Bone marrow mesenchymal stem cells can improve the motor function of a Huntington's disease rat model.

abstract：INTRODUCTION:Cerebrospinal fluid (CSF) oligoclonal bands (OB) imply intrathecal immunoglobulin synthesis and B-cell immune process. There is scarce evidence of OB having a role in disease prognosis. The objective of the present study was to determine OB's prognostic value regarding disease progression. METHODS:Betwee...

journal_title：Neurological research

authors： Rojas JI,Tizio S,Patrucco L,Cristiano E

更新日期：2012-11-01 00:00:00

abstract：:We investigated the neuroprotective effects of a novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (pitavastatin) on ischemic neuronal damage in gerbils using immunohistochemistry. The animals were allowed to survive for 14 days after 5 min of ischemia induced by bilateral occlusion of the comm...

journal_title：Neurological research

authors： Kurosaki R,Muramatsu Y,Kato H,Araki T

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Intracranial artery stenosis may be the most frequent cause of ischemic stroke in the world. Early detection of asymptomatic intracranial artery stenosis may allow for therapeutic intervention. Most elements of the Framingham stroke risk profile (FSRP) are also risk factors for intracranial artery stenosis....

journal_title：Neurological research

authors： Zhang Y,Wu S,Jia Z,Zhou Y,Liu X,Wang W,Wang T,Wang L,Zhang S,Jin C,Zhao X

更新日期：2012-05-01 00:00:00

abstract：:Complete thrombosis followed by recanalization of giant aneurysms is an infrequent process that has been exceptionally mentioned in relation to nongiant saccular aneurysms. A 25-year-old male presented with a right temporal hematoma and associated subarachnoid hemorrhage. Cerebral angiography revealed a small blister-...

journal_title：Neurological research

authors： Cohen JE,Rajz G,Umansky F,Spektor S

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METH...

journal_title：Neurological research

authors： Tang J,Li YJ,Mu J,Li Q,Yang DY,Xie P

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to analyse inflammatory cells in lumbar disc tissue under cyclooxygenase-2 (COX-2) inhibitor therapy, to detect their prevalence in different subtypes of lumbar disc herniations and to assess the influence of inflammatory reactions in herniated disc tissue on postoperative out...

journal_title：Neurological research

authors： Aydin MV,Sen O,Kayaselcuk F,Bolat F,Tufan K,Caner H,Altinors N

更新日期：2005-09-01 00:00:00

abstract：:Until recently, endovascular management of intracranial aneurysms has focused on mechanical and hemodynamic aspects: characterizing aneurysm morphology by angiogram, mechanical obstruction by detachable coils, and flow diversion with endovascular stents. Although now common practice, these interventions only ward off ...

journal_title：Neurological research

authors： Esfahani DR,Viswanathan V,Alaraj A

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in ...

journal_title：Neurological research

authors： Wang YC,Zou YB,Xiao J,Pan CD,Jiang SD,Zheng ZJ,Yan ZR,Tang KY,Tan LM,Tang MS

更新日期：2019-04-01 00:00:00

abstract：:Background: Surgery of parasagittal meningiomas (PSMs) is still technically challenging, for the balance between radical resection and preservation of venous circulation. In this article, we'd systemically introduce the technical nuances of a simplified strategy for radical resection of all types of PSMs. All the case...

journal_title：Neurological research

authors： Zhang N,Yang T,Hameed F,Zhang X,Yao Y,Li D,Li C,Yu S,Xu Y,Xia C,Fu X

更新日期：2020-11-11 00:00:00

abstract：:We performed proton magnetic resonance spectroscopy (1H-MRS) in three patients with amyotrophic lateral sclerosis (ALS) to evaluate the distribution and extent of cortical neuronal damage as demonstrated by decreased N-acetyl-aspartate (NAA) levels. We examined primary motor (precentral gyrus) and parietal neocortical...

journal_title：Neurological research

authors： Giroud M,Walker P,Bernard D,Lemesle M,Martin D,Baudouin N,Brunotte F,Dumas R

更新日期：1996-06-01 00:00:00

abstract：:The authors have done a revision of 450 patients admitted during the last 3 years to the emergency service of the Hospital de S. José with the diagnosis of CVA. In this retrospective study were included the patients of greater than or equal to 3 degree of the RLS/85 coma scale, the diagnostic being confirmed by CAT, a...

journal_title：Neurological research

authors： Costa B,Candido J,Girbal A,Afonso L,Ribeiro J,Gonçalves V,Luis V,Antunes J

更新日期：1992-01-01 00:00:00

abstract：:The possible role of nitric oxide (NO) on vibrissa-stimulated increase of regional cerebral cerebral blood flow (rCBF) and cerebral metabolic rate of glucose (rCMRglu) was investigated in conscious Wistar rats by using an inhibitor of NO synthase, NG-nitro-L-arginine (NOLAG) at a concentration of 30 mg/kg. In vivo aut...

journal_title：Neurological research

authors： Wang Q,Kjaer T,Jørgensen MB,Paulson OB,Lassen NA,Diemer NH,Lou HC

更新日期：1993-02-01 00:00:00

abstract：:This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monke...

journal_title：Neurological research

authors： Tranmer BI,Iacobacci R,Feiler S

更新日期：1990-03-01 00:00:00

abstract：:Decreased metabolic rate may precede cognitive impairment in Alzheimer's disease (AD) and is thus an early occurring hallmark. Several observations in post-mortem brain indicate that activated neurons are better able to withstand aging and AD, a phenomenon paraphrased by us as 'use it or lose it'. Moreover, a number o...

journal_title：Neurological research

authors： Swaab DF

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVES:Intracranial aneurysms (IAs) of the posterior circulation (PC) rupture more frequently and their morbidity and mortality rates are higher compared to anterior circulation. Morphological parameters such as size ratio (SR), inflow angle and parent artery geometry are believed to contribute significantly in det...

journal_title：Neurological research

authors： Tykocki T,Nauman P,Dow Enko A

更新日期：2014-08-01 00:00:00

abstract：:From 118 transsphenoidally operated patients, 100 had a pituitary adenoma; 33 prolactinomas, 20 HGH-producing, 2 ACTH-producing and 45 inactive adenomas. The first transsphenoidal operation did not cause any mortality; after reoperation for suspected recurrence on follow-up, 2 patients died; thus, the global managemen...

journal_title：Neurological research

authors： Auer LM,Clarici G

更新日期：1985-09-01 00:00:00

abstract：:Aspirin therapy for stroke prophylaxis in low risk patients has paradoxically demonstrated an increased risk of ischemic stroke in several studies. Moreover, the MAST-Italy trial reported a near doubling of mortality with the addition of aspirin to thrombolytics while experimentally, we have noted that aspirin antagon...

journal_title：Neurological research

authors： Bednar MM,Gross CE

更新日期：1999-07-01 00:00:00

abstract：:A prospective study of the expression of the chemokine receptor CCR7 was performed in 11 relapsing-remitting multiple sclerosis (MS) patients during 12 months of interferon-beta (IFNbeta) treatment. The results show increased expression of CCR7 on peripheral blood lymphocytes (PBL) of MS patients receiving IFNbeta tre...

journal_title：Neurological research

authors： Vallittu AM,Saraste M,Airas L

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:The amyloid hypothesis stimulates the discovery of compounds, which promotes beta-amyloid peptide (Aβ) clearance, thereby altering the underlying pathophysiology of Alzheimer's disease (AD). Hence, the present study aims at the evaluation of anti-amyloidogenic potential of Gelidiella acerosa. METHODS:Prevent...

journal_title：Neurological research

authors： Syad AN,Devi KP

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level ...

journal_title：Neurological research

authors： Khalatbary AR,Tiraihi T

更新日期：2007-01-01 00:00:00

abstract：:The objective of this study was to improve the ability to detect cerebrovascular complications in patients undergoing complicated neurosurgical procedures using on-line monitoring of cerebral pH with in vivo microdialysis. We employed on-line pH monitoring in patients with a variety of neurosurgical procedures includi...

journal_title：Neurological research

authors： Mendelowitsch A,Sekhar LN,Caputy AJ,Shuaib A

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:Although magnesium is a well-known treatment for vasospasm following subarachnoid hemorrhage, its mechanism of action for cerebral vascular relaxation is not clear. In addition, it is known that L-type calcium (Ca(2+)) channels play a pivotal role in smooth muscle contraction. To investigate the role of L-t...

journal_title：Neurological research

authors： Sharma N,Cho DH,Kim SY,Bhattarai JP,Hwang PH,Han SK

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...

journal_title：Neurological research

authors： Liebetrau M,Burggraf D,Büscher C,Linz W,Hamann GF

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:Susceptibility-weighted (SW) magnetic resonance (MR) imaging is a sensitive test to detect intravenous deoxygenated blood. On SW images, dilated appearing draining veins in tissue with perfusion impairment occur due to an increase in intravenous deoxyhemoglobin levels, and could indicate poor perfusion areas...

journal_title：Neurological research

authors： Sorimachi T,Morita K,Sasaki O,Koike T,Fujii Y

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:To find new biomarkers by stimulating acupuncture point GB34 (Yangneungcheon) which has neuroprotective effect on the mouse model of Parkinson's disease, analysis of cDNA microarray on mRNAs of the substantia nigra was performed. METHODS:Male C57BL/6 mice were divided into two groups: 1-methyl-4-phenyl-1,2,...

journal_title：Neurological research

authors： Hong MS,Park HK,Yang JS,Park HJ,Kim ST,Kim SN,Park JY,Song JY,Park HK,Jo DJ,Park SW,HwanYun D,Ban JY,Chung JH

更新日期：2010-02-01 00:00:00

abstract：:The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...

journal_title：Neurological research

authors： Chung YH,Shin CM,Kim MJ,Lee EY,Kim G,Cha CI

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To assess the clinical significance of hepatitis B virus (HBV) infection in patients with cerebral venous sinus thrombosis (CVST). METHODS:Twenty-two patients with CVST confirmed by magnetic resonance venography (MRV) or digital subtraction angiography (DSA) and 743 controls with ischemic stroke confirmed by...

journal_title：Neurological research

authors： Shan F,Gao C,Long Y,Huang L,Zheng Y,Chen M,Fan Y,Yin J

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Tadalafil is a selective phosphodiesterase type 5 (PDE-5) inhibitor approved for the treatment of erectile dysfunction. Less is known about the electroencephalography (EEG) effects of PDE-5 inhibitors, and the present study, therefore, examined the risk of EEG abnormalities associated with tadalafil. METHOD:...

journal_title：Neurological research

authors： Okuyucu EE,Guven O,Duman T,Gorur S,Melek IM,Akcin S,Yilmazer S

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Neurotoxic homocysteine (Hcy) is thought to be an independent risk factor for neurodegenerative diseases, including Alzheimer's disease. This study is to determine whether HT22 cells, a murine hippocampal neuronal model, can be used as an in vitro model, besides the primary neuronal cultures, to investiga...

journal_title：Neurological research

authors： Zhao Z,Lu R,Zhang B,Shen J,Yang L,Xiao S,Liu J,Suo WZ

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...

journal_title：Neurological research

authors： Stark AM,Schem C,Maass N,Hugo HH,Jonat W,Mehdorn HM,Held-Feindt J

更新日期：2010-04-01 00:00:00