Effect of labetalol on cerebral blood flow and middle cerebral arterial flow velocity in healthy volunteers.


:The effect of labetalol, a combined alpha- and beta-adrenoceptor antagonist, on the cerebral circulation was investigated in 7 normotensive subjects. Cerebral blood flow (CBF) was measured with the intravenous 133Xe method and mean flow velocity (Vmean) in the middle cerebral artery was determined using transcranial Doppler (TCD) ultrasound. Examination was performed before and then 15, 60 and 120 min after 0.75 mg/kg i.v. labetalol. Reactivity to inhalation of 5% CO2 in air was studied before, and again 90 min after labetalol administration. Neither CBF nor Vmean changed following labetalol administration, whereas a marked increase occurred during inhalation of CO2. The median CO2 reactivity was 3.2%/mmHg (range: 1.8-4.0) for CBF and 4.4%/mmHg (1.5-5.6) for Vmean. These results indicate that labetalol, given in moderate but clinically relevant doses, does not affect the cerebral circulation in normotensive subjects. Neither does it affect CO2 reactivity. The uniform results obtained with the two methods suggest TCD as a usable alternative to conventional CBF technique in the assessment of cerebral vasoactivity of various drugs in subjects with a normal cerebral circulation.


Neurol Res


Neurological research


Schroeder T,Schierbeck J,Howardy P,Knudsen L,Skafte-Holm P,Gefke K




Has Abstract


1991-03-01 00:00:00












  • Management of petrosal veins during microvascular decompression for trigeminal neuralgia.

    abstract:OBJECTIVE:Venous compression might be the main cause of incomplete decompression and symptom recurrence after microvascular decompression (MVD) in patients with trigeminal neuralgia. Although it can be killed in most cases, cutting the vein sometimes has the potential risk arising from venous congestion. To maneuver th...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zhong J,Li ST,Xu SQ,Wan L,Wang X

    更新日期:2008-09-01 00:00:00

  • Hyperglycaemia protects against neuronal injury around experimental brain infarcts.

    abstract::Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism r...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Nedergaard M,Gjedde A,Diemer NH

    更新日期:1987-12-01 00:00:00

  • Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow.

    abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Tsutsui S,Nanba T,Yoshioka Y,Sasaki M,Fujiwara S,Kobayashi M,Yoshida K,Miyoshi K,Sato S,Ogasawara K

    更新日期:2018-08-01 00:00:00

  • Cerebral and peripheral effects of laser needle-stimulation.

    abstract::This study comprises scientific-theoretic fundamental investigations of laserneedle technology, a new and painless method of acupuncture stimulation. Laserneedles are not inserted in the skin, but are merely placed on the surface of the acupuncture point. The study documents the significant changes in peripheral micro...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Litscher G

    更新日期:2003-10-01 00:00:00

  • Predictors of early vs. late permanent shunt insertion after aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:Numerous studies have identified different predictors for secondary hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH), although predictors regarding timing of the shunt operation have never been reported. Predictors for an early shunt, which was defined as a shunt operation performed ≤30 days after...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Shigematsu H,Sorimachi T,Osada T,Aoki R,Srivatanakul K,Oda S,Matsumae M

    更新日期:2016-07-01 00:00:00

  • Uncorrected traumatic coagulopathy is associated with severe brain swelling during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury.

    abstract:OBJECTIVE:This study investigated the relationship between traumatic coagulopathy and severe brain swelling (SBS) during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury (TBI). METHODS:A retrospective study was conducted in 96 patients who consecutively ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Wang K,Xue Y,Chen X,Zhou B,Lou M

    更新日期:2013-07-01 00:00:00

  • Alzheimer's disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior.

    abstract:OBJECTIVES:Amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer's disease (AD), but soluble oligomeric Aβ is considered to be more potent and has been hypothesized to directly impair learning and memory. Also, evidences from some clinical studies indicated that Aβ oligomer...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Sharma S,Verma S,Kapoor M,Saini A,Nehru B

    更新日期:2016-09-01 00:00:00

  • Occipital petalia as a predictive imaging sign for transverse sinus dominance.

    abstract:OBJECTIVES:Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the associati...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Arsava EY,Arsava EM,Oguz KK,Topcuoglu MA

    更新日期:2019-04-01 00:00:00

  • Relationship between neurological complications, cerebrovascular and cerebral perfusion following off-pump coronary artery bypass grafting.

    abstract:OBJECTIVE:To investigate risk factors for neurological complications after off-pump coronary artery bypass grafting (OPCABG). METHODS:We reviewed the cases of 813 patients who underwent OPCABG between August 2010 and September 2013.Data from preoperative 320 dynamic volume computed tomography (CT), CT angiography (CTA...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Xu B,Qiao Q,Chen M,Rastogi R,Luo D,Bi Q

    更新日期:2015-05-01 00:00:00

  • Patient selection for endovascular treatment of intracranial aneurysms.

    abstract::With recent advancement in medical imaging, techniques, and endovascular tools more patients are diagnosed with unruptured intracranial aneurysms. The main aim of offering aneurysm treatment is to ameliorate the risk of future aneurysm bleeding, while not posing additional risks on the patient from the treatment itsel...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Alaraj A,Ti J,Dashti R,Aletich V

    更新日期:2014-04-01 00:00:00

  • Initial experience with silver-impregnated polyurethane ventricular catheter for shunting of cerebrospinal fluid in patients with infected hydrocephalus.

    abstract:OBJECTIVE:Infection is a major complication and risk factor of cerebrospinal fluid (CSF) shunting procedures. Recently, antibiotic-impregnated shunt systems have been developed in an attempt to prevent or reduce the CSF infection. The aim of this study was to determine the efficacy of silver-impregnated polyurethane ve...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Izci Y,Secer H,Akay C,Gonul E

    更新日期:2009-04-01 00:00:00

  • Sleep promoting effects of intravenously administered acidic fibroblast growth factor.

    abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Galan JM,Cuevas B,Dujovny N,Giménez-Gallego G,Cuevas P

    更新日期:1996-12-01 00:00:00

  • Association between peridural scar and activity-related pain after lumbar discectomy.

    abstract::The purpose of this study was to investigate the correlation between activity-related pain six months after first surgery for herniated lumbar disc, and the extent of lumbar epidural fibrosis present at the surgical site, assessed by magnetic resonance imaging. The 298 patients who underwent surgery for lumbar disc he...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: BenDebba M,Augustus van Alphen H,Long DM

    更新日期:1999-01-01 00:00:00

  • Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury.

    abstract:OBJECTIVE:Glutamate antagonists are very attractive drugs in laboratory works to protect neural tissue against ischemia. In this work, the effects of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier (BBB) and brain edema after experimentally induced traumatic brain injury are evaluated. ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Imer M,Omay B,Uzunkol A,Erdem T,Sabanci PA,Karasu A,Albayrak SB,Sencer A,Hepgul K,Kaya M

    更新日期:2009-11-01 00:00:00

  • Characterisation of DWI-MRI confirmed cerebral infarcts in patients with subarachnoid haemorrhage and their association with MMP-9 levels.

    abstract:OBJECTIVES:It has been suggested that metalloproteinase-9 (MMP-9) could predict the onset of cerebral vasospasm after subarachnoidal haemorrhage (SAH). The aim of this study was to analyse, in patients with SAH, the difference between patients with MRI ischaemic infarcts and patients without, and to investigate the rol...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Lago A,Tembl JI,López-Cuevas R,Vallés J,Santos MT,Moscardó A,Parkhutik V

    更新日期:2015-08-01 00:00:00

  • The changes of systemic immune responses during the neuroprotection induced by remote ischemic postconditioning against focal cerebral ischemia in mice.

    abstract::Objective: Remote limb ischemic postconditioning (RIPostC) protects the brain from damage induced by transient focal ischemia/reperfusion. However, the underlying mechanism remains unclear. Methods: RIPostC induced by 10 min of occlusion and another 10 min releasing of blood flow for three cycles in the hind limbs was...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Liu C,Yang J,Zhang C,Geng X,Zhao H

    更新日期:2019-01-01 00:00:00

  • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke.

    abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1993-10-01 00:00:00

  • Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging.

    abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Lo EH,Rogowska J,Batchelder KF,Wolf GL

    更新日期:1996-04-01 00:00:00

  • Intraluminal suture occlusion of the middle cerebral artery in Spontaneously Hypertensive rats.

    abstract::In models of middle cerebral artery occlusion using intraluminal suture, the size and the distribution of ischemic injury vary considerably among laboratories. In transcranial models of cerebral ischemia, a more consistent cerebral ischemic lesion is seen in Spontaneously Hypertensive rats (SHR). In the present study,...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Dogan A,Başkaya MK,Rao VL,Rao AM,Dempsey RJ

    更新日期:1998-04-01 00:00:00

  • Iodine-125 interstitial irradiation of virally induced dog brain tumours.

    abstract::Brain tumours were induced by intracerebral inoculation of beagle puppies with Avian sarcoma virus (ASV) suspension. The inoculation produced solitary or multiple sarcomas in three dogs and intraventricular anaplastic gliomas in four dogs. At the time of the first tumour positive CT-control Iodine-125 seeds (activity ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Ostertag CB,Warnke P,Kleihues P,Bigner DD

    更新日期:1984-12-01 00:00:00

  • Hyperbaric oxygen therapy and cerebral ischemia: neuroprotective mechanisms.

    abstract:INTRODUCTION:Numerous studies have demonstrated a protective effect of hyperbaric oxygen therapy in experimental ischemic brain injury, and many physiological and molecular mechanisms of hyperbaric oxygen therapy-related neuroprotection have been identified. METHODS:Review of articles pertaining to hyperbaric oxygen t...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Matchett GA,Martin RD,Zhang JH

    更新日期:2009-03-01 00:00:00

  • Cerebrospinal fluid membrane-bound tissue factor and myelin basic protein in the course of vasospasm after subarachnoid hemorrhage.

    abstract::No marker that predicts accurately the time of occurrence of cerebral vasospasm due to subarachnoid hemorrhage (SAH) has been reported. In the present study, membrane-bound tissue factor (mTF) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) were evaluated as a predictor of the time of occurr...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Hirashima Y,Endo S,Nakamura S,Kurimoto M,Takaku A

    更新日期:2001-10-01 00:00:00

  • The effect of encephalo-myo-synangiosis on abnormal collateral vessels in childhood moyamoya disease.

    abstract::Child patients with Moyamoya disease initially present with ischemic symptoms. However, the long-term risk of intracranial hemorrhage for childhood Moyamoya disease is unknown. Hemodynamic overload to the fragile collateral vessels has been considered to cause hemorrhage. We reviewed angiograms to evaluate the effect ...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Irikura K,Miyasaka Y,Kurata A,Tanaka R,Yamada M,Kan S,Fujii K

    更新日期:2000-06-01 00:00:00

  • Diffusion tensor tractography to visualize axonal outgrowth and regeneration in a 4-cm reverse autograft sciatic nerve rabbit injury model.

    abstract:BACKGROUND:Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical techniqu...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Farinas AF,Pollins AC,Stephanides M,O'Neill D,Al-Kassis S,Esteve IVM,Colazo JM,Keller PR,Rankin T,Wormer BA,Kaoutzanis C,Dortch RD,Thayer WP

    更新日期:2019-03-01 00:00:00

  • Noninvasive assessment of cerebral oxygenation during high altitude trekking in the Nepal Himalayas (2850-5600 m).

    abstract::Mountain trekking is significantly increasing in popularity. Hypoxia seems to play a key role in the pathogenesis of acute mountain sickness (AMS). The purpose of this study was to investigate regional cerebral (rSO2) and peripheral (SaO2) oxygen saturation for the first time, during 22 days high altitude trekking (me...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Hadolt I,Litscher G

    更新日期:2003-03-01 00:00:00

  • The effect of normothermic and hypothermic hypoxia-ischemia on brain hypoxanthine phosphoribosyl transferase activity.

    abstract:OBJECTIVES:Cerebral hypoxia-ischemia leads to the depletion of ATP. Hypoxanthine, a degradation product of ATP, can be salvaged by hypoxanthine phosphoribosyl transferase (HPRT) and used to reform high-energy purines. Hypothermia conserves ATP in hypoxia-ischemia, possibly by preserving HPRT activity. We hypothesized t...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Cherin T,Catbagan M,Treiman S,Mink R

    更新日期:2006-12-01 00:00:00

  • Cerebellar contusion associated with type I Chiari malformation following supratentorial head trauma: case report.

    abstract::Acute presentation of Type I Chiari malformation in children is distinctly rare. An 11 year old male suffered a trauma to the right temporal-parietal region in a tobogganing accident resulting in an open depressed skull fracture. Radiographic evaluation included a Computed Tomographic scan which also demonstrated a si...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Couldwell WT,Zhang W,Allen R,Arce D,Stillerman CB

    更新日期:1998-01-01 00:00:00

  • Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.

    abstract:OBJECTIVES:We attempted to determine whether a functional polymorphism of TRPM6 (rs2274924) is associated with susceptibility to epilepsy following ischemic stroke, and to further explore the effect of this polymorphism on serum levels of Mg2+ in post-stroke patients. METHODS:We carried out a case-control study on 378...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Fu CY,Chen SJ,Cai NH,Liu ZH,Zhang M,Wang PC,Zhao JN

    更新日期:2019-04-01 00:00:00

  • Blood-brain barrier restoration following cold injury.

    abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Pollay M,Stevens FA

    更新日期:1980-01-01 00:00:00

  • Cerebral venous sinus thrombosis may be associated with hepatitis B virus infection: a preliminary finding.

    abstract:OBJECTIVE:To assess the clinical significance of hepatitis B virus (HBV) infection in patients with cerebral venous sinus thrombosis (CVST). METHODS:Twenty-two patients with CVST confirmed by magnetic resonance venography (MRV) or digital subtraction angiography (DSA) and 743 controls with ischemic stroke confirmed by...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Shan F,Gao C,Long Y,Huang L,Zheng Y,Chen M,Fan Y,Yin J

    更新日期:2015-06-01 00:00:00