Abstract:
:Cerebral hemorrhages are subject to a heavy short- and long-term case fatality. A study of prognostic factors and of relative survival based on the data of a population registry is of great value to study patients having a hematoma of all ages, irrespective of the method of care. We have listed 183 patients having a cerebral hemorrhage between 1 January 1985 and 31 December 1996 and living in the city of Dijon, France. Eighteen clinical and CT-scanning variables have been studied. We have found four predictive factors of death at one month from cerebral hemorrhages. These are, in decreasing order: the existence of consciousness disorders at the initial clinical examination (OR = 5.80, p < 0.0001); an intraventricular hemorrhage (OR = 5.60, p < 0.0001); a hematoma volume over 11 cubic centimeters (OR = 3.53, p = 0.027); lastly, in male patients an age over 70 years (OR = 4.90, p = 0.039). With regard to long-term survival, the existence of consciousness disorders remains the principal predictive factor of case fatality in both crude and relative survival (OR = 5.52, p < 0.0001, in crude survival versus OR = 22.2 in relative survival, p < 0.0001), followed by age over 70 years (OR = 3.71, p < 0.0001 in crude survival and OR = 2.41 in relative survival, p = 0.086). The existence of consciousness disorders at the initial examination following a cerebral hemorrhage would seem to be the principal worst prognostic factor of short- and long-term survival and of relative survival, age and sex having less importance. Moreover, intraventricular hemorrhage and hematoma volume are short-term, pejorative factors. These data, based on a population-based registry, are an important consideration in the acute management of hemorrhagic therapy, and for the design of further therapeutic trials on this severe pathology.
journal_name
Neurol Resjournal_title
Neurological researchauthors
el Chami B,Milan C,Giroud M,Sautreaux JL,Faivre Jdoi
10.1080/01616412.2000.11740754subject
Has Abstractpub_date
2000-12-01 00:00:00pages
791-6issue
8eissn
0161-6412issn
1743-1328journal_volume
22pub_type
杂志文章abstract:OBJECTIVE:Neurovascular ultrasound (nUS) is widely used as a screening and monitoring tool in patients with spontaneous cervical artery dissection (sCAD). The aim of the study was to describe the sonographical course of the affected arteries in patients with a MRI-proven sCAD by repetitive nUS. METHODS:Thirty-seven co...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X319080
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Mapping of brain perfusion using bolus tracking methods is increasingly used to assess the amount and severity of cerebral ischemia in acute stroke. Using relative perfusion maps, however, it is difficult to identify the tissue at risk-maximum (TARM) of infarction with sufficient reliability and reproducibil...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X158956
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:The syntheses of endothelin receptors A and B were previously shown to be upregulated in rat dorsal hippocampus after traumatic brain injury. Here we characterize endothelin receptor A and endothelin receptor B cellular distribution in hippocampus after permanent global brain ischemia and their possible asso...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164111X12881719352291
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:After a spinal cord injury (SCI), most men experience fertility related problems including poor semen quality in which decreased sperm viability and motility, have been proposed to be related to the accessory sex glands dysfunction. In this study, we investigated the probable effects of SCI on the seminal ves...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X268287
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to investigate the effect of bone mesenchymal stem cells (BMSCs) conditioned medium on BMP4-induced activation of the Smad signaling pathway during the process of neural stem cells differentiation. METHODS:We designed four experimental groups: (A) control group, (B) BMP-4 treatment g...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1232549
更新日期:2016-11-01 00:00:00
abstract::Background Transtemporal Doppler (TTD) with middle cerebral artery (MCA) is widely used for right-to-left shunt (RLS) detection. However, an alternative method for patients without suitable temporal bone windows should be established. The present study prospectively evaluated the effectiveness of transorbital Doppler ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1428276
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To investigate mechanisms behind the faster rehabilitation of limb fractures when associated with traumatic brain injury (TBI). METHODS:New Zealand rabbits were divided into TBI group and sham-operation group for four studies as follows: (1) blood and cerebrospinal fluid (CSF) were drawn on days 1, 3, and 7 ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000201
更新日期:2013-06-01 00:00:00
abstract::Magnetic resonance (MR) is a powerful new imaging modality which has recently become competitive with X-ray computed tomography (CT) for imaging of the central nervous system (CNS). The advantages of MR include lack of ionizing radiation and the necessity to use iodinated contrast. MR is able to image directly in the ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1984.11739671
更新日期:1984-09-01 00:00:00
abstract::The relationship between the states of spinal impact injuries and magnetically evoked electromyograms (EMGs) were studied in rats. Impact injuries to the spinal cord were induced at a depth of 0.25-2.0 mm by insertion of a cylinder tip measuring 2 mm in diameter into the lumbar vertebrae L1-L2. Magnetically induced el...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740747
更新日期:2000-10-01 00:00:00
abstract::Synthesized Mn-TPPS, a paramagnetic metalloporphyrin, is expected to be a tumour specific contrast media for magnetic resonance (MR) imaging. We investigated the enhancing characteristics of Mn-TPPS using a transplanted rat C6 glioma model with peripheral type benzodiazepine (PBD) receptors since porphyrins are though...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740260
更新日期:1994-10-01 00:00:00
abstract::Two hundred and sixty-one neurologically asymptomatic patients were examined by computed tomography (CT) following a variable number of transient ischaemic attacks (TIAs) experienced over different time intervals. Cerebral infarcts were discovered in 101 patients. Dominant hemisphere infarcts were usually small, of re...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739720
更新日期:1985-12-01 00:00:00
abstract::It is known that mitochondrial ATP-sensitive potassium channels (mitoKATP) play a significant role in protecting cerebral function from ischemia-reperfusion injury, which is related with a decrease in the mitochondrial matrix calcium. However, the effect of mitochondrial calcium uniporter (MCU) on diazoxide-induced ce...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000299
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172167
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of ne...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1576356
更新日期:2019-05-01 00:00:00
abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740543
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:High blood pressure (BP) is a major risk factor for stroke and all of its pathological subtypes including subarachnoid hemorrhage (SAH). However, there is little evidence demonstrating whether failure to have regular BP measured could result in underestimation of people at risk for SAH. Therefore, we aimed ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000020
更新日期:2011-12-01 00:00:00
abstract::Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga ('Yoga-plus') among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ± 8.7 years old) participated in a 12-month (M) exercise ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1672380
更新日期:2019-11-01 00:00:00
abstract::Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198208
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Recurrent lumbar disc herniation (rLDH) is a common issue after primary discectomy and can cause severe pain, morbidity, and reoperation. The purpose of this systematic review was to evaluate the surgical management of recurrent lumbar disc herniation. METHODS:A systematic literature search was conducted usi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1787661
更新日期:2020-12-01 00:00:00
abstract::The frequency of skull metastasis from hepatocellular carcinoma (HCC) is increasing together with the recent progress in the management of the primary lesion. Cases are often complicated with poor general conditions or metastasis to the other organs, and not readily indicated for surgery. A direct injection of ethanol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740593
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other poss...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X159261
更新日期:2007-07-01 00:00:00
abstract::The purpose of the present study was to examine the effect of nilvadipine (a dihydropyridine-type calcium entry blocker) on the cerebral circulation, experimental models of cerebral ischemia were used to measure abrupt changes in the cortical cerebral blood flow (CBF) at the 'penumbra' (the boundary region between the...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740430
更新日期:1996-08-01 00:00:00
abstract::This study comprises scientific-theoretic fundamental investigations of laserneedle technology, a new and painless method of acupuncture stimulation. Laserneedles are not inserted in the skin, but are merely placed on the surface of the acupuncture point. The study documents the significant changes in peripheral micro...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/016164103101202237
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:Numerous studies have identified different predictors for secondary hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH), although predictors regarding timing of the shunt operation have never been reported. Predictors for an early shunt, which was defined as a shunt operation performed ≤30 days after...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1199184
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:Ischemia/hypoxia (I/H) causes severe neonatal brain injury, such as periventricular leukomaracia and hypoxic/ischemic encephalopathy. Neural stem cell research could lead to a treatment for such disorders. In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we inve...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49283
更新日期:2006-06-01 00:00:00
abstract::The selection of drugs to prevent the development of pathology in cerebral infarction remains an important problem. For the selection of effective drugs from among a large number of possible candidates, widely-used test screening techniques are sufficient for obtaining a good understanding of candidate drug effects. T...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739810
更新日期:1988-03-01 00:00:00
abstract::In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740128
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:We sought to determine whether cerebral inflammation in ischemic rats was reduced by a neuroprotective action of pre-ischemic tumor necrosis factor-alpha up-regulation, which down-regulated matrix metalloproteinase-9 activity via extracellular signal-regulated kinase 1/2 phosphorylation. MATERIAL AND METHODS...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X459101
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Spinal cord injury (SCI) causes muscle atrophy, which is particularly severe, due to inability to perform tetanic contractions, when lower motor neurons (LMN) are involved. We performed a longitudinal study in 25 Europeans suffering from complete conus cauda syndrome from 0.7 to 8.7 years comparing functional...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X385644
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:The study objectives are (1) to identify factors predicting the excellent visual recovery after transsphenoidal removal of pituitary tumors and (2) to describe the association of excellent visual recovery and early restoration of symmetry of the decompressed optic chiasm. METHODS:Thirty-five patients with v...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000407
更新日期:2015-01-01 00:00:00