Abstract:
OBJECTIVE:Cerebral hyperperfusion syndrome (HPS) is a potential complication of extracranial-intracranial (EC-IC) bypass for moyamoya disease; however, the pathological threshold of the early cerebral blood flow (CBF) increases after EC-IC bypass has yet to be determined. The purpose of this study is to evaluate the predictive and diagnostic values of early quantitative CBF analysis for the detection of HPS after EC-IC bypass for moyamoya disease. METHODS:We quantitatively evaluated regional CBF at the site of the anastomosis in 23 patients with moyamoya disease aged between 18 and 66 years (mean, 39.6) before and 1 day after superficial temporal artery-middle cerebral artery anastomosis by an auto-radiographic method using N-isopropyl-p-[(123)I]iodoamphetamine single-photon emission computed tomography. RESULTS:Regional CBF 1 day after surgery was significantly higher in patients with HPS (n = 5; mean, 54.6 ml/100 g/minutes) than in patients without HPS (n = 18; mean, 40.5 ml/100 g/minutes) (P = 0.038). The postoperative/preoperative CBF ratio was significantly higher in patients with HPS (1.84) than in patients without HPS (1.34) (P = 0.044). Multivariate analyses showed that the regional CBF value 1 day after surgery (P = 0.036) and operating on the left hemisphere (P = 0.026) significantly correlated with HPS. All patients with HPS developed symptoms and/or intracerebral hemorrhage more than 2 days after EC-IC bypass. Receiver operating characteristic analysis indicated that the cutoff value of pathological postoperative CBF increase was 46.1 ml/100 g/minutes (sensitivity = 80%, specificity = 77.8%, AUC value = 0.81). CONCLUSION:Quantitative analysis of early postoperative CBF is useful for predicting and diagnosing HPS after revascularization surgery for moyamoya disease.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Fujimura M,Niizuma K,Endo H,Sato K,Inoue T,Shimizu H,Tominaga Tdoi
10.1179/1743132814Y.0000000432subject
Has Abstractpub_date
2015-02-01 00:00:00pages
131-8issue
2eissn
0161-6412issn
1743-1328journal_volume
37pub_type
杂志文章abstract:OBJECTIVES:To assess prospectively the significance of sonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome (CTS), to look for proper parameters and cutoff values for the sonographic diagnosis, and to correlate with the electrophysiological findings. MATERIALS AND METHODS:This study ...
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abstract::The ocular microtremor (OMT) is mediated by the oculomotor area of the brainstem and is altered in several pathologic states, including traumatic brain injury, general anesthesia, brain death, coma, Parkinsonism and multiple sclerosis. The EYETECT tremor monitor is a non-invasive means of measuring the frequency and a...
journal_title:Neurological research
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journal_title:Neurological research
pub_type: 临床试验,杂志文章
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更新日期:2020-11-01 00:00:00
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更新日期:2014-06-01 00:00:00
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更新日期:2017-04-01 00:00:00
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abstract:OBJECTIVES:The aim of this study was to investigate the effects of oral administration of a novel benzodiazepine derivative, JM-20, on the neurological behavior of different rodent models, focusing on the GABAergic effect. We have also investigated the acute toxicity of oral administration of JM-20 in mice. METHODS:Mi...
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更新日期:2013-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2009-04-01 00:00:00
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更新日期:2015-03-01 00:00:00
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更新日期:2015-03-01 00:00:00