Sleep promoting effects of intravenously administered acidic fibroblast growth factor.

Abstract:

:The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF administration and lasted about 75 min. Furthermore, the somnogenic effects of aFGF were prevented by pretreatment with the nitric oxide synthase inhibitor L-NAME. Our findings demonstrate a somnogenic effect of aFGF which requires crossing the blood-brain barrier (BBB) and implicate that nitric oxide sleep pathway may be involved in this biological effect.

journal_name

Neurol Res

journal_title

Neurological research

authors

Galan JM,Cuevas B,Dujovny N,Giménez-Gallego G,Cuevas P

doi

10.1080/01616412.1996.11740472

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

567-9

issue

6

eissn

0161-6412

issn

1743-1328

journal_volume

18

pub_type

杂志文章
  • Gene expression in neurotrauma.

    abstract::It has been established that following injury to the central nervous system two types of damage take place, the initial insult and the secondary response to injury. This review will focus on the secondary molecular aspects of neurotrauma. These responses may be either deleterious or have protective effects upon the in...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164101101198343

    authors: Dutcher SA,Michael DB

    更新日期:2001-03-01 00:00:00

  • Cardiac risk factors and potential treatments in Alzheimer's disease.

    abstract::Dementia is one of the commonest neurological disorders in the elderly population. In regards to the increasing longevity of populations worldwide, prevention of dementia has become a major public health challenge. There has been an intense research in the identification of modifiable risk factors for dementia. These ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164106X130498

    authors: Bergmann C,Sano M

    更新日期:2006-09-01 00:00:00

  • The effect of encephalo-myo-synangiosis on abnormal collateral vessels in childhood moyamoya disease.

    abstract::Child patients with Moyamoya disease initially present with ischemic symptoms. However, the long-term risk of intracranial hemorrhage for childhood Moyamoya disease is unknown. Hemodynamic overload to the fragile collateral vessels has been considered to cause hemorrhage. We reviewed angiograms to evaluate the effect ...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1080/01616412.2000.11740680

    authors: Irikura K,Miyasaka Y,Kurata A,Tanaka R,Yamada M,Kan S,Fujii K

    更新日期:2000-06-01 00:00:00

  • Is mild vascular cognitive impairment reversible? Evidence from a study on the effect of carotid endarterectomy.

    abstract::Mild vascular cognitive impairment (mVCI) is a broader term that is intended to detect cognitive loss before the development of dementia. The identification of preventable risk factors as well as therapeutic strategies of intervention is still unclear. It has been suggested that carotid endarterectomy (CEA) improves c...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164104225016245

    authors: Borroni B,Tiberio G,Bonardelli S,Cottini E,Facheris M,Akkawi N,Pezzini A,Cervi E,Giulini SM,Padovani A

    更新日期:2004-07-01 00:00:00

  • The multifunctional role of IGF-1 in peripheral nerve regeneration.

    abstract::The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cel...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164104225013851

    authors: Rabinovsky ED

    更新日期:2004-03-01 00:00:00

  • Sonographic and electrophysiological detection in patients with carpal tunnel syndrome.

    abstract:OBJECTIVES:To assess prospectively the significance of sonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome (CTS), to look for proper parameters and cutoff values for the sonographic diagnosis, and to correlate with the electrophysiological findings. MATERIALS AND METHODS:This study ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132811Y.0000000028

    authors: Guan J,Ji F,Chen W,Chu H,Lu Z

    更新日期:2011-11-01 00:00:00

  • Microtechnology and nanotechnology in nerve repair.

    abstract:OBJECTIVE:This review will describe the novel contributions to the field of nerve repair from the emerging disciplines of microtechnology and nanotechnology. METHOD:This broad review will cover the advances described in the literature of the medical and biological fields and the engineering and physical sciences. The ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/174313208X362532

    authors: Chang WC,Kliot M,Sretavan DW

    更新日期:2008-12-01 00:00:00

  • Comparisons of 2/3Sh estimation technique to computer-assisted planimetric analysis in epidural, subdural and intracerebral hematomas.

    abstract:OBJECTIVE:The formula 1/2abc was suitable for the estimation of the epidural, acute subdural, most intracerebral and even some chronic subdural hematoma volume, but its accuracy was prone to be affected by some particular shapes of hematomas. In this study, we aimed to validate a more accurate method for the estimation...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12681290831441

    authors: Zhao KJ,Zhang RY,Sun QF,Wang XQ,Gu XY,Qiang Q,Gao C,Shen JK

    更新日期:2010-11-01 00:00:00

  • Alteration of aminergic neurotransmitter release after two consecutive transient global ischaemias: an in vivo microdialysis study in rat.

    abstract::This study was designed to evaluate the effects of two consecutive ischaemias on extracellular monoaminergic neurotransmitter concentrations. The data on the neuroamine changes induced by the second ischaemia could be used to assess the delay in aminergic neurotransmission subsequent to the primary injury. Dopamine (D...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740134

    authors: Decombe R,Bentué-Ferrer D,Allain H,Van den Driessche J

    更新日期:1993-06-01 00:00:00

  • Detection of experimentally induced brain tumors in rats using high resolution computed tomography.

    abstract:OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X18250

    authors: Psarros TG,Mickey B,Giller C

    更新日期:2005-01-01 00:00:00

  • Atrial fibrillation as an important clinical condition of cognitive decline; diagnosis, comorbidities and severity of symptoms in patients with dementia.

    abstract::Objective: To determine the time of dementia diagnosis, symptom intensity and to assess the comorbidities.Methods: 110 patients with dementia or mild cognitive impairment were enrolled in this retrospective study. The study group was divided into subgroups: patients with a maximum of three (S ≤ 3 n = 62) and four or m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1738648

    authors: Niedziela N,Nowak MM,Lis M,Blaszkowska M,Kośmider R,Adamczyk-Sowa M

    更新日期:2020-05-01 00:00:00

  • A tactile feedback hexapod operating robot for endoscopic procedures.

    abstract::This paper describes a test prototype for precision robot-assisted surgery using a hexapod operating robot and a movable operating cockpit for tactile feedback. The objective of the work described is twofold: 1, to evaluate the use of hexapod robots for precisely manipulating endoscopes and surgical instruments in sub...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740887

    authors: Urban V,Wapler M,Weisener T,Schönmayr R

    更新日期:1999-01-01 00:00:00

  • Early combined cranioplasty and programmable shunt in patients with skull bone defects and CSF-circulation disorders.

    abstract:OBJECTIVE:This study assesses the clinical outcome after early combined cranioplasty (own frozen bone) and shunt implantation (Codman-Medos programmable VP shunt) in patients with skull bone defects and cerebrospinal fluid (CSF) circulation disorders. METHOD:Medical records were reviewed retrospectively for the last 1...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164106X98008

    authors: Carvi Y Nievas MN,Höllerhage HG

    更新日期:2006-03-01 00:00:00

  • Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging.

    abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1996.11740394

    authors: Lo EH,Rogowska J,Batchelder KF,Wolf GL

    更新日期:1996-04-01 00:00:00

  • Beta-amyloid-induced reactive astrocytes display altered ability to support dendrite and axon growth from mouse cerebral cortical neurons in vitro.

    abstract:OBJECTIVES:The presence of beta-amyloid (betaA) deposition, induction of reactive gliosis and dystrophic neurites, is a characteristic feature of neuritic plaques in Alzheimer's disease. In vitro, betaA-exposed astrocytes become reactive, similar to astrocytes in contact with betaA plaques in vivo. How betaA-exposed re...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X40020

    authors: Monnerie H,Esquenazi S,Shashidhara S,Le Roux PD

    更新日期:2005-07-01 00:00:00

  • Albumin ameliorates tissue plasminogen activator-mediated blood-brain barrier permeability and ischemic brain injury in rats.

    abstract:OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METH...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X393898

    authors: Tang J,Li YJ,Mu J,Li Q,Yang DY,Xie P

    更新日期:2009-03-01 00:00:00

  • fMRI review on brain responses to acupuncture: the limitations and possibilities in traditional Korean acupuncture.

    abstract:BACKGROUND:Since the late 1990s, imaging studies have allowed the visualization of brain response to acupuncture stimulation with alteration in blood flow. In 1998, the first functional magnetic resonance imaging (fMRI) study for the Korean acupuncture was published and thereafter, many subsequent neuroimaging studies ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164107X172284

    authors: Chae Y,Park HJ,Hahm DH,Hong M,Ha E,Park HK,Lee H

    更新日期:2007-01-01 00:00:00

  • Microsurgical approach for symptomatic brain AVMs - single center experience.

    abstract::Objectives: Brain arteriovenous malformations (AVMs) represent high-flow vascular lesions made up of a complex network of feeding arteries and draining veins interposed by a nidus and without a capillary bed. The management of the AVMs represents a challenge, and the optimal treatment should be considered based on the...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1803604

    authors: Gorgan RM,Petrescu GED,Brehar FM

    更新日期:2020-12-01 00:00:00

  • The relationship between SDF-1alpha/CXCR4 and neural stem cells appearing in damaged area after traumatic brain injury in rats.

    abstract:OBJECTIVE:The actual relationship between neural stem cells and SDF-1alpha/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, could contribute to neural stem cells migration after brain injury. In th...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313208X332995

    authors: Itoh T,Satou T,Ishida H,Nishida S,Tsubaki M,Hashimoto S,Ito H

    更新日期:2009-02-01 00:00:00

  • Enhanced expression of p53 in reactive astrocytes following transient focal ischemia.

    abstract::The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101199828

    authors: Chung YH,Shin CM,Kim MJ,Lee EY,Kim G,Cha CI

    更新日期:2002-04-01 00:00:00

  • The first 100 transsphenoidally operated pituitary adenomas in a non-specialised centre: surgical results and tumour-recurrence.

    abstract::From 118 transsphenoidally operated patients, 100 had a pituitary adenoma; 33 prolactinomas, 20 HGH-producing, 2 ACTH-producing and 45 inactive adenomas. The first transsphenoidal operation did not cause any mortality; after reoperation for suspected recurrence on follow-up, 2 patients died; thus, the global managemen...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1985.11739714

    authors: Auer LM,Clarici G

    更新日期:1985-09-01 00:00:00

  • The role of high-sensitivity C-reactive protein levels in functional outcomes in patients with large-artery atherosclerosis and small-artery occlusion.

    abstract:BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2017.1358937

    authors: Hou D,Liu J,Feng R,Gao Y,Wang Y,Wu J

    更新日期:2017-11-01 00:00:00

  • An endoscopic pedicle probe: preliminary development.

    abstract::Insertion of pedicle screws in the thoracolumbar spine can be challenging. Incorrect placement can lead to a failure of fusion or to significant neurologic morbidity. Recently, techniques utilizing intraoperative monitoring and stereotaxis have been developed to achieve proper screw placement. While these techniques m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740877

    authors: Frank EH,Chamberland DL

    更新日期:1997-12-01 00:00:00

  • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke.

    abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740159

    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1993-10-01 00:00:00

  • A technical approach to dissecting and assessing cadaveric veins pertinent to chronic cerebrospinal venous insufficiency in multiple sclerosis.

    abstract:OBJECTIVE:To establish a detailed technical procedure for studying the anatomical correlates of chronic cerebrospinal venous insufficiency in cadavers of multiple sclerosis and control subjects, and to present our findings of the normal anatomic venous structures, with reference to previous descriptions from the liter...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000071

    authors: Diaconu CI,Staugaitis SM,Fox RJ,Rae-Grant A,Schwanger C,McBride JM

    更新日期:2012-10-01 00:00:00

  • Effects of cerebral small vessel disease on the outcome of patients with ischemic stroke caused by large artery atherosclerosis.

    abstract:OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.2018.1446283

    authors: Zhu H,Li Z,Lv J,Zhao R

    更新日期:2018-05-01 00:00:00

  • B-waves in healthy persons.

    abstract::The objective of this study was to determine, whether 0.5-2/min oscillations in intracranial pressure ('B-waves') are a physiological phenomenon. In a group of 5 patients 0.5-2/min oscillations of ventricular pressure simultaneous with oscillations in the middle cerebral artery (MCA) flow velocity, as assessed by tran...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1989.11739891

    authors: Mautner-Huppert D,Haberl RL,Dirnagl U,Villringer A,Schmiedek P,Einhäupl K

    更新日期:1989-12-01 00:00:00

  • The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.

    abstract:OBJECTIVES:There is no definitive data regarding the usefulness of Brain microbleeds (BMBs) as an imaging marker with homeostatic markers to predict intracerebral hemorrhage (ICH) and ischemic stroke risk to personalize decisions on anticoagulation in AF. In this study, we prospectively evaluated clinical, radiological...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1517111

    authors: Altintas O,Niftaliyev E,Asil T

    更新日期:2018-12-01 00:00:00

  • Exposure time and frequency of irradiation in brain tumours.

    abstract::The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1987.11739796

    authors: Christensen JC

    更新日期:1987-09-01 00:00:00

  • The effect of papaverine on ion channels in rat basilar smooth muscle cells.

    abstract:OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164107X191021

    authors: Han DH,Bai GY,Yang TK,Sim BS,Kwak YG,Kim CJ

    更新日期:2007-09-01 00:00:00