Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease.

abstract：OBJECTIVES:The aim of the study was to investigate the effects of the GLP-1 analog liraglutide on beta-amyloid (Aβ)-induced neurotoxicity in the human neuroblastoma cell line SH-SY5Y and study the underlying mechanisms. METHODS:Cultured SH-SY5Y cells in vitro were randomly divided into normal control group, beta-amylo...

journal_title：Neurological research

authors： Liu XY,Wang LX,Chen Z,Liu LB

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this prospective observational study was to investigate the relation between the frequency of critical neuromonitoring parameters (brain tissue pO2, (PtiO2) < or = 10 mmHg, intracranial pressure (ICP) > 20 mmHg, cerebral perfusion pressure (CPP) < or = 70 mmHg) and outcome after severe aneurysmal subara...

journal_title：Neurological research

authors： Meixensberger J,Vath A,Jaeger M,Kunze E,Dings J,Roosen K

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...

journal_title：Neurological research

authors： Balser D,Rodgers SD,Johnson B,Shi C,Tabak E,Samadani U

更新日期：2013-04-01 00:00:00

abstract：:Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS).Methods: A total of 20 patients with relapsing remitting m...

journal_title：Neurological research

authors： Ulusoy MO,Horasanlı B,Işık-Ulusoy S

更新日期：2020-04-01 00:00:00

abstract：:Changes in membrane AChRs in skeletal muscles located near or distant from burn injury similar to denervated muscles may make electrodiagnostic features indistinguishable from true neuropathic changes. The aim of this study was to examine electrodiagnostic changes of muscles at sites local and distant from the burn af...

journal_title：Neurological research

authors： Sajadi S,Mansoori K,Forogh B,Fatemi MJ,Ahadi T,Chahardoli Razji M

更新日期：2016-04-01 00:00:00

abstract：:Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...

journal_title：Neurological research

authors： Zunker P,Haase C,Borggrefe M,Georgiadis D,Georgiadis A,Ringelstein EB

更新日期：1998-09-01 00:00:00

abstract：:The purpose of this study was to determine the efficacy of nicardipine prolonged-release implants for preventing vasospasm in a canine SAH model in a dose-escalating placebo-controlled blind fashion. Drug-release kinetics of copoly(lactic/glycolic acid) pellet containing nicardipine were evaluated in vitro. In vivo, 1...

journal_title：Neurological research

authors： Kawashima A,Kasuya H,Sasahara A,Miyajima M,Izawa M,Hori T

更新日期：2000-09-01 00:00:00

abstract：:From 118 transsphenoidally operated patients, 100 had a pituitary adenoma; 33 prolactinomas, 20 HGH-producing, 2 ACTH-producing and 45 inactive adenomas. The first transsphenoidal operation did not cause any mortality; after reoperation for suspected recurrence on follow-up, 2 patients died; thus, the global managemen...

journal_title：Neurological research

authors： Auer LM,Clarici G

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level ...

journal_title：Neurological research

authors： Khalatbary AR,Tiraihi T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:High blood pressure (BP) is a major risk factor for stroke and all of its pathological subtypes including subarachnoid hemorrhage (SAH). However, there is little evidence demonstrating whether failure to have regular BP measured could result in underestimation of people at risk for SAH. Therefore, we aimed ...

journal_title：Neurological research

authors： Shiue I,Hankey GJ,Arima H,Anderson CS

更新日期：2011-12-01 00:00:00

abstract：:Single-cell experiments were undertaken to characterize the neurons of the rat habenular complex (Hab) which respond to noxious input and the extent to which the noxious responses can be modulated by dorsal raphe stimulation. The reported observations demonstrate that habenular neurons exhibit two response patterns to...

journal_title：Neurological research

authors： Dafny N,Qiao JT

更新日期：1990-06-01 00:00:00

abstract：:Microsurgical anatomy for the pterional approach was studied regarding the origin and the course of the ophthalmic artery and the distal dural ring using human cadaveric specimens, with special reference to the surrounding bony structures. In 50 human adult formalin-fixed cadaveric cerebral hemispheres and 10 block sp...

journal_title：Neurological research

authors： Hokama M,Hongo K,Gibo H,Kyoshima K,Kobayashi S

更新日期：2001-06-01 00:00:00

abstract：:Treatment modalities for metastatic spine disease have significantly expanded over the last two decades. This expansion occurred in many different fields. Improvement in surgical techniques and instrumentation now allow the oncologic spine surgeons to effectively circumferentially decompress the neural elements withou...

journal_title：Neurological research

authors： Dea N,Fisher CG

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Parkinson's disease (PD) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of PD. The purpose of this study was to assess the role of B-cell lymphoma 2 (Bcl-2)-associated athanogene 5 (BAG5) protein, whic...

journal_title：Neurological research

authors： Ma M,Wang X,Ding X,Jing J,Ma Y,Teng J

更新日期：2012-12-01 00:00:00

abstract：:The endogenous clock of humans can be influenced by light application to the popliteal region. Previously, it had been assumed that light must fall directly into the eye in order to influence the inner circadian clock. This study, published in 1998, has not been reproduced. We investigated the effects of laser light i...

journal_title：Neurological research

authors： Litscher G

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The predictive effect of blood cell ratio on ischemic event has been widely confirmed. Whether PWR and PNR can assess the risk of endovascular treatment (EVT) is largely unclear. This study aimed to investigate the prognostic value of PNR and PWR in acute ischemic stroke patients treated with EVT...

journal_title：Neurological research

authors： Wang L,Cheng Q,Peng M,Lv D,Zi W,Xu G,Liu X

更新日期：2020-10-01 00:00:00

abstract：:Although radiation injuries to the brain are well documented, immediate early histological changes in the brain remain to be defined. The present study characterizes glial injury provoked in adult rat white matter within 24 h after a single irradiation of the whole brain (10 or 20 Gray). Irradiated brains were histolo...

journal_title：Neurological research

authors： Kurita H,Kawahara N,Asai A,Ueki K,Shin M,Kirino T

更新日期：2001-12-01 00:00:00

abstract：:The decrease in intracellular creatine concentration in Duchenne muscular dystrophy may contribute to the deterioration of intracellular energy homeostasis and may thus be one of the factors aggravating muscle weakness and degeneration. Oral creatine supplementation should have potential in alleviating the clinical sy...

journal_title：Neurological research

authors： Felber S,Skladal D,Wyss M,Kremser C,Koller A,Sperl W

更新日期：2000-03-01 00:00:00

abstract：OBJECT:The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo® application on brain injury in experimental TBI mice using S...

journal_title：Neurological research

authors： Guo D,Li D,Li J,Li Y,Hu X,Guan F,Yang B

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Epilepsy is a common seizure disorder affecting approximately 70 million people worldwide. Mitochondrial dysfunction and antioxidant/prooxidant imbalance are emerging as factors that contribute to epileptogenesis. As medical ozone was able to reestablish cellular redox balance and to maintain the protective ...

journal_title：Neurological research

authors： Mallok A,Vaillant JD,Soto MT,Viebahn-Hänsler R,Viart Mde L,Pérez AF,Cedeño RI,Fernández OS

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other poss...

journal_title：Neurological research

authors： Mohammadi B,Krampfl K,Kollewe K,Seyfadini A,Bufler J,Dengler R

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:Surgical management of tumors in the sacropelvic region is a challenging field of spine surgery because of the region's complex local anatomy and biomechanics. Recent developments in anesthesia and intensive care have allowed us to perform extended surgeries focused on the en bloc resection of sacropelvic tu...

journal_title：Neurological research

authors： Varga PP,Szoverfi Z,Lazary A

更新日期：2014-06-01 00:00:00

abstract：:Although the circulation of cerebrospinal fluid enjoys an apparent simplicity, its underlying basis is amazingly complex. Many factors influence how CSF flows through the human central nervous system. In the presence of hydrocephalus and subsequent shunt placement, this system is further complicated. The challenge bef...

journal_title：Neurological research

authors： Magram G,Liakos AM

更新日期：2000-01-01 00:00:00

abstract：:The haemodynamic mechanisms responsible for the appearance of paraparetic transient ischaemic attacks in ten patients with childhood moyamoya disease who subsequently underwent bifrontal omental transplantation were investigated. Cerebral perfusion (CP) was measured with 99mTc-hexamethylene-propyleneamine oxime single...

journal_title：Neurological research

authors： Touho H,Karasawa J,Ohnishi H

更新日期：1995-06-01 00:00:00

abstract：:Neural stem cells (NSCs) are self-renewable, multipotential cells capable of differentiating into the three major neural cell types, but the mechanisms which regulate their development are not fully understood. Both basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote the proliferation of NS...

journal_title：Neurological research

authors： Reimers D,López-Toledano MA,Mason I,Cuevas P,Redondo C,Herranz AS,Lobo MV,Bazán E

更新日期：2001-09-01 00:00:00

abstract：:A case is reported of intractable epilepsy associated with a hypothalamic hamartoma in an 18 year old man. The patient underwent a two-third anterior callsotomy and, subsequently, removal of the hamartoma. Callosotomy did not affect the generalized seizure pattern. The authors believe this to be the first documented c...

journal_title：Neurological research

authors： Pallini R,Bozzini V,Colicchio G,Lauretti L,Scerrati M,Rossi GF

更新日期：1993-04-01 00:00:00

abstract：:The possibility of the evaluation of ischemia solely by the momentary values of regional cerebral blood flow (rCBF) was investigated. Ischaemic damage was evaluated histopathologically and by observing albumin extravasation. Unilateral carotid clippings were performed for 1 h and the gerbils evaluated with regard to t...

journal_title：Neurological research

authors： Kadota E

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...

journal_title：Neurological research

authors： Zhu H,Li Z,Lv J,Zhao R

更新日期：2018-05-01 00:00:00

abstract：:Six cases of very large anterior circulation intracranial aneurysms are presented. Aneurysms of 53-84 mm in three female and two male adults and a 40 mm lesion in a seven week infant were successfully excised. Three patients tolerated trial intraluminal balloon occlusion preoperatively and underwent subsequent parent ...

journal_title：Neurological research

authors： Cahill DW

更新日期：1992-01-01 00:00:00

abstract：:The present study aimed to examine the effects of N omega-nitro-L-arginine (LNA) on the early ischemic neuronal damage (EIND). All the experiments were carried out under general anesthesia, maintaining the blood gases and the body temperature within the physiological ranges. The local CBF, the topographically correspo...

journal_title：Neurological research

authors： Matsui T,Nagafuji T,Mori T,Asano T

更新日期：1997-04-01 00:00:00