Reactivation of atrophic neurons in Alzheimer's disease.

Abstract:

:Decreased metabolic rate may precede cognitive impairment in Alzheimer's disease (AD) and is thus an early occurring hallmark. Several observations in post-mortem brain indicate that activated neurons are better able to withstand aging and AD, a phenomenon paraphrased by us as 'use it or lose it'. Moreover, a number of pharmacological and nonpharmacological studies support the concept that activation of the brain has beneficial effects and may to a certain degree restore several aspects of cognition and other central functions. For instance, the circadian system may be restimulated in Alzheimer patients by exposing them to more light or transcutaneous nerve stimulation. A procedure has been developed to culture human post-mortem brain tissue that allows testing of the efficacy of putative stimulatory compounds such as neurotrophins.

journal_name

Neurol Res

journal_title

Neurological research

authors

Swaab DF

doi

10.1179/016164103101201959

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

652-60

issue

6

eissn

0161-6412

issn

1743-1328

journal_volume

25

pub_type

杂志文章,评审
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    authors: Droste DW,Sonne M,Siemens HJ,Kaps M

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    authors: Peviani SM,Russo TL,Durigan JL,Vieira BS,Pinheiro CM,Galassi MS,Salvini TF

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  • Microsurgical anatomy of the ophthalmic artery and the distal dural ring for the juxta-dural ring aneurysms via the pterional approach.

    abstract::Microsurgical anatomy for the pterional approach was studied regarding the origin and the course of the ophthalmic artery and the distal dural ring using human cadaveric specimens, with special reference to the surrounding bony structures. In 50 human adult formalin-fixed cadaveric cerebral hemispheres and 10 block sp...

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    authors: Hokama M,Hongo K,Gibo H,Kyoshima K,Kobayashi S

    更新日期:2001-06-01 00:00:00

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    abstract::The present study was designed to investigate the beneficial effects of cornel iridoid glycoside (CIG), a main component extract from Cornus officinalis, on neurotrophin expression in mouse experimental autoimmune encephalomyelitis (EAE), a classical model of multiple sclerosis (MS). After EAE initiation, CIG was intr...

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    authors: Qu Z,Zheng N,Zhang Y,Zhang L,Liu J,Wang Q,Yin L

    更新日期:2016-09-01 00:00:00

  • An ultrastructural study on the reactive oligodendrocytes, myeloclasts, and myelophages in transected dog spinal cord.

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    pub_type: 杂志文章

    doi:10.1080/01616412.1980.11739566

    authors: Chang LW,Kao CC

    更新日期:1980-01-01 00:00:00

  • Leptin's effect on accelerated fracture healing after traumatic brain injury.

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    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000201

    authors: Yan H,Zhang HW,Fu P,Liu BL,Jin WZ,Duan SB,Xue J,Liu K,Sun ZM,Zeng XW

    更新日期:2013-06-01 00:00:00

  • The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

    abstract:INTRODUCTION:Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. METHODS:Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. RESULTS:We found intraepidermal nerve fiber degener...

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    pub_type: 杂志文章

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    authors: Kosacka J,Woidt K,Toyka KV,Paeschke S,Klöting N,Bechmann I,Blüher M,Thiery J,Ossmann S,Baum P,Nowicki M

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  • Mapping the primary motor cortex in healthy subjects and patients with peri-rolandic brain lesions before neurosurgery.

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    authors: Berntsen EM,Samuelsen P,Lagopoulos J,Rasmussen IA Jr,Håberg AK,Haraldseth O

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    pub_type: 杂志文章

    doi:10.1080/01616412.1989.11739860

    authors: Gilsbach JM,Harders AG

    更新日期:1989-03-01 00:00:00

  • Loss of essential membrane lipids and ascorbic acid from rat brain following cryogenic injury and protection by methylprednisolone.

    abstract::Previous work has shown that unsaturated fatty acid components of model membrane phospholipids in vitro, damaged via a free radical mechanism, are protected by the presence of cholesterol in these membranes. The participation of these membrane lipids in the pathogenesis of traumatic injury to brain was studied in vivo...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1981.11739608

    authors: Mitamura JA,Seligman ML,Solomon JJ,Flamm ES,Demopoulos HB,Ransohoff J

    更新日期:1981-01-01 00:00:00

  • Neurological aspects of tuberous sclerosis in relation to MRI/MR spectroscopy findings in children with epilepsy.

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    pub_type: 杂志文章

    doi:10.1179/016164107X163996

    authors: Yapici Z,Dörtcan N,Baykan BB,Okan F,Dinçer A,Baykal C,Eraksoy M,Roach S

    更新日期:2007-07-01 00:00:00

  • Cerebral hemodynamics during induced tachycardia in routine electrophysiologic studies: a transcranial Doppler study.

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    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740555

    authors: Zunker P,Haase C,Borggrefe M,Georgiadis D,Georgiadis A,Ringelstein EB

    更新日期:1998-09-01 00:00:00

  • Stereotactic software for the GE 8800 CT scanner.

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    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1987.11739781

    authors: Lunsford LD,Listerud JA,Rowberg AH,Latchaw RE

    更新日期:1987-06-01 00:00:00

  • Blood-brain barrier restoration following cold injury.

    abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1980.11739556

    authors: Pollay M,Stevens FA

    更新日期:1980-01-01 00:00:00

  • Aspirin reduces experimental cerebral blood flow in vivo.

    abstract::Aspirin therapy for stroke prophylaxis in low risk patients has paradoxically demonstrated an increased risk of ischemic stroke in several studies. Moreover, the MAST-Italy trial reported a near doubling of mortality with the addition of aspirin to thrombolytics while experimentally, we have noted that aspirin antagon...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:

    authors: Bednar MM,Gross CE

    更新日期:1999-07-01 00:00:00

  • Cerebral density and perfusion measured among heart disease patients with and without stroke.

    abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:

    authors: Obara K,Meyer JS,Muramatsu K,Mortel KF

    更新日期:1995-10-01 00:00:00

  • WITHDRAWN: Activation of TLR4/NF-kappaB signaling pathway in early brain injury after subarachnoid hemorrhage.

    abstract::Ahead of Print article withdrawn by publisher. ...

    journal_title:Neurological research

    pub_type: 杂志文章

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    authors: Ma CX,Yin WN,Cai BW,He M,Wu J,Wang JY,Zeng Y,Ding JL,You C

    更新日期:2009-08-21 00:00:00

  • A comparison of polysomnographic and actigraphic evaluation of periodic limb movements in sleep.

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    authors: Kemlink D,Pretl M,Sonka K,Nevsimalova S

    更新日期:2008-04-01 00:00:00

  • Relationship between the states of spinal impact injuries and magnetically evoked EMGs in rats.

    abstract::The relationship between the states of spinal impact injuries and magnetically evoked electromyograms (EMGs) were studied in rats. Impact injuries to the spinal cord were induced at a depth of 0.25-2.0 mm by insertion of a cylinder tip measuring 2 mm in diameter into the lumbar vertebrae L1-L2. Magnetically induced el...

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    authors: Chiba A,Hiruma S,Hashimoto S,Inase M

    更新日期:2000-10-01 00:00:00

  • In vitro and in vivo experiments of a novel intra-arterial neurovascular decompressor for treating neurovascular compression syndromes: a brief report.

    abstract::Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1611009

    authors: Chun Y,Chen Y,Elsisy M,Sukinik J,Shridhar P,Park JK,Kim YB,Hong CK,Chung J

    更新日期:2019-07-01 00:00:00

  • The effects of early insulin treatment combined with thrombolysis in rat embolic stroke.

    abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101200096

    authors: Meden P,Andersen M,Overgaard K,Rasmussen RS,Boysen G

    更新日期:2002-06-01 00:00:00

  • Radiation-induced apoptosis of oligodendrocytes in the adult rat optic chiasm.

    abstract:OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...

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    pub_type: 杂志文章

    doi:10.1179/016164105X48833

    authors: Nagayama K,Kurita H,Nakamura M,Kusuda J,Tonari A,Takayama M,Fujioka Y,Shiokawa Y

    更新日期:2005-06-01 00:00:00

  • Fructose-added glycerol (Glyceol) for therapy of elevated intracranial pressure: analysis of the side effects of long-term administration in a multi-institutional trial.

    abstract::The effects of long-term administration of fructose-added glycerol solution (Glyceol): 10% glycerol, 5% fructose, 0.9% sodium chloride; 600-2000 ml/d intravenously for 7-63 d) were evaluated in a multi-institutional trial involving 1346 cases. Improvement of the neurological signs and symptoms of elevated intracranial...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1080/01616412.1989.11739901

    authors: Tsubokawa T,Katayama Y,Ishii S

    更新日期:1989-12-01 00:00:00

  • Pulsation-pressure relationship in experimental aneurysms: observation of aneurysmal hysteresis.

    abstract::In this study the pulsation-pressure relationship in an experimental model of aneurysms was analyzed. In addition, we have examined pulsatility of the aneurysmal wall reinforced by Guglielmi Detachable Coils (GDC). Bifurcation (BAn), aneurysms (LAn) and bilobar (BiA) aneurysms were produced in 15 mongrel dogs. The ane...

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    pub_type: 杂志文章

    doi:10.1080/01616412.1996.11740440

    authors: Novak P,Glikstein R,Mohr G

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  • Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson's disease.

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    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1249997

    authors: Pal R,Tiwari PC,Nath R,Pant KK

    更新日期:2016-12-01 00:00:00

  • CT observations on the natural history of asymptomatic cerebral infarction following transient ischaemic attacks.

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    authors: Turnbull IW,Bannister CM

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  • Reduced expression of L-selectin in T-cells correlates with relative lymphocyte increase in patients with RRMS treated with natalizumab - functional implication towards PML risk.

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    doi:10.1080/01616412.2020.1722913

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    更新日期:2009-06-01 00:00:00