Mutations in GBA and risk of Parkinson's disease: a meta-analysis based on 25 case-control studies.

Abstract:

:The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the relationship between the most common GBA mutations, L444P and N370S and PD susceptibility, an updated meta-analysis was performed by searching PUBMED, EMBASE, MEDLINE, and EBSCO databases. Twenty five studies including 9, 599 cases and 13, 541 controls were collected in the end. The summary of odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated using fixed- and random-effects models, when appropriate. Overall, our meta-analysis provided evidence that both were risk factors associated with increased PD susceptibility. When stratified by ethnicities, the associations varied among different ethnical origins.

journal_name

Neurol Res

journal_title

Neurological research

authors

Mao X,Wang T,Peng R,Chang X,Li N,Gu Y,Zhao D,Liao Q,Liu M

doi

10.1179/1743132813Y.0000000224

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

873-8

issue

8

eissn

0161-6412

issn

1743-1328

pii

ner3182

journal_volume

35

pub_type

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