Abstract:
OBJECTIVE:To evaluate the characteristics of atherosclerotic middle cerebral artery (MCA) stenosis by high-resolution magnetic resonance imaging (HR-MRI) and determine the relationship between wall characteristics and infarction patterns. METHODS:Thirty-six patients with acute ischaemic stroke due to MCA stenosis underwent diffusion-weighted magnetic resonance imaging (DWI) and HR MRI. Wall characteristics of MCA, including irregular surface, superior location, T2-hyperintense of plaques and positive remodelling (PR), were analysed. Characteristics of acute infarct on DWI were categorised according to the number (single or multiple infarcts) and the pattern of cerebral infarcts (cortical, border zone or perforating artery territory infarcts). The relationship between wall characteristics and infarction patterns was evaluated. RESULTS:PR was observed in 20 patients, irregular surface plaque in 18 patients, superior location of plaques in 14 patients and T2-hyperintense foci in 13 patients. Seventeen patients had multiple acute cerebral infarcts and 13 showed single acute cerebral infarcts. Border zone infarcts were the most common (76.5%) among multiple acute infarcts. Penetrating artery infarcts (PAI) accounted for 76.9% of all single infarcts. Multiple infarcts were more frequently observed in patients with PR (P = 0.007) or plaque surface irregularity (P = 0.035). Single infarcts, especially PAI, were more prevalent in patients with superior plaque (P = 0.030). No statistically significant differences were observed between multiple and single infarcts in patients with T2-hyperintense lesions (P = 0.638). CONCLUSIONS:PR or irregular surface plaques were associated with artery-to-artery embolism. Superior location of plaques was associated with PAI. HR-MRI provides insights into intracranial atherosclerosis in vivo, predictive of infarction patterns.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Zhao DL,Deng G,Xie B,Gao B,Peng CY,Nie F,Yang M,Ju S,Teng GJdoi
10.1179/1743132815Y.0000000088subject
Has Abstractpub_date
2016-07-01 00:00:00pages
606-13issue
7eissn
0161-6412issn
1743-1328journal_volume
38pub_type
杂志文章abstract::The purpose of this study was to investigate the correlation between activity-related pain six months after first surgery for herniated lumbar disc, and the extent of lumbar epidural fibrosis present at the surgical site, assessed by magnetic resonance imaging. The 298 patients who underwent surgery for lumbar disc he...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1080/01616412.1999.11741025
更新日期:1999-01-01 00:00:00
abstract::A 52-year-old male underwent lumboperitoneal shunting after external decompressive craniectomy. His postoperative course was accompanied by remarkable displacement of the intracranial structures to the opposite side of craniectomy. This phenomenon, probably caused by the siphon effect of cerebrospinal fluid shunting, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739979
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X165642
更新日期:2007-01-01 00:00:00
abstract::The goal of this paper is to provide scientists with a comprehensive review of the state-of-the-art influence the ischemic blood-brain barrier (BBB) has on the final development of Alzheimer's disease and to provide detailed food-for-thought which will hopefully stimulate more researchers in this area of neuroscience....
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X130399
更新日期:2006-09-01 00:00:00
abstract::Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS).Methods: A total of 20 patients with relapsing remitting m...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1726585
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:Natalizumab is a drug with documented efficacy in relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of natalizumab has immunosuppressive properties and it is not yet investigated if treatment with natalizumab affects the immunological response to vaccination. This study aims to investig...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000059
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Giant and large intracranial aneurysms represent enormous therapeutic challenges for neurosurgeons as well as for endovascular therapists. Since they may involve entire vessels or be irregular in shape, the rate of complete obliteration with GDCs is low and the incidence of recanalization is very high. So th...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/174313208X319017
更新日期:2008-07-01 00:00:00
abstract::Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1454092
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Microglial cells in spinal dorsal horn can be activated by nociceptive stimuli and the activated microglial cells release various cytokines enhancing the nociceptive transmission. However, the mechanisms underlying the activation of spinal microglia during nociceptive stimuli have not been well understood. I...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1281198
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate the effects of the GLP-1 analog liraglutide on beta-amyloid (Aβ)-induced neurotoxicity in the human neuroblastoma cell line SH-SY5Y and study the underlying mechanisms. METHODS:Cultured SH-SY5Y cells in vitro were randomly divided into normal control group, beta-amylo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1145914
更新日期:2016-04-01 00:00:00
abstract::Choroid plexus carcinoma in an adult case is a very rare tumor and difficult to differentiate from metastatic tumors. The authors report a case of a 49-year-old female with choroid plexus carcinoma who previously had multiple carcinomas. In this case, synaptophysin immunohistochemistry proved to be extremely helpful f...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740704
更新日期:2000-07-01 00:00:00
abstract::The treatment of arteriovenous malformations depends on the efforts of a multidisciplinary team whose ultimate goal is to achieve better results when compared to the natural history of the pathology. The role of adjuvant treatment modalities such as radiosurgery and endovascular embolization is discussed. Treatment st...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1998.11740583
更新日期:1998-12-01 00:00:00
abstract::Background: Surgery of parasagittal meningiomas (PSMs) is still technically challenging, for the balance between radical resection and preservation of venous circulation. In this article, we'd systemically introduce the technical nuances of a simplified strategy for radical resection of all types of PSMs. All the case...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1847530
更新日期:2020-11-11 00:00:00
abstract:OBJECT:The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo® application on brain injury in experimental TBI mice using S...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1330815
更新日期:2017-09-01 00:00:00
abstract::We postulate that severe atherosclerotic occlusion of the circle of Willis and leptomeningeal arteries is an important factor in the pathogenesis of some sporadic Alzheimer's disease (AD) cases. These arterial stenoses are complicated by an overwhelming amyloid accumulation in the walls of leptomeningeal and cortical ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225017668
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:Susceptibility-weighted (SW) magnetic resonance (MR) imaging is a sensitive test to detect intravenous deoxygenated blood. On SW images, dilated appearing draining veins in tissue with perfusion impairment occur due to an increase in intravenous deoxyhemoglobin levels, and could indicate poor perfusion areas...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12644252260510
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Multiple lines of evidence suggest that general anesthesia helps the recovery from sleep deprivation. However, little is known about the underlying neurochemical mechanisms. In the current study, we investigated the effect of anesthetic propofol on the release of glutamate (Glu) and γ-amino butyric acid (GABA...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2015.1114231
更新日期:2015-01-01 00:00:00
abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740472
更新日期:1996-12-01 00:00:00
abstract::We currently have used three drugs in combination [mannitol, vitamin E and glucocorticoid (beta-methasone)] for the treatment of cerebral infarction in the acute stage. For the purpose of evaluating the efficacy of this therapy, we have conducted experiments evaluated by chemiluminescence (CL), energy metabolism and w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739819
更新日期:1988-06-01 00:00:00
abstract::We describe a case of rebleeding from an intracranial vertebral dissecting aneurysm following proximal clipping. This case suggests that proximal clipping alone may not be an adequate surgical procedure to prevent rebleeding. Surgical treatment of intracranial dissecting aneurysms in the vertebral artery presenting as...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1994.11740213
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVES:We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS:Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS:A(2A) ant...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X21913
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The aim of this report was to set up an effective experimental model of cocultures between cells from spinal cord explants and myotubes from adductor muscle. METHODS:We obtained neuronal cells from chick spinal cord explants at embryonic day 5 (ED5) by means of an enzymatic digestion. Small spinal cord fragm...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X281064
更新日期:2008-03-01 00:00:00
abstract::A computer software program (Seapit) was developed for precise determination of intracranial targets identified by stereotactic computed tomography (CT). This program was added to the software of a GE 8800 CT scanner to perform the following operations: millimetre precise calculation and display of the rectilinear coo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739781
更新日期:1987-06-01 00:00:00
abstract:OBJECTIVE:To explore the value of dynamically monitored levels of plasma prothrombin fragment(1+2) (F(1+2)) and D-dimer in the process of thrombolysis with urokinase. METHODS:Blood samples were collected at baseline and at hours 1, 2, 3, 6, 12, 24, 48, 72, and 96 after urokinase infusion finished. The levels of plasma...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X443991
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Neurotoxic homocysteine (Hcy) is thought to be an independent risk factor for neurodegenerative diseases, including Alzheimer's disease. This study is to determine whether HT22 cells, a murine hippocampal neuronal model, can be used as an in vitro model, besides the primary neuronal cultures, to investiga...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000057
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Disturbances in the hypothalamo-pituitary axis are supposed to modulate activity of multiple sclerosis (MS). We hypothesised that the extent of HYP damage may determine severity of MS and may be associated with the disease evolution. We suggested fatigue and depression may depend on the degree of damage of t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1275460
更新日期:2017-04-01 00:00:00
abstract::In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740128
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Misery perfusion increases the risk of stroke recurrence in patients with symptomatic major cerebral artery occlusion. The ratio of brain perfusion contralateral-to-affected asymmetry in the cerebellar hemisphere to brain perfusion affected-to-contralateral asymmetry in the cerebral hemisphere ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000300
更新日期:2014-03-01 00:00:00
abstract::The purpose of this prospective observational study was to investigate the relation between the frequency of critical neuromonitoring parameters (brain tissue pO2, (PtiO2) < or = 10 mmHg, intracranial pressure (ICP) > 20 mmHg, cerebral perfusion pressure (CPP) < or = 70 mmHg) and outcome after severe aneurysmal subara...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164103101201823
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies have shown that awareness of early stroke symptoms and the use of ambulances are two important factors in decreasing pre-hospital stroke delay. The purpose of this study is to evaluate a comprehensive educational stroke protocol in improving stroke response times. METHOD:Two urban commun...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000203
更新日期:2013-06-01 00:00:00