Abstract:
OBJECTIVES:Ischemia/hypoxia (I/H) causes severe neonatal brain injury, such as periventricular leukomaracia and hypoxic/ischemic encephalopathy. Neural stem cell research could lead to a treatment for such disorders. In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we investigated the proliferation of new cells in the subventricular zone (SVZ). METHODS:Seven-day-old Wister rats were subjected to ligation of the left carotid artery followed by 2 hours of hypoxic stress (8% O(2) and 92% N(2), at 33 degrees C). In order to elucidate the dynamic change of neural stem cells in the SVZ, single bromodeoxyuridine (BrdU; 50 mg/kg) was administered 2 hours before death 1, 7, 14 and 21 days after I/H. Immunohistochemical and immunofluorescent studies for BrdU and doublecortin (DCX) were carried out. As a control, a group of rats was subjected to sham surgery (incision of skin, but no ligation of the carotid artery) and no I/H. RESULTS:The numbers of BrdU-labeled cells in the SVZ, for both the ipsilateral side and the contralateral side of the I/H brain, were twice the level of the control at 7 days after I/H, but the numbers for both sides returned to the control level at 21 days. In the ipsilateral side of the I/H brain, the number of BrdU-labeled cells in the SVZb (lining the upper wall of lateral ventricle) was 4-fold at 7 days and 15-fold at 21 days after I/H compared with the control level. This chronological pattern is very similar to the pattern for I/H results of the posterior periventricle (pPV). DCX appeared in most BrdU-labeled cells in the SVZb and pPV. DISCUSSION:These findings indicate that I/H enhances neural stem cell proliferation in the SVZ, and some newborn cells migrate as neural precursors to the SVZb and pPV after I/H in the neonatal rat brain.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Iwai M,Ikeda T,Hayashi T,Sato K,Nagata T,Nagano I,Shoji M,Ikenoue T,Abe Kdoi
10.1179/016164105X49283subject
Has Abstractpub_date
2006-06-01 00:00:00pages
461-8issue
4eissn
0161-6412issn
1743-1328journal_volume
28pub_type
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pub_type: 杂志文章,评审
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更新日期:1998-12-01 00:00:00
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doi:10.1179/016164105X25171
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doi:10.1179/016164101101198839
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739967
更新日期:1991-03-01 00:00:00
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更新日期:2004-01-01 00:00:00
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doi:10.1179/1743132811Y.0000000041
更新日期:2011-11-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740472
更新日期:1996-12-01 00:00:00
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journal_title:Neurological research
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doi:10.1080/01616412.1997.11740765
更新日期:1997-02-01 00:00:00
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doi:10.1179/1743132812Y.0000000016
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journal_title:Neurological research
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doi:10.1080/01616412.1992.11740065
更新日期:1992-06-01 00:00:00
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doi:10.1179/1743132812Y.0000000133
更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1179/016164104225017947
更新日期:2004-10-01 00:00:00
abstract::We describe the advantages and clarify the technical key points of a microendoscopic, minimally invasive technique to the posterior surgical approach for cervical degenerative disease. The authors studied the microendoscopic posterior approach using the METRx system in both cadaver models and in clinical cases. This n...
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doi:10.1179/016164103101201058
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To establish a detailed technical procedure for studying the anatomical correlates of chronic cerebrospinal venous insufficiency in cadavers of multiple sclerosis and control subjects, and to present our findings of the normal anatomic venous structures, with reference to previous descriptions from the liter...
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doi:10.1179/1743132812Y.0000000071
更新日期:2012-10-01 00:00:00
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更新日期:2009-02-01 00:00:00
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更新日期:2010-02-01 00:00:00
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更新日期:2007-09-01 00:00:00