期:1996-04-01 00:00:00
abstract::Excessive entry of Ca2+ into injured cochlear neurons activates various Ca(2+)-activated enzymes and subsequent spiral ganglion cell death. Therefore, preventing intracellular calcium overload by using Ca2+ channel antagonists may become an important countermeasure to spiral ganglion cell death. We experimentally inve...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200889
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:Intravenous administration of recombinant tissue plasminogen activator (rtPA) is known as the only approved treatment for acute ischemic stroke. However, it is still controversial whether acute ischemic stroke patients with atrial fibrillation should receive rtPA therapy. METHODS:We studied 99 patients altog...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12656393665206
更新日期:2010-05-01 00:00:00
abstract::Background Transtemporal Doppler (TTD) with middle cerebral artery (MCA) is widely used for right-to-left shunt (RLS) detection. However, an alternative method for patients without suitable temporal bone windows should be established. The present study prospectively evaluated the effectiveness of transorbital Doppler ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1428276
更新日期:2018-03-01 00:00:00
abstract::We elected to compare the clinical outcomes of carotid endarterectomy (CEA) patients who were thought to be at increased risk for peri-operative complications because of advanced age (> 79 years), medical comorbidities and contralateral internal carotid artery occlusion to patients without these risk factors. A prospe...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101199936
更新日期:2002-01-01 00:00:00
abstract::Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739882
更新日期:1989-09-01 00:00:00
abstract::OBJECTIVE: To explore the neural substrates of implicit self-esteem in university students. METHODS: The subjects comprised four females and six males (aged 20-25 years). They were asked to finish the implicit association test (IAT) for implicit self-esteem while brain electrical activity was recorded at 64 scalp site...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X431138
更新日期:2009-07-08 00:00:00
abstract:OBJECTIVES:To find new biomarkers by stimulating acupuncture point GB34 (Yangneungcheon) which has neuroprotective effect on the mouse model of Parkinson's disease, analysis of cDNA microarray on mRNAs of the substantia nigra was performed. METHODS:Male C57BL/6 mice were divided into two groups: 1-methyl-4-phenyl-1,2,...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12537002794165
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:Brain death is a clinical diagnosis often confirmed with supplementary tests. In this study, we examined the relationship between brain death and the partial pressure of brain tissue oxygen (PbtO(2)). We hypothesized that a sustained PbtO(2) of 0 is associated with brain death. METHODS:One hundred and twent...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X208121
更新日期:2007-10-01 00:00:00
abstract::Corticotrophin releasing factor has been shown in several models of tissue injury to be an effective treatment for edema. In a previous study we demonstrated this ability in two models of traumatic brain injury (TBI). The aim of this study was to assess whether human corticotrophin releasing factor (hCRF) could additi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740737
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164109X12445505689607
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:Cerebral hyperperfusion syndrome (HPS) is a potential complication of extracranial-intracranial (EC-IC) bypass for moyamoya disease; however, the pathological threshold of the early cerebral blood flow (CBF) increases after EC-IC bypass has yet to be determined. The purpose of this study is to evaluate the pr...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000432
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12700393823651
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:To review the historical development and current status of endovascular techniques used in the treatment of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. METHODS:This article summarizes the relevant literature on neurointerventional therapy for vasospasm, namely instillation of intraar...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X152043
更新日期:2006-10-01 00:00:00
abstract::Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 1...
journal_title:Neurological research
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::Background The distribution of risk factors for stroke is related to gender and age. The main objective of study was to determine the type and frequency of stroke risk factors in patients with first-in-life stroke before the age of 50. Methods Our study included patients under the age of 50 with first-in-life stroke. ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1455367
更新日期:2018-07-01 00:00:00
abstract::Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimu...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103771953862
更新日期:2003-12-01 00:00:00
abstract::We currently have used three drugs in combination [mannitol, vitamin E and glucocorticoid (beta-methasone)] for the treatment of cerebral infarction in the acute stage. For the purpose of evaluating the efficacy of this therapy, we have conducted experiments evaluated by chemiluminescence (CL), energy metabolism and w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739819
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVES:To assess whether a weaning protocol reduces the mechanical ventilation (MV) duration compared to physician's judgement-based weaning in neurological patients and to determine whether patient consciousness influences this reduction. METHODS:A randomised controlled trial was conducted in a neurological inten...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/1743132815Y.0000000092
更新日期:2015-11-01 00:00:00