Abstract:
BACKGROUND/AIMS:Both of neuromyelitis optica spectrum disease (NMOSDs) and idiopathic transverse myelitis (ITM) could present as acute transverse myelitis. However, long-term immunological treatment and prognosis are different for high recurrence of NMOSDs. In this study, we summarized clinical differences between acute attack myelitis of NMOSDs and ITM, we further screened serum auto-antibodies to help understand the two distinct clinical entities. METHODS:This is a retrospective study on 48 NMOSD patients and 49 ITM patients in neurological department of Nanjing Drum Tower Hospital from 2013 to 2019. Clinical, CSF and MRI profiles on the acute episode were also compared between NMOSD patients and ITM patients. Serum AQP4 and auto-antibodies were tested. Clinical parameters were further compared between NMOSD patients with and without auto-antibodies. RESULTS:Compared with ITM patients, NMOSD patients manifested with longer vertebral segments (5.42 ± 3.17 segments vs. 2.31 ± 2.36 segments, p < 0.001), higher female/male ratio (13:3 vs. 20:29, p < 0.001), higher IgG index (30.30% vs. 9.09%, p < 0.05). Positive rates of anti-Ro-52 (47.92% vs. 14.29%, p < 0.001), anti-ANAs (50.00% vs.10.20%, p < 0.001) and anti-SSA (35.42% vs. 6.12%, p = 0.001) were significantly higher in the NMOSD patients than the ITM patients. Seropositive Ro-52 and SSA were associated with longer injured spinal cord segments. However, Ro-52 antibody may not be associated with NMOSD relapsing during our follow up. CONCLUSIONS:NMOSD patients manifested with longer vertebral segments, higher female/male ratio, IgG index, anti-ANAs, anti-Ro-52 and anti-SSA seroprevalence than ITM patients. These features may help clinicians better distinguish NMOSD from ITM and provide long-term immunotherapy reasonably.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Liu Z,Xie M,Lu Z,Zhang C,Chen H,Xu Y,Zhang Mdoi
10.1080/01616412.2020.1773628subject
Has Abstractpub_date
2020-07-01 00:00:00pages
612-617issue
7eissn
0161-6412issn
1743-1328journal_volume
42pub_type
杂志文章abstract::We examined whether or not NF-kappaB, a factor that regulates expression of the genes that code for pro-inflammatory cytokines, is activated in cerebrospinal fluid (CSF) cells to investigate the production of pro-inflammatory cytokines by CSF cells in patients with meningitis. Western blotting demonstrated that NF-kap...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200627
更新日期:2002-10-01 00:00:00
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journal_title:Neurological research
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doi:10.1080/01616412.1998.11740605
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abstract::Vestibular neuritis (VN) rapidly damages unilateral vestibular periphery, inducing severe balance disorders. In most cases, such vestibular imbalance is gradually restored to within the normal level after clinical therapies. This successive clinical recovery occurs due to regeneration of vestibular periphery and/or ac...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/016164103101201364
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journal_title:Neurological research
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doi:10.1080/01616412.1980.11739556
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journal_title:Neurological research
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doi:10.1080/01616412.2018.1564188
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journal_title:Neurological research
pub_type: 临床试验,杂志文章
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abstract::Ninety percent of cerebral aneurysms were diagnosed after their first rupture with consecutive subarachnoid haemorrhage. In order to detect the aneurysms before rupture investigation by transcranial Doppler sonography was used on the basis of intra-operative evaluation of the normal aneurysmal flow pattern. In 34 pati...
journal_title:Neurological research
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journal_title:Neurological research
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pub_type: 临床试验,杂志文章
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journal_title:Neurological research
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journal_title:Neurological research
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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doi:10.1179/016164105X18494
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journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.1998.11740573
更新日期:1998-10-01 00:00:00
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更新日期:2014-06-01 00:00:00
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journal_title:Neurological research
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更新日期:1998-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-09-01 00:00:00
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doi:10.1080/01616412.1990.11739907
更新日期:1990-03-01 00:00:00
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更新日期:2013-10-01 00:00:00