Resveratrol prevents global cerebral ischemia-induced decrease in lipid content.

Abstract:

OBJECTIVE:The present study was undertaken to evaluate whether resveratrol (RSV) modulates membrane lipid composition, as well as on ganglioside profile in ischemia/reperfusion injury. METHODS:Global cerebral ischemia was induced by four-vessel occlusion for 10 minutes. RSV (30 mg/kg) or vehicle was intraperitoneally administered to rats 7 days prior to ischemia. Brain structures were homogenized with chloroform/methanol for ganglioside, phospholipids, and cholesterol levels. RESULTS:RSV significantly prevented the reduction in the total content of gangliosides, phospholipids, and cholesterol in hippocampi and cerebral cortex induced by global cerebral ischemia. Although ischemia/reperfusion decreased ganglioside content, the ganglioside profiles were apparently not modified. CONCLUSIONS:Our experiments suggest that lipid metabolism is important for development of ischemic damage and indicate that RSV treatment 7 days prior to ischemia may prevent membrane lipid loss.

journal_name

Neurol Res

journal_title

Neurological research

authors

Simão F,Matté A,Breier AC,Kreutz F,Trindade VM,Netto CA,Salbego CG

doi

10.1179/1743132812Y.0000000116

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

59-64

issue

1

eissn

0161-6412

issn

1743-1328

journal_volume

35

pub_type

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