Thyrotropin-releasing hormone and its receptor in the cerebellum of inferior olive destroyed rat brain.

Abstract:

:To study the pathophysiology of olivopontocerebellar atrophy (OPCA), we destroyed inferior olive nuclei of male Wistar rats using 3-acetyl pyridine (3-AP) + harmaline + niacinamide. These rats showed a sluggish and ataxic gait. To elucidate the relationship between thyrotropin releasing hormone (TRH) in the Purkinje cell of cerebellum and the inferior olive nucleus, we investigated the concentrations of TRH in the cerebellar cortex, nuclei, and medulla oblongata including the inferior olive nuclei using radioimmunoassay method as well as TRH receptor in the Purkinje cells of cerebellum using immunohistochemical method. All statistical comparisons were done using non-parametric tests (Mann-Whitney U-test). We found that two weeks after the treatment, TRH concentrations in the cerebellar cortex as well as nuclei were significantly lower than in the controls but no significant difference in the medulla oblongata was observed between 3-AP treated rats and controls. Moreover, four weeks after the treatment, TRH-receptor positive Purkinje cell counts were significantly fewer than in the controls. These results suggest that TRH in the Purkinje cell of cerebellum may play a role in the ataxic gait observed in the rats whose inferior olive were destroyed.

journal_name

Neurol Res

journal_title

Neurological research

authors

Adachi K,Rhue BN,Li M,Izumi M,Osano H,Mitsuma T

doi

10.1080/01616412.2000.11740690

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

401-3

issue

4

eissn

0161-6412

issn

1743-1328

journal_volume

22

pub_type

杂志文章
  • Electrical stimulation for the treatment of bladder dysfunction: current status and future possibilities.

    abstract::Electrical stimulation of peripheral nerves can be used to cause muscle contraction, to activate reflexes, and to modulate some functions of the central nervous system (neuromodulation). If applied to the spinal cord or nerves controlling the lower urinary tract, electrical stimulation can produce bladder or sphincter...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164102101200294

    authors: Jezernik S,Craggs M,Grill WM,Creasey G,Rijkhoff NJ

    更新日期:2002-07-01 00:00:00

  • Evaluation of cerebral autoregulation following diffuse brain injury in rats.

    abstract::The normal cerebral circulation has the ability to maintain a stable cerebral blood flow over a wide range of cerebral perfusion pressures and this is known as cerebral autoregulation. This autoregulation may be impaired in the injured brain. Closed head injury was induced in 28 Sprague-Dawley rats weighing 400-450 g....

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740832

    authors: Prat R,Markiv V,Dujovny M,Misra M

    更新日期:1997-08-01 00:00:00

  • Effect of midbrain raphe nucleus stimulation on somatosensory evoked potential in cat.

    abstract::Experiments were carried out to clarify the effect of serotonin [5-hydroxytryptamine (5-HT)] upon the somatosensory evoked potential (SEP) elicited by superficial radial nerve stimulation in cat, and the following results were obtained: (i) in untreated (control) animals, a significant reduction occurred in amplitude ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1989.11739871

    authors: Iwayama K,Mori K,Fukushima M,Yamashiro K

    更新日期:1989-06-01 00:00:00

  • Positron emission tomographic evaluation of histological malignancy in gliomas using oxygen-15 and fluorine-18-fluorodeoxyglucose.

    abstract::HEADTOME III, a high resolution PET, has been employed using 15O and 18F labelled pharmaceuticals to evaluate histological malignancy of gliomas preoperatively. PET study was applied on eighteen preoperative gliomas including two recurrent cases. Haemocirculatory and metabolic indices of regional cerebral blood flow (...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1986.11739749

    authors: Mineura K,Yasuda T,Kowada M,Shishido F,Ogawa T,Uemura K

    更新日期:1986-09-01 00:00:00

  • Loss of essential membrane lipids and ascorbic acid from rat brain following cryogenic injury and protection by methylprednisolone.

    abstract::Previous work has shown that unsaturated fatty acid components of model membrane phospholipids in vitro, damaged via a free radical mechanism, are protected by the presence of cholesterol in these membranes. The participation of these membrane lipids in the pathogenesis of traumatic injury to brain was studied in vivo...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1981.11739608

    authors: Mitamura JA,Seligman ML,Solomon JJ,Flamm ES,Demopoulos HB,Ransohoff J

    更新日期:1981-01-01 00:00:00

  • Online assessment of brain tissue oxygen autoregulation in traumatic brain injury and subarachnoid hemorrhage.

    abstract::Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164103101201580

    authors: Soehle M,Jaeger M,Meixensberger J

    更新日期:2003-06-01 00:00:00

  • Haemodynamic study of arteriovenous malformations using a hydraulic model.

    abstract::Despite the accumulation of intraoperative data on arteriovenous malformations (AVMs), details of the haemodynamics have not yet been elucidated. A hydraulic model was constructed from silicone and glass tubes to simulate a high-flow AVM. During stepwise obliteration of the nidus, haemodynamic changes were continuousl...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740174

    authors: Nagasawa S,Kawanishi M,Tanaka H,Ohta T,Nagayasu S,Kikuchi H

    更新日期:1993-12-01 00:00:00

  • Diffusion tensor MRI for the assessment of cerebral ischemia/reperfusion injury in the penumbra of non-human primate stroke model.

    abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12761752770177

    authors: Guo J,Zheng HB,Duan JC,He L,Chen N,Gong QY,Tang HH,Li HX,Wang L,Cheng JQ

    更新日期:2011-01-01 00:00:00

  • Clinically presenting acute/subacute ischemic stroke: differential diagnosis of the non-enhanced CT hypodensity by advanced neuroimaging.

    abstract:OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164109X12445505689607

    authors: Misra V,Fadil H,Hoque R,Menon U,Gonzalez-Toledo E,Jaffe S

    更新日期:2009-10-01 00:00:00

  • The role of high-sensitivity C-reactive protein levels in functional outcomes in patients with large-artery atherosclerosis and small-artery occlusion.

    abstract:BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2017.1358937

    authors: Hou D,Liu J,Feng R,Gao Y,Wang Y,Wu J

    更新日期:2017-11-01 00:00:00

  • Radiation-induced apoptosis of oligodendrocytes in the adult rat optic chiasm.

    abstract:OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X48833

    authors: Nagayama K,Kurita H,Nakamura M,Kusuda J,Tonari A,Takayama M,Fujioka Y,Shiokawa Y

    更新日期:2005-06-01 00:00:00

  • Prognostic value of perfusion-weighted magnetic resonance imaging in acute intracerebral hemorrhage.

    abstract:OBJECTIVE:This study intends to investigate the prognostic value of perfusion-weighted magnetic resonance imaging in acute intracerebral hemorrhage. METHODS:Demographic, clinical and biochemical data between acute intracerebral hemorrhage (AICH) and healthy volunteer groups were assessed in this study, such as rCBV an...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1177932

    authors: Hu X,Bai X,Zai N,Sun X,Zhu L,Li X

    更新日期:2016-07-01 00:00:00

  • Glycerol attenuates the adherence of leukocytes in rat pial venules after transient middle cerebral artery occlusion.

    abstract::Intravenous infusion of glycerol has been used in patients with a cerebral infarction, expecting improvement in brain edema and cerebral blood flow (CBF). However, the mechanism of the improvement of CBF has not been clearly demonstrated. The aim of this study in the rat pial microvasculature after transient middle ce...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11741015

    authors: Ishikawa M,Sekizuka E,Sato S,Yamaguchi N,Inamasu J,Kawase T

    更新日期:1999-12-01 00:00:00

  • Vasoconstrictor mechanism of neuropeptides augmented after endothelial removal in isolated, perfused canine basilar arteries.

    abstract::In order to investigate the functional role of endothelium and vasoeffector mechanism in cerebrovascular responses to neuropeptides, the stainless steel cannula inserting method was applied to examine the responses to intraluminally-applied bradykinin, substance P and vasopressin in isolated and perfused canine basila...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1995.11758611

    authors: Tsuji T,Cook DA

    更新日期:1995-06-01 00:00:00

  • Relationship of hypotension and cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVES:Changes in systemic arterial blood pressure and the degree of cerebral vasospasm were investigated in 125 patients with aneurysmal subarachnoid hemorrhage. METHODS:Systemic arterial blood pressure was measured every 2 hours in each patient for a period of more than 2 weeks, and a fall in systemic blood pres...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X48761

    authors: Tabuchi S,Hirano N,Tanabe M,Kurosaki M,Okamoto H,Kamitani H,Yokota M,Watanabe T

    更新日期:2006-03-01 00:00:00

  • Nitric oxide synthase inhibitor augments post-ischemic leukocyte adhesion in the cerebral microcirculation in vivo.

    abstract::The objective was to examine the effect of the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME) on leukocyte adhesion in the cerebral microcirculation during reperfusion following partial forebrain ischemia in the rat. Intravital fluorescence video-microscopy through a closed cranial win...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740947

    authors: Hudetz AG,Wood JD,Kampine JP

    更新日期:1999-06-01 00:00:00

  • Angiogenic capacity of human omental stem cells.

    abstract:OBJECTIVES:The goals of the present study are to obtain, expand and characterize a stem cell population from human omentum and to evaluate its in vivo angiogenic capacities. METHODS:Human omental CD34+ cells were obtained from samples of human omentum by density gradient centrifugation in Ficoll. Proliferative pattern...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X63674

    authors: García-Gómez I,Goldsmith HS,Angulo J,Prados A,López-Hervás P,Cuevas B,Dujovny M,Cuevas P

    更新日期:2005-12-01 00:00:00

  • Wall characteristics and mechanisms of ischaemic stroke in patients with atherosclerotic middle cerebral artery stenosis: a high-resolution MRI study.

    abstract:OBJECTIVE:To evaluate the characteristics of atherosclerotic middle cerebral artery (MCA) stenosis by high-resolution magnetic resonance imaging (HR-MRI) and determine the relationship between wall characteristics and infarction patterns. METHODS:Thirty-six patients with acute ischaemic stroke due to MCA stenosis unde...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132815Y.0000000088

    authors: Zhao DL,Deng G,Xie B,Gao B,Peng CY,Nie F,Yang M,Ju S,Teng GJ

    更新日期:2016-07-01 00:00:00

  • MRI lesions after invasive therapy of carotid artery stenosis: a risk-modeling analysis.

    abstract:BACKGROUND:Diffusion-weighted imaging (DWI) abnormalities can frequently be detected after carotid endarterectomy (CEA) and carotid angioplasty with stent placement (CAS) of the carotid arteries. We looked for possible predictors for the development of DWI lesions during the intervention. METHODS:We investigated 41 pa...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X49391

    authors: Poppert H,Wolf O,Theiss W,Heider P,Hollweck R,Roettinger M,Sander D

    更新日期:2006-07-01 00:00:00

  • Supergiant anterior circulation aneurysms.

    abstract::Six cases of very large anterior circulation intracranial aneurysms are presented. Aneurysms of 53-84 mm in three female and two male adults and a 40 mm lesion in a seven week infant were successfully excised. Three patients tolerated trial intraluminal balloon occlusion preoperatively and underwent subsequent parent ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1992.11740053

    authors: Cahill DW

    更新日期:1992-01-01 00:00:00

  • An efficient method for fractionated whole rodent brain radiation.

    abstract:OBJECTIVE:In order to test for mechanisms of whole brain radio therapy side effects and possible neuroprotective measures, a rodent model is desirable. In many models, a high single dose of 8-20 Gray (Gy) of whole brain irradiation is used. These experimental radiation protocols do not closely reflect the clinical situ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000143

    authors: Semmler A,Garbe S,Moskau S,Frisch C,Eter N,Schlegel U,Linnebank M

    更新日期:2013-05-01 00:00:00

  • Mediation of endothelium-dependent relaxation: different response patterns in rat and rabbit basilar artery.

    abstract::The endothelial lining of blood vessels plays an important role in the control of arterial tone by releasing a number of vasoactive factors. Among these, nitric oxide (NO) or a NO containing moiety, some cyclooxygenase products such as prostacyclin (PGl2) and a still hypothetical hyperpolarizing factor may induce dila...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740851

    authors: Mackert JL,Parsons AA,Wahl M,Schilling L

    更新日期:1997-10-01 00:00:00

  • The deafferented nonhuman primate is not a reliable model of intractable pain.

    abstract::Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to reveal severe dyses...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164103101201274

    authors: Pioli EY,Gross CE,Meissner W,Bioulac BH,Bezard E

    更新日期:2003-03-01 00:00:00

  • Brain tissue oxygenation monitoring supplementary to somatosensory evoked potential monitoring for aneurysm surgery. Initial clinical experience.

    abstract::The object of the study was to evaluate brain tissue oxygenation (p(ti)O2) for intra-operative monitoring of critical ischemic events during early cerebral aneurysm surgery of the anterior circulation supplementary to somatosensory evoked potentials (SEPs). P(ti)O2 was continuously evaluated during surgery for an intr...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1179/016164102101200528

    authors: Szelényi A,Jung CS,Schön H,Seifert V

    更新日期:2002-09-01 00:00:00

  • Effects of cerebral small vessel disease on the outcome of patients with ischemic stroke caused by large artery atherosclerosis.

    abstract:OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.2018.1446283

    authors: Zhu H,Li Z,Lv J,Zhao R

    更新日期:2018-05-01 00:00:00

  • Correction of ischaemic brain acidosis with SQ29,548/1-benzylimidazole.

    abstract::Thromboxane A2 (TXA2) is a proaggregatory vasoconstrictor that is synthesized and released during reperfusion of ischaemic brain. We administered a TXA2 receptor antagonist, SQ29,548, and a thromboxane A synthase inhibitor, 1-benzylimidazole (1-BI), to rats subjected to 30 min of reversible forebrain ischaemia. Cerebr...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1992.11740080

    authors: Pettigrew LC,Hazle JD,Gutierrez G,Smith CD,Ogletree ML

    更新日期:1992-09-01 00:00:00

  • Amyotrophic lateral sclerosis immunoglobulins are ineffective in altering calcium influx through presynaptic voltage-sensitive calcium channels.

    abstract::Recent work has suggested that one factor in the etiology of the neuromuscular disease, amyotrophic lateral sclerosis (ALS), may be an autoimmune mechanism in which presynaptic voltage-sensitive calcium channels are an antigenic target. We have developed a fluorescence technique to measure rapid Ca2+ influx through pr...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740785

    authors: Thomas MM,Dunn SM

    更新日期:1997-04-01 00:00:00

  • Cell proliferation in ependymal/subventricular zone and nNOS expression following focal cerebral ischemia in adult rats.

    abstract::Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in normal developing brain, but the role of nNOS in neurogenesis in the ischemic brain remains unclear. To investigate the temporal and spatial relationship between cell proliferation of the ependymal/subventricular zone (SVZ), a principal neuroproliferative...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164106X91942

    authors: Zhang P,Liu Y,Li J,Kang Q,Tian Y,Chen X,Shi Q,Song T

    更新日期:2006-01-01 00:00:00

  • Risk factors of stroke-associated pneumonia in Chinese patients.

    abstract:OBJECTIVE:To explore the risk factors for stroke-associated pneumonia (SAP). METHODS:A retrospective research study was carried out to investigate the clinical data of 1435 patients admitted to the neurological intensive care unit at our university hospital between 1 January 2000 and 31 December 2009. RESULTS:A multi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164111X13007856084205

    authors: Sui R,Zhang L

    更新日期:2011-06-01 00:00:00

  • Thrombosis and recanalization of symptomatic nongiant saccular aneurysm.

    abstract::Complete thrombosis followed by recanalization of giant aneurysms is an infrequent process that has been exceptionally mentioned in relation to nongiant saccular aneurysms. A 25-year-old male presented with a right temporal hematoma and associated subarachnoid hemorrhage. Cerebral angiography revealed a small blister-...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164103771953961

    authors: Cohen JE,Rajz G,Umansky F,Spektor S

    更新日期:2003-12-01 00:00:00