Abstract：
:Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative motor neuron disease in adults, whose relentless course leads to death within 2-5 years, generally due to respiratory failure. Apart from the age and site of onset, no other factors have consistently demonstrated to be related to the ALS outcome. The aim of the study was to investigate the influence of fasting serum lipid levels (cholesterol and triglycerides) and the body mass index (BMI) at the time of diagnosis on survival in ALS patients. The study included 82 patients with ALS residing in the Belgrade area who were diagnosed with ALS over a time period of 4 years (2006-2009). Survival was assessed by the Kaplan-Meier method. In this retrospective study, 39 (47.56%) patients had normal values of lipids and 43 (52.43%) patients had hyperlipidemia. The mean survival time from the onset of symptoms for patients with normal lipidemia was 4.21 ± 0.5 years, while the mean survival time from the onset of symptoms for patients with hyperlipidemia was 5.0 ± 0.67 years (P = 0.36). We also did not register a significant difference in survival in relation to gender, the site or age of onset, even though we noticed a longer survival in patients with hyperlipidemia in all of the examined groups, especially in the group of younger patients, with the onset of the disease before the age of 45 years. If we take into account the fact that BMI is pathophysiologically associated with cholesterol and triglyceride serum levels, the results in our study complement each other showing that patients with a higher BMI, registered in 28.8% of the cases, do not live longer. Our findings show that hyperlipidemia, which we found in 52.43% of our ALS patients, at the time of diagnosis, is not related to significantly longer survival.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Dedic SI,Stevic Z,Dedic V,Stojanovic VR,Milicev M,Lavrnic Ddoi
10.1179/1743132812Y.0000000049subject
Has Abstractpub_date
2012-07-01 00:00:00pages
576-80issue
6eissn
0161-6412issn
1743-1328pii
ner2784journal_volume
34pub_type
杂志文章abstract：OBJECTIVE:To investigate mechanisms behind the faster rehabilitation of limb fractures when associated with traumatic brain injury (TBI). METHODS:New Zealand rabbits were divided into TBI group and sham-operation group for four studies as follows: (1) blood and cerebrospinal fluid (CSF) were drawn on days 1, 3, and 7 ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132813Y.0000000201
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. A contribution from complement has long been suspected. We investigated the association of complement factor H (CFH) Tyr402 His gene polymorphism and serum level in Egyptian patients with MS to examine whet...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132815Y.0000000075
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:There is no definitive data regarding the usefulness of Brain microbleeds (BMBs) as an imaging marker with homeostatic markers to predict intracerebral hemorrhage (ICH) and ischemic stroke risk to personalize decisions on anticoagulation in AF. In this study, we prospectively evaluated clinical, radiological...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2018.1517111
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:In order to avoid occurrence of post-operative hygromas in specific hydrocephalus patients being at high risk of overdrainage, a combination of programmable valve and anti-gravity device is widely recommended. We analyzed our series of hydrocephalus patients implanted with such a shunt configuration focusin...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132811Y.0000000079
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:Vascular endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production. The present study examined if thrombin modulates vascular endoth...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/174313209X385699
更新日期：2009-09-01 00:00:00
abstract：:The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and environmental factors play important roles in its pathogenesis. While demyelination of axons is a hallmark histological feature of MS, axonal and neuronal dysfunction may correlate better with clinical disability. All major immune cell ...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/016164106X98125
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:Intravenous administration of recombinant tissue plasminogen activator (rtPA) is known as the only approved treatment for acute ischemic stroke. However, it is still controversial whether acute ischemic stroke patients with atrial fibrillation should receive rtPA therapy. METHODS:We studied 99 patients altog...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164110X12656393665206
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To explore the risk factors for stroke-associated pneumonia (SAP). METHODS:A retrospective research study was carried out to investigate the clinical data of 1435 patients admitted to the neurological intensive care unit at our university hospital between 1 January 2000 and 31 December 2009. RESULTS:A multi...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164111X13007856084205
更新日期：2011-06-01 00:00:00
abstract：:This paper describes a test prototype for precision robot-assisted surgery using a hexapod operating robot and a movable operating cockpit for tactile feedback. The objective of the work described is twofold: 1, to evaluate the use of hexapod robots for precisely manipulating endoscopes and surgical instruments in sub...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740887
更新日期：1999-01-01 00:00:00
abstract：:Dementia is one of the commonest neurological disorders in the elderly population. In regards to the increasing longevity of populations worldwide, prevention of dementia has become a major public health challenge. There has been an intense research in the identification of modifiable risk factors for dementia. These ...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/016164106X130498
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVES:Disturbances in the hypothalamo-pituitary axis are supposed to modulate activity of multiple sclerosis (MS). We hypothesised that the extent of HYP damage may determine severity of MS and may be associated with the disease evolution. We suggested fatigue and depression may depend on the degree of damage of t...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2016.1275460
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164107X172167
更新日期：2007-09-01 00:00:00
abstract：:Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 1...
journal_title：Neurological research
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP.Methods: A total of 36 male Sprague-Dawley rats were divi...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2019.1685064
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:To explore clinical features and compare of the difference between conservative treatment and surgical treatmentin prognosis of intracranial aneurysms associated with moyamoya disease (MMD). METHODS:104 patients with MMD a ssociated with intracranial aneurysms diagnosed by digital subtraction angiography (D...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2020.1773663
更新日期：2020-09-01 00:00:00
abstract：:Cerebral aneurysms are composed principally of collagen, a birefringent protein which is responsible for withstanding the forces of blood pressure. The known correlation between collagen birefringence and its mechanics provides the basis for using polarizing microscopy to evaluate the strength of collagen, layer by la...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740986
更新日期：1999-10-01 00:00:00
abstract：:Cyclic GMP (cGMP) mediates smooth muscle relaxation in the central nervous system. In subarachnoid hemorrhage (SAH), decreases in intrinsic nitric oxide (NO) cause cerebral vasospasms due to the regulation of cGMP formation by NO-mediated pathways. As phosphodiesterase type V (PDE V) selectively hydrolyzes cGMP, we hy...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164102101200447
更新日期：2002-09-01 00:00:00
abstract：:The STA-MCA (superficial temporal artery-middle cerebral artery) bypass has become increasingly popular in the treatment of cerebral vascular disease. Indication and assessment of postoperative results have been based on clinical grounds and on findings from cerebral angiography (10). In order to obtain objective data...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1983.11739638
更新日期：1983-01-01 00:00:00
abstract：:We elected to compare the clinical outcomes of carotid endarterectomy (CEA) patients who were thought to be at increased risk for peri-operative complications because of advanced age (> 79 years), medical comorbidities and contralateral internal carotid artery occlusion to patients without these risk factors. A prospe...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164102101199936
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:To study whether Clopidogrel-Aspirin combined treatment for high risk transient ischaemic attack (TIA) or minor stroke results in increased number of lesions associated with anti-thrombotic cerebral haemorrhage or cerebral micro-bleeds (CMB) than aspirin alone treatment. METHODS:The patients recruited in CH...
journal_title：Neurological research
pub_type： 杂志文章,随机对照试验
doi：10.1179/1743132815Y.0000000087
更新日期：2015-11-01 00:00:00
abstract：:Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164101101198208
更新日期：2001-01-01 00:00:00
abstract：:The objective of this study was to improve the ability to detect cerebrovascular complications in patients undergoing complicated neurosurgical procedures using on-line monitoring of cerebral pH with in vivo microdialysis. We employed on-line pH monitoring in patients with a variety of neurosurgical procedures includi...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1998.11740497
更新日期：1998-03-01 00:00:00
abstract：:The object of the study was to evaluate brain tissue oxygenation (p(ti)O2) for intra-operative monitoring of critical ischemic events during early cerebral aneurysm surgery of the anterior circulation supplementary to somatosensory evoked potentials (SEPs). P(ti)O2 was continuously evaluated during surgery for an intr...
journal_title：Neurological research
pub_type： 临床试验,杂志文章
doi：10.1179/016164102101200528
更新日期：2002-09-01 00:00:00
abstract：:As early as 1 to 3 hr after cord transection, proliferation of many reactive oligodendrocytes was observed. Bundles of microfilaments and microtubules were observed in those cells that sent out long, complex pseudopodlike processes near the area of injury. These reactive oligodendrocytes may be comparable to Vaughn's ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1980.11739566
更新日期：1980-01-01 00:00:00
abstract：INTRODUCTION:Neurotoxic homocysteine (Hcy) is thought to be an independent risk factor for neurodegenerative diseases, including Alzheimer's disease. This study is to determine whether HT22 cells, a murine hippocampal neuronal model, can be used as an in vitro model, besides the primary neuronal cultures, to investiga...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132811Y.0000000057
更新日期：2012-01-01 00:00:00
abstract：:A prospective study of the expression of the chemokine receptor CCR7 was performed in 11 relapsing-remitting multiple sclerosis (MS) patients during 12 months of interferon-beta (IFNbeta) treatment. The results show increased expression of CCR7 on peripheral blood lymphocytes (PBL) of MS patients receiving IFNbeta tre...
journal_title：Neurological research
pub_type： 临床试验,杂志文章
doi：10.1179/016164107X228633
更新日期：2007-12-01 00:00:00
abstract：:Recent publications have suggested that intra-ocular pressure (IOP) may be an indirect assessment of intra-cranial pressure (ICP). Both IOP and ICP have similar physiologic pressure ranges and similar responses to changes in intra-abdominal, intra-thoracic and aortic pressure. Previous studies have demonstrated the re...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740925
更新日期：1999-04-01 00:00:00
abstract：:At present, no practical method exists for monitoring the progression and severity of cerebral oedema in a clinical setting on a continuous basis. In search for such a method, we investigated the electrical characteristics of cerebral tissue at microwave frequencies to quantify cerebral oedema. The dielectric constant...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1992.11740065
更新日期：1992-06-01 00:00:00
abstract：:Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/016164105X25225
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family. In this family, male patients were moderately to severely affected. METHODS:We performed immunofluorescence to ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2016.1204494
更新日期：2016-10-01 00:00:00
