Is mild vascular cognitive impairment reversible? Evidence from a study on the effect of carotid endarterectomy.

abstract：BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...

journal_title：Neurological research

authors： Hou D,Liu J,Feng R,Gao Y,Wang Y,Wu J

更新日期：2017-11-01 00:00:00

abstract：:A simple and reproducible method of polymerase chain reaction (PCR) assay was established to detect trinucleotide repeat expansion for Huntington's disease (HD) using a new DNA polymerase and buffer system. The system consists of an extremely heat stable DNA polymerase (Pfu), and a buffer supplemented with ammonium su...

journal_title：Neurological research

authors： Watanabe M,Abe K,Aoki M,Kameya T,Itoyama Y,Shoji M,Ikeda M,Iizuka T,Hirai S

更新日期：1996-02-01 00:00:00

abstract：:Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...

journal_title：Neurological research

authors： Zhang N,Zhang B,Rajah GB,Geng X,Singh R,Yang Y,Yan X,Li Z,Zhou W,Ding Y,Sun W

更新日期：2018-06-01 00:00:00

abstract：:Background: IVS5-91G>A (rs3812718) polymorphism of the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene has been associated with inadequate responsiveness to common antiepileptic drugs which act as sodium channel blockers. This study was performed to investigate the effect of IVS5-91G>A (rs3812718) polymorphi...

journal_title：Neurological research

authors： Markovic I,Pejanovic-Skobic N,Bozina N,Susak Sporis I,Sporis D,Basic S

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...

journal_title：Neurological research

authors： Stark AM,Schem C,Maass N,Hugo HH,Jonat W,Mehdorn HM,Held-Feindt J

更新日期：2010-04-01 00:00:00

abstract：:Somatosensory-evoked potentials induced by electrical stimulation of the median nerve were recorded in patients with intracerebral lesions and in normal controls and were studied by means of spectral analysis. The results shown that (1) there is a statistically-significant difference between spectral distributions obt...

journal_title：Neurological research

authors： Kusske JA,Romiti JA,Porter RW,Verzeano M

更新日期：1980-01-01 00:00:00

abstract：:In 75 patients with completed stroke hypervolemic haemodilution was performed for 1 day with 500 ml 6% HES 200.000/0.6-0.66 (Elohäst) to test the acute influence of application time for haemorheological changes. The patients were divided into 3 groups randomly selected: group A received the infusion for 2 hours, group...

journal_title：Neurological research

authors： Költringer P,Langsteger W,Reisecker F,Eber O

更新日期：1992-01-01 00:00:00

abstract：:The STA-MCA (superficial temporal artery-middle cerebral artery) bypass has become increasingly popular in the treatment of cerebral vascular disease. Indication and assessment of postoperative results have been based on clinical grounds and on findings from cerebral angiography (10). In order to obtain objective data...

journal_title：Neurological research

authors： Gratzl O,Schmiedek P

更新日期：1983-01-01 00:00:00

abstract：:The aim of this study was to examine the pre-operative clinical and neuromonitoring courses in patients with a decompressive craniectomy to assess and to compare clinical and neuromonitoring signs indicating extensive cerebral edema. We conducted a retrospective analysis of the clinical signs and courses of simultaneo...

journal_title：Neurological research

authors： Strege RJ,Lang EW,Stark AM,Scheffner H,Fritsch MJ,Barth H,Mehdorn HM

更新日期：2003-07-01 00:00:00

abstract：:Synthesized Mn-TPPS, a paramagnetic metalloporphyrin, is expected to be a tumour specific contrast media for magnetic resonance (MR) imaging. We investigated the enhancing characteristics of Mn-TPPS using a transplanted rat C6 glioma model with peripheral type benzodiazepine (PBD) receptors since porphyrins are though...

journal_title：Neurological research

authors： Ikezaki K,Nomura T,Takahashi M,Fritz-Zieroth B,Inamura T,Fukui M

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:The presence of beta-amyloid (betaA) deposition, induction of reactive gliosis and dystrophic neurites, is a characteristic feature of neuritic plaques in Alzheimer's disease. In vitro, betaA-exposed astrocytes become reactive, similar to astrocytes in contact with betaA plaques in vivo. How betaA-exposed re...

journal_title：Neurological research

authors： Monnerie H,Esquenazi S,Shashidhara S,Le Roux PD

更新日期：2005-07-01 00:00:00

abstract：:Lectin-like oxidized low-density lipoprotein receptor (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) are molecules involving in the initiation and progression of atherosclerosis. In order to examine a possible difference in LOX-1 and MCP-1 expressions depending on the severity of early stage of atherosclerosis...

journal_title：Neurological research

authors： Hamakawa Y,Omori N,Ouchida M,Nagase M,Sato K,Nagano I,Shoji M,Fujita T,Abe K

更新日期：2004-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of the dopamine producing neurons projecting from the substantia nigra into the corpus striatum. Current medical therapy is limited and cannot stop or reverse the degeneration. Over the past 30 years, attempts were m...

journal_title：Neurological research

authors： Roitberg B,Urbaniak K,Emborg M

更新日期：2004-06-01 00:00:00

abstract：:Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...

journal_title：Neurological research

authors： Soehle M,Jaeger M,Meixensberger J

更新日期：2003-06-01 00:00:00

abstract：:To study the pathophysiology of olivopontocerebellar atrophy (OPCA), we destroyed inferior olive nuclei of male Wistar rats using 3-acetyl pyridine (3-AP) + harmaline + niacinamide. These rats showed a sluggish and ataxic gait. To elucidate the relationship between thyrotropin releasing hormone (TRH) in the Purkinje c...

journal_title：Neurological research

authors： Adachi K,Rhue BN,Li M,Izumi M,Osano H,Mitsuma T

更新日期：2000-06-01 00:00:00

abstract：:Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP.Methods: A total of 36 male Sprague-Dawley rats were divi...

journal_title：Neurological research

authors： Shen M,Zheng Y,Zhu K,Cai Z,Liu W,Sun X,Liu J,Zhu D

更新日期：2020-01-01 00:00:00

abstract：:Different surgical approaches exist for the treatment of chronic subdural hematoma. None of these approaches is superior to the other, so a minimal-invasive device (a hollow screw) was developed. The system consists of a stable hollow screw of surgical steel with a perforated tip, a hand-drill, screwdriver with guide,...

journal_title：Neurological research

authors： Emonds N,Hassler WE

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS:Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS:A(2A) ant...

journal_title：Neurological research

authors： Pedata F,Gianfriddo M,Turchi D,Melani A

更新日期：2005-03-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and environmental factors play important roles in its pathogenesis. While demyelination of axons is a hallmark histological feature of MS, axonal and neuronal dysfunction may correlate better with clinical disability. All major immune cell ...

journal_title：Neurological research

authors： McDole J,Johnson AJ,Pirko I

更新日期：2006-04-01 00:00:00

abstract：:Brain tumours were induced by intracerebral inoculation of beagle puppies with Avian sarcoma virus (ASV) suspension. The inoculation produced solitary or multiple sarcomas in three dogs and intraventricular anaplastic gliomas in four dogs. At the time of the first tumour positive CT-control Iodine-125 seeds (activity ...

journal_title：Neurological research

authors： Ostertag CB,Warnke P,Kleihues P,Bigner DD

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate the effects of the GLP-1 analog liraglutide on beta-amyloid (Aβ)-induced neurotoxicity in the human neuroblastoma cell line SH-SY5Y and study the underlying mechanisms. METHODS:Cultured SH-SY5Y cells in vitro were randomly divided into normal control group, beta-amylo...

journal_title：Neurological research

authors： Liu XY,Wang LX,Chen Z,Liu LB

更新日期：2016-04-01 00:00:00

abstract：:To estimate the regional perfusion pressure and possibly the stump pressure during carotid endarterectomy, cerebral blood flow (CBF) measurements including a vasodilatory test were performed preoperatively. CBF was measured by 133Xe inhalation and emission tomography. An intravenous dose of 1g acetazolamide (Diamox) w...

journal_title：Neurological research

authors： Vorstrup S,Boysen G,Brun B,Engell HC

更新日期：1987-03-01 00:00:00

abstract：INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...

journal_title：Neurological research

authors： Reed LK,Wen J,Liang B,Wang X,Feng D,Huang JH

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:Parkinson's disease (PD) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of PD. The purpose of this study was to assess the role of B-cell lymphoma 2 (Bcl-2)-associated athanogene 5 (BAG5) protein, whic...

journal_title：Neurological research

authors： Ma M,Wang X,Ding X,Jing J,Ma Y,Teng J

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...

journal_title：Neurological research

authors： Oishi A,Tobimatsu S,Ogata K,Taniwaki T,Kinukawa N,Toyoshiba H,Kira J

更新日期：2008-12-01 00:00:00

abstract：:Sinus pericranii is a rare circumscribed fluctuating vascular swelling of the scalp that communicates with the intracranial venous system. It has been associated with other intracranial vascular malformations. The tumour is usually round, fluctuant, nonpulsatile, and disappears with compression. Its size increases dur...

journal_title：Neurological research

authors： Vinas FC,Valenzuela S,Zuleta A

更新日期：1994-12-01 00:00:00

abstract：:Cerebral aneurysms are composed principally of collagen, a birefringent protein which is responsible for withstanding the forces of blood pressure. The known correlation between collagen birefringence and its mechanics provides the basis for using polarizing microscopy to evaluate the strength of collagen, layer by la...

journal_title：Neurological research

authors： Canham PB,Finlay HM,Kiernan JA,Ferguson GG

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment. METHODS:Data from 10 patients already on statins at stro...

journal_title：Neurological research

authors： Schultz NEØ,Hasseldam H,Rasmussen RS,Vindegaard N,McWilliam O,Iversen HK,Johansen FF

更新日期：2019-04-01 00:00:00

abstract：:Recent publications have suggested that intra-ocular pressure (IOP) may be an indirect assessment of intra-cranial pressure (ICP). Both IOP and ICP have similar physiologic pressure ranges and similar responses to changes in intra-abdominal, intra-thoracic and aortic pressure. Previous studies have demonstrated the re...

journal_title：Neurological research

authors： Dickerman RD,Smith GH,Langham-Roof L,McConathy WJ,East JW,Smith AB

更新日期：1999-04-01 00:00:00

abstract：:The objective of this study was to determine, whether 0.5-2/min oscillations in intracranial pressure ('B-waves') are a physiological phenomenon. In a group of 5 patients 0.5-2/min oscillations of ventricular pressure simultaneous with oscillations in the middle cerebral artery (MCA) flow velocity, as assessed by tran...

journal_title：Neurological research

authors： Mautner-Huppert D,Haberl RL,Dirnagl U,Villringer A,Schmiedek P,Einhäupl K

更新日期：1989-12-01 00:00:00