Abstract:
:Coupling of neuronal activity to cerebral blood flow (CBF) is widely accepted, but the exact mechanism is still under investigation. We assessed the responses of CBF coupled with electrical activity over the primary somatosensory cortex (S-I) during electrical stimulation of the contralateral forearm in cats. CBF in S-I was monitored using laser-Doppler flowmetry (LDF), and electrical activity was recorded with a tungsten microelectrode. The effects of varying stimulus intensity and frequency were examined to assess the optimal stimulation parameters. CBF increased within 10 sec after onset of stimulation, sustained the plateau level, and returned to the pre-stimulus level after cessation of stimulation. The maximum response was obtained at 4 Hz under a constant intensity. Optimal stimulus intensity at 4 Hz ranged from 8 to 10 V. At intensity higher than 10 V, CBF increases reached a near-plateau level, while mean arterial blood pressure (MABP) decreased slightly. Electrical activity was recorded at the same restricted area where CBF increased. Low frequency components of the power spectrum of electrical activity increased as the CBF increase became greater. A tight coupling of CBF increases to neuronal activation is suggested, and CBF regulation may be affected by stimulation parameters.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Ichimi K,Kuchiwaki H,Inao S,Shibayama M,Yoshida Jdoi
10.1080/01616412.1999.11740980subject
Has Abstractpub_date
1999-09-01 00:00:00pages
579-84issue
6eissn
0161-6412issn
1743-1328journal_volume
21pub_type
杂志文章abstract:OBJECTIVE:Diabetes is one of the major risk factors for ischemic stroke and is reported to aggravate the ischemic brain damage in different experimental models as well as clinical situations. However, the mechanisms underlying the exacerbated ischemia/reperfusion (I/R) brain injury associated with comorbid diabetes ar...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000015
更新日期:2011-10-01 00:00:00
abstract::We postulate that severe atherosclerotic occlusion of the circle of Willis and leptomeningeal arteries is an important factor in the pathogenesis of some sporadic Alzheimer's disease (AD) cases. These arterial stenoses are complicated by an overwhelming amyloid accumulation in the walls of leptomeningeal and cortical ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225017668
更新日期:2004-07-01 00:00:00
abstract::The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739995
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12518779082192
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to investigate the effect of bone mesenchymal stem cells (BMSCs) conditioned medium on BMP4-induced activation of the Smad signaling pathway during the process of neural stem cells differentiation. METHODS:We designed four experimental groups: (A) control group, (B) BMP-4 treatment g...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1232549
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND/AIMS:Both of neuromyelitis optica spectrum disease (NMOSDs) and idiopathic transverse myelitis (ITM) could present as acute transverse myelitis. However, long-term immunological treatment and prognosis are different for high recurrence of NMOSDs. In this study, we summarized clinical differences between acut...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1773628
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other poss...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X159261
更新日期:2007-07-01 00:00:00
abstract::We have reliable data on the degree of stenosis above which endarterectomy for symptomatic carotid stenosis is beneficial, but benefit is also influenced by other factors, particularly age, sex, the timing of surgery, plaque surface morphology and the nature of the presenting symptomatic event(s). This review will con...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X25298
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of electrical stimulation (ES), stretching and their combined effects in matrix metalloproteinases (MMPs) gene expression and activity during early denervation of rat tibialis anterior (TA) muscle by axonotmesis. METHODS:Thirty adult male Wistar rats were divided into five groups: no...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X459093
更新日期:2010-10-01 00:00:00
abstract::The objective of this study was to determine, whether 0.5-2/min oscillations in intracranial pressure ('B-waves') are a physiological phenomenon. In a group of 5 patients 0.5-2/min oscillations of ventricular pressure simultaneous with oscillations in the middle cerebral artery (MCA) flow velocity, as assessed by tran...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739891
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:Cerebral hyperperfusion syndrome (HPS) is a potential complication of extracranial-intracranial (EC-IC) bypass for moyamoya disease; however, the pathological threshold of the early cerebral blood flow (CBF) increases after EC-IC bypass has yet to be determined. The purpose of this study is to evaluate the pr...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000432
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X165642
更新日期:2007-01-01 00:00:00
abstract::L-644,711 is a novel anion channel inhibitor which has previously been shown to decrease brain injury in two related rabbit models of cerebral ischaemia. We hypothesize two mechanisms of action of L-644,711 for its salutary effects on cerebral ischaemia: inhibition of neutrophil function and prevention of excitotoxin ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740011
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:To investigate risk factors for neurological complications after off-pump coronary artery bypass grafting (OPCABG). METHODS:We reviewed the cases of 813 patients who underwent OPCABG between August 2010 and September 2013.Data from preoperative 320 dynamic volume computed tomography (CT), CT angiography (CTA...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000030
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:The actual relationship between neural stem cells and SDF-1alpha/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, could contribute to neural stem cells migration after brain injury. In th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X332995
更新日期:2009-02-01 00:00:00
abstract::We currently have used three drugs in combination [mannitol, vitamin E and glucocorticoid (beta-methasone)] for the treatment of cerebral infarction in the acute stage. For the purpose of evaluating the efficacy of this therapy, we have conducted experiments evaluated by chemiluminescence (CL), energy metabolism and w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739819
更新日期:1988-06-01 00:00:00
abstract::Intravenous infusion of glycerol has been used in patients with a cerebral infarction, expecting improvement in brain edema and cerebral blood flow (CBF). However, the mechanism of the improvement of CBF has not been clearly demonstrated. The aim of this study in the rat pial microvasculature after transient middle ce...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11741015
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:Repetitive magnetic stimulation (rMS) is mainly used in transcranial applications. Only a few works have described its potential peripheral use. The aim of this investigation was to determine if conditioning peripheral (paravertebral) rMS of the cervical nerve roots in a group of healthy subjects induces chan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X297959
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To explore clinical features and compare of the difference between conservative treatment and surgical treatmentin prognosis of intracranial aneurysms associated with moyamoya disease (MMD). METHODS:104 patients with MMD a ssociated with intracranial aneurysms diagnosed by digital subtraction angiography (D...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1773663
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To explore the influences of mammalian target of rapamycin (mTOR) signaling pathway on ketamine-induced apoptosis, oxidative stress and Ca2+ concentration in the hippocampal neurons of rats. METHODS:The primary hippocampal neurons isolated from fetal Sprague Dawley rats were treated with ketamine (0, 50, 100...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1531203
更新日期:2019-01-01 00:00:00
abstract::Six cases of very large anterior circulation intracranial aneurysms are presented. Aneurysms of 53-84 mm in three female and two male adults and a 40 mm lesion in a seven week infant were successfully excised. Three patients tolerated trial intraluminal balloon occlusion preoperatively and underwent subsequent parent ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740053
更新日期:1992-01-01 00:00:00
abstract::Advances in neuromodulation techniques offer the promise of new therapeutic interventions for patients with neuropsychiatric maladies. Several complex social, ethical and policy issues will attend developments in this area. In this paper an ethical framework for clinical research in interventional cognitive neuroscien...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2000.11740670
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Surgical resection of complex glomus vagale tumors can be complicated by extensive blood loss and might require surgical sacrifice of an encased internal carotid artery. METHODS:A young patient presented with mass effect from glomus valage tumor. Computerized tomography angiography showed an encased interna...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132812Y.0000000036
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2018.1446283
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To explore the value of dynamically monitored levels of plasma prothrombin fragment(1+2) (F(1+2)) and D-dimer in the process of thrombolysis with urokinase. METHODS:Blood samples were collected at baseline and at hours 1, 2, 3, 6, 12, 24, 48, 72, and 96 after urokinase infusion finished. The levels of plasma...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X443991
更新日期:2009-05-01 00:00:00
abstract::Fifteen patients with symptoms of cerebral ischaemia and angiographically confirmed unilateral stenoses or occlusions of the extracranial internal carotid artery (ICA) and 20 controls were studied by a 2 MHz transcranial Doppler (TCD) at rest and after stimulation with 1 g acetazolamide i.v., a cerebral vasodilator. I...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740033
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Late-onset Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder. Associations of the glutathione S-transferases (GSTs) polymorphisms with the risk factors for AD have not been definitely confirmed. We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1390902
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The aim of this report was to set up an effective experimental model of cocultures between cells from spinal cord explants and myotubes from adductor muscle. METHODS:We obtained neuronal cells from chick spinal cord explants at embryonic day 5 (ED5) by means of an enzymatic digestion. Small spinal cord fragm...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X281064
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of ne...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1576356
更新日期:2019-05-01 00:00:00
abstract::Endolymphatic sac tumors are rare, low-grade adenocarcinomas of the petrous bone. These tumors are highly vascularized and surgical removal is often challenging. We present a staged endovascular-neurosurgical approach consisting of stent-assisted angioplasty of the petrous carotid, selective endovascular embolization ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201436
更新日期:2003-04-01 00:00:00