Abstract:
:A computer software program (Seapit) was developed for precise determination of intracranial targets identified by stereotactic computed tomography (CT). This program was added to the software of a GE 8800 CT scanner to perform the following operations: millimetre precise calculation and display of the rectilinear coordinates of a target identified on axial CT images; preplotting of phantom target trajectories on the CT images or electronic radiographs; calculation of probe angles required to achieve various trajectories; display of a coordinate scale on each CT image to allow direct target determination without mathematical calculations; calculation of the intercommissural plane for functional neurosurgery. In a series of 100 patients undergoing stereotactic surgery, the Seapit program proved to be a superior and accurate method of target coordinate calculation. Preview display on the CT images of 'phantom' probes significantly enhanced the safety of stereotactic intervention.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Lunsford LD,Listerud JA,Rowberg AH,Latchaw REdoi
10.1080/01616412.1987.11739781subject
Has Abstractpub_date
1987-06-01 00:00:00pages
118-22issue
2eissn
0161-6412issn
1743-1328journal_volume
9pub_type
杂志文章abstract::Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199162
更新日期:2001-10-01 00:00:00
abstract::Treatment modalities for metastatic spine disease have significantly expanded over the last two decades. This expansion occurred in many different fields. Improvement in surgical techniques and instrumentation now allow the oncologic spine surgeons to effectively circumferentially decompress the neural elements withou...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000365
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Traumatic brain injuries (TBIs) cause a substantial burden to the patient, relatives, and the society as a whole. Much experience and knowledge during the last two decades have improved the neurosurgical treatment as well as the outcome. However, there is still much debate on what actually happens when exter...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000227
更新日期:2013-10-01 00:00:00
abstract::Cyclic GMP (cGMP) mediates smooth muscle relaxation in the central nervous system. In subarachnoid hemorrhage (SAH), decreases in intrinsic nitric oxide (NO) cause cerebral vasospasms due to the regulation of cGMP formation by NO-mediated pathways. As phosphodiesterase type V (PDE V) selectively hydrolyzes cGMP, we hy...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200447
更新日期:2002-09-01 00:00:00
abstract::Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739882
更新日期:1989-09-01 00:00:00
abstract:INTRODUCTION:To investigate the prevalence of Parkinson's disease (PD), a three-phase study was conducted. METHODS:In phase 1, standardized interviews were performed in a random sample of elderly aged 65 years or older using a questionnaire. In phase 2, neurological examinations were performed to clinically diagnose P...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/016164109X12581096796396
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Recent preclinical studies suggest that treating glioblastoma (GBM) with a combination of targeted chemotherapy and radiotherapy may enhance the anti-tumor effects of both therapies. However, the effects of these treatments on glioma growth and progression are poorly understood. METHODS:In this study, we h...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000005
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:Although magnesium is a well-known treatment for vasospasm following subarachnoid hemorrhage, its mechanism of action for cerebral vascular relaxation is not clear. In addition, it is known that L-type calcium (Ca(2+)) channels play a pivotal role in smooth muscle contraction. To investigate the role of L-t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000016
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION:Alzheimer's disease (AD) is the most common neurodegenerative disease across the world. The major cause of AD is extensive oxidative stress and inflammation in central nervous system (CNS). Vitamin D3 and E are the most known vitamins that control oxidative stress and mitochondrial respiratory function. Th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1787624
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To assess the clinical significance of hepatitis B virus (HBV) infection in patients with cerebral venous sinus thrombosis (CVST). METHODS:Twenty-two patients with CVST confirmed by magnetic resonance venography (MRV) or digital subtraction angiography (DSA) and 743 controls with ischemic stroke confirmed by...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000003
更新日期:2015-06-01 00:00:00
abstract::The selection of drugs to prevent the development of pathology in cerebral infarction remains an important problem. For the selection of effective drugs from among a large number of possible candidates, widely-used test screening techniques are sufficient for obtaining a good understanding of candidate drug effects. T...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739810
更新日期:1988-03-01 00:00:00
abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740472
更新日期:1996-12-01 00:00:00
abstract::In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740128
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:Surgical resection of complex glomus vagale tumors can be complicated by extensive blood loss and might require surgical sacrifice of an encased internal carotid artery. METHODS:A young patient presented with mass effect from glomus valage tumor. Computerized tomography angiography showed an encased interna...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132812Y.0000000036
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVES:Microglial cells in spinal dorsal horn can be activated by nociceptive stimuli and the activated microglial cells release various cytokines enhancing the nociceptive transmission. However, the mechanisms underlying the activation of spinal microglia during nociceptive stimuli have not been well understood. I...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1281198
更新日期:2017-03-01 00:00:00
abstract::Traumatic brain injuries (TBIs) are a leading cause of morbidity, mortality, disability and socioeconomic losses in India and other developing countries. Specific topics addressed in this paper include magnitude of the problem, causes, context of injury occurrence, risk factors, severity, outcome and impact of TBIs on...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164102101199503
更新日期:2002-01-01 00:00:00
abstract::Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP.Methods: A total of 36 male Sprague-Dawley rats were divi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1685064
更新日期:2020-01-01 00:00:00
abstract::The purpose of this study was to determine the efficacy of nicardipine prolonged-release implants for preventing vasospasm in a canine SAH model in a dose-escalating placebo-controlled blind fashion. Drug-release kinetics of copoly(lactic/glycolic acid) pellet containing nicardipine were evaluated in vitro. In vivo, 1...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740733
更新日期:2000-09-01 00:00:00
abstract::Different surgical approaches exist for the treatment of chronic subdural hematoma. None of these approaches is superior to the other, so a minimal-invasive device (a hollow screw) was developed. The system consists of a stable hollow screw of surgical steel with a perforated tip, a hand-drill, screwdriver with guide,...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740897
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49256
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury after subarachnoid hemorrhage (SAH). METHOD:Sprague-Dawley male rats (n=36) weighing between 250 and 300 g were used. SAH was produced by injecting autologous arterial blood into the pre-chiasmatic cistern. MMP-9 pro...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12478302362491
更新日期:2010-09-01 00:00:00
abstract::Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in normal developing brain, but the role of nNOS in neurogenesis in the ischemic brain remains unclear. To investigate the temporal and spatial relationship between cell proliferation of the ependymal/subventricular zone (SVZ), a principal neuroproliferative...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X91942
更新日期:2006-01-01 00:00:00
abstract::The goal of this paper is to provide scientists with a comprehensive review of the state-of-the-art influence the ischemic blood-brain barrier (BBB) has on the final development of Alzheimer's disease and to provide detailed food-for-thought which will hopefully stimulate more researchers in this area of neuroscience....
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X130399
更新日期:2006-09-01 00:00:00
abstract::We examined the effect of local anaesthesia of the skin on somatosensory evoked potentials (SEPs) and psychophysical magnitude estimates for a constant intensity air-puff stimulation (7 kg.cm-2) in 23 normal subjects. Before and after intradermal injection (0.1 ml of 1% xylocain) to the tip of the right index finger, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740283
更新日期:1995-02-01 00:00:00
abstract::The effects of acupuncture have been described and handed down empirically for centuries but there are few reports based on objective data. The aim of this study was to provide selective evidence of a specific effect of acupuncture on the brain and the eye using a Doppler ultrasound technique. A transcranial Doppler s...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.1999.11740970
更新日期:1999-09-01 00:00:00
abstract:INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1781455
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical techniqu...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1554284
更新日期:2019-03-01 00:00:00
abstract::No marker that predicts accurately the time of occurrence of cerebral vasospasm due to subarachnoid hemorrhage (SAH) has been reported. In the present study, membrane-bound tissue factor (mTF) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) were evaluated as a predictor of the time of occurr...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199225
更新日期:2001-10-01 00:00:00
abstract::Based on the successful use of fetal striatal brain grafting in the restoration of striatal function in rat and nonhuman primate models of Huntington's disease, as well as on the evidence for the clinical potential of fetal brain grafting in the treatment of Parkinson's disease, homotopic fetal striatal homotransplant...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740334
更新日期:1995-08-01 00:00:00
abstract::At present, no practical method exists for monitoring the progression and severity of cerebral oedema in a clinical setting on a continuous basis. In search for such a method, we investigated the electrical characteristics of cerebral tissue at microwave frequencies to quantify cerebral oedema. The dielectric constant...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740065
更新日期:1992-06-01 00:00:00