The effect of papaverine on ion channels in rat basilar smooth muscle cells.

Abstract:

OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role of potassium and calcium channels in papaverine-induced vascular relaxation, we examined the effect of papaverine on potassium and calcium channels in freshly isolated smooth muscle cells from rat basilar artery. METHOD:The isolation of rat basilar smooth muscle cells was performed by special techniques. The whole cell currents were recorded by whole cell patch clamp technique in freshly isolated smooth muscle cells from rat basilar artery. Papaverine was added to the bath solution. RESULTS:Papaverine of 100 microM into bath solution increased the amplitude of the outward K(+) current which was completely blocked by BKCa blocker, IBX (iberiotoxin) and a calcium chelator, BAPTA (1,2-bis(o-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid) in whole cell mode. Papaverine (100 microM) also inhibited L type Ca(2+) current recorded in isolated smooth muscle cells from rat basilar artery. DISCUSSION:These results strongly suggest that Ca(2+)-activated potassium channels and L type Ca(2+) channels may be involved in papaverine-induced vascular relaxation in rat basilar artery.

journal_name

Neurol Res

journal_title

Neurological research

authors

Han DH,Bai GY,Yang TK,Sim BS,Kwak YG,Kim CJ

doi

10.1179/016164107X191021

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

544-50

issue

6

eissn

0161-6412

issn

1743-1328

journal_volume

29

pub_type

杂志文章
  • STA-MCA bypass: results 10 years postoperatively.

    abstract::The STA-MCA (superficial temporal artery-middle cerebral artery) bypass has become increasingly popular in the treatment of cerebral vascular disease. Indication and assessment of postoperative results have been based on clinical grounds and on findings from cerebral angiography (10). In order to obtain objective data...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1983.11739638

    authors: Gratzl O,Schmiedek P

    更新日期:1983-01-01 00:00:00

  • Investigation of subdural electrode displacement in invasive epilepsy surgery workup using neuronavigation and intraoperative MRI.

    abstract:OBJECTIVES:One of the main obstacles of electrode implantation in epilepsy surgery is the electrode shift between implantation and the day of explantation. We evaluated this possible electrode displacement using intraoperative MRI (iopMRI) data and CT/MRI reconstruction. METHODS:Thirteen patients (nine female, four ma...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1484588

    authors: Sommer B,Rampp S,Doerfler A,Stefan H,Hamer HM,Buchfelder M,Roessler K

    更新日期:2018-10-01 00:00:00

  • Comparative study among three different methods of bone marrow mesenchymal stem cell transplantation following cerebral infarction in rats.

    abstract::The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological sco...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000152

    authors: Ruan GP,Han YB,Wang TH,Xing ZG,Zhu XB,Yao X,Ruan GH,Wang JX,Pang RQ,Cai XM,He J,Zhao J,Pan XH

    更新日期:2013-03-01 00:00:00

  • Infratentorial infarction: correlation of MR findings with neurological and angiographical features.

    abstract::Using magnetic resonance imaging, we reviewed 141 infratentorial infarcts in 81 consecutive cases: 65 infarcts were seen in the paramedian pons, while 18 in the posterior inferior cerebellar artery (PICA) territory and 17 in the watershed area between PICA and superior cerebellar artery. No comparable sign or symptom ...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1080/01616412.1994.11740217

    authors: Yin WM,Nagata K,Satoh Y,Yokoyama E,Watahiki Y,Yuya H,Hirata Y,Ogawa T,Inugami A

    更新日期:1994-06-01 00:00:00

  • Reduction of nerve growth factor receptor immunoreactivity in ischaemic gerbil hippocampal CA1 neurons after treatment with L-threo-3,4-dihydroxyphenylserine (DOPS).

    abstract::Nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells can be increased after the treatment with L-threo-3,4-dihydroxyphenylserine (DOPS). Since the increase of NGF is not blocked by the treatment with decarboxylase inhibitor, DOPS may have direct effect to increase the NGF content. ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740227

    authors: Lee TH,Abe K,Nakamura M,Kogure K,Itoyama Y

    更新日期:1994-06-01 00:00:00

  • Bone marrow mesenchymal stem cells can improve the motor function of a Huntington's disease rat model.

    abstract:OBJECTIVES:The purpose of this study was to investigate the ability of bone marrow mesenchymal stem cells (BMSCs) to survive in the striatum and improve motor function in the quinolinic acid (QA) lesion rat model of Huntington's disease (HD). METHODS:One week following QA lesioning of the striatum, rats were transplan...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12816242542571

    authors: Jiang Y,Lv H,Huang S,Tan H,Zhang Y,Li H

    更新日期:2011-04-01 00:00:00

  • Effects of tetrahydrobiopterin on cerebral infarction after transient focal ischemia in rats.

    abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12700393823651

    authors: Tang LL,Zheng JS

    更新日期:2011-12-01 00:00:00

  • Neurosurgical treatment of multiple sclerosis.

    abstract:OBJECTIVES:To describe the role of neurosurgical techniques in treatment of symptoms of multiple sclerosis (MS). METHODS:A review of the existing world literature searching (using PubMed, August 22, 2005) for key words 'multiple sclerosis' and multiple symptoms associated with MS including trigeminal neuralgia, pain (...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164106X98224

    authors: Patwardhan RV,Minagar A,Kelley RE,Nanda A

    更新日期:2006-04-01 00:00:00

  • Nimodipine ameliorates trauma-induced cochlear neuronal death.

    abstract::Excessive entry of Ca2+ into injured cochlear neurons activates various Ca(2+)-activated enzymes and subsequent spiral ganglion cell death. Therefore, preventing intracellular calcium overload by using Ca2+ channel antagonists may become an important countermeasure to spiral ganglion cell death. We experimentally inve...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101200889

    authors: Sekiya T,Yagihashi A,Asano K,Suzuki S

    更新日期:2002-12-01 00:00:00

  • Thyrotropin-releasing hormone and its receptor in the cerebellum of inferior olive destroyed rat brain.

    abstract::To study the pathophysiology of olivopontocerebellar atrophy (OPCA), we destroyed inferior olive nuclei of male Wistar rats using 3-acetyl pyridine (3-AP) + harmaline + niacinamide. These rats showed a sluggish and ataxic gait. To elucidate the relationship between thyrotropin releasing hormone (TRH) in the Purkinje c...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2000.11740690

    authors: Adachi K,Rhue BN,Li M,Izumi M,Osano H,Mitsuma T

    更新日期:2000-06-01 00:00:00

  • The effects of early insulin treatment combined with thrombolysis in rat embolic stroke.

    abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101200096

    authors: Meden P,Andersen M,Overgaard K,Rasmussen RS,Boysen G

    更新日期:2002-06-01 00:00:00

  • Chronic vascular irritation of the facial nerve causes facial spasm in rats.

    abstract::The abnormal muscle response, elicited by electrical stimulation of one branch of the facial nerve and recorded from muscles innervated by another branch, has been used previously as an objective sign of hemifacial spasm in the development of animal models of this disorder. In the present study we recorded spontaneous...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740241

    authors: Kuroki A,Møller AR

    更新日期:1994-08-01 00:00:00

  • Combination of high-sensitivity C-reactive protein and homocysteine predicts the short-term outcomes of Chinese patients with acute ischemic stroke.

    abstract:BACKGROUND:Ischemic stroke is one of the most common causes of death worldwide. Early and accurate prediction of outcome in acute ischemic stroke (AIS) is important and influences risk-optimized therapeutic strategies. We investigated the changes in high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) le...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000228

    authors: Tu WJ,Zhao SJ,Liu TG,Yang DG,Chen H

    更新日期:2013-11-01 00:00:00

  • Risk factors of stroke-associated pneumonia in Chinese patients.

    abstract:OBJECTIVE:To explore the risk factors for stroke-associated pneumonia (SAP). METHODS:A retrospective research study was carried out to investigate the clinical data of 1435 patients admitted to the neurological intensive care unit at our university hospital between 1 January 2000 and 31 December 2009. RESULTS:A multi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164111X13007856084205

    authors: Sui R,Zhang L

    更新日期:2011-06-01 00:00:00

  • Effect of Fluosol-DA and hetastarch on local cerebral blood flow, cortical O2 availability and computerized EEG data during cerebral ischaemia.

    abstract::This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monke...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1990.11739906

    authors: Tranmer BI,Iacobacci R,Feiler S

    更新日期:1990-03-01 00:00:00

  • AST to ALT ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke.

    abstract:BACKGROUND:Hemorrhagic transformation (HT) is a common complication of ischemic stroke. We performed this study to determine whether aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR) was related to HT, as well as compare the predictive values of AAR, ALT and AST for HT in patients with isch...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1796403

    authors: Wang Y,Qiu K,Song Q,Cheng Y,Liu J,Liu M

    更新日期:2020-11-01 00:00:00

  • Thrombin up-regulates vascular endothelial growth factor in experimental gliomas.

    abstract:OBJECTIVE:Vascular endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production. The present study examined if thrombin modulates vascular endoth...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X385699

    authors: Xu Y,Gu Y,Keep RF,Heth J,Muraszko KM,Xi G,Hua Y

    更新日期:2009-09-01 00:00:00

  • Protective effect of low molecular weight polyethylene glycol on the repair of experimentally damaged neural membranes in rat's spinal cord.

    abstract:OBJECTIVES:Membrane disruption is one of the main factors that cause axonal damage and functional deficits manifested in spinal cord injury (SCI). In this study, we used polyethylene glycol (PEG) to induce immediate membrane sealing and to promote functional recovery after SCI. METHODS:The effects of PEG (200-2000 Da)...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000133

    authors: Kouhzaei S,Rad I,Mousavidoust S,Mobasheri H

    更新日期:2013-05-01 00:00:00

  • Neuroprotective effect of basic fibroblast growth factor on wobbler mouse motor neuron disease.

    abstract::Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 1...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:

    authors: Ikeda K,Iwasaki Y,Tagaya N,Shiojima T,Kobayashi T,Kinoshita M

    更新日期:1995-12-01 00:00:00

  • Layered structure of saccular aneurysms assessed by collagen birefringence.

    abstract::Cerebral aneurysms are composed principally of collagen, a birefringent protein which is responsible for withstanding the forces of blood pressure. The known correlation between collagen birefringence and its mechanics provides the basis for using polarizing microscopy to evaluate the strength of collagen, layer by la...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740986

    authors: Canham PB,Finlay HM,Kiernan JA,Ferguson GG

    更新日期:1999-10-01 00:00:00

  • Endovascular thrombolysis and stenting of a middle cerebral artery occlusion beyond 6 hours post-attack: special reference to the usefulness of diffusion-perfusion MRI.

    abstract::Intra-arterial thrombolysis and percutaneous angioplasty is feasible in patients with acute middle cerebral artery (MCA) occlusion limited to 6 hours post-ictus, but there are some limitations such as reocclusion or hemorrhagic complications. In this report, we describe a stent placement in the treatment of a refracto...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X49355

    authors: Ahn JY,Han IB,Chung SS,Chung YS,Kim SH,Yoon PH

    更新日期:2006-12-01 00:00:00

  • Extracellular vesicles isolated from human olfactory ensheathing cells enhance the viability of neural progenitor cells.

    abstract:OBJECTIVE:Acquired neurological diseases such as severe traumatic brain or spinal cord injury (SCI) cause irreversible disability. Olfactory ensheathing cell (OEC) transplantation has been trialed as a promising SCI treatment. Extracellular vesicles (EVs), which regulate cell-cell interactions, have recently garnered e...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1794371

    authors: Tu YK,Hsueh YH

    更新日期:2020-11-01 00:00:00

  • Blockade of NMDA receptors decreased spinal microglia activation in bee venom induced acute inflammatory pain in rats.

    abstract:OBJECTIVES:Microglial cells in spinal dorsal horn can be activated by nociceptive stimuli and the activated microglial cells release various cytokines enhancing the nociceptive transmission. However, the mechanisms underlying the activation of spinal microglia during nociceptive stimuli have not been well understood. I...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2017.1281198

    authors: Li L,Wu Y,Bai Z,Hu Y,Li W

    更新日期:2017-03-01 00:00:00

  • Change in cortical vein appearance on susceptibility-weighted MR imaging before and after carotid artery stenting.

    abstract:OBJECTIVES:Susceptibility-weighted (SW) magnetic resonance (MR) imaging is a sensitive test to detect intravenous deoxygenated blood. On SW images, dilated appearing draining veins in tissue with perfusion impairment occur due to an increase in intravenous deoxyhemoglobin levels, and could indicate poor perfusion areas...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12644252260510

    authors: Sorimachi T,Morita K,Sasaki O,Koike T,Fujii Y

    更新日期:2011-04-01 00:00:00

  • Detection of experimentally induced brain tumors in rats using high resolution computed tomography.

    abstract:OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X18250

    authors: Psarros TG,Mickey B,Giller C

    更新日期:2005-01-01 00:00:00

  • Non-invasive brainstem monitoring: the ocular microtremor.

    abstract::The ocular microtremor (OMT) is mediated by the oculomotor area of the brainstem and is altered in several pathologic states, including traumatic brain injury, general anesthesia, brain death, coma, Parkinsonism and multiple sclerosis. The EYETECT tremor monitor is a non-invasive means of measuring the frequency and a...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164107X240198

    authors: Robertson J,Timmons S

    更新日期:2007-10-01 00:00:00

  • Vascular aspects of neuroprotection.

    abstract::It is being increasingly suggested that the microcirculation, which is known to be in a large part responsible for maintaining an adequate and constant microenvironment for function of the central nervous system, functions as part of a neurovascular unit. The neurovascular unit includes neurons, astrocytes and element...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164104X3815

    authors: Takahashi M,Macdonald RL

    更新日期:2004-12-01 00:00:00

  • Protocol-directed weaning from mechanical ventilation in neurological patients: a randomised controlled trial and subgroup analyses based on consciousness.

    abstract:OBJECTIVES:To assess whether a weaning protocol reduces the mechanical ventilation (MV) duration compared to physician's judgement-based weaning in neurological patients and to determine whether patient consciousness influences this reduction. METHODS:A randomised controlled trial was conducted in a neurological inten...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1743132815Y.0000000092

    authors: Fan L,Su Y,Elmadhoun OA,Zhang Y,Zhang Y,Gao D,Ye H,Chen W

    更新日期:2015-11-01 00:00:00

  • Prognostic value of perfusion-weighted magnetic resonance imaging in acute intracerebral hemorrhage.

    abstract:OBJECTIVE:This study intends to investigate the prognostic value of perfusion-weighted magnetic resonance imaging in acute intracerebral hemorrhage. METHODS:Demographic, clinical and biochemical data between acute intracerebral hemorrhage (AICH) and healthy volunteer groups were assessed in this study, such as rCBV an...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1177932

    authors: Hu X,Bai X,Zai N,Sun X,Zhu L,Li X

    更新日期:2016-07-01 00:00:00

  • Severity dependent up-regulations of LOX-1 and MCP-1 in early sclerotic changes of common carotid arteries in spontaneously hypertensive rats.

    abstract::Lectin-like oxidized low-density lipoprotein receptor (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) are molecules involving in the initiation and progression of atherosclerosis. In order to examine a possible difference in LOX-1 and MCP-1 expressions depending on the severity of early stage of atherosclerosis...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164104225016074

    authors: Hamakawa Y,Omori N,Ouchida M,Nagase M,Sato K,Nagano I,Shoji M,Fujita T,Abe K

    更新日期:2004-10-01 00:00:00