Abstract:
: Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age 28.4 ± 9.3 years; 28 female/33 male) with unilateral signs of HS (TLE-HS+) and 25 TLE patients (mean age 29.8 ± 8.0 years; 17 female/8 male) without HS (TLE-HS-) were included. Thirty healthy volunteers served as controls (mean age 26.0 ± 8.7 years; 22 female/8 male). Brain segmentation and volume calculation were performed. Quantitative cerebral blood flow (CBF) values were measured based on arterial spin labeling (ASL). The asymmetry indices (AIs) of volume and perfusion were calculated. Results : TLE-HS+ (adjusted P = 0.001) and TLE-HS- patients (adjusted P = 0.006) had significantly higher hippocampal perfusion AIs than controls. TLE-HS+ and TLE-HS- had similar hippocampal perfusion AIs (adjusted P = 1.00). TLE-HS+ had higher hippocampal volume AIs than TLE-HS- and controls (adjusted P < 0.001). TLE-HS- and controls had similar hippocampal volume AIs (adjusted P = 1.00). All (100%) TLE-HS+ patients had positive hippocampal perfusion or volume AIs. No significant correlation between the AIs of hippocampal perfusion and volume was found in both TLE-HS+(P = 0.894) and TLE-HS- (P = 0.106) patients. TLE-HS+ patients demonstrated more extensive whole-brain asymmetry of both perfusion and volume than TLE-HS- patients. Conclusion : TLE-HS+ and TLE-HS- patients have different patterns of whole-brain perfusion and volume asymmetry. Hippocampal perfusion asymmetry was revealed in both TLE-HS+ and TLE-HS- patients.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Zhang Y,Dou W,Zuo Z,You H,Lv Y,Hou B,Shi L,Feng Fdoi
10.1080/01616412.2020.1853988subject
Has Abstractpub_date
2020-12-15 00:00:00pages
1-8eissn
0161-6412issn
1743-1328pub_type
杂志文章abstract::Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X25225
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journal_title:Neurological research
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doi:10.1080/01616412.1988.11739810
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abstract::Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga ('Yoga-plus') among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ± 8.7 years old) participated in a 12-month (M) exercise ...
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journal_title:Neurological research
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doi:10.1080/01616412.1996.11740394
更新日期:1996-04-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740301
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000152
更新日期:2013-03-01 00:00:00
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更新日期:2002-12-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740481
更新日期:1998-01-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740765
更新日期:1997-02-01 00:00:00
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更新日期:2002-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000445
更新日期:2015-03-01 00:00:00
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doi:10.1179/1743132814Y.0000000373
更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1179/174313208X289589
更新日期:2008-09-01 00:00:00
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00
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更新日期:2010-11-01 00:00:00
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journal_title:Neurological research
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doi:10.1080/01616412.1999.11740920
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journal_title:Neurological research
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doi:10.1080/01616412.1991.11739995
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pub_type: 杂志文章
doi:10.1080/01616412.1996.11740370
更新日期:1996-02-01 00:00:00