Abstract:
:Cyclic GMP (cGMP) mediates smooth muscle relaxation in the central nervous system. In subarachnoid hemorrhage (SAH), decreases in intrinsic nitric oxide (NO) cause cerebral vasospasms due to the regulation of cGMP formation by NO-mediated pathways. As phosphodiesterase type V (PDE V) selectively hydrolyzes cGMP, we hypothesized that PDE V may function in the initiation of vasospasm. This study sought to identify the altered PDE V expression and activity in the vasospastic artery in a canine SAH model. We also used this system to examine possible therapeutic strategies to prevent vasospasm. Using a canine model of SAH, we induced cerebral vasospasm in the basilar artery (BA). Following angiographic confirmation of vasospasm on day 7, PDE V expression was immunohistochemically identified in smooth muscle cells of the vasospastic BA but not in cells of a control artery. The isolation of PDE enzymes using a sepharose column confirmed increased PDE V activity in the vasospastic artery only through both inhibition studies, using the highly selective PDE V inhibitor, sildenafil citrate, and Western blotting. Preliminary in vivo experiment using an oral PDE V inhibitor at 0.83 mg kg(-1) demonstrated partial relaxation of the spastic BA. PDE V activity was increased from control levels within the BA seven days after SAH. PDE V expression was most prominent in smooth muscle cells following SAH. These results suggest that clinical administration of a PDE V inhibitor may be a useful therapeutic tool in the prevention of vasospasm following SAH.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Inoha S,Inamura T,Ikezaki K,Nakamizo A,Amano T,Fukui Mdoi
10.1179/016164102101200447subject
Has Abstractpub_date
2002-09-01 00:00:00pages
607-12issue
6eissn
0161-6412issn
1743-1328journal_volume
24pub_type
杂志文章abstract:OBJECTIVES:Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the associati...
journal_title:Neurological research
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journal_title:Neurological research
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journal_title:Neurological research
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更新日期:2016-04-01 00:00:00
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doi:10.1179/174313208X340969
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journal_title:Neurological research
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journal_title:Neurological research
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doi:10.1080/01616412.2000.11741051
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更新日期:1998-09-01 00:00:00
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journal_title:Neurological research
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doi:10.1080/01616412.1997.11740795
更新日期:1997-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1999-09-01 00:00:00
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更新日期:2007-09-01 00:00:00
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更新日期:2011-11-01 00:00:00
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更新日期:2003-03-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740260
更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/01616412.1980.11739576
更新日期:1980-01-01 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:2005-07-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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更新日期:2010-02-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
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