Abstract:
INTRODUCTION:Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. METHODS:Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. RESULTS:We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Low dietary iron load caused more pronounced abnormalities than high iron load in ob/ob mice. DISCUSSION:Our data suggest that dietary non-heme iron deficiency may be a modulating factor in the pathogenesis of peripheral neuropathy in obese ob/ob mice with metabolic syndrome. Once the mechanisms can be further elucidated, how low dietary iron augments peripheral nerve degeneration and dysfunction via pro-inflammatory pathways and new therapeutic strategies could be developed. ABBREVIATIONS:CMAP: compound muscle action potential; cSNCV: compound sensory nerve conduction velocity; IENFD: intraepidermal nerve fiber density; LDL: low-density lipoprotein; MetS: metabolic syndrome; MNCV: motor conduction velocity; NCV: nerve conduction velocity; PN: peripheral neuropathy; PNS: peripheral nervous system; STZ: streptozotocin; T2D: type 2 diabetes mellitus; TNF alpha: tumor necrosis factor alpha; WHO: World Health Organization.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Kosacka J,Woidt K,Toyka KV,Paeschke S,Klöting N,Bechmann I,Blüher M,Thiery J,Ossmann S,Baum P,Nowicki Mdoi
10.1080/01616412.2018.1564191subject
Has Abstractpub_date
2019-04-01 00:00:00pages
341-353issue
4eissn
0161-6412issn
1743-1328journal_volume
41pub_type
杂志文章abstract::Because clinicians require objectively demonstrable neurological deficits to confirm a diagnosis, the recognition of embolic events in the nervous system is generally restricted to the effects of ischemic necrosis produced by arterial occlusion. However, magnetic resonance imaging (MRI) has shown that lesser degrees o...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164107X181789
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X338043
更新日期:2009-06-01 00:00:00
abstract::We have reliable data on the degree of stenosis above which endarterectomy for symptomatic carotid stenosis is beneficial, but benefit is also influenced by other factors, particularly age, sex, the timing of surgery, plaque surface morphology and the nature of the presenting symptomatic event(s). This review will con...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X25298
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies have shown that awareness of early stroke symptoms and the use of ambulances are two important factors in decreasing pre-hospital stroke delay. The purpose of this study is to evaluate a comprehensive educational stroke protocol in improving stroke response times. METHOD:Two urban commun...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000203
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:One of the main obstacles of electrode implantation in epilepsy surgery is the electrode shift between implantation and the day of explantation. We evaluated this possible electrode displacement using intraoperative MRI (iopMRI) data and CT/MRI reconstruction. METHODS:Thirteen patients (nine female, four ma...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1484588
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To investigate risk factors for neurological complications after off-pump coronary artery bypass grafting (OPCABG). METHODS:We reviewed the cases of 813 patients who underwent OPCABG between August 2010 and September 2013.Data from preoperative 320 dynamic volume computed tomography (CT), CT angiography (CTA...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000030
更新日期:2015-05-01 00:00:00
abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739556
更新日期:1980-01-01 00:00:00
abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1457130
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:To review the historical development and current status of endovascular techniques used in the treatment of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. METHODS:This article summarizes the relevant literature on neurointerventional therapy for vasospasm, namely instillation of intraar...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X152043
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:The syntheses of endothelin receptors A and B were previously shown to be upregulated in rat dorsal hippocampus after traumatic brain injury. Here we characterize endothelin receptor A and endothelin receptor B cellular distribution in hippocampus after permanent global brain ischemia and their possible asso...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164111X12881719352291
更新日期:2011-03-01 00:00:00
abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...
journal_title:Neurological research
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739995
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVES:The presence of beta-amyloid (betaA) deposition, induction of reactive gliosis and dystrophic neurites, is a characteristic feature of neuritic plaques in Alzheimer's disease. In vitro, betaA-exposed astrocytes become reactive, similar to astrocytes in contact with betaA plaques in vivo. How betaA-exposed re...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X40020
更新日期:2005-07-01 00:00:00
abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740472
更新日期:1996-12-01 00:00:00
abstract::Vestibular neuritis (VN) rapidly damages unilateral vestibular periphery, inducing severe balance disorders. In most cases, such vestibular imbalance is gradually restored to within the normal level after clinical therapies. This successive clinical recovery occurs due to regeneration of vestibular periphery and/or ac...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/016164103101201364
更新日期:2003-04-01 00:00:00
abstract::Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X25225
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To assess the effect of sensory nerve stimulation in older people with peripheral neuropathy associated with diabetes (DPN). MATERIALS AND METHODS:A randomized, placebo controlled, double blind trial was used to assess the effect of 12 weeks of low frequency sensory nerve stimulation (LF-SNS) in the lower li...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/016164107X208095
更新日期:2007-10-01 00:00:00
abstract::To study the pathophysiology of olivopontocerebellar atrophy (OPCA), we destroyed inferior olive nuclei of male Wistar rats using 3-acetyl pyridine (3-AP) + harmaline + niacinamide. These rats showed a sluggish and ataxic gait. To elucidate the relationship between thyrotropin releasing hormone (TRH) in the Purkinje c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740690
更新日期:2000-06-01 00:00:00
abstract::Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164103101202002
更新日期:2003-09-01 00:00:00
abstract::A prospective study of the expression of the chemokine receptor CCR7 was performed in 11 relapsing-remitting multiple sclerosis (MS) patients during 12 months of interferon-beta (IFNbeta) treatment. The results show increased expression of CCR7 on peripheral blood lymphocytes (PBL) of MS patients receiving IFNbeta tre...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164107X228633
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:Progesterone modulates dopamine (DA) release in corpus striatum. Our objective was to evaluate the effect of the i.c.v injection of the neurosteroid allopregnanolone (ALL), a progesterone metabolite on dopaminergic activity in the corpus striatum of rats under different gonadal hormonal conditions. METHODS:...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X166281
更新日期:2007-09-01 00:00:00
abstract::This paper describes a test prototype for precision robot-assisted surgery using a hexapod operating robot and a movable operating cockpit for tactile feedback. The objective of the work described is twofold: 1, to evaluate the use of hexapod robots for precisely manipulating endoscopes and surgical instruments in sub...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740887
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To assess prospectively the significance of sonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome (CTS), to look for proper parameters and cutoff values for the sonographic diagnosis, and to correlate with the electrophysiological findings. MATERIALS AND METHODS:This study ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000028
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:Brain death is a clinical diagnosis often confirmed with supplementary tests. In this study, we examined the relationship between brain death and the partial pressure of brain tissue oxygen (PbtO(2)). We hypothesized that a sustained PbtO(2) of 0 is associated with brain death. METHODS:One hundred and twent...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X208121
更新日期:2007-10-01 00:00:00
abstract::As early as 1 to 3 hr after cord transection, proliferation of many reactive oligodendrocytes was observed. Bundles of microfilaments and microtubules were observed in those cells that sent out long, complex pseudopodlike processes near the area of injury. These reactive oligodendrocytes may be comparable to Vaughn's ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739566
更新日期:1980-01-01 00:00:00
abstract::A new and reproducible saccular aneurysm model has been developed at the bifurcation of the common carotid artery in rats. The details of the experimental methods and results are described. It is strongly suggested that the internal elastic lamina is a critical layer in saccular aneurysm formation, because an experime...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1990.11739953
更新日期:1990-12-01 00:00:00
abstract::The role of intra-operative pathological diagnosis increases along with a development of minimally invasive neurosurgery, especially stereotactic and endoscopic techniques. The authors present their own experience with the cytological method and evaluate its usefulness in intra-operative diagnosis of brain tumors. Bra...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.1999.11740907
更新日期:1999-01-01 00:00:00
abstract::In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740128
更新日期:1993-06-01 00:00:00
abstract::Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1611009
更新日期:2019-07-01 00:00:00
abstract::Huntington's disease is an inherited neurodegenerative disorder, characterized by loss of spiny neurons in the striatum and cortex, which usually happens in the third or fourth decades of life. In advanced form of the disease, progressive striatum atrophy happens and medium spiny neurons, which occupy more than 80% of...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X327955
更新日期:2008-12-01 00:00:00