Positron emission tomographic evaluation of histological malignancy in gliomas using oxygen-15 and fluorine-18-fluorodeoxyglucose.

Abstract:

:HEADTOME III, a high resolution PET, has been employed using 15O and 18F labelled pharmaceuticals to evaluate histological malignancy of gliomas preoperatively. PET study was applied on eighteen preoperative gliomas including two recurrent cases. Haemocirculatory and metabolic indices of regional cerebral blood flow (rCBF), cerebral blood volume (rCBV), oxygen extraction fraction (rOEF), cerebral metabolic rates for oxygen (rCMRO2) and glucose (rCMRGI) were measured in the viable portion of the tumour, and the contralateral grey and white matter. In the tumour region, rCBF and rCBV were variable and unrelated to grades of tumour malignancy. rCMRO2 and rOEF values reduced significantly (p less than 0.01) relative to the contralateral brain tissue. The average rCMRGI values was 3.00 +/- 1.06 mg 100 ml-1 min-1 (mean +/- SD) for 7 low grade gliomas (grade II), and 5.91 +/- 3.61 mg 100 ml-1 min-1 for 11 high grade gliomas (grade III and IV). These results would support that anaerobic glycolysis increased in the metabolism of gliomas with malignancy. In comparison with normal volunteers, rCBF, rCMRO2, and rCMRGI values in the contralateral grey matter of gliomas were markedly reduced (p less than 0.01, p less than 0.05, p less than 0.01, respectively) possibly due in part to raised intracranial pressure and depressed cerebral functional activity, so that rOEF was increased to a level of approximately 0.5.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Neurol Res

journal_title

Neurological research

authors

Mineura K,Yasuda T,Kowada M,Shishido F,Ogawa T,Uemura K

doi

10.1080/01616412.1986.11739749

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

164-8

issue

3

eissn

0161-6412

issn

1743-1328

journal_volume

8

pub_type

杂志文章
  • In vitro evidence supporting two mechanisms of action for the anion transport inhibitor L-644,711 in cerebral ischaemia.

    abstract::L-644,711 is a novel anion channel inhibitor which has previously been shown to decrease brain injury in two related rabbit models of cerebral ischaemia. We hypothesize two mechanisms of action of L-644,711 for its salutary effects on cerebral ischaemia: inhibition of neutrophil function and prevention of excitotoxin ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1992.11740011

    authors: Bednar MM,Kohut JJ,Kimelberg HK,Gross JJ,Gross CE

    更新日期:1992-03-01 00:00:00

  • Risk modeling to identify patients with symptomatic carotid stenosis most at risk of stroke.

    abstract::We have reliable data on the degree of stenosis above which endarterectomy for symptomatic carotid stenosis is beneficial, but benefit is also influenced by other factors, particularly age, sex, the timing of surgery, plaque surface morphology and the nature of the presenting symptomatic event(s). This review will con...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164105X25298

    authors: Rothwell PM

    更新日期:2005-01-01 00:00:00

  • Effects of cerebral small vessel disease on the outcome of patients with ischemic stroke caused by large artery atherosclerosis.

    abstract:OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.2018.1446283

    authors: Zhu H,Li Z,Lv J,Zhao R

    更新日期:2018-05-01 00:00:00

  • Quantitative analysis of early postoperative cerebral blood flow contributes to the prediction and diagnosis of cerebral hyperperfusion syndrome after revascularization surgery for moyamoya disease.

    abstract:OBJECTIVE:Cerebral hyperperfusion syndrome (HPS) is a potential complication of extracranial-intracranial (EC-IC) bypass for moyamoya disease; however, the pathological threshold of the early cerebral blood flow (CBF) increases after EC-IC bypass has yet to be determined. The purpose of this study is to evaluate the pr...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000432

    authors: Fujimura M,Niizuma K,Endo H,Sato K,Inoue T,Shimizu H,Tominaga T

    更新日期:2015-02-01 00:00:00

  • Improved maze learning through early music exposure in rats.

    abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740543

    authors: Rauscher FH,Robinson KD,Jens JJ

    更新日期:1998-07-01 00:00:00

  • Callosotomy for generalized seizures associated with hypothalamic hamartoma.

    abstract::A case is reported of intractable epilepsy associated with a hypothalamic hamartoma in an 18 year old man. The patient underwent a two-third anterior callsotomy and, subsequently, removal of the hamartoma. Callosotomy did not affect the generalized seizure pattern. The authors believe this to be the first documented c...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740125

    authors: Pallini R,Bozzini V,Colicchio G,Lauretti L,Scerrati M,Rossi GF

    更新日期:1993-04-01 00:00:00

  • Intraluminal suture occlusion of the middle cerebral artery in Spontaneously Hypertensive rats.

    abstract::In models of middle cerebral artery occlusion using intraluminal suture, the size and the distribution of ischemic injury vary considerably among laboratories. In transcranial models of cerebral ischemia, a more consistent cerebral ischemic lesion is seen in Spontaneously Hypertensive rats (SHR). In the present study,...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740517

    authors: Dogan A,Başkaya MK,Rao VL,Rao AM,Dempsey RJ

    更新日期:1998-04-01 00:00:00

  • Wall characteristics and mechanisms of ischaemic stroke in patients with atherosclerotic middle cerebral artery stenosis: a high-resolution MRI study.

    abstract:OBJECTIVE:To evaluate the characteristics of atherosclerotic middle cerebral artery (MCA) stenosis by high-resolution magnetic resonance imaging (HR-MRI) and determine the relationship between wall characteristics and infarction patterns. METHODS:Thirty-six patients with acute ischaemic stroke due to MCA stenosis unde...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132815Y.0000000088

    authors: Zhao DL,Deng G,Xie B,Gao B,Peng CY,Nie F,Yang M,Ju S,Teng GJ

    更新日期:2016-07-01 00:00:00

  • Combination of blood flow asymmetry in the cerebral and cerebellar hemispheres on brain perfusion SPECT predicts 5-year outcome in patients with symptomatic unilateral major cerebral artery occlusion.

    abstract:BACKGROUND AND OBJECTIVE:Misery perfusion increases the risk of stroke recurrence in patients with symptomatic major cerebral artery occlusion. The ratio of brain perfusion contralateral-to-affected asymmetry in the cerebellar hemisphere to brain perfusion affected-to-contralateral asymmetry in the cerebral hemisphere ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000300

    authors: Nomura J,Ogasawara K,Saito H,Terasaki K,Matsumoto Y,Takahashi Y,Ogasawara Y,Saura H,Yoshida K,Sato Y,Kubo Y,Ogawa A

    更新日期:2014-03-01 00:00:00

  • Chronic vascular irritation of the facial nerve causes facial spasm in rats.

    abstract::The abnormal muscle response, elicited by electrical stimulation of one branch of the facial nerve and recorded from muscles innervated by another branch, has been used previously as an objective sign of hemifacial spasm in the development of animal models of this disorder. In the present study we recorded spontaneous...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740241

    authors: Kuroki A,Møller AR

    更新日期:1994-08-01 00:00:00

  • Developmental expression of fibroblast growth factor (FGF) receptors in neural stem cell progeny. Modulation of neuronal and glial lineages by basic FGF treatment.

    abstract::Neural stem cells (NSCs) are self-renewable, multipotential cells capable of differentiating into the three major neural cell types, but the mechanisms which regulate their development are not fully understood. Both basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote the proliferation of NS...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164101101199090

    authors: Reimers D,López-Toledano MA,Mason I,Cuevas P,Redondo C,Herranz AS,Lobo MV,Bazán E

    更新日期:2001-09-01 00:00:00

  • Noninvasive assessment of cerebral oxygenation during high altitude trekking in the Nepal Himalayas (2850-5600 m).

    abstract::Mountain trekking is significantly increasing in popularity. Hypoxia seems to play a key role in the pathogenesis of acute mountain sickness (AMS). The purpose of this study was to investigate regional cerebral (rSO2) and peripheral (SaO2) oxygen saturation for the first time, during 22 days high altitude trekking (me...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164103101201175

    authors: Hadolt I,Litscher G

    更新日期:2003-03-01 00:00:00

  • An efficient method for fractionated whole rodent brain radiation.

    abstract:OBJECTIVE:In order to test for mechanisms of whole brain radio therapy side effects and possible neuroprotective measures, a rodent model is desirable. In many models, a high single dose of 8-20 Gray (Gy) of whole brain irradiation is used. These experimental radiation protocols do not closely reflect the clinical situ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000143

    authors: Semmler A,Garbe S,Moskau S,Frisch C,Eter N,Schlegel U,Linnebank M

    更新日期:2013-05-01 00:00:00

  • A new method of noninvasive brain-edema monitoring in stroke: cerebral electrical impedance measurement.

    abstract:OBJECTIVE:To explore the primary regularity of cerebral electrical impedance (CEI) change in healthy people, patients with intracerebral hemorrhage (ICH) and patients with cerebral infarction (CI). METHODS:CEI of 200 healthy volunteers, 78 patients with ICH and 51 patients with CI were measured by noninvasive brain-ed...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164106X91843

    authors: Liu L,Dong W,Ji X,Chen L,Chen L,He W,Jia J

    更新日期:2006-01-01 00:00:00

  • The dynamic triple peak impact factor in traumatic brain injury influences native protein structures in gray and white matter as measured with computational simulation.

    abstract:BACKGROUND:Traumatic brain injuries (TBIs) cause a substantial burden to the patient, relatives, and the society as a whole. Much experience and knowledge during the last two decades have improved the neurosurgical treatment as well as the outcome. However, there is still much debate on what actually happens when exter...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000227

    authors: Holst Hv,Li X

    更新日期:2013-10-01 00:00:00

  • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke.

    abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740159

    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1993-10-01 00:00:00

  • Extracellular vesicles isolated from human olfactory ensheathing cells enhance the viability of neural progenitor cells.

    abstract:OBJECTIVE:Acquired neurological diseases such as severe traumatic brain or spinal cord injury (SCI) cause irreversible disability. Olfactory ensheathing cell (OEC) transplantation has been trialed as a promising SCI treatment. Extracellular vesicles (EVs), which regulate cell-cell interactions, have recently garnered e...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1794371

    authors: Tu YK,Hsueh YH

    更新日期:2020-11-01 00:00:00

  • The effect of papaverine on ion channels in rat basilar smooth muscle cells.

    abstract:OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164107X191021

    authors: Han DH,Bai GY,Yang TK,Sim BS,Kwak YG,Kim CJ

    更新日期:2007-09-01 00:00:00

  • Evolving management of symptomatic chronic subdural hematoma: experience of a single institution and review of the literature.

    abstract:OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/1743132813Y.0000000166

    authors: Balser D,Rodgers SD,Johnson B,Shi C,Tabak E,Samadani U

    更新日期:2013-04-01 00:00:00

  • Cerebrospinal fluid membrane-bound tissue factor and myelin basic protein in the course of vasospasm after subarachnoid hemorrhage.

    abstract::No marker that predicts accurately the time of occurrence of cerebral vasospasm due to subarachnoid hemorrhage (SAH) has been reported. In the present study, membrane-bound tissue factor (mTF) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) were evaluated as a predictor of the time of occurr...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164101101199225

    authors: Hirashima Y,Endo S,Nakamura S,Kurimoto M,Takaku A

    更新日期:2001-10-01 00:00:00

  • Tethered cord syndrome: overview of diagnosis and treatment.

    abstract::This article covers the basis of tethered cord syndrome as a stretch-induced spinal cord disorder, including pathophysiology, signs and symptoms, imaging diagnosis, indication for surgical treatment, and surgical procedures. Anomalies that cause mechanical spinal cord tethering are listed, and the surgical untethering...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164104225017947

    authors: Yamada S,Won DJ,Siddiqi J,Yamada SM

    更新日期:2004-10-01 00:00:00

  • COMT Val158Met polymorphism and Parkinson's disease risk: a pooled analysis in different populations.

    abstract:OBJECTIVE:Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in ...

    journal_title:Neurological research

    pub_type: 杂志文章,meta分析

    doi:10.1080/01616412.2018.1564183

    authors: Wang YC,Zou YB,Xiao J,Pan CD,Jiang SD,Zheng ZJ,Yan ZR,Tang KY,Tan LM,Tang MS

    更新日期:2019-04-01 00:00:00

  • fMRI review on brain responses to acupuncture: the limitations and possibilities in traditional Korean acupuncture.

    abstract:BACKGROUND:Since the late 1990s, imaging studies have allowed the visualization of brain response to acupuncture stimulation with alteration in blood flow. In 1998, the first functional magnetic resonance imaging (fMRI) study for the Korean acupuncture was published and thereafter, many subsequent neuroimaging studies ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164107X172284

    authors: Chae Y,Park HJ,Hahm DH,Hong M,Ha E,Park HK,Lee H

    更新日期:2007-01-01 00:00:00

  • Peripheral repetitive magnetic stimulation induces intracortical inhibition in healthy subjects.

    abstract:OBJECTIVE:Repetitive magnetic stimulation (rMS) is mainly used in transcranial applications. Only a few works have described its potential peripheral use. The aim of this investigation was to determine if conditioning peripheral (paravertebral) rMS of the cervical nerve roots in a group of healthy subjects induces chan...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313208X297959

    authors: Krause P,Straube A

    更新日期:2008-09-01 00:00:00

  • Cognitive functions in pediatric multiple sclerosis: 2-years follow-up.

    abstract::Objective: To assess the neuropsychological status of pediatric multiple sclerosis (MS) patients and its relationship with clinical variables in a longitudinal study.Methods: Patients with MS (n = 46) and age- and gender-matched healthy control subjects (HCs, n = 53) were given tests of non-verbal reasoning, attention...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1710417

    authors: Öztürk Z,Gücüyener K,Soysal Ş,Konuşkan GD,Konuşkan B,Dikmen AU,Anlar B

    更新日期:2020-02-01 00:00:00

  • Microsurgical anatomy of the supratentorial arachnoidal trabecular membranes and cisterns.

    abstract::We examined the microsurgical anatomy of the supratentorial subarachnoid cisterns with a surgical microscope in 20 brains prepared using the immersion technique. The adult brains were immersed in Ringer's solution and air was injected into the subarachnoid cisterns while the brains remained submerged in solution. We i...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740266

    authors: Vinas FC,Fandino R,Dujovny M,Chavez V

    更新日期:1994-12-01 00:00:00

  • Temporal profile of neural stem cell proliferation in the subventricular zone after ischemia/hypoxia in the neonatal rat brain.

    abstract:OBJECTIVES:Ischemia/hypoxia (I/H) causes severe neonatal brain injury, such as periventricular leukomaracia and hypoxic/ischemic encephalopathy. Neural stem cell research could lead to a treatment for such disorders. In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we inve...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X49283

    authors: Iwai M,Ikeda T,Hayashi T,Sato K,Nagata T,Nagano I,Shoji M,Ikenoue T,Abe K

    更新日期:2006-06-01 00:00:00

  • Albumin ameliorates tissue plasminogen activator-mediated blood-brain barrier permeability and ischemic brain injury in rats.

    abstract:OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METH...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X393898

    authors: Tang J,Li YJ,Mu J,Li Q,Yang DY,Xie P

    更新日期:2009-03-01 00:00:00

  • Protective effect of pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-induced neuronal damage.

    abstract::We investigated the neuroprotective effects of a novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (pitavastatin) on ischemic neuronal damage in gerbils using immunohistochemistry. The animals were allowed to survive for 14 days after 5 min of ischemia induced by bilateral occlusion of the comm...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164104225014102

    authors: Kurosaki R,Muramatsu Y,Kato H,Araki T

    更新日期:2004-09-01 00:00:00

  • Intra-ocular pressure changes during maximal isometric contraction: does this reflect intra-cranial pressure or retinal venous pressure?

    abstract::Recent publications have suggested that intra-ocular pressure (IOP) may be an indirect assessment of intra-cranial pressure (ICP). Both IOP and ICP have similar physiologic pressure ranges and similar responses to changes in intra-abdominal, intra-thoracic and aortic pressure. Previous studies have demonstrated the re...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740925

    authors: Dickerman RD,Smith GH,Langham-Roof L,McConathy WJ,East JW,Smith AB

    更新日期:1999-04-01 00:00:00