Abstract:
OBJECTIVES:Our objective was to characterize the heat shock response (HSR) in a model of traumatic brain injury (TBI) and to determine the association of HSR to cell death. METHODS:We used immunofluorescent detection of HSP-70 to characterize HSR and TUNEL labeling to determine the pattern of cell death. RESULTS:HSP-70 immunofluorescence revealed a steady increase from 4 to 48 hours following TBI, culminating in a ubiquitous expression with the capillary bed 48 hours post-TBI. TUNEL labeling revealed a small subset of endothelial cell death and a most robust staining of putative pericyte cell death. DISCUSSION:Our results show that while injury causes a detectable stress response, cell death is not a direct consequence of the HSR.
journal_name
Neurol Resjournal_title
Neurological researchauthors
DeGracia DJ,Kreipke CW,Kayali FM,Rafols JAdoi
10.1179/016164107X204666subject
Has Abstractpub_date
2007-06-01 00:00:00pages
356-61issue
4eissn
0161-6412issn
1743-1328journal_volume
29pub_type
杂志文章abstract::Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of the dopamine producing neurons projecting from the substantia nigra into the corpus striatum. Current medical therapy is limited and cannot stop or reverse the degeneration. Over the past 30 years, attempts were m...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225017604
更新日期:2004-06-01 00:00:00
abstract::The effect of labetalol, a combined alpha- and beta-adrenoceptor antagonist, on the cerebral circulation was investigated in 7 normotensive subjects. Cerebral blood flow (CBF) was measured with the intravenous 133Xe method and mean flow velocity (Vmean) in the middle cerebral artery was determined using transcranial D...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739958
更新日期:1991-03-01 00:00:00
abstract::A prospective study of the expression of the chemokine receptor CCR7 was performed in 11 relapsing-remitting multiple sclerosis (MS) patients during 12 months of interferon-beta (IFNbeta) treatment. The results show increased expression of CCR7 on peripheral blood lymphocytes (PBL) of MS patients receiving IFNbeta tre...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164107X228633
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Interleukin-21 (IL-21) is a cytokine that is an important modulator of immune responses. However, its roles in epilepsy are not completely clear. Here, we investigated the expression and distribution of IL-21 in a kainic acid (KA)-induced acute seizure mouse model. MATERIALS AND METHODS:Mice (n = 146) were r...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2015.1135557
更新日期:2016-02-01 00:00:00
abstract::Objective: Remote limb ischemic postconditioning (RIPostC) protects the brain from damage induced by transient focal ischemia/reperfusion. However, the underlying mechanism remains unclear. Methods: RIPostC induced by 10 min of occlusion and another 10 min releasing of blood flow for three cycles in the hind limbs was...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1523037
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X338043
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to investigate the effect of bone mesenchymal stem cells (BMSCs) conditioned medium on BMP4-induced activation of the Smad signaling pathway during the process of neural stem cells differentiation. METHODS:We designed four experimental groups: (A) control group, (B) BMP-4 treatment g...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1232549
更新日期:2016-11-01 00:00:00
abstract::This article covers the basis of tethered cord syndrome as a stretch-induced spinal cord disorder, including pathophysiology, signs and symptoms, imaging diagnosis, indication for surgical treatment, and surgical procedures. Anomalies that cause mechanical spinal cord tethering are listed, and the surgical untethering...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225017947
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Infection is a major complication and risk factor of cerebrospinal fluid (CSF) shunting procedures. Recently, antibiotic-impregnated shunt systems have been developed in an attempt to prevent or reduce the CSF infection. The aim of this study was to determine the efficacy of silver-impregnated polyurethane ve...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/174313209X380973
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To investigate the perfusion parameters of computed tomography (CT) in hypoxicischemic encephalopathy (HIE) after off-pump coronary artery bypass grafting (OPCABG), and its potential in predicting the occurrence and prognosis of hypoxic-ischemic encephalopathy. METHODS:We selected 830 patients. The patients ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1315862
更新日期:2017-06-01 00:00:00
abstract::This study comprises scientific-theoretic fundamental investigations of laserneedle technology, a new and painless method of acupuncture stimulation. Laserneedles are not inserted in the skin, but are merely placed on the surface of the acupuncture point. The study documents the significant changes in peripheral micro...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/016164103101202237
更新日期:2003-10-01 00:00:00
abstract::Changes in membrane AChRs in skeletal muscles located near or distant from burn injury similar to denervated muscles may make electrodiagnostic features indistinguishable from true neuropathic changes. The aim of this study was to examine electrodiagnostic changes of muscles at sites local and distant from the burn af...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2015.1105583
更新日期:2016-04-01 00:00:00
abstract::Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimu...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103771953862
更新日期:2003-12-01 00:00:00
abstract::[15O]-water PET was performed on 12 patients with structural lesions for localization of the motor (n = 5), language (receptive and expressive; n = 6), and visual cortex (n = 1). All these patients underwent interactive image-guided surgery using an infrared digitizer and intraoperative electrical stimulation mapping ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740867
更新日期:1997-12-01 00:00:00
abstract::Severe head injuries tend to be associated with hypermetabolism and hypercatabolism resulting in negative nitrogen balances which may exceed 30 grams day-1. Enteral feeding should begin as soon as the patient is hemodynamically stable, attempting to reach a non-protein caloric intake of at least 30-35 kcal kg-1 day-1 ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164101101198451
更新日期:2001-03-01 00:00:00
abstract::We describe the technique of percutaneous carotid artery stent placement with distal protection in a patient in whom marked innominate artery ectasia prevented transfemoral access to the right common carotid artery. After induction of general anesthesia, ultrasound was used to guide direct puncture of the common carot...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225013978
更新日期:2004-04-01 00:00:00
abstract::Sixty-five years old patient suffering from acute stroke was treated by rTPA intravenously. TCD monitoring of both middle cerebral arteries (MCA) was carried out simultaneously with administration of rTPA. Seven microemboli were found in right and four in left MCA. Duplex ultrasound, CT angiography and digital subtrac...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X289589
更新日期:2008-09-01 00:00:00
abstract::Twenty-four patients presenting an acute stroke with watershed cerebral infarct on CT scan or MRI were included in this retrospective study. Age was 63 +/- 14 years (mean +/- SD), and sex ratio was 2 men for 1 woman. Main clinical features were: in anterior location, lower limb weakness and frontal syndrome with trans...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740022
更新日期:1992-01-01 00:00:00
abstract::Mild vascular cognitive impairment (mVCI) is a broader term that is intended to detect cognitive loss before the development of dementia. The identification of preventable risk factors as well as therapeutic strategies of intervention is still unclear. It has been suggested that carotid endarterectomy (CEA) improves c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225016245
更新日期:2004-07-01 00:00:00
abstract::Synthesized Mn-TPPS, a paramagnetic metalloporphyrin, is expected to be a tumour specific contrast media for magnetic resonance (MR) imaging. We investigated the enhancing characteristics of Mn-TPPS using a transplanted rat C6 glioma model with peripheral type benzodiazepine (PBD) receptors since porphyrins are though...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740260
更新日期:1994-10-01 00:00:00
abstract::This paper describes a test prototype for precision robot-assisted surgery using a hexapod operating robot and a movable operating cockpit for tactile feedback. The objective of the work described is twofold: 1, to evaluate the use of hexapod robots for precisely manipulating endoscopes and surgical instruments in sub...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740887
更新日期:1999-01-01 00:00:00
abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740543
更新日期:1998-07-01 00:00:00
abstract::Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to reveal severe dyses...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201274
更新日期:2003-03-01 00:00:00
abstract::Following cerebral ischemia, the extracellular concentration of excitatory amino acids increases, and the excitatory cell death may play an important role contributing to ischemic neuronal damage. Although sequential metabolic changes in permanent local cerebral ischemia have been reported, the effect of reperfusion i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740462
更新日期:1996-12-01 00:00:00
abstract::This paper reviews our recent studies of the role of cortical spreading depression (CSD) in the pathogenesis of brain disorders. Our investigation is a computational one, involving the development and utilization of a complex neuro-metabolic model of the interactions assumed to occur in the cortex during the passage o...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198839
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to evaluate whether resveratrol (RSV) modulates membrane lipid composition, as well as on ganglioside profile in ischemia/reperfusion injury. METHODS:Global cerebral ischemia was induced by four-vessel occlusion for 10 minutes. RSV (30 mg/kg) or vehicle was intraperitoneally...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000116
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the associati...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1560643
更新日期:2019-04-01 00:00:00
abstract::Endovascular reconstruction of basilar artery (BA) apex aneurysms has been augmented by adjunctive techniques such as balloon and stent assistance. We present three cases of a wide-necked BA apex aneurysm involving the bilateral P1 segments of both posterior cerebral arteries (PCAs) treated by placement of BA to PCA s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225013969
更新日期:2004-04-01 00:00:00
abstract::The effects of acupuncture have been described and handed down empirically for centuries but there are few reports based on objective data. The aim of this study was to provide selective evidence of a specific effect of acupuncture on the brain and the eye using a Doppler ultrasound technique. A transcranial Doppler s...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.1999.11740970
更新日期:1999-09-01 00:00:00
abstract::We currently have used three drugs in combination [mannitol, vitamin E and glucocorticoid (beta-methasone)] for the treatment of cerebral infarction in the acute stage. For the purpose of evaluating the efficacy of this therapy, we have conducted experiments evaluated by chemiluminescence (CL), energy metabolism and w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739819
更新日期:1988-06-01 00:00:00