Cardiac risk factors and potential treatments in Alzheimer's disease.

abstract：:We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...

journal_title：Neurological research

authors： Lo EH,Rogowska J,Batchelder KF,Wolf GL

更新日期：1996-04-01 00:00:00

abstract：:In addition to its possible role as a replacement source in CNS degenerative diseases, neural transplantation may be used to augment the normal production of neuroactive substances. Our laboratory at the University of Illinois at Chicago has shown, in both acute and chronic pain models, that transplantation of adrenal...

journal_title：Neurological research

authors： Pappas GD,Lazorthes Y,Bès JC,Tafani M,Winnie AP

更新日期：1997-02-01 00:00:00

abstract：:Neural stem cells (NSCs) are self-renewable, multipotential cells capable of differentiating into the three major neural cell types, but the mechanisms which regulate their development are not fully understood. Both basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote the proliferation of NS...

journal_title：Neurological research

authors： Reimers D,López-Toledano MA,Mason I,Cuevas P,Redondo C,Herranz AS,Lobo MV,Bazán E

更新日期：2001-09-01 00:00:00

abstract：:Mild vascular cognitive impairment (mVCI) is a broader term that is intended to detect cognitive loss before the development of dementia. The identification of preventable risk factors as well as therapeutic strategies of intervention is still unclear. It has been suggested that carotid endarterectomy (CEA) improves c...

journal_title：Neurological research

authors： Borroni B,Tiberio G,Bonardelli S,Cottini E,Facheris M,Akkawi N,Pezzini A,Cervi E,Giulini SM,Padovani A

更新日期：2004-07-01 00:00:00

abstract：:In order to evaluate the relationship between brain oxygen supply and demand (O2 balance) in real time, it is necessary to use a multiparametric monitoring approach. Cerebral blood flow (CBF) is a representative parameter of O2 supply. The extracellular level of K+ is a reliable indicator of O2 demand since more than ...

journal_title：Neurological research

authors： Mayevsky A,Meilin S,Manor T,Ornstein E,Zarchin N,Sonn J

更新日期：1998-01-01 00:00:00

abstract：:Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to reveal severe dyses...

journal_title：Neurological research

authors： Pioli EY,Gross CE,Meissner W,Bioulac BH,Bezard E

更新日期：2003-03-01 00:00:00

abstract：:1-Aminocyclopropanecarboxylic acid is a high affinity ligand with partial agonist properties at strychnine-insensitive glycine sites associated with the N-methyl-D-aspartate subtype of glutamate receptors. Since occupation of these sites appears required for operation of N-methyl-D-aspartate, receptor coupled cation c...

journal_title：Neurological research

authors： Fossom LH,Von Lubitz DK,Lin RC,Skolnick P

更新日期：1995-08-01 00:00:00

abstract：:The effects of etomidate on focal cerebral ischaemia following transorbital occlusion of the cat middle cerebral artery were investigated. Etomidate had no effect on CBF before or after onset of ischaemia by comparison with controls, but caused a greater fall in CBF in cats with high preocclusion or initial ischaemic ...

journal_title：Neurological research

authors： Venables GS,Strong AJ,Miller SA,Gibson G,Hardy JA

更新日期：1986-12-01 00:00:00

abstract：:Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...

journal_title：Neurological research

authors： Chun Y,Chen Y,Elsisy M,Sukinik J,Shridhar P,Park JK,Kim YB,Hong CK,Chung J

更新日期：2019-07-01 00:00:00

abstract：:The aim of this study was to examine the pre-operative clinical and neuromonitoring courses in patients with a decompressive craniectomy to assess and to compare clinical and neuromonitoring signs indicating extensive cerebral edema. We conducted a retrospective analysis of the clinical signs and courses of simultaneo...

journal_title：Neurological research

authors： Strege RJ,Lang EW,Stark AM,Scheffner H,Fritsch MJ,Barth H,Mehdorn HM

更新日期：2003-07-01 00:00:00

abstract：:Recent work has suggested that one factor in the etiology of the neuromuscular disease, amyotrophic lateral sclerosis (ALS), may be an autoimmune mechanism in which presynaptic voltage-sensitive calcium channels are an antigenic target. We have developed a fluorescence technique to measure rapid Ca2+ influx through pr...

journal_title：Neurological research

authors： Thomas MM,Dunn SM

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...

journal_title：Neurological research

authors： Oishi A,Tobimatsu S,Ogata K,Taniwaki T,Kinukawa N,Toyoshiba H,Kira J

更新日期：2008-12-01 00:00:00

abstract：:Anesthesia is an essential element during the induction of ischemia/reperfusion and cerebral blood flow (CBF) measurement in most animal models. Cerebral neuroprotection and intrinsic effects on CBF afforded by anesthetics are confounding variables in those models. A new model of global forebrain ischemia/reperfusion ...

journal_title：Neurological research

authors： Melgar MA,Park H,Rafols JA,Diaz FG

更新日期：2002-01-01 00:00:00

abstract：:The mechanism of cerebral ischaemic injury is complex and likely involves more than a single pathophysiologic event. Drugs are available which interfere with numerous harmful biochemical and pharmacologic processes begun by ischaemia. Hence, combination chemotherapy might be useful in cerebral ischaemia. The purpose o...

journal_title：Neurological research

authors： Auer RN

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:In conditions with reduced glucose levels/inability of glucose utilization, ketone bodies, especially beta-hydroxybutyrate (BHB), become a major energy source in the brain. In animal models, BHB infusion shows acute beneficial effects on the hypoxic brain. The present prospective observational study is the f...

journal_title：Neurological research

authors： Pikija S,Trkulja V,Simundic AM,Vrcek E,Boskovic K,Bacani S

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the characteristics of atherosclerotic middle cerebral artery (MCA) stenosis by high-resolution magnetic resonance imaging (HR-MRI) and determine the relationship between wall characteristics and infarction patterns. METHODS:Thirty-six patients with acute ischaemic stroke due to MCA stenosis unde...

journal_title：Neurological research

authors： Zhao DL,Deng G,Xie B,Gao B,Peng CY,Nie F,Yang M,Ju S,Teng GJ

更新日期：2016-07-01 00:00:00

abstract：:This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monke...

journal_title：Neurological research

authors： Tranmer BI,Iacobacci R,Feiler S

更新日期：1990-03-01 00:00:00

abstract：:Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism r...

journal_title：Neurological research

authors： Nedergaard M,Gjedde A,Diemer NH

更新日期：1987-12-01 00:00:00

abstract：:Magnetic resonance (MR) is a powerful new imaging modality which has recently become competitive with X-ray computed tomography (CT) for imaging of the central nervous system (CNS). The advantages of MR include lack of ionizing radiation and the necessity to use iodinated contrast. MR is able to image directly in the ...

journal_title：Neurological research

authors： Bradley WG Jr

更新日期：1984-09-01 00:00:00

abstract：:The objective was to examine the effect of the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME) on leukocyte adhesion in the cerebral microcirculation during reperfusion following partial forebrain ischemia in the rat. Intravital fluorescence video-microscopy through a closed cranial win...

journal_title：Neurological research

authors： Hudetz AG,Wood JD,Kampine JP

更新日期：1999-06-01 00:00:00

abstract：:Coupling of neuronal activity to cerebral blood flow (CBF) is widely accepted, but the exact mechanism is still under investigation. We assessed the responses of CBF coupled with electrical activity over the primary somatosensory cortex (S-I) during electrical stimulation of the contralateral forearm in cats. CBF in S...

journal_title：Neurological research

authors： Ichimi K,Kuchiwaki H,Inao S,Shibayama M,Yoshida J

更新日期：1999-09-01 00:00:00

abstract：:Somatosensory-evoked potentials induced by electrical stimulation of the median nerve were recorded in patients with intracerebral lesions and in normal controls and were studied by means of spectral analysis. The results shown that (1) there is a statistically-significant difference between spectral distributions obt...

journal_title：Neurological research

authors： Kusske JA,Romiti JA,Porter RW,Verzeano M

更新日期：1980-01-01 00:00:00

abstract：:Despite the accumulation of intraoperative data on arteriovenous malformations (AVMs), details of the haemodynamics have not yet been elucidated. A hydraulic model was constructed from silicone and glass tubes to simulate a high-flow AVM. During stepwise obliteration of the nidus, haemodynamic changes were continuousl...

journal_title：Neurological research

authors： Nagasawa S,Kawanishi M,Tanaka H,Ohta T,Nagayasu S,Kikuchi H

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Giant and large intracranial aneurysms represent enormous therapeutic challenges for neurosurgeons as well as for endovascular therapists. Since they may involve entire vessels or be irregular in shape, the rate of complete obliteration with GDCs is low and the incidence of recanalization is very high. So th...

journal_title：Neurological research

authors： Yang X,Wu Z,Mu S,Li Y,Lv M

更新日期：2008-07-01 00:00:00

abstract：:From 118 transsphenoidally operated patients, 100 had a pituitary adenoma; 33 prolactinomas, 20 HGH-producing, 2 ACTH-producing and 45 inactive adenomas. The first transsphenoidal operation did not cause any mortality; after reoperation for suspected recurrence on follow-up, 2 patients died; thus, the global managemen...

journal_title：Neurological research

authors： Auer LM,Clarici G

更新日期：1985-09-01 00:00:00

abstract：:Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...

journal_title：Neurological research

authors： Zhang N,Zhang B,Rajah GB,Geng X,Singh R,Yang Y,Yan X,Li Z,Zhou W,Ding Y,Sun W

更新日期：2018-06-01 00:00:00

abstract：:Microsurgical anatomy for the pterional approach was studied regarding the origin and the course of the ophthalmic artery and the distal dural ring using human cadaveric specimens, with special reference to the surrounding bony structures. In 50 human adult formalin-fixed cadaveric cerebral hemispheres and 10 block sp...

journal_title：Neurological research

authors： Hokama M,Hongo K,Gibo H,Kyoshima K,Kobayashi S

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...

journal_title：Neurological research

authors： Hou D,Liu J,Feng R,Gao Y,Wang Y,Wu J

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To estimate the incidence of cognitive impairment (CI) among cognitively healthy, Mexican subjects, and to evaluate the impact of demographic and vascular factors on the conversion to CI and mortality. METHODS:734 eligible subjects (aged 55 to >90 years) from a population-based sample were examined. The cog...

journal_title：Neurological research

authors： Arauz A,Alonso E,Rodríguez-Saldaña J,Reynoso-Marenco M,Benitez IT,Mayorga AM,Rodríguez-Agudelo Y,Romero AV,Cantú C

更新日期：2005-12-01 00:00:00

abstract：:In patients with head trauma and consecutive acute diffuse cerebral swelling the sudden initial rise in intracranial pressure with subsequent impairment of cerebral blood flow is explained by engorgement due to vasoparalysis. How quickly hyperaemic brain swelling can occur is shown by a case report. The review of clin...

journal_title：Neurological research

authors： Krasznai L,Grote EH

更新日期：1994-02-01 00:00:00