Post-ischemic administration of DY-9760e, a novel calmodulin antagonist, reduced infarct volume in the permanent focal ischemia model of spontaneously hypertensive rat.

abstract：:Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in normal developing brain, but the role of nNOS in neurogenesis in the ischemic brain remains unclear. To investigate the temporal and spatial relationship between cell proliferation of the ependymal/subventricular zone (SVZ), a principal neuroproliferative...

journal_title：Neurological research

authors： Zhang P,Liu Y,Li J,Kang Q,Tian Y,Chen X,Shi Q,Song T

更新日期：2006-01-01 00:00:00

abstract：:We describe a case of rebleeding from an intracranial vertebral dissecting aneurysm following proximal clipping. This case suggests that proximal clipping alone may not be an adequate surgical procedure to prevent rebleeding. Surgical treatment of intracranial dissecting aneurysms in the vertebral artery presenting as...

journal_title：Neurological research

authors： Kawamata T,Tanikawa T,Takeshita M,Onda H,Takakura K,Toyoda C

更新日期：1994-04-01 00:00:00

abstract：:Objectives: To investigate the thrombolysis with recombinant human prourokinase (rhPro-UK) on thromboembolic stroke in rats at different therapeutic time windows (TTW). Methods: Rats were subjected to embolic middle cerebral artery occlusion. RhPro-UK and positive control drugs rt-PA,UK were administered 3 h, 4.5 h, 6...

journal_title：Neurological research

authors： Hao CH,Ding WX,Sun Q,Li XX,Wang WT,Zhao ZY,Tang LD

更新日期：2019-11-01 00:00:00

abstract：:Intraoperative use of somatosensory evoked potentials (SEP's) to monitor intracranial aneurysm surgery and flash visual evoked potentials (F-VEP's) for parasellar surgery have been routinely employed in our clinic. We found that both EP modalities are sensitive to the changing concentration of our standard hypotensive...

journal_title：Neurological research

authors： Wang AD,Costa e Silva I,Symon L,Jewkes D

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND/AIMS:Both of neuromyelitis optica spectrum disease (NMOSDs) and idiopathic transverse myelitis (ITM) could present as acute transverse myelitis. However, long-term immunological treatment and prognosis are different for high recurrence of NMOSDs. In this study, we summarized clinical differences between acut...

journal_title：Neurological research

authors： Liu Z,Xie M,Lu Z,Zhang C,Chen H,Xu Y,Zhang M

更新日期：2020-07-01 00:00:00

abstract：:Sinus pericranii is a rare circumscribed fluctuating vascular swelling of the scalp that communicates with the intracranial venous system. It has been associated with other intracranial vascular malformations. The tumour is usually round, fluctuant, nonpulsatile, and disappears with compression. Its size increases dur...

journal_title：Neurological research

authors： Vinas FC,Valenzuela S,Zuleta A

更新日期：1994-12-01 00:00:00

abstract：:We currently have used three drugs in combination [mannitol, vitamin E and glucocorticoid (beta-methasone)] for the treatment of cerebral infarction in the acute stage. For the purpose of evaluating the efficacy of this therapy, we have conducted experiments evaluated by chemiluminescence (CL), energy metabolism and w...

journal_title：Neurological research

authors： Uenohara H,Imaizumi S,Suzuki J,Yoshimoto T

更新日期：1988-06-01 00:00:00

abstract：:To study the pathophysiology of olivopontocerebellar atrophy (OPCA), we destroyed inferior olive nuclei of male Wistar rats using 3-acetyl pyridine (3-AP) + harmaline + niacinamide. These rats showed a sluggish and ataxic gait. To elucidate the relationship between thyrotropin releasing hormone (TRH) in the Purkinje c...

journal_title：Neurological research

authors： Adachi K,Rhue BN,Li M,Izumi M,Osano H,Mitsuma T

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...

journal_title：Neurological research

authors： Misra V,Fadil H,Hoque R,Menon U,Gonzalez-Toledo E,Jaffe S

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...

journal_title：Neurological research

authors： Oishi A,Tobimatsu S,Ogata K,Taniwaki T,Kinukawa N,Toyoshiba H,Kira J

更新日期：2008-12-01 00:00:00

abstract：:The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...

journal_title：Neurological research

authors： Chung YH,Shin CM,Kim MJ,Lee EY,Kim G,Cha CI

更新日期：2002-04-01 00:00:00

abstract：:We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio--percen...

journal_title：Neurological research

authors： McCormick PW,Stewart M,Ray P,Lewis G,Dujovny M,Ausman JI

更新日期：1991-03-01 00:00:00

abstract：:Background: IVS5-91G>A (rs3812718) polymorphism of the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene has been associated with inadequate responsiveness to common antiepileptic drugs which act as sodium channel blockers. This study was performed to investigate the effect of IVS5-91G>A (rs3812718) polymorphi...

journal_title：Neurological research

authors： Markovic I,Pejanovic-Skobic N,Bozina N,Susak Sporis I,Sporis D,Basic S

更新日期：2019-10-01 00:00:00

abstract：:The endogenous clock of humans can be influenced by light application to the popliteal region. Previously, it had been assumed that light must fall directly into the eye in order to influence the inner circadian clock. This study, published in 1998, has not been reproduced. We investigated the effects of laser light i...

journal_title：Neurological research

authors： Litscher G

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:The formula 1/2abc was suitable for the estimation of the epidural, acute subdural, most intracerebral and even some chronic subdural hematoma volume, but its accuracy was prone to be affected by some particular shapes of hematomas. In this study, we aimed to validate a more accurate method for the estimation...

journal_title：Neurological research

authors： Zhao KJ,Zhang RY,Sun QF,Wang XQ,Gu XY,Qiang Q,Gao C,Shen JK

更新日期：2010-11-01 00:00:00

abstract：:The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological sco...

journal_title：Neurological research

authors： Ruan GP,Han YB,Wang TH,Xing ZG,Zhu XB,Yao X,Ruan GH,Wang JX,Pang RQ,Cai XM,He J,Zhao J,Pan XH

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To explore the value of dynamically monitored levels of plasma prothrombin fragment(1+2) (F(1+2)) and D-dimer in the process of thrombolysis with urokinase. METHODS:Blood samples were collected at baseline and at hours 1, 2, 3, 6, 12, 24, 48, 72, and 96 after urokinase infusion finished. The levels of plasma...

journal_title：Neurological research

authors： Meng R,Ji X,Li B,Zhou J,Li W,Ding Y

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:Numerous studies have demonstrated a protective effect of hyperbaric oxygen therapy in experimental ischemic brain injury, and many physiological and molecular mechanisms of hyperbaric oxygen therapy-related neuroprotection have been identified. METHODS:Review of articles pertaining to hyperbaric oxygen t...

journal_title：Neurological research

authors： Matchett GA,Martin RD,Zhang JH

更新日期：2009-03-01 00:00:00

abstract：:Insertion of pedicle screws in the thoracolumbar spine can be challenging. Incorrect placement can lead to a failure of fusion or to significant neurologic morbidity. Recently, techniques utilizing intraoperative monitoring and stereotaxis have been developed to achieve proper screw placement. While these techniques m...

journal_title：Neurological research

authors： Frank EH,Chamberland DL

更新日期：1997-12-01 00:00:00

abstract：:Intra- and extracranial atherosclerotic stenosis has been shown to be associated with an increased risk of secondary stroke mortality. Advances in invasive and non-invasive imaging modalities have improved analysis of hemodynamic changes and allowed better delineation of the integrity of intracranial collateralization...

journal_title：Neurological research

authors： Ding J,Wang X

更新日期：2016-10-01 00:00:00

abstract：:The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cel...

journal_title：Neurological research

authors： Rabinovsky ED

更新日期：2004-03-01 00:00:00

abstract：:In this study the pulsation-pressure relationship in an experimental model of aneurysms was analyzed. In addition, we have examined pulsatility of the aneurysmal wall reinforced by Guglielmi Detachable Coils (GDC). Bifurcation (BAn), aneurysms (LAn) and bilobar (BiA) aneurysms were produced in 15 mongrel dogs. The ane...

journal_title：Neurological research

authors： Novak P,Glikstein R,Mohr G

更新日期：1996-08-01 00:00:00

abstract：:The decrease in intracellular creatine concentration in Duchenne muscular dystrophy may contribute to the deterioration of intracellular energy homeostasis and may thus be one of the factors aggravating muscle weakness and degeneration. Oral creatine supplementation should have potential in alleviating the clinical sy...

journal_title：Neurological research

authors： Felber S,Skladal D,Wyss M,Kremser C,Koller A,Sperl W

更新日期：2000-03-01 00:00:00

abstract：:The effects of etomidate on focal cerebral ischaemia following transorbital occlusion of the cat middle cerebral artery were investigated. Etomidate had no effect on CBF before or after onset of ischaemia by comparison with controls, but caused a greater fall in CBF in cats with high preocclusion or initial ischaemic ...

journal_title：Neurological research

authors： Venables GS,Strong AJ,Miller SA,Gibson G,Hardy JA

更新日期：1986-12-01 00:00:00

abstract：:Although neuronal death has been studied in experimental models of ischemia, the precise mechanisms regulating cell death remain unclear. Furthermore, the timing and pattern of neuronal death in human stroke has not been extensively studied. To further our understanding of ischemia-induced neuronal death, we examined ...

journal_title：Neurological research

authors： Guglielmo MA,Chan PT,Cortez S,Stopa EG,McMillan P,Johanson CE,Epstein M,Doberstein CE

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVES:Catalpol has been identified to have neuroprotective effect on gerbils subjected to transient global cerebral ischemia. However, the mechanism that catalpol prevents ischemia is still unclear. In the present study, PC12 cells, exposed to oxygen and glucose deprivation (OGD) followed by reperfusion, were used...

journal_title：Neurological research

authors： Wang Z,An LJ,Duan YL,Li YC,Jiang B

更新日期：2008-02-01 00:00:00

abstract：:The purpose of this study was to investigate the correlation between activity-related pain six months after first surgery for herniated lumbar disc, and the extent of lumbar epidural fibrosis present at the surgical site, assessed by magnetic resonance imaging. The 298 patients who underwent surgery for lumbar disc he...

journal_title：Neurological research

authors： BenDebba M,Augustus van Alphen H,Long DM

更新日期：1999-01-01 00:00:00

abstract：:Localization of the pathological structures in relation to the surrounding anatomy and understanding of the surgical anatomy are probably the most important keys to successful neurosurgery. Image-guided surgery is an important tool for understanding an individual's anatomy and for precisely locating the lesion. Head r...

journal_title：Neurological research

authors： Alp MS,Dujovny M,Misra M,Charbel FT,Ausman JI

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...

journal_title：Neurological research

authors： Strassner C,Buhl R,Mehdorn HM

更新日期：2009-06-01 00:00:00

abstract：:To estimate the regional perfusion pressure and possibly the stump pressure during carotid endarterectomy, cerebral blood flow (CBF) measurements including a vasodilatory test were performed preoperatively. CBF was measured by 133Xe inhalation and emission tomography. An intravenous dose of 1g acetazolamide (Diamox) w...

journal_title：Neurological research

authors： Vorstrup S,Boysen G,Brun B,Engell HC

更新日期：1987-03-01 00:00:00