Abstract:
OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METHODS:In the present study, we attempted to determine the effects of albumin on cerebral injury and blood-brain barrier disruption induced by middle cerebral artery occlusion for 2 hours followed by 24 hours of reperfusion and tPA. RESULTS:We found that infarct volume in rats which received saline and tPA was 35.6 +/- 3.8% (mean +/- SEM) and 50.9 +/- 4.5%, respectively. There was significant difference between the two groups (p<0.01). The infarct volume in rats that received tPA with albumin was significantly decreased to 29.2 +/- 3.3% (p<0.05), compared with tPA-only-treated group. Combination therapy using tPA with albumin also improved neurological deficits and reduced brain edema significantly (p<0.05). Relative to tPA-treated group, rats that received combination therapy using tPA with albumin had significantly reduced blood-brain barrier permeability, evaluated by quantitation of Evans blue leakage (p<0.05). CONCLUSION:In acute ischemic stroke, combination therapy using tPA with albumin can attenuate the deleterious effects of tPA.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Tang J,Li YJ,Mu J,Li Q,Yang DY,Xie Pdoi
10.1179/174313209X393898subject
Has Abstractpub_date
2009-03-01 00:00:00pages
189-94issue
2eissn
0161-6412issn
1743-1328journal_volume
31pub_type
杂志文章abstract::The role of intra-operative pathological diagnosis increases along with a development of minimally invasive neurosurgery, especially stereotactic and endoscopic techniques. The authors present their own experience with the cytological method and evaluate its usefulness in intra-operative diagnosis of brain tumors. Bra...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.1999.11740907
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in ...
journal_title:Neurological research
pub_type: 杂志文章,meta分析
doi:10.1080/01616412.2018.1564183
更新日期:2019-04-01 00:00:00
abstract::Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740555
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:Numerous studies have identified different predictors for secondary hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH), although predictors regarding timing of the shunt operation have never been reported. Predictors for an early shunt, which was defined as a shunt operation performed ≤30 days after...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1199184
更新日期:2016-07-01 00:00:00
abstract::Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga ('Yoga-plus') among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ± 8.7 years old) participated in a 12-month (M) exercise ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1672380
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:The actual relationship between neural stem cells and SDF-1alpha/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, could contribute to neural stem cells migration after brain injury. In th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X332995
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To assess the clinical significance of hepatitis B virus (HBV) infection in patients with cerebral venous sinus thrombosis (CVST). METHODS:Twenty-two patients with CVST confirmed by magnetic resonance venography (MRV) or digital subtraction angiography (DSA) and 743 controls with ischemic stroke confirmed by...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000003
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:Cell-free DNA (cf-DNA) is a marker of inflammation and cell death. The purpose of the present study was to analyze the role of cf-DNA as a putative biomarker in refractory epilepsy. METHODS:Baseline concentration of cf-DNA was measured in the serum of 51 carefully evaluated refractory epilepsy patients under...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2015.1127004
更新日期:2016-01-01 00:00:00
abstract::Serial magnetic resonance (MR) imaging has not yet been validated in the therapy of experimental intracerebral hematomas in a rat model. It is possible to test the effect of local fibrinolysis and aspiration on the clot volume using serial magnetic resonance imaging and different MR-sequences. Experiments were carried...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740530
更新日期:1998-06-01 00:00:00
abstract::Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739882
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVES:Intracranial aneurysms (IAs) of the posterior circulation (PC) rupture more frequently and their morbidity and mortality rates are higher compared to anterior circulation. Morphological parameters such as size ratio (SR), inflow angle and parent artery geometry are believed to contribute significantly in det...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000306
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family. In this family, male patients were moderately to severely affected. METHODS:We performed immunofluorescence to ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1204494
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Alteration of sensorium or an encephalopathy is a common diagnostic dilemma in critically ill patients and can be caused by a number of conditions. Sepsis associated encephalopathy (SAE) is now the most common encephalopathy encountered among intensive care unit (ICU) patients. DEFINITIONS:SAE is an encep...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164107X240233
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:The study objectives are (1) to identify factors predicting the excellent visual recovery after transsphenoidal removal of pituitary tumors and (2) to describe the association of excellent visual recovery and early restoration of symmetry of the decompressed optic chiasm. METHODS:Thirty-five patients with v...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000407
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To explore the value of dynamically monitored levels of plasma prothrombin fragment(1+2) (F(1+2)) and D-dimer in the process of thrombolysis with urokinase. METHODS:Blood samples were collected at baseline and at hours 1, 2, 3, 6, 12, 24, 48, 72, and 96 after urokinase infusion finished. The levels of plasma...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X443991
更新日期:2009-05-01 00:00:00
abstract::The purpose of this prospective observational study was to investigate the relation between the frequency of critical neuromonitoring parameters (brain tissue pO2, (PtiO2) < or = 10 mmHg, intracranial pressure (ICP) > 20 mmHg, cerebral perfusion pressure (CPP) < or = 70 mmHg) and outcome after severe aneurysmal subara...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164103101201823
更新日期:2003-07-01 00:00:00
abstract::In patients with head trauma and consecutive acute diffuse cerebral swelling the sudden initial rise in intracranial pressure with subsequent impairment of cerebral blood flow is explained by engorgement due to vasoparalysis. How quickly hyperaemic brain swelling can occur is shown by a case report. The review of clin...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740190
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment. METHODS:Data from 10 patients already on statins at stro...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1558000
更新日期:2019-04-01 00:00:00
abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739556
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:The unified Parkinson's disease rating scale (UPDRS) is the most widely used tool to rate the severity and the stage of Parkinson's disease (PD). However, the mentation, behavior and mood (MBM) subscale of the UPDRS has received little investigation regarding its validity and sensitivity. Three items of this ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X251772
更新日期:2008-06-01 00:00:00
abstract::Endolymphatic sac tumors are rare, low-grade adenocarcinomas of the petrous bone. These tumors are highly vascularized and surgical removal is often challenging. We present a staged endovascular-neurosurgical approach consisting of stent-assisted angioplasty of the petrous carotid, selective endovascular embolization ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201436
更新日期:2003-04-01 00:00:00
abstract::Six cases of very large anterior circulation intracranial aneurysms are presented. Aneurysms of 53-84 mm in three female and two male adults and a 40 mm lesion in a seven week infant were successfully excised. Three patients tolerated trial intraluminal balloon occlusion preoperatively and underwent subsequent parent ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740053
更新日期:1992-01-01 00:00:00
abstract::A computer software program (Seapit) was developed for precise determination of intracranial targets identified by stereotactic computed tomography (CT). This program was added to the software of a GE 8800 CT scanner to perform the following operations: millimetre precise calculation and display of the rectilinear coo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739781
更新日期:1987-06-01 00:00:00
abstract::Intraoperative use of somatosensory evoked potentials (SEP's) to monitor intracranial aneurysm surgery and flash visual evoked potentials (F-VEP's) for parasellar surgery have been routinely employed in our clinic. We found that both EP modalities are sensitive to the changing concentration of our standard hypotensive...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739701
更新日期:1985-06-01 00:00:00
abstract:OBJECTIVES:Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the associati...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1560643
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:Vascular endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production. The present study examined if thrombin modulates vascular endoth...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X385699
更新日期:2009-09-01 00:00:00
abstract::The endothelial lining of blood vessels plays an important role in the control of arterial tone by releasing a number of vasoactive factors. Among these, nitric oxide (NO) or a NO containing moiety, some cyclooxygenase products such as prostacyclin (PGl2) and a still hypothetical hyperpolarizing factor may induce dila...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740851
更新日期:1997-10-01 00:00:00
abstract::A case is reported of intractable epilepsy associated with a hypothalamic hamartoma in an 18 year old man. The patient underwent a two-third anterior callsotomy and, subsequently, removal of the hamartoma. Callosotomy did not affect the generalized seizure pattern. The authors believe this to be the first documented c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740125
更新日期:1993-04-01 00:00:00
abstract::With recent advancement in medical imaging, techniques, and endovascular tools more patients are diagnosed with unruptured intracranial aneurysms. The main aim of offering aneurysm treatment is to ameliorate the risk of future aneurysm bleeding, while not posing additional risks on the patient from the treatment itsel...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132814Y.0000000328
更新日期:2014-04-01 00:00:00
abstract::Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1611009
更新日期:2019-07-01 00:00:00