Brain endothelial HSP-70 stress response coincides with endothelial and pericyte death after brain trauma.

Abstract:

OBJECTIVES:Our objective was to characterize the heat shock response (HSR) in a model of traumatic brain injury (TBI) and to determine the association of HSR to cell death. METHODS:We used immunofluorescent detection of HSP-70 to characterize HSR and TUNEL labeling to determine the pattern of cell death. RESULTS:HSP-70 immunofluorescence revealed a steady increase from 4 to 48 hours following TBI, culminating in a ubiquitous expression with the capillary bed 48 hours post-TBI. TUNEL labeling revealed a small subset of endothelial cell death and a most robust staining of putative pericyte cell death. DISCUSSION:Our results show that while injury causes a detectable stress response, cell death is not a direct consequence of the HSR.

journal_name

Neurol Res

journal_title

Neurological research

authors

DeGracia DJ,Kreipke CW,Kayali FM,Rafols JA

doi

10.1179/016164107X204666

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

356-61

issue

4

eissn

0161-6412

issn

1743-1328

journal_volume

29

pub_type

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