Abstract：
OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level and SCI was carried out using the weight drop method. BMSCs were isolated from adult rats, labeled with bromodeoxyuridine (BrdU) and administered intravenously to the rats 1 week after SCI, which were killed after 4 weeks. The non-treated animals were used as negative control, which showed cavitations of the spinal cord after 5 weeks of SCI. Rats in another group were killed immediately and used to study the hemorrhagic lesions. The volume densities (Vv) of the hemorrhage and cavitation were the highest at the site of direct trauma. RESULTS:The numerical densities of the transmigrated cells per area (Nat) were as follows: 0.3 +/- 0.2, 3.9 +/- 0.4, 5.4 +/- 0.4, 8.4 +/- 0.5, 5.5 +/- 0.3, 3.6 +/- 0.3 and 0.4 +/- 0.2 at the end and the middle of the thoracic vertebra 13 (T13), the region between T13 and the first lumbar vertebra, the middle of L1, the region between L1 and L2, and the middle and the end of L2 vertebra, respectively. The distribution of Nat at the above regions was a Gaussian model. The volume densities of hemorrhage in the spinal cord taken from the above regions showed that hemorrhage with the highest volume density occurred at the impact site and the volume density declined as the samples taken were more distant from the impact site. DISCUSSION:The migration of BMSCs in the injured region depends on the amount of the hemorrhage and damage to blood vessels of the spinal cord.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Khalatbary AR,Tiraihi Tdoi
10.1179/016164107X165642subject
Has Abstractpub_date
2007-01-01 00:00:00pages
21-6issue
1eissn
0161-6412issn
1743-1328journal_volume
29pub_type
杂志文章abstract：:Mountain trekking is significantly increasing in popularity. Hypoxia seems to play a key role in the pathogenesis of acute mountain sickness (AMS). The purpose of this study was to investigate regional cerebral (rSO2) and peripheral (SaO2) oxygen saturation for the first time, during 22 days high altitude trekking (me...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164103101201175
更新日期：2003-03-01 00:00:00
abstract：:This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...
journal_title：Neurological research
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Various surgical approaches have been described for treating lesions which arise in the sellar region. The popular transnasal-transsphenoidal and transethmoidal-transsphenoidal approaches avoid the morbidity associated with transcranial operations while allowing enough exposure to successfully remove most lesions that...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164101101198280
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to analyse inflammatory cells in lumbar disc tissue under cyclooxygenase-2 (COX-2) inhibitor therapy, to detect their prevalence in different subtypes of lumbar disc herniations and to assess the influence of inflammatory reactions in herniated disc tissue on postoperative out...
journal_title：Neurological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1179/016164105X49210
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:The present study was undertaken to evaluate whether resveratrol (RSV) modulates membrane lipid composition, as well as on ganglioside profile in ischemia/reperfusion injury. METHODS:Global cerebral ischemia was induced by four-vessel occlusion for 10 minutes. RSV (30 mg/kg) or vehicle was intraperitoneally...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132812Y.0000000116
更新日期：2013-01-01 00:00:00
abstract：:Background The distribution of risk factors for stroke is related to gender and age. The main objective of study was to determine the type and frequency of stroke risk factors in patients with first-in-life stroke before the age of 50. Methods Our study included patients under the age of 50 with first-in-life stroke. ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2018.1455367
更新日期：2018-07-01 00:00:00
abstract：:Intraoperative use of somatosensory evoked potentials (SEP's) to monitor intracranial aneurysm surgery and flash visual evoked potentials (F-VEP's) for parasellar surgery have been routinely employed in our clinic. We found that both EP modalities are sensitive to the changing concentration of our standard hypotensive...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1985.11739701
更新日期：1985-06-01 00:00:00
abstract：:Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimu...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164103771953862
更新日期：2003-12-01 00:00:00
abstract：:Different surgical approaches exist for the treatment of chronic subdural hematoma. None of these approaches is superior to the other, so a minimal-invasive device (a hollow screw) was developed. The system consists of a stable hollow screw of surgical steel with a perforated tip, a hand-drill, screwdriver with guide,...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740897
更新日期：1999-01-01 00:00:00
abstract：:Regional CBF was measured by 133Xe inhalation in unilateral cerebral infarction, carotid TIAs, and normal volunteers. Regional CBF values were bilaterally and symmetrically reduced in patients measured within 3 weeks after stroke. Later, rCBF values returned toward normal in the contralateral hemisphere of patients wi...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1979.11739545
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of electrical stimulation (ES), stretching and their combined effects in matrix metalloproteinases (MMPs) gene expression and activity during early denervation of rat tibialis anterior (TA) muscle by axonotmesis. METHODS:Thirty adult male Wistar rats were divided into five groups: no...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/174313209X459093
更新日期：2010-10-01 00:00:00
abstract：:The objective was to examine the effect of the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME) on leukocyte adhesion in the cerebral microcirculation during reperfusion following partial forebrain ischemia in the rat. Intravital fluorescence video-microscopy through a closed cranial win...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740947
更新日期：1999-06-01 00:00:00
abstract：:The possible role of nitric oxide (NO) on vibrissa-stimulated increase of regional cerebral cerebral blood flow (rCBF) and cerebral metabolic rate of glucose (rCMRglu) was investigated in conscious Wistar rats by using an inhibitor of NO synthase, NG-nitro-L-arginine (NOLAG) at a concentration of 30 mg/kg. In vivo aut...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1993.11740103
更新日期：1993-02-01 00:00:00
abstract：:Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP.Methods: A total of 36 male Sprague-Dawley rats were divi...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2019.1685064
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Alteration of sensorium or an encephalopathy is a common diagnostic dilemma in critically ill patients and can be caused by a number of conditions. Sepsis associated encephalopathy (SAE) is now the most common encephalopathy encountered among intensive care unit (ICU) patients. DEFINITIONS:SAE is an encep...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/016164107X240233
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVES:Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the associati...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2018.1560643
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:The amyloid hypothesis stimulates the discovery of compounds, which promotes beta-amyloid peptide (Aβ) clearance, thereby altering the underlying pathophysiology of Alzheimer's disease (AD). Hence, the present study aims at the evaluation of anti-amyloidogenic potential of Gelidiella acerosa. METHODS:Prevent...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132814Y.0000000422
更新日期：2015-01-01 00:00:00
abstract：:The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1996.11740472
更新日期：1996-12-01 00:00:00
abstract：:Recent work has suggested that one factor in the etiology of the neuromuscular disease, amyotrophic lateral sclerosis (ALS), may be an autoimmune mechanism in which presynaptic voltage-sensitive calcium channels are an antigenic target. We have developed a fluorescence technique to measure rapid Ca2+ influx through pr...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1997.11740785
更新日期：1997-04-01 00:00:00
abstract：:Spinal cord neuron and dorsal column fiber responses to electrical stimulation of the sciatic nerve in anesthetized cats were recorded before, during, and after periods of repetitive electrical stimulation of the sciatic nerve through an implantable nerve cuff stimulator device of the type and method used in human pat...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1981.11739598
更新日期：1981-01-01 00:00:00
abstract：OBJECTIVES:Microglial cells in spinal dorsal horn can be activated by nociceptive stimuli and the activated microglial cells release various cytokines enhancing the nociceptive transmission. However, the mechanisms underlying the activation of spinal microglia during nociceptive stimuli have not been well understood. I...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2017.1281198
更新日期：2017-03-01 00:00:00
abstract：:Complete thrombosis followed by recanalization of giant aneurysms is an infrequent process that has been exceptionally mentioned in relation to nongiant saccular aneurysms. A 25-year-old male presented with a right temporal hematoma and associated subarachnoid hemorrhage. Cerebral angiography revealed a small blister-...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164103771953961
更新日期：2003-12-01 00:00:00
abstract：OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/1743132813Y.0000000166
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVES:Surgical management of tumors in the sacropelvic region is a challenging field of spine surgery because of the region's complex local anatomy and biomechanics. Recent developments in anesthesia and intensive care have allowed us to perform extended surgeries focused on the en bloc resection of sacropelvic tu...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/1743132814Y.0000000370
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:This study assesses the clinical outcome after early combined cranioplasty (own frozen bone) and shunt implantation (Codman-Medos programmable VP shunt) in patients with skull bone defects and cerebrospinal fluid (CSF) circulation disorders. METHOD:Medical records were reviewed retrospectively for the last 1...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164106X98008
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:Vascular endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production. The present study examined if thrombin modulates vascular endoth...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/174313209X385699
更新日期：2009-09-01 00:00:00
abstract：:Endolymphatic sac tumors are rare, low-grade adenocarcinomas of the petrous bone. These tumors are highly vascularized and surgical removal is often challenging. We present a staged endovascular-neurosurgical approach consisting of stent-assisted angioplasty of the petrous carotid, selective endovascular embolization ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164103101201436
更新日期：2003-04-01 00:00:00
abstract：:Anoxic depolarization (AD) is one of the major physiological characteristics in the ischemic core. The effect of mild hypothermia on the appearance of AD and subsequent brain injury following profound ischemia is studied to evaluate the protective mechanism of hypothermia against severe ischemia. Sprague-Dawley rats w...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740996
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVES:Natalizumab is a drug with documented efficacy in relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of natalizumab has immunosuppressive properties and it is not yet investigated if treatment with natalizumab affects the immunological response to vaccination. This study aims to investig...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132812Y.0000000059
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVES:Parkinson's disease (PD) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of PD. The purpose of this study was to assess the role of B-cell lymphoma 2 (Bcl-2)-associated athanogene 5 (BAG5) protein, whic...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132812Y.0000000102
更新日期：2012-12-01 00:00:00
