Brain volume and perfusion asymmetry in temporal lobe epilepsy with and without hippocampal sclerosis.

Abstract:

: Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age 28.4 ± 9.3 years; 28 female/33 male) with unilateral signs of HS (TLE-HS+) and 25 TLE patients (mean age 29.8 ± 8.0 years; 17 female/8 male) without HS (TLE-HS-) were included. Thirty healthy volunteers served as controls (mean age 26.0 ± 8.7 years; 22 female/8 male). Brain segmentation and volume calculation were performed. Quantitative cerebral blood flow (CBF) values were measured based on arterial spin labeling (ASL). The asymmetry indices (AIs) of volume and perfusion were calculated. Results : TLE-HS+ (adjusted P = 0.001) and TLE-HS- patients (adjusted P = 0.006) had significantly higher hippocampal perfusion AIs than controls. TLE-HS+ and TLE-HS- had similar hippocampal perfusion AIs (adjusted P = 1.00). TLE-HS+ had higher hippocampal volume AIs than TLE-HS- and controls (adjusted P < 0.001). TLE-HS- and controls had similar hippocampal volume AIs (adjusted P = 1.00). All (100%) TLE-HS+ patients had positive hippocampal perfusion or volume AIs. No significant correlation between the AIs of hippocampal perfusion and volume was found in both TLE-HS+(P = 0.894) and TLE-HS- (P = 0.106) patients. TLE-HS+ patients demonstrated more extensive whole-brain asymmetry of both perfusion and volume than TLE-HS- patients. Conclusion : TLE-HS+ and TLE-HS- patients have different patterns of whole-brain perfusion and volume asymmetry. Hippocampal perfusion asymmetry was revealed in both TLE-HS+ and TLE-HS- patients.

journal_name

Neurol Res

journal_title

Neurological research

authors

Zhang Y,Dou W,Zuo Z,You H,Lv Y,Hou B,Shi L,Feng F

doi

10.1080/01616412.2020.1853988

subject

Has Abstract

pub_date

2020-12-15 00:00:00

pages

1-8

eissn

0161-6412

issn

1743-1328

pub_type

杂志文章
  • New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies.

    abstract::Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164105X25225

    authors: Aronowski J,Hall CE

    更新日期:2005-04-01 00:00:00

  • Evidence-based medicine in metastatic spine disease.

    abstract::Treatment modalities for metastatic spine disease have significantly expanded over the last two decades. This expansion occurred in many different fields. Improvement in surgical techniques and instrumentation now allow the oncologic spine surgeons to effectively circumferentially decompress the neural elements withou...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000365

    authors: Dea N,Fisher CG

    更新日期:2014-06-01 00:00:00

  • The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma.

    abstract:OBJECTIVES:Recent preclinical studies suggest that treating glioblastoma (GBM) with a combination of targeted chemotherapy and radiotherapy may enhance the anti-tumor effects of both therapies. However, the effects of these treatments on glioma growth and progression are poorly understood. METHODS:In this study, we h...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000005

    authors: D'Amico R,Lei L,Kennedy BC,Sisti J,Ebiana V,Crisman C,Christensen JG,Gil O,Rosenfeld SS,Canoll P,Bruce JN

    更新日期:2012-04-01 00:00:00

  • Superior protective effects of phenytoin against hypoxia in a pharmacological screening test.

    abstract::The selection of drugs to prevent the development of pathology in cerebral infarction remains an important problem. For the selection of effective drugs from among a large number of possible candidates, widely-used test screening techniques are sufficient for obtaining a good understanding of candidate drug effects. T...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1988.11739810

    authors: Imaizumi S,Suzuki J,Kinouchi H,Yoshimoto T

    更新日期:1988-03-01 00:00:00

  • Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people.

    abstract::Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga ('Yoga-plus') among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ± 8.7 years old) participated in a 12-month (M) exercise ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1672380

    authors: Hishikawa N,Takahashi Y,Fukui Y,Tokuchi R,Furusawa J,Takemoto M,Sato K,Yamashita T,Ohta Y,Abe K

    更新日期:2019-11-01 00:00:00

  • Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging.

    abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1996.11740394

    authors: Lo EH,Rogowska J,Batchelder KF,Wolf GL

    更新日期:1996-04-01 00:00:00

  • Direct percutaneous carotid artery stenting with distal protection: technical case report.

    abstract::We describe the technique of percutaneous carotid artery stent placement with distal protection in a patient in whom marked innominate artery ectasia prevented transfemoral access to the right common carotid artery. After induction of general anesthesia, ultrasound was used to guide direct puncture of the common carot...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164104225013978

    authors: Perez-Arjona EA,DelProsto Z,Fessler RD

    更新日期:2004-04-01 00:00:00

  • Combination therapy with U74006F (tirilazad mesylate), MK-801, insulin and diazepam in transient forebrain ischaemia.

    abstract::The mechanism of cerebral ischaemic injury is complex and likely involves more than a single pathophysiologic event. Drugs are available which interfere with numerous harmful biochemical and pharmacologic processes begun by ischaemia. Hence, combination chemotherapy might be useful in cerebral ischaemia. The purpose o...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1995.11740301

    authors: Auer RN

    更新日期:1995-04-01 00:00:00

  • Comparative study among three different methods of bone marrow mesenchymal stem cell transplantation following cerebral infarction in rats.

    abstract::The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological sco...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000152

    authors: Ruan GP,Han YB,Wang TH,Xing ZG,Zhu XB,Yao X,Ruan GH,Wang JX,Pang RQ,Cai XM,He J,Zhao J,Pan XH

    更新日期:2013-03-01 00:00:00

  • Nimodipine ameliorates trauma-induced cochlear neuronal death.

    abstract::Excessive entry of Ca2+ into injured cochlear neurons activates various Ca(2+)-activated enzymes and subsequent spiral ganglion cell death. Therefore, preventing intracellular calcium overload by using Ca2+ channel antagonists may become an important countermeasure to spiral ganglion cell death. We experimentally inve...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101200889

    authors: Sekiya T,Yagihashi A,Asano K,Suzuki S

    更新日期:2002-12-01 00:00:00

  • Head registration techniques for image-guided surgery.

    abstract::Localization of the pathological structures in relation to the surrounding anatomy and understanding of the surgical anatomy are probably the most important keys to successful neurosurgery. Image-guided surgery is an important tool for understanding an individual's anatomy and for precisely locating the lesion. Head r...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740481

    authors: Alp MS,Dujovny M,Misra M,Charbel FT,Ausman JI

    更新日期:1998-01-01 00:00:00

  • Music training causes long-term enhancement of preschool children's spatial-temporal reasoning.

    abstract::Predictions from a structured cortical model led us to test the hypothesis that music training enhances young children's spatial-temporal reasoning. Seventy-eight preschool children participated in this study. Thirty-four children received private piano keyboard lessons, 20 children received private computer lessons, ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740765

    authors: Rauscher FH,Shaw GL,Levine LJ,Wright EL,Dennis WR,Newcomb RL

    更新日期:1997-02-01 00:00:00

  • Enhanced expression of p53 in reactive astrocytes following transient focal ischemia.

    abstract::The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101199828

    authors: Chung YH,Shin CM,Kim MJ,Lee EY,Kim G,Cha CI

    更新日期:2002-04-01 00:00:00

  • SELDI-TOF analysis of glioblastoma cyst fluid is an approach for assessing cellular protein expression.

    abstract:OBJECTIVES:In about 10% of glioblastoma patients, preoperative MRI discloses the presence of tumor cysts. Whereas the impact of cystic appearance on prognosis has been discussed extensively, only little is known about the tumor cyst fluid. In this study, we tested the feasibility of the surface enhanced laser desorptio...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164113X13756993777580

    authors: Hoelscher M,Richter N,Melle C,von Eggeling F,Schaenzer A,Nestler U

    更新日期:2013-12-01 00:00:00

  • Bone mesenchymal stem cell-conditioned medium induces the upregulation of Smad6, which inhibits the BMP-4/Smad1/5/8 signaling pathway.

    abstract:OBJECTIVES:In this study, we aimed to investigate the effect of bone mesenchymal stem cells (BMSCs) conditioned medium on BMP4-induced activation of the Smad signaling pathway during the process of neural stem cells differentiation. METHODS:We designed four experimental groups: (A) control group, (B) BMP-4 treatment g...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1232549

    authors: Fang H,Song P,Shen C,Liu X,Li H

    更新日期:2016-11-01 00:00:00

  • Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors.

    abstract:OBJECTIVES:Epilepsy is a common seizure disorder affecting approximately 70 million people worldwide. Mitochondrial dysfunction and antioxidant/prooxidant imbalance are emerging as factors that contribute to epileptogenesis. As medical ozone was able to reestablish cellular redox balance and to maintain the protective ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000445

    authors: Mallok A,Vaillant JD,Soto MT,Viebahn-Hänsler R,Viart Mde L,Pérez AF,Cedeño RI,Fernández OS

    更新日期:2015-03-01 00:00:00

  • Straight from the horse's mouth: neurological injury in equestrian sports.

    abstract:OBJECTIVES:Equestrian sports can result in a variety of injuries to the nervous system due to many factors. We describe our series of 80 patients with injuries sustained during participation in equestrian sports. METHODS AND RESULTS:All patients seen at the regional trauma center with injuries associated with equestri...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000373

    authors: Srinivasan V,Pierre C,Plog B,Srinivasan K,Petraglia AL,Huang JH

    更新日期:2014-10-01 00:00:00

  • Microemboli in MCA ipsilateral to occluded common carotid artery: an observation and short review of the literature.

    abstract::Sixty-five years old patient suffering from acute stroke was treated by rTPA intravenously. TCD monitoring of both middle cerebral arteries (MCA) was carried out simultaneously with administration of rTPA. Seven microemboli were found in right and four in left MCA. Duplex ultrasound, CT angiography and digital subtrac...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313208X289589

    authors: Telman G,Kouperberg E,Eran A,Goldsher D,Yarnitsky D

    更新日期:2008-09-01 00:00:00

  • Catalpol protects rat pheochromocytoma cells against oxygen and glucose deprivation-induced injury.

    abstract:OBJECTIVES:Catalpol has been identified to have neuroprotective effect on gerbils subjected to transient global cerebral ischemia. However, the mechanism that catalpol prevents ischemia is still unclear. In the present study, PC12 cells, exposed to oxygen and glucose deprivation (OGD) followed by reperfusion, were used...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164107X229894

    authors: Wang Z,An LJ,Duan YL,Li YC,Jiang B

    更新日期:2008-02-01 00:00:00

  • Clinical features and prognostic analysis of moyamoya disease associated with intracranial aneurysms.

    abstract:OBJECTIVES:To explore clinical features and compare of the difference between conservative treatment and surgical treatmentin prognosis of intracranial aneurysms associated with moyamoya disease (MMD). METHODS:104 patients with MMD a ssociated with intracranial aneurysms diagnosed by digital subtraction angiography (D...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1773663

    authors: Yan J,Lv M,Zeng E,Tang B,Xie S,Hong T

    更新日期:2020-09-01 00:00:00

  • Clinically presenting acute/subacute ischemic stroke: differential diagnosis of the non-enhanced CT hypodensity by advanced neuroimaging.

    abstract:OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164109X12445505689607

    authors: Misra V,Fadil H,Hoque R,Menon U,Gonzalez-Toledo E,Jaffe S

    更新日期:2009-10-01 00:00:00

  • The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

    abstract:INTRODUCTION:Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. METHODS:Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. RESULTS:We found intraepidermal nerve fiber degener...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1564191

    authors: Kosacka J,Woidt K,Toyka KV,Paeschke S,Klöting N,Bechmann I,Blüher M,Thiery J,Ossmann S,Baum P,Nowicki M

    更新日期:2019-04-01 00:00:00

  • Mapping the primary motor cortex in healthy subjects and patients with peri-rolandic brain lesions before neurosurgery.

    abstract:OBJECTIVE:The aim of this study was to establish a robust set of motor tasks that could be used to functionally delineate the motor cortex with blood oxygenation level dependent functional magnetic resonance imaging (BOLD fMRI) at 3 T and produce precise functional maps for pre-operative planning and functional neurona...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1179/016164108X323753

    authors: Berntsen EM,Samuelsen P,Lagopoulos J,Rasmussen IA Jr,Håberg AK,Haraldseth O

    更新日期:2008-11-01 00:00:00

  • The effectiveness of cortico-cortical evoked potential in detecting seizure onset zones.

    abstract::Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1454092

    authors: Zhang N,Zhang B,Rajah GB,Geng X,Singh R,Yang Y,Yan X,Li Z,Zhou W,Ding Y,Sun W

    更新日期:2018-06-01 00:00:00

  • Comparisons of 2/3Sh estimation technique to computer-assisted planimetric analysis in epidural, subdural and intracerebral hematomas.

    abstract:OBJECTIVE:The formula 1/2abc was suitable for the estimation of the epidural, acute subdural, most intracerebral and even some chronic subdural hematoma volume, but its accuracy was prone to be affected by some particular shapes of hematomas. In this study, we aimed to validate a more accurate method for the estimation...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12681290831441

    authors: Zhao KJ,Zhang RY,Sun QF,Wang XQ,Gu XY,Qiang Q,Gao C,Shen JK

    更新日期:2010-11-01 00:00:00

  • Severity dependent up-regulations of LOX-1 and MCP-1 in early sclerotic changes of common carotid arteries in spontaneously hypertensive rats.

    abstract::Lectin-like oxidized low-density lipoprotein receptor (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) are molecules involving in the initiation and progression of atherosclerosis. In order to examine a possible difference in LOX-1 and MCP-1 expressions depending on the severity of early stage of atherosclerosis...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164104225016074

    authors: Hamakawa Y,Omori N,Ouchida M,Nagase M,Sato K,Nagano I,Shoji M,Fujita T,Abe K

    更新日期:2004-10-01 00:00:00

  • Early decrease of P-glycoprotein in the endothelium of the rat brain capillaries after moderate dose of irradiation.

    abstract::In this study, we examined the degree of disruption of blood-brain barrier (BBB) in irradiated rat brains using P-glycoprotein, one of the functional molecules of BBB, as a marker. In the animal experiments, disruption of BBB has been mainly studied at the acute stage of brain edema caused by a lethal dose of irradiat...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740920

    authors: Mima T,Toyonaga S,Mori K,Taniguchi T,Ogawa Y

    更新日期:1999-03-01 00:00:00

  • On the rupture of an aneurysm.

    abstract::The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1991.11739995

    authors: Duros J,Clark ME,Kufahl RH,Nadvornik P

    更新日期:1991-12-01 00:00:00

  • Cognitive functions in pediatric multiple sclerosis: 2-years follow-up.

    abstract::Objective: To assess the neuropsychological status of pediatric multiple sclerosis (MS) patients and its relationship with clinical variables in a longitudinal study.Methods: Patients with MS (n = 46) and age- and gender-matched healthy control subjects (HCs, n = 53) were given tests of non-verbal reasoning, attention...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1710417

    authors: Öztürk Z,Gücüyener K,Soysal Ş,Konuşkan GD,Konuşkan B,Dikmen AU,Anlar B

    更新日期:2020-02-01 00:00:00

  • A reproducible assay of polymerase chain reaction to detect trinucleotide repeat expansion of Huntington's disease and senile chorea.

    abstract::A simple and reproducible method of polymerase chain reaction (PCR) assay was established to detect trinucleotide repeat expansion for Huntington's disease (HD) using a new DNA polymerase and buffer system. The system consists of an extremely heat stable DNA polymerase (Pfu), and a buffer supplemented with ammonium su...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1996.11740370

    authors: Watanabe M,Abe K,Aoki M,Kameya T,Itoyama Y,Shoji M,Ikeda M,Iizuka T,Hirai S

    更新日期:1996-02-01 00:00:00