Abstract:
OBJECTIVE:To evaluate the effects of electrical stimulation (ES), stretching and their combined effects in matrix metalloproteinases (MMPs) gene expression and activity during early denervation of rat tibialis anterior (TA) muscle by axonotmesis. METHODS:Thirty adult male Wistar rats were divided into five groups: normal (N), denervated TA (D), denervated TA submitted to daily ES (D + ES), denervated TA submitted to daily stretching (D + St) and denervated TA submitted daily to both ES and stretching concurrently (D + ES + St). Both zimographic analysis and real time polymerase chain reaction of MMPs were used to muscular evaluation. In addition, muscle fiber cross-section area (CSA) was also evaluated. RESULTS:Stretching increased MMP-2 activity in denervated muscle when performed alone as well as in association with ES (p<0·01). Both stretching and ES, individually and in association, increased MMP-2 gene expression in denervated muscle compared to N and D (p<0·05). All denervated groups decreased muscle fiber CSA compared to N (p<0·05). DISCUSSION:While stretching is the main stimulus leading to the activation of MMP-2, both ES and stretching are able to increase MMP-2 gene expression in rat denervated muscle suggesting ECM remodeling.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Peviani SM,Russo TL,Durigan JL,Vieira BS,Pinheiro CM,Galassi MS,Salvini TFdoi
10.1179/174313209X459093subject
Has Abstractpub_date
2010-10-01 00:00:00pages
891-6issue
8eissn
0161-6412issn
1743-1328pii
ner1973journal_volume
32pub_type
杂志文章abstract::Anesthesia is an essential element during the induction of ischemia/reperfusion and cerebral blood flow (CBF) measurement in most animal models. Cerebral neuroprotection and intrinsic effects on CBF afforded by anesthetics are confounding variables in those models. A new model of global forebrain ischemia/reperfusion ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101199477
更新日期:2002-01-01 00:00:00
abstract::The present study aimed to examine the effects of N omega-nitro-L-arginine (LNA) on the early ischemic neuronal damage (EIND). All the experiments were carried out under general anesthesia, maintaining the blood gases and the body temperature within the physiological ranges. The local CBF, the topographically correspo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740795
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVES:Membrane disruption is one of the main factors that cause axonal damage and functional deficits manifested in spinal cord injury (SCI). In this study, we used polyethylene glycol (PEG) to induce immediate membrane sealing and to promote functional recovery after SCI. METHODS:The effects of PEG (200-2000 Da)...
journal_title:Neurological research
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abstract::We describe a case of rebleeding from an intracranial vertebral dissecting aneurysm following proximal clipping. This case suggests that proximal clipping alone may not be an adequate surgical procedure to prevent rebleeding. Surgical treatment of intracranial dissecting aneurysms in the vertebral artery presenting as...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1994.11740213
更新日期:1994-04-01 00:00:00
abstract::Acute blood-brain barrier (BBB) opening in cerebral ischemia is an often observed but seldom studied phenomenon. Increased permeability has been implicated with several consequences including exacerbating ischemic injury, leading to hemorrhagic transformation (HT) and also predictive of chronic damage and a way of del...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313206X153815
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Microglial cells in spinal dorsal horn can be activated by nociceptive stimuli and the activated microglial cells release various cytokines enhancing the nociceptive transmission. However, the mechanisms underlying the activation of spinal microglia during nociceptive stimuli have not been well understood. I...
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doi:10.1080/01616412.2017.1281198
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abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...
journal_title:Neurological research
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abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739556
更新日期:1980-01-01 00:00:00
abstract::In addition to its possible role as a replacement source in CNS degenerative diseases, neural transplantation may be used to augment the normal production of neuroactive substances. Our laboratory at the University of Illinois at Chicago has shown, in both acute and chronic pain models, that transplantation of adrenal...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/01616412.1997.11740775
更新日期:1997-02-01 00:00:00
abstract::Nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells can be increased after the treatment with L-threo-3,4-dihydroxyphenylserine (DOPS). Since the increase of NGF is not blocked by the treatment with decarboxylase inhibitor, DOPS may have direct effect to increase the NGF content. ...
journal_title:Neurological research
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abstract::The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the rela...
journal_title:Neurological research
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-10-01 00:00:00
abstract::Recent publications have suggested that intra-ocular pressure (IOP) may be an indirect assessment of intra-cranial pressure (ICP). Both IOP and ICP have similar physiologic pressure ranges and similar responses to changes in intra-abdominal, intra-thoracic and aortic pressure. Previous studies have demonstrated the re...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740925
更新日期:1999-04-01 00:00:00
abstract::Using the previously reported method of experimental localized brainstem infarct in dogs, we designed this study to elucidate sequential changes of regional cerebral blood flow (rCBF) in three separate regions of the central nervous system: the cerebral cortex, thalamus, and midbrain. The data obtained were referred t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11741061
更新日期:2000-03-01 00:00:00
abstract::Two hundred and sixty-one neurologically asymptomatic patients were examined by computed tomography (CT) following a variable number of transient ischaemic attacks (TIAs) experienced over different time intervals. Cerebral infarcts were discovered in 101 patients. Dominant hemisphere infarcts were usually small, of re...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739720
更新日期:1985-12-01 00:00:00
abstract::The objective of this study was to determine, whether 0.5-2/min oscillations in intracranial pressure ('B-waves') are a physiological phenomenon. In a group of 5 patients 0.5-2/min oscillations of ventricular pressure simultaneous with oscillations in the middle cerebral artery (MCA) flow velocity, as assessed by tran...
journal_title:Neurological research
pub_type: 杂志文章
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更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1179/016164106X98125
更新日期:2006-04-01 00:00:00
abstract::Endovascular reconstruction of basilar artery (BA) apex aneurysms has been augmented by adjunctive techniques such as balloon and stent assistance. We present three cases of a wide-necked BA apex aneurysm involving the bilateral P1 segments of both posterior cerebral arteries (PCAs) treated by placement of BA to PCA s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225013969
更新日期:2004-04-01 00:00:00
abstract::Huntington's disease is an inherited neurodegenerative disorder, characterized by loss of spiny neurons in the striatum and cortex, which usually happens in the third or fourth decades of life. In advanced form of the disease, progressive striatum atrophy happens and medium spiny neurons, which occupy more than 80% of...
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pub_type: 杂志文章
doi:10.1179/174313208X327955
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a multi-factorial disease influenced by both genetic and environmental factors. The aim of this case-control study was to determine the association between Endothelial Nitric Oxide Synthase G894T (rs1799983) gene polymorphism and susceptibility to ischemic stroke (IS) in North Indian po...
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doi:10.1080/01616412.2016.1181376
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pub_type: 杂志文章
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doi:10.1080/01616412.2017.1330815
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journal_title:Neurological research
pub_type: 临床试验,杂志文章
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000255
更新日期:2014-01-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740283
更新日期:1995-02-01 00:00:00
abstract::We examined the microsurgical anatomy of the supratentorial subarachnoid cisterns with a surgical microscope in 20 brains prepared using the immersion technique. The adult brains were immersed in Ringer's solution and air was injected into the subarachnoid cisterns while the brains remained submerged in solution. We i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740266
更新日期:1994-12-01 00:00:00
abstract:INTRODUCTION:Numerous studies have demonstrated a protective effect of hyperbaric oxygen therapy in experimental ischemic brain injury, and many physiological and molecular mechanisms of hyperbaric oxygen therapy-related neuroprotection have been identified. METHODS:Review of articles pertaining to hyperbaric oxygen t...
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pub_type: 杂志文章,评审
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更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739714
更新日期:1985-09-01 00:00:00