Abstract:
:This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monkeys by right unilateral middle cerebral artery (MCA) occlusion by the transorbital technique. Following occlusion of the right MCA, monkeys were randomized into one of the following treatment groups: Group A--Fluosol-DA 15 ml kg-1 i.v. + 40% O2; Group B--Fluosol-DA 15 ml kg-1 i.v. + 100% O2; Group C--hetastarch 30 ml kg-1 i.v. + 40% O2; Group D--hetastarch 30 ml kg-1 i.v. + 100% O2. In Group A, local CBF increased and EEG power data improved while O2a showed no change in the right MCA territory. In Group B, local CBF increased from 84% (P less than 0.001), O2a improved significantly, and EEG power data showed significant improvement in the right hemisphere. Cardiac output did not change during the Fluosol-DA infusions. In Groups C and D, local CBF increased significantly, O2a did not change, and EEG power data improved significantly in the right hemisphere. Cardiac output also increased significantly during the hetastarch infusions. These results show that Fluosol-DA and hetastarch improve local CBF and EEG power data in ischaemic brain. Only the Fluosol-DA + 100% O2 increased the O2a in the ischaemic brain. We conclude that the benefits with Fluosol-DA are due to its ability to increase O2 delivery to ischaemic brain.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Tranmer BI,Iacobacci R,Feiler Sdoi
10.1080/01616412.1990.11739906subject
Has Abstractpub_date
1990-03-01 00:00:00pages
17-22issue
1eissn
0161-6412issn
1743-1328journal_volume
12pub_type
杂志文章abstract:OBJECTIVES:We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS:Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS:A(2A) ant...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X21913
更新日期:2005-03-01 00:00:00
abstract::The frequency of skull metastasis from hepatocellular carcinoma (HCC) is increasing together with the recent progress in the management of the primary lesion. Cases are often complicated with poor general conditions or metastasis to the other organs, and not readily indicated for surgery. A direct injection of ethanol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740593
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:The actual relationship between neural stem cells and SDF-1alpha/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, could contribute to neural stem cells migration after brain injury. In th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X332995
更新日期:2009-02-01 00:00:00
abstract::The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739796
更新日期:1987-09-01 00:00:00
abstract::Mountain trekking is significantly increasing in popularity. Hypoxia seems to play a key role in the pathogenesis of acute mountain sickness (AMS). The purpose of this study was to investigate regional cerebral (rSO2) and peripheral (SaO2) oxygen saturation for the first time, during 22 days high altitude trekking (me...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201175
更新日期:2003-03-01 00:00:00
abstract::Regional CBF was measured by 133Xe inhalation in unilateral cerebral infarction, carotid TIAs, and normal volunteers. Regional CBF values were bilaterally and symmetrically reduced in patients measured within 3 weeks after stroke. Later, rCBF values returned toward normal in the contralateral hemisphere of patients wi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1979.11739545
更新日期:1979-01-01 00:00:00
abstract::A 52-year-old male underwent lumboperitoneal shunting after external decompressive craniectomy. His postoperative course was accompanied by remarkable displacement of the intracranial structures to the opposite side of craniectomy. This phenomenon, probably caused by the siphon effect of cerebrospinal fluid shunting, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739979
更新日期:1991-06-01 00:00:00
abstract::The effect of labetalol, a combined alpha- and beta-adrenoceptor antagonist, on the cerebral circulation was investigated in 7 normotensive subjects. Cerebral blood flow (CBF) was measured with the intravenous 133Xe method and mean flow velocity (Vmean) in the middle cerebral artery was determined using transcranial D...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739958
更新日期:1991-03-01 00:00:00
abstract::Compromise of blood flow to the brain leads to cerebral ischemia, which if left untreated may even result in cerebral infarction. This has been the main cause of major morbidity and mortality over the years in the US and around the world. Cerebral ischemia to the posterior fossa is more critical and difficult to treat...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104773026552
更新日期:2004-01-01 00:00:00
abstract::Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1454092
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Epilepsy is a common seizure disorder affecting approximately 70 million people worldwide. Mitochondrial dysfunction and antioxidant/prooxidant imbalance are emerging as factors that contribute to epileptogenesis. As medical ozone was able to reestablish cellular redox balance and to maintain the protective ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000445
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Cerebral hypoxia-ischemia leads to the depletion of ATP. Hypoxanthine, a degradation product of ATP, can be salvaged by hypoxanthine phosphoribosyl transferase (HPRT) and used to reform high-energy purines. Hypothermia conserves ATP in hypoxia-ischemia, possibly by preserving HPRT activity. We hypothesized t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49229
更新日期:2006-12-01 00:00:00
abstract::A mathematical model, using differential equations, of heterosynaptic plasticity is proposed. The model is based on physiological studies of invertebrates in which nonspecific conditioning, such as sensitization and heterosynaptic inhibition, starts to be elucidated and behavioral studies of classical and instrumental...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739576
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132813Y.0000000166
更新日期:2013-04-01 00:00:00
abstract::Child patients with Moyamoya disease initially present with ischemic symptoms. However, the long-term risk of intracranial hemorrhage for childhood Moyamoya disease is unknown. Hemodynamic overload to the fragile collateral vessels has been considered to cause hemorrhage. We reviewed angiograms to evaluate the effect ...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.2000.11740680
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12518779082192
更新日期:2010-04-01 00:00:00
abstract::Using magnetic resonance imaging, we reviewed 141 infratentorial infarcts in 81 consecutive cases: 65 infarcts were seen in the paramedian pons, while 18 in the posterior inferior cerebellar artery (PICA) territory and 17 in the watershed area between PICA and superior cerebellar artery. No comparable sign or symptom ...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.1994.11740217
更新日期:1994-06-01 00:00:00
abstract::Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740555
更新日期:1998-09-01 00:00:00
abstract::Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1611009
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:In the present study, we investigated the effects of treadmill exercise on microglial activation and the subsequent release of tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1-beta in the hippocampus in a rat model of type 2 diabetes. METHODS:At 30 weeks of age, diabetic (Zucker diabeti...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000015
更新日期:2015-08-01 00:00:00
abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200096
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Intracranial artery stenosis may be the most frequent cause of ischemic stroke in the world. Early detection of asymptomatic intracranial artery stenosis may allow for therapeutic intervention. Most elements of the Framingham stroke risk profile (FSRP) are also risk factors for intracranial artery stenosis....
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000024
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:To review the use of immunoassays in the diagnosis and research of disorders affecting the nervous system. METHODS:Systematic review of the English literature. RESULTS:Immunoassays have demonstrated utility for: (1) the detection of antigen (molecules, genes, gene products, peptides, hormones and drug meta...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X49535
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2018.1446283
更新日期:2018-05-01 00:00:00
abstract::We studied brain temperature and the effect of mild hypothermia in 58 patients after severe head injury (SHI). Brain tissue oxygen tension (ptiO2), carbon dioxide tension (ptiCO2), tissuie pH (pHti) and temperature (T.br) were measured using a multiparameter probe. Microdialysis was performed to measure glucose, lacta...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101199710
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:Repetitive magnetic stimulation (rMS) is mainly used in transcranial applications. Only a few works have described its potential peripheral use. The aim of this investigation was to determine if conditioning peripheral (paravertebral) rMS of the cervical nerve roots in a group of healthy subjects induces chan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X297959
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Glutamate antagonists are very attractive drugs in laboratory works to protect neural tissue against ischemia. In this work, the effects of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier (BBB) and brain edema after experimentally induced traumatic brain injury are evaluated. ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X385617
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:Parkinson's disease (PD) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of PD. The purpose of this study was to assess the role of B-cell lymphoma 2 (Bcl-2)-associated athanogene 5 (BAG5) protein, whic...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000102
更新日期:2012-12-01 00:00:00
abstract::We describe the advantages and clarify the technical key points of a microendoscopic, minimally invasive technique to the posterior surgical approach for cervical degenerative disease. The authors studied the microendoscopic posterior approach using the METRx system in both cadaver models and in clinical cases. This n...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201058
更新日期:2003-01-01 00:00:00
abstract::The present study was performed to compare brain infarct size assessment by routine histology (haematoxylin and eosin) and by 2,3,5-triphenyltetrazolium chloride staining techniques. New Zealand white rabbits were subjected to autologous clot embolization to the anterior circulation of the brain. After a study period ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740210
更新日期:1994-04-01 00:00:00