Abstract:
:The selection of drugs to prevent the development of pathology in cerebral infarction remains an important problem. For the selection of effective drugs from among a large number of possible candidates, widely-used test screening techniques are sufficient for obtaining a good understanding of candidate drug effects. The effects of various drugs on the survival time of mice made hypoxic by exposure to a 4% O2-96% N2 gas have been examined. The survival time of 110 control animals was 170 +/- 6 s, showing a nearly normal distribution pattern. No control mouse had a survival time beyond 8 min. The survival time after the drugs were administered was as follows: suloctidil (12.5 mg/kg, n = 11), 1833 +/- 487 s; vitamin E (200 mg/kg, n = 15), 1160 +/- 342 s; pentobarbital (50 mg/kg, n = 12), 602 +/- 74 s; and phenytoin (100 mg/kg, n = 10), 2667 +/- 452 s. In contrast, administration of vitamin C, coenzyme Q, cytochrome c, beta-methasone, mannitol or germanium-132 did not result in prolongation of survival time. Comparison of the percentage of animals in each group which survived for more than 1 h showed 0% in the control group, 45.5% in the suloctidil group (12.5 mg/kg), 23.5% in the vitamin E group (200 mg/kg), 0% in the pentobarbital group (50 mg/kg) and 70% in the phenytoin group (100 mg/kg). These findings suggest that phenytoin is the most effective drug in combatting the effects of hypoxia (survival time was expressed as mean +/- SE).
journal_name
Neurol Resjournal_title
Neurological researchauthors
Imaizumi S,Suzuki J,Kinouchi H,Yoshimoto Tdoi
10.1080/01616412.1988.11739810subject
Has Abstractpub_date
1988-03-01 00:00:00pages
18-24issue
1eissn
0161-6412issn
1743-1328journal_volume
10pub_type
杂志文章abstract::From 118 transsphenoidally operated patients, 100 had a pituitary adenoma; 33 prolactinomas, 20 HGH-producing, 2 ACTH-producing and 45 inactive adenomas. The first transsphenoidal operation did not cause any mortality; after reoperation for suspected recurrence on follow-up, 2 patients died; thus, the global managemen...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739714
更新日期:1985-09-01 00:00:00
abstract::Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201580
更新日期:2003-06-01 00:00:00
abstract::In 75 patients with completed stroke hypervolemic haemodilution was performed for 1 day with 500 ml 6% HES 200.000/0.6-0.66 (Elohäst) to test the acute influence of application time for haemorheological changes. The patients were divided into 3 groups randomly selected: group A received the infusion for 2 hours, group...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/01616412.1992.11740043
更新日期:1992-01-01 00:00:00
abstract::The abnormal muscle response, elicited by electrical stimulation of one branch of the facial nerve and recorded from muscles innervated by another branch, has been used previously as an objective sign of hemifacial spasm in the development of animal models of this disorder. In the present study we recorded spontaneous...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740241
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X165642
更新日期:2007-01-01 00:00:00
abstract::This paper presents the results of transsphenoidal surgery in 41 consecutive patients with visual loss from pituitary adenomas. The most common pattern of loss was bitemporal hemianopia. Transsphenoidal decompression resulted in visual improvement in 78% of patients. If patients with optic atrophy and pre-operative co...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1990.11739907
更新日期:1990-03-01 00:00:00
abstract::Advances in neuromodulation techniques offer the promise of new therapeutic interventions for patients with neuropsychiatric maladies. Several complex social, ethical and policy issues will attend developments in this area. In this paper an ethical framework for clinical research in interventional cognitive neuroscien...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2000.11740670
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. A contribution from complement has long been suspected. We investigated the association of complement factor H (CFH) Tyr402 His gene polymorphism and serum level in Egyptian patients with MS to examine whet...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000075
更新日期:2015-10-01 00:00:00
abstract::Background: Surgery of parasagittal meningiomas (PSMs) is still technically challenging, for the balance between radical resection and preservation of venous circulation. In this article, we'd systemically introduce the technical nuances of a simplified strategy for radical resection of all types of PSMs. All the case...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1847530
更新日期:2020-11-11 00:00:00
abstract::Previous work has shown that unsaturated fatty acid components of model membrane phospholipids in vitro, damaged via a free radical mechanism, are protected by the presence of cholesterol in these membranes. The participation of these membrane lipids in the pathogenesis of traumatic injury to brain was studied in vivo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1981.11739608
更新日期:1981-01-01 00:00:00
abstract::The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cel...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225013851
更新日期:2004-03-01 00:00:00
abstract::Precocious puberty and amenorrhea have been associated with hydrocephalus, but the pathogenesis has not been determined. Approximately 22 cases of amenorrhea, and a few cases of precocious puberty, have been reported in hydrocephalic patients. Shunt treatment leads to initiation and maintenance of normal reproductive ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2000.11741047
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:Neurotoxic homocysteine (Hcy) is thought to be an independent risk factor for neurodegenerative diseases, including Alzheimer's disease. This study is to determine whether HT22 cells, a murine hippocampal neuronal model, can be used as an in vitro model, besides the primary neuronal cultures, to investiga...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000057
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate by MR diffusion weighted image (DWI-MR) the presence of new ischemic cerebral lesions after carotid artery stenting (CAS) and distal cerebral protection, in patients with internal carotid artery (ICA) stenosis >70. METHODS:Sixty-seven CAS were performed under cerebral protection with a distal fil...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X35431
更新日期:2005-01-01 00:00:00
abstract::We elected to compare the clinical outcomes of carotid endarterectomy (CEA) patients who were thought to be at increased risk for peri-operative complications because of advanced age (> 79 years), medical comorbidities and contralateral internal carotid artery occlusion to patients without these risk factors. A prospe...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101199936
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:To review the historical development and current status of endovascular techniques used in the treatment of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. METHODS:This article summarizes the relevant literature on neurointerventional therapy for vasospasm, namely instillation of intraar...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X152043
更新日期:2006-10-01 00:00:00
abstract::Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in normal developing brain, but the role of nNOS in neurogenesis in the ischemic brain remains unclear. To investigate the temporal and spatial relationship between cell proliferation of the ependymal/subventricular zone (SVZ), a principal neuroproliferative...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X91942
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patient...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X383259
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:Parkinson's disease (PD) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of PD. The purpose of this study was to assess the role of B-cell lymphoma 2 (Bcl-2)-associated athanogene 5 (BAG5) protein, whic...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000102
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:There is no definitive data regarding the usefulness of Brain microbleeds (BMBs) as an imaging marker with homeostatic markers to predict intracerebral hemorrhage (ICH) and ischemic stroke risk to personalize decisions on anticoagulation in AF. In this study, we prospectively evaluated clinical, radiological...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1517111
更新日期:2018-12-01 00:00:00
abstract::Endolymphatic sac tumors are rare, low-grade adenocarcinomas of the petrous bone. These tumors are highly vascularized and surgical removal is often challenging. We present a staged endovascular-neurosurgical approach consisting of stent-assisted angioplasty of the petrous carotid, selective endovascular embolization ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201436
更新日期:2003-04-01 00:00:00
abstract::It is being increasingly suggested that the microcirculation, which is known to be in a large part responsible for maintaining an adequate and constant microenvironment for function of the central nervous system, functions as part of a neurovascular unit. The neurovascular unit includes neurons, astrocytes and element...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104X3815
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:Epilepsy is a common seizure disorder affecting approximately 70 million people worldwide. Mitochondrial dysfunction and antioxidant/prooxidant imbalance are emerging as factors that contribute to epileptogenesis. As medical ozone was able to reestablish cellular redox balance and to maintain the protective ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000445
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Traumatic brain injuries (TBIs) cause a substantial burden to the patient, relatives, and the society as a whole. Much experience and knowledge during the last two decades have improved the neurosurgical treatment as well as the outcome. However, there is still much debate on what actually happens when exter...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000227
更新日期:2013-10-01 00:00:00
abstract::At present, no practical method exists for monitoring the progression and severity of cerebral oedema in a clinical setting on a continuous basis. In search for such a method, we investigated the electrical characteristics of cerebral tissue at microwave frequencies to quantify cerebral oedema. The dielectric constant...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740065
更新日期:1992-06-01 00:00:00
abstract::Anoxic depolarization (AD) is one of the major physiological characteristics in the ischemic core. The effect of mild hypothermia on the appearance of AD and subsequent brain injury following profound ischemia is studied to evaluate the protective mechanism of hypothermia against severe ischemia. Sprague-Dawley rats w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740996
更新日期:1999-10-01 00:00:00
abstract::Cyclic GMP (cGMP) mediates smooth muscle relaxation in the central nervous system. In subarachnoid hemorrhage (SAH), decreases in intrinsic nitric oxide (NO) cause cerebral vasospasms due to the regulation of cGMP formation by NO-mediated pathways. As phosphodiesterase type V (PDE V) selectively hydrolyzes cGMP, we hy...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200447
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1358937
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12700393823651
更新日期:2011-12-01 00:00:00
abstract::Anesthesia is an essential element during the induction of ischemia/reperfusion and cerebral blood flow (CBF) measurement in most animal models. Cerebral neuroprotection and intrinsic effects on CBF afforded by anesthetics are confounding variables in those models. A new model of global forebrain ischemia/reperfusion ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101199477
更新日期:2002-01-01 00:00:00