Abstract:
OBJECTIVES:Catalpol has been identified to have neuroprotective effect on gerbils subjected to transient global cerebral ischemia. However, the mechanism that catalpol prevents ischemia is still unclear. In the present study, PC12 cells, exposed to oxygen and glucose deprivation (OGD) followed by reperfusion, were used as an in vitro model of ischemia. The protective effects of catalpol were investigated in ischemic-induced apoptosis in PC12 cells. METHODS:After OGD for 3 hours and reoxygenation for 18 hours, cell survival was quantified by the reduction of 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were determined using commercially available kits. Caspase-3 assay was performed using caspase-3 assay kit. Microplate reader was used to detect the intensities of rhodamine123 (Rh123) and reactive oxygen species (ROS). The level of Bcl-2 protein was measured by flow cytometry. RESULTS:Catalpol attenuated ischemia-induced apoptotic death via preventing the decrease in the level of Bcl-2 protein and the activities of SOD and GSH-PX, inhibiting the reduction of mitochondrial membrane potential and suppressing activation of caspase-3. DISCUSSION:The results suggest that the catalpol has the potential to prevent ischemic-induced apoptosis.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Wang Z,An LJ,Duan YL,Li YC,Jiang Bdoi
10.1179/016164107X229894subject
Has Abstractpub_date
2008-02-01 00:00:00pages
106-12issue
1eissn
0161-6412issn
1743-1328journal_volume
30pub_type
杂志文章abstract::Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to reveal severe dyses...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201274
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION:Cocaine- and amphetamine-regulated transcript (CART) peptide has been demonstrated to exert neuroprotective effects in stroke and some neurodegeneration diseases. In current study, we investigated the protective effects and underlying mechanisms of CART in APP/PS1 mice. METHODS:The protein levels of CART,...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1348689
更新日期:2017-10-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X163996
更新日期:2007-07-01 00:00:00
abstract::Analysis of the blood flow velocities in the middle cerebral artery by transcranial Doppler ultrasonography was performed in 158 healthy volunteers (aged 14-70 years; 82 men and 76 women). In a subgroup of 38 men and 21 women the end-tidal [CO2] was also measured. The influence of biological factors such as age, sex, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1990.11739941
更新日期:1990-09-01 00:00:00
abstract::Somatosensory-evoked potentials induced by electrical stimulation of the median nerve were recorded in patients with intracerebral lesions and in normal controls and were studied by means of spectral analysis. The results shown that (1) there is a statistically-significant difference between spectral distributions obt...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739571
更新日期:1980-01-01 00:00:00
abstract::1-Aminocyclopropanecarboxylic acid is a high affinity ligand with partial agonist properties at strychnine-insensitive glycine sites associated with the N-methyl-D-aspartate subtype of glutamate receptors. Since occupation of these sites appears required for operation of N-methyl-D-aspartate, receptor coupled cation c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740324
更新日期:1995-08-01 00:00:00
abstract::Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism r...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739802
更新日期:1987-12-01 00:00:00
abstract::Ninety percent of cerebral aneurysms were diagnosed after their first rupture with consecutive subarachnoid haemorrhage. In order to detect the aneurysms before rupture investigation by transcranial Doppler sonography was used on the basis of intra-operative evaluation of the normal aneurysmal flow pattern. In 34 pati...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739860
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to characterize mouse neural stem cells (NSC) transduced by a multigenic lentiviral vector (LV) and stably express recombinant human nerve growth factor (rhNGF). We obtained NSC-derived cell lines which express human NGF in relevant amount to exploit their ability for therapeuti...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X115161
更新日期:2006-07-01 00:00:00
abstract::Serial magnetic resonance (MR) imaging has not yet been validated in the therapy of experimental intracerebral hematomas in a rat model. It is possible to test the effect of local fibrinolysis and aspiration on the clot volume using serial magnetic resonance imaging and different MR-sequences. Experiments were carried...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740530
更新日期:1998-06-01 00:00:00
abstract::Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of the dopamine producing neurons projecting from the substantia nigra into the corpus striatum. Current medical therapy is limited and cannot stop or reverse the degeneration. Over the past 30 years, attempts were m...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225017604
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:To assess whether a weaning protocol reduces the mechanical ventilation (MV) duration compared to physician's judgement-based weaning in neurological patients and to determine whether patient consciousness influences this reduction. METHODS:A randomised controlled trial was conducted in a neurological inten...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/1743132815Y.0000000092
更新日期:2015-11-01 00:00:00
abstract::To estimate the regional perfusion pressure and possibly the stump pressure during carotid endarterectomy, cerebral blood flow (CBF) measurements including a vasodilatory test were performed preoperatively. CBF was measured by 133Xe inhalation and emission tomography. An intravenous dose of 1g acetazolamide (Diamox) w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739765
更新日期:1987-03-01 00:00:00
abstract::Acute presentation of Type I Chiari malformation in children is distinctly rare. An 11 year old male suffered a trauma to the right temporal-parietal region in a tobogganing accident resulting in an open depressed skull fracture. Radiographic evaluation included a Computed Tomographic scan which also demonstrated a si...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740599
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X191021
更新日期:2007-09-01 00:00:00
abstract::The aim of this study was to examine the pre-operative clinical and neuromonitoring courses in patients with a decompressive craniectomy to assess and to compare clinical and neuromonitoring signs indicating extensive cerebral edema. We conducted a retrospective analysis of the clinical signs and courses of simultaneo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201742
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate the effects of the GLP-1 analog liraglutide on beta-amyloid (Aβ)-induced neurotoxicity in the human neuroblastoma cell line SH-SY5Y and study the underlying mechanisms. METHODS:Cultured SH-SY5Y cells in vitro were randomly divided into normal control group, beta-amylo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1145914
更新日期:2016-04-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative motor neuron disease in adults, whose relentless course leads to death within 2-5 years, generally due to respiratory failure. Apart from the age and site of onset, no other factors have consistently demonstrated to be related to the ALS outc...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000049
更新日期:2012-07-01 00:00:00
abstract::Excessive entry of Ca2+ into injured cochlear neurons activates various Ca(2+)-activated enzymes and subsequent spiral ganglion cell death. Therefore, preventing intracellular calcium overload by using Ca2+ channel antagonists may become an important countermeasure to spiral ganglion cell death. We experimentally inve...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200889
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Intracranial artery stenosis may be the most frequent cause of ischemic stroke in the world. Early detection of asymptomatic intracranial artery stenosis may allow for therapeutic intervention. Most elements of the Framingham stroke risk profile (FSRP) are also risk factors for intracranial artery stenosis....
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000024
更新日期:2012-05-01 00:00:00
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journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164105X17224
更新日期:2005-06-01 00:00:00
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journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164102101200528
更新日期:2002-09-01 00:00:00
abstract::Lectin-like oxidized low-density lipoprotein receptor (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) are molecules involving in the initiation and progression of atherosclerosis. In order to examine a possible difference in LOX-1 and MCP-1 expressions depending on the severity of early stage of atherosclerosis...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225016074
更新日期:2004-10-01 00:00:00
abstract::Advances in neuromodulation techniques offer the promise of new therapeutic interventions for patients with neuropsychiatric maladies. Several complex social, ethical and policy issues will attend developments in this area. In this paper an ethical framework for clinical research in interventional cognitive neuroscien...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2000.11740670
更新日期:2000-04-01 00:00:00
abstract::The frequency of skull metastasis from hepatocellular carcinoma (HCC) is increasing together with the recent progress in the management of the primary lesion. Cases are often complicated with poor general conditions or metastasis to the other organs, and not readily indicated for surgery. A direct injection of ethanol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740593
更新日期:1998-12-01 00:00:00
abstract::This study was designed to evaluate the effects of two consecutive ischaemias on extracellular monoaminergic neurotransmitter concentrations. The data on the neuroamine changes induced by the second ischaemia could be used to assess the delay in aminergic neurotransmission subsequent to the primary injury. Dopamine (D...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740134
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:Surgical management of sphenoorbital meningiomas ranges among the most complex of intracranial tumors. We report on our experience of surgical technique, outcome, and tumor recurrence in sphenoorbital meningiomas. METHODS:Between 2003 and 2013, surgical resections for sphenoorbital meningioma were performed ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000329
更新日期:2014-08-01 00:00:00
abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1457130
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12761752770177
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Diabetes is one of the major risk factors for ischemic stroke and is reported to aggravate the ischemic brain damage in different experimental models as well as clinical situations. However, the mechanisms underlying the exacerbated ischemia/reperfusion (I/R) brain injury associated with comorbid diabetes ar...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000015
更新日期:2011-10-01 00:00:00