Pros, cons, and current indications of open craniotomy versus gamma knife in the treatment of arteriovenous malformations and the role of endovascular embolization.


:The successful treatment of an intracranial arteriovenous malformation poses both technical and conceptual problems to the neurosurgeon. Treatment decisions are made in light of current understanding of the natural history of these lesions. It is important to understand the pros, cons and current indication of open craniotomy vs. gamma knife in the treatment of arteriovenous malformations and the role of endovascular embolization. Surgical removal of an arteriovenous malformation is indicated when the operative risk is less than the morbidity and mortality associated with its natural history. The treatment goal of complete angiographic obliteration of arteriovenous malformations is achieved most effectively by microneurosurgery in low-grade lesions. Large lesions frequently require a combination of embolization and microsurgery. Although recent advances in technology and medical management have allowed previously inoperable arteriovenous malformations to be surgically excised, there is still a small group of arteriovenous malformations that cannot be excised safely due to their size and location. Stereotactic radiosurgery is clearly an important adjunct in the multimodality treatment approach for large arteriovenous malformations. Endovascular embolization can potentially increase safety and efficacy in the treatment of arteriovenous malformations when applied to selective cases with well-defined treatment goals.


Neurol Res


Neurological research


Surdell DL Jr,Bhattacharjee S,Loftus CM




Has Abstract


2002-06-01 00:00:00












  • Matrix metalloproteinase-9 potentiates early brain injury after subarachnoid hemorrhage.

    abstract:OBJECTIVE:This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury after subarachnoid hemorrhage (SAH). METHOD:Sprague-Dawley male rats (n=36) weighing between 250 and 300 g were used. SAH was produced by injecting autologous arterial blood into the pre-chiasmatic cistern. MMP-9 pro...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo Z,Sun X,He Z,Jiang Y,Zhang X,Zhang JH

    更新日期:2010-09-01 00:00:00

  • Unusual presentation of carcinomatous meningitis: case report and review of typical CSF findings.

    abstract::This paper describes a previously unreported clinical onset of carcinomatous meningitis with bilateral deafness. Typical changes in the cerebrospinal fluid aside from positive cytology findings are reviewed. In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased gluc...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zeller JA,Zunker P,Witt K,Schlueter E,Deuschl G

    更新日期:2002-10-01 00:00:00

  • Carotid endarterectomy in high risk patients.

    abstract::We elected to compare the clinical outcomes of carotid endarterectomy (CEA) patients who were thought to be at increased risk for peri-operative complications because of advanced age (> 79 years), medical comorbidities and contralateral internal carotid artery occlusion to patients without these risk factors. A prospe...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Harbaugh RE,Magnadottir HB

    更新日期:2002-01-01 00:00:00

  • Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: the effect of mild hypothermia.

    abstract::We studied brain temperature and the effect of mild hypothermia in 58 patients after severe head injury (SHI). Brain tissue oxygen tension (ptiO2), carbon dioxide tension (ptiCO2), tissuie pH (pHti) and temperature ( were measured using a multiparameter probe. Microdialysis was performed to measure glucose, lacta...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Soukup J,Zauner A,Doppenberg EM,Menzel M,Gilman C,Bullock R,Young HF

    更新日期:2002-03-01 00:00:00

  • Atrial fibrillation as an important clinical condition of cognitive decline; diagnosis, comorbidities and severity of symptoms in patients with dementia.

    abstract::Objective: To determine the time of dementia diagnosis, symptom intensity and to assess the comorbidities.Methods: 110 patients with dementia or mild cognitive impairment were enrolled in this retrospective study. The study group was divided into subgroups: patients with a maximum of three (S ≤ 3 n = 62) and four or m...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Niedziela N,Nowak MM,Lis M,Blaszkowska M,Kośmider R,Adamczyk-Sowa M

    更新日期:2020-05-01 00:00:00

  • Microanatomical evidences for potential of mesenchymal stem cells in amelioration of striatal degeneration.

    abstract::Huntington's disease is an inherited neurodegenerative disorder, characterized by loss of spiny neurons in the striatum and cortex, which usually happens in the third or fourth decades of life. In advanced form of the disease, progressive striatum atrophy happens and medium spiny neurons, which occupy more than 80% of...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Amin EM,Reza BA,Morteza BR,Maryam MM,Ali M,Zeinab N

    更新日期:2008-12-01 00:00:00

  • Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI mice.

    abstract:OBJECT:The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo® application on brain injury in experimental TBI mice using S...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo D,Li D,Li J,Li Y,Hu X,Guan F,Yang B

    更新日期:2017-09-01 00:00:00

  • Laterality of seizure onset and the simple reaction time: revamping the Poffenberger's paradigm for seizure surgery.

    abstract:BACKGROUND:Crossed-uncrossed differentials (CUDs) are viewed as surrogates for interhemispheric transfer time (IHTT). Not uncommonly CUDs assume statistically significant negative values (inverted CUDs). This raises doubts of the accepted interpretation of CUDs, i.e. intra- and inter-hemispheric routings of signals in ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Derakhshan I

    更新日期:2006-10-01 00:00:00

  • Sonographic and electrophysiological detection in patients with carpal tunnel syndrome.

    abstract:OBJECTIVES:To assess prospectively the significance of sonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome (CTS), to look for proper parameters and cutoff values for the sonographic diagnosis, and to correlate with the electrophysiological findings. MATERIALS AND METHODS:This study ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guan J,Ji F,Chen W,Chu H,Lu Z

    更新日期:2011-11-01 00:00:00

  • Current evidence of temozolomide and bevacizumab in treatment of gliomas.

    abstract:OBJECTIVE:This review article summarizes in vitro, in vivo, and clinical evidence pertaining to temozolomide (TMZ) and bevacizumab (BEV) efficacy and mechanism of action in gliomas. METHODS:Relevant publications published before June 2013 in PubMed database were reviewed. RESULTS:Temozolomide and BEV are current chem...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Nanegrungsunk D,Onchan W,Chattipakorn N,Chattipakorn SC

    更新日期:2015-02-01 00:00:00

  • The effectiveness of cortico-cortical evoked potential in detecting seizure onset zones.

    abstract::Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zhang N,Zhang B,Rajah GB,Geng X,Singh R,Yang Y,Yan X,Li Z,Zhou W,Ding Y,Sun W

    更新日期:2018-06-01 00:00:00

  • Local fibrinolysis and aspiration of intracerebral hematomas in rats. An experimental study using MR monitoring.

    abstract::Serial magnetic resonance (MR) imaging has not yet been validated in the therapy of experimental intracerebral hematomas in a rat model. It is possible to test the effect of local fibrinolysis and aspiration on the clot volume using serial magnetic resonance imaging and different MR-sequences. Experiments were carried...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Deinsberger W,Hartmann M,Vogel J,Jansen O,Kuschinsky W,Sartor K,Böker DK

    更新日期:1998-06-01 00:00:00

  • Early combined cranioplasty and programmable shunt in patients with skull bone defects and CSF-circulation disorders.

    abstract:OBJECTIVE:This study assesses the clinical outcome after early combined cranioplasty (own frozen bone) and shunt implantation (Codman-Medos programmable VP shunt) in patients with skull bone defects and cerebrospinal fluid (CSF) circulation disorders. METHOD:Medical records were reviewed retrospectively for the last 1...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Carvi Y Nievas MN,Höllerhage HG

    更新日期:2006-03-01 00:00:00

  • Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications.

    abstract::Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Cacabelos R,Fernández-Novoa L,Lombardi V,Corzo L,Pichel V,Kubota Y

    更新日期:2003-09-01 00:00:00

  • Endovascular treatment of giant and large intracranial aneurysms using the neuroform stent-assisted coil placement.

    abstract:BACKGROUND:Giant and large intracranial aneurysms represent enormous therapeutic challenges for neurosurgeons as well as for endovascular therapists. Since they may involve entire vessels or be irregular in shape, the rate of complete obliteration with GDCs is low and the incidence of recanalization is very high. So th...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Yang X,Wu Z,Mu S,Li Y,Lv M

    更新日期:2008-07-01 00:00:00

  • Improved maze learning through early music exposure in rats.

    abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Rauscher FH,Robinson KD,Jens JJ

    更新日期:1998-07-01 00:00:00

  • The effect of papaverine on ion channels in rat basilar smooth muscle cells.

    abstract:OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Han DH,Bai GY,Yang TK,Sim BS,Kwak YG,Kim CJ

    更新日期:2007-09-01 00:00:00

  • In vitro evidence supporting two mechanisms of action for the anion transport inhibitor L-644,711 in cerebral ischaemia.

    abstract::L-644,711 is a novel anion channel inhibitor which has previously been shown to decrease brain injury in two related rabbit models of cerebral ischaemia. We hypothesize two mechanisms of action of L-644,711 for its salutary effects on cerebral ischaemia: inhibition of neutrophil function and prevention of excitotoxin ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Bednar MM,Kohut JJ,Kimelberg HK,Gross JJ,Gross CE

    更新日期:1992-03-01 00:00:00

  • Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds.

    abstract:OBJECTIVES:To study whether Clopidogrel-Aspirin combined treatment for high risk transient ischaemic attack (TIA) or minor stroke results in increased number of lesions associated with anti-thrombotic cerebral haemorrhage or cerebral micro-bleeds (CMB) than aspirin alone treatment. METHODS:The patients recruited in CH...

    journal_title:Neurological research

    pub_type: 杂志文章,随机对照试验


    authors: Wang Z,Xu C,Wang P,Wang Y,Xin H

    更新日期:2015-11-01 00:00:00

  • The combination of a programmable valve and a subclavicular anti-gravity device in hydrocephalus patients at high risk for hygromas.

    abstract:OBJECTIVES:In order to avoid occurrence of post-operative hygromas in specific hydrocephalus patients being at high risk of overdrainage, a combination of programmable valve and anti-gravity device is widely recommended. We analyzed our series of hydrocephalus patients implanted with such a shunt configuration focusin...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zachenhofer I,Donat M,Roessler K

    更新日期:2012-04-01 00:00:00

  • A reproducible assay of polymerase chain reaction to detect trinucleotide repeat expansion of Huntington's disease and senile chorea.

    abstract::A simple and reproducible method of polymerase chain reaction (PCR) assay was established to detect trinucleotide repeat expansion for Huntington's disease (HD) using a new DNA polymerase and buffer system. The system consists of an extremely heat stable DNA polymerase (Pfu), and a buffer supplemented with ammonium su...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Watanabe M,Abe K,Aoki M,Kameya T,Itoyama Y,Shoji M,Ikeda M,Iizuka T,Hirai S

    更新日期:1996-02-01 00:00:00

  • Comparison of transcranial Doppler ultrasonography and positron emission tomography using a three-dimensional template of the middle cerebral artery.

    abstract:OBJECTIVE:Transcranial Doppler (TCD) measures blood flow velocities (BFV) and is an indirect method of assessing cerebral blood flow (CBF). Positron emission tomography (PET) is a direct method to measure CBF. This study evaluates the correlations between TCD and PET findings Methods: Nine patients with a symptomatic c...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Rijbroek A,Boellaard R,Vriens EM,Lammertsma AA,Rauwerda JA

    更新日期:2009-02-01 00:00:00

  • Is on-admission capillary blood beta-hydroxybutyrate concentration associated with the acute stroke severity and short-term functional outcome?

    abstract:OBJECTIVES:In conditions with reduced glucose levels/inability of glucose utilization, ketone bodies, especially beta-hydroxybutyrate (BHB), become a major energy source in the brain. In animal models, BHB infusion shows acute beneficial effects on the hypoxic brain. The present prospective observational study is the f...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Pikija S,Trkulja V,Simundic AM,Vrcek E,Boskovic K,Bacani S

    更新日期:2013-11-01 00:00:00

  • Reduced brain N-acetyl-aspartate in frontal lobes suggests neuronal loss in patients with amyotrophic lateral sclerosis.

    abstract::We performed proton magnetic resonance spectroscopy (1H-MRS) in three patients with amyotrophic lateral sclerosis (ALS) to evaluate the distribution and extent of cortical neuronal damage as demonstrated by decreased N-acetyl-aspartate (NAA) levels. We examined primary motor (precentral gyrus) and parietal neocortical...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Giroud M,Walker P,Bernard D,Lemesle M,Martin D,Baudouin N,Brunotte F,Dumas R

    更新日期:1996-06-01 00:00:00

  • A technical approach to dissecting and assessing cadaveric veins pertinent to chronic cerebrospinal venous insufficiency in multiple sclerosis.

    abstract:OBJECTIVE:To establish a detailed technical procedure for studying the anatomical correlates of chronic cerebrospinal venous insufficiency in cadavers of multiple sclerosis and control subjects, and to present our findings of the normal anatomic venous structures, with reference to previous descriptions from the liter...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Diaconu CI,Staugaitis SM,Fox RJ,Rae-Grant A,Schwanger C,McBride JM

    更新日期:2012-10-01 00:00:00

  • Exposure time and frequency of irradiation in brain tumours.

    abstract::The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Christensen JC

    更新日期:1987-09-01 00:00:00

  • Stretching and electrical stimulation regulate the metalloproteinase-2 in rat denervated skeletal muscle.

    abstract:OBJECTIVE:To evaluate the effects of electrical stimulation (ES), stretching and their combined effects in matrix metalloproteinases (MMPs) gene expression and activity during early denervation of rat tibialis anterior (TA) muscle by axonotmesis. METHODS:Thirty adult male Wistar rats were divided into five groups: no...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Peviani SM,Russo TL,Durigan JL,Vieira BS,Pinheiro CM,Galassi MS,Salvini TF

    更新日期:2010-10-01 00:00:00

  • Cognitive functions in pediatric multiple sclerosis: 2-years follow-up.

    abstract::Objective: To assess the neuropsychological status of pediatric multiple sclerosis (MS) patients and its relationship with clinical variables in a longitudinal study.Methods: Patients with MS (n = 46) and age- and gender-matched healthy control subjects (HCs, n = 53) were given tests of non-verbal reasoning, attention...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Öztürk Z,Gücüyener K,Soysal Ş,Konuşkan GD,Konuşkan B,Dikmen AU,Anlar B

    更新日期:2020-02-01 00:00:00

  • Microsurgical approach for symptomatic brain AVMs - single center experience.

    abstract::Objectives: Brain arteriovenous malformations (AVMs) represent high-flow vascular lesions made up of a complex network of feeding arteries and draining veins interposed by a nidus and without a capillary bed. The management of the AVMs represents a challenge, and the optimal treatment should be considered based on the...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Gorgan RM,Petrescu GED,Brehar FM

    更新日期:2020-12-01 00:00:00

  • Association between intracranial, arterial pulse pressure amplitudes and cerebral autoregulation in head injury patients.

    abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Eide PK,Czosnyka M,Sorteberg W,Pickard JD,Smielewski P

    更新日期:2007-09-01 00:00:00