Serum complement factor H and Tyr402 His gene polymorphism among Egyptians with multiple sclerosis.

Abstract:

BACKGROUND AND OBJECTIVES:Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. A contribution from complement has long been suspected. We investigated the association of complement factor H (CFH) Tyr402 His gene polymorphism and serum level in Egyptian patients with MS to examine whether complement might identify or predict specific pathological processes and outcomes in MS. DESIGN AND SETTING:This case-control study was performed during 2013 on MS subjects who attended the Department of Neurology, Cairo University Teaching Hospital. PATIENTS AND METHODS:The study included 86 subjects with MS and 74 healthy controls (HC). They were divided into two sets of patients: we measured serum CFH level in 42 patients and 34 HC, and CFH Tyr402 His gene polymorphism in 44 MS patients and 40 HC. Serum CFH was measured by an enzyme-linked immunosorbent assay. Complement factor H Tyr402 His gene polymorphism was detected using polymerase chain reaction followed by restriction fragment length polymorphism analysis. RESULTS:Serum CFH levels were significantly higher in the MS group and subgroups (P < 0.05) than those in the control group. There was no significant difference in the frequency of CFH Tyr402 His genotypes and alleles between MS patients and healthy controls. CONCLUSION:There was evidence that serum CFH level may be associated with disease risk. There was no evidence that CFH Tyr402 His gene polymorphism is associated with disease risk.

journal_name

Neurol Res

journal_title

Neurological research

authors

Abdel Rasol HA,Helmy H,Aziz MA

doi

10.1179/1743132815Y.0000000075

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

845-52

issue

10

eissn

0161-6412

issn

1743-1328

journal_volume

37

pub_type

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