Abstract:
OBJECTIVE:The present study was undertaken to evaluate whether resveratrol (RSV) modulates membrane lipid composition, as well as on ganglioside profile in ischemia/reperfusion injury. METHODS:Global cerebral ischemia was induced by four-vessel occlusion for 10 minutes. RSV (30 mg/kg) or vehicle was intraperitoneally administered to rats 7 days prior to ischemia. Brain structures were homogenized with chloroform/methanol for ganglioside, phospholipids, and cholesterol levels. RESULTS:RSV significantly prevented the reduction in the total content of gangliosides, phospholipids, and cholesterol in hippocampi and cerebral cortex induced by global cerebral ischemia. Although ischemia/reperfusion decreased ganglioside content, the ganglioside profiles were apparently not modified. CONCLUSIONS:Our experiments suggest that lipid metabolism is important for development of ischemic damage and indicate that RSV treatment 7 days prior to ischemia may prevent membrane lipid loss.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Simão F,Matté A,Breier AC,Kreutz F,Trindade VM,Netto CA,Salbego CGdoi
10.1179/1743132812Y.0000000116subject
Has Abstractpub_date
2013-01-01 00:00:00pages
59-64issue
1eissn
0161-6412issn
1743-1328journal_volume
35pub_type
杂志文章abstract::We postulate that severe atherosclerotic occlusion of the circle of Willis and leptomeningeal arteries is an important factor in the pathogenesis of some sporadic Alzheimer's disease (AD) cases. These arterial stenoses are complicated by an overwhelming amyloid accumulation in the walls of leptomeningeal and cortical ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225017668
更新日期:2004-07-01 00:00:00
abstract::This study was performed to test whether GYKI 52466, a nonNMDA receptor antagonist, would improve microregional oxygen supply and consumption balance in the focal cerebral ischemic area. Rats were anesthetized with 1.4% isoflurane. For the GYKI Group (n = 8), 10 min before middle cerebral artery (MCA) occlusion, a bol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740935
更新日期:1999-04-01 00:00:00
abstract:INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1781455
更新日期:2020-10-01 00:00:00
abstract::Various surgical approaches have been described for treating lesions which arise in the sellar region. The popular transnasal-transsphenoidal and transethmoidal-transsphenoidal approaches avoid the morbidity associated with transcranial operations while allowing enough exposure to successfully remove most lesions that...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198280
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:As a standard method, periodic limb movements in sleep (PLMS) are detected by means of polysomnography (PSG). Actigraphic detection of PLMS is a recently developed method for performing of multiple-night recordings in an outpatient setting. The aim of our study was to assess sensitivity-related parameters of ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X229911
更新日期:2008-04-01 00:00:00
abstract::We assessed the effect of a novel calmodulin antagonist, DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) in a spontaneously hypertensive rat (SHR) permanent focal cerebral ischemia. In experiment I, the left middle cerebral ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198992
更新日期:2001-09-01 00:00:00
abstract::Regional CBF was measured by 133Xe inhalation in unilateral cerebral infarction, carotid TIAs, and normal volunteers. Regional CBF values were bilaterally and symmetrically reduced in patients measured within 3 weeks after stroke. Later, rCBF values returned toward normal in the contralateral hemisphere of patients wi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1979.11739545
更新日期:1979-01-01 00:00:00
abstract::The present study aimed to examine the effects of N omega-nitro-L-arginine (LNA) on the early ischemic neuronal damage (EIND). All the experiments were carried out under general anesthesia, maintaining the blood gases and the body temperature within the physiological ranges. The local CBF, the topographically correspo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740795
更新日期:1997-04-01 00:00:00
abstract::This paper describes a previously unreported clinical onset of carcinomatous meningitis with bilateral deafness. Typical changes in the cerebrospinal fluid aside from positive cytology findings are reviewed. In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased gluc...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200708
更新日期:2002-10-01 00:00:00
abstract::The effect of labetalol, a combined alpha- and beta-adrenoceptor antagonist, on the cerebral circulation was investigated in 7 normotensive subjects. Cerebral blood flow (CBF) was measured with the intravenous 133Xe method and mean flow velocity (Vmean) in the middle cerebral artery was determined using transcranial D...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739958
更新日期:1991-03-01 00:00:00
abstract::The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the rela...
journal_title:Neurological research
pub_type: 杂志文章,meta分析,评审
doi:10.1179/1743132813Y.0000000224
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patient...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X383259
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:In the present study, we investigated the effects of treadmill exercise on microglial activation and the subsequent release of tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1-beta in the hippocampus in a rat model of type 2 diabetes. METHODS:At 30 weeks of age, diabetic (Zucker diabeti...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000015
更新日期:2015-08-01 00:00:00
abstract::The craniocervical regions of seven cadavers (14 sides) injected with silicone rubber were dissected under a Zeiss OPMI surgical microscope. The present study provides a detailed description of the suboccipital segment of the vertebral artery, with particular attention to its loops, branches, supporting osteofibrous s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740507
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a multi-factorial disease influenced by both genetic and environmental factors. The aim of this case-control study was to determine the association between Endothelial Nitric Oxide Synthase G894T (rs1799983) gene polymorphism and susceptibility to ischemic stroke (IS) in North Indian po...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1181376
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Neurocysticercosis is a parasitic infection of the central nervous system caused by the larval stage of the tapeworm Taenia solium and is the most common parasitic infection involving the human nervous system. Neurocysticercosis represents one of the most common causes of symptomatic epilepsy in developing c...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164110X12644252260592
更新日期:2010-04-01 00:00:00
abstract::We currently have used three drugs in combination [mannitol, vitamin E and glucocorticoid (beta-methasone)] for the treatment of cerebral infarction in the acute stage. For the purpose of evaluating the efficacy of this therapy, we have conducted experiments evaluated by chemiluminescence (CL), energy metabolism and w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739819
更新日期:1988-06-01 00:00:00
abstract::We examined the microsurgical anatomy of the supratentorial subarachnoid cisterns with a surgical microscope in 20 brains prepared using the immersion technique. The adult brains were immersed in Ringer's solution and air was injected into the subarachnoid cisterns while the brains remained submerged in solution. We i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740266
更新日期:1994-12-01 00:00:00
abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739556
更新日期:1980-01-01 00:00:00
abstract::Intra-arterial thrombolysis and percutaneous angioplasty is feasible in patients with acute middle cerebral artery (MCA) occlusion limited to 6 hours post-ictus, but there are some limitations such as reocclusion or hemorrhagic complications. In this report, we describe a stent placement in the treatment of a refracto...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49355
更新日期:2006-12-01 00:00:00
abstract::Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events such as stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11741005
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:The study objectives are (1) to identify factors predicting the excellent visual recovery after transsphenoidal removal of pituitary tumors and (2) to describe the association of excellent visual recovery and early restoration of symmetry of the decompressed optic chiasm. METHODS:Thirty-five patients with v...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000407
更新日期:2015-01-01 00:00:00
abstract::A mathematical model, using differential equations, of heterosynaptic plasticity is proposed. The model is based on physiological studies of invertebrates in which nonspecific conditioning, such as sensitization and heterosynaptic inhibition, starts to be elucidated and behavioral studies of classical and instrumental...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739576
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:Infection is a major complication and risk factor of cerebrospinal fluid (CSF) shunting procedures. Recently, antibiotic-impregnated shunt systems have been developed in an attempt to prevent or reduce the CSF infection. The aim of this study was to determine the efficacy of silver-impregnated polyurethane ve...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/174313209X380973
更新日期:2009-04-01 00:00:00
abstract::Although radiation injuries to the brain are well documented, immediate early histological changes in the brain remain to be defined. The present study characterizes glial injury provoked in adult rat white matter within 24 h after a single irradiation of the whole brain (10 or 20 Gray). Irradiated brains were histolo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199324
更新日期:2001-12-01 00:00:00
abstract::Monitoring of regional cerebral oxygen saturation (r. cereb. O2 satn.) was carried out continuously in 12 healthy subjects (mean age 35.2 +/- 4.4 years; range 26-41 years; 4 women, 8 men), prior to, during and following acupuncture. Measurements were obtained with the INVOS 3100 cerebral oximeter (Somanetics Corp., Tr...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740605
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To explore clinical features and compare of the difference between conservative treatment and surgical treatmentin prognosis of intracranial aneurysms associated with moyamoya disease (MMD). METHODS:104 patients with MMD a ssociated with intracranial aneurysms diagnosed by digital subtraction angiography (D...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1773663
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:We have investigated whether magnetic stimulation of the sural nerve can evoke a flexor reflex recorded from the ipsilateral short head of the biceps femoris muscle. METHODS:The sural nerve was subjected to magnetic stimulation as well as by single-pulse electrical stimulation in healthy subjects. RESULTS:...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/1743132810Y.0000000026
更新日期:2011-07-01 00:00:00
abstract::Cerebral aneurysms are composed principally of collagen, a birefringent protein which is responsible for withstanding the forces of blood pressure. The known correlation between collagen birefringence and its mechanics provides the basis for using polarizing microscopy to evaluate the strength of collagen, layer by la...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740986
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:Numerous studies have identified different predictors for secondary hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH), although predictors regarding timing of the shunt operation have never been reported. Predictors for an early shunt, which was defined as a shunt operation performed ≤30 days after...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1199184
更新日期:2016-07-01 00:00:00