Interleukin-21 expression in hippocampal astrocytes is enhanced following kainic acid-induced seizures.

abstract：OBJECTIVES:Disturbances in the hypothalamo-pituitary axis are supposed to modulate activity of multiple sclerosis (MS). We hypothesised that the extent of HYP damage may determine severity of MS and may be associated with the disease evolution. We suggested fatigue and depression may depend on the degree of damage of t...

journal_title：Neurological research

authors： Kantorová E,Poláček H,Bittšanský M,Baranovičová E,Hnilicová P,Čierny D,Sivák Š,Nosáľ V,Zeleňák K,Kurča E

更新日期：2017-04-01 00:00:00

abstract：:Acute blood-brain barrier (BBB) opening in cerebral ischemia is an often observed but seldom studied phenomenon. Increased permeability has been implicated with several consequences including exacerbating ischemic injury, leading to hemorrhagic transformation (HT) and also predictive of chronic damage and a way of del...

journal_title：Neurological research

authors： Nagaraja TN,Keenan KA,Brown SL,Fenstermacher JD,Knight RA

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Susceptibility-weighted (SW) magnetic resonance (MR) imaging is a sensitive test to detect intravenous deoxygenated blood. On SW images, dilated appearing draining veins in tissue with perfusion impairment occur due to an increase in intravenous deoxyhemoglobin levels, and could indicate poor perfusion areas...

journal_title：Neurological research

authors： Sorimachi T,Morita K,Sasaki O,Koike T,Fujii Y

更新日期：2011-04-01 00:00:00

abstract：:Objective: To assess the neuropsychological status of pediatric multiple sclerosis (MS) patients and its relationship with clinical variables in a longitudinal study.Methods: Patients with MS (n = 46) and age- and gender-matched healthy control subjects (HCs, n = 53) were given tests of non-verbal reasoning, attention...

journal_title：Neurological research

authors： Öztürk Z,Gücüyener K,Soysal Ş,Konuşkan GD,Konuşkan B,Dikmen AU,Anlar B

更新日期：2020-02-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...

journal_title：Neurological research

authors： Aronowski J,Hall CE

更新日期：2005-04-01 00:00:00

abstract：:Parkinson's disease (PD) the second most common age-associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons, cytoplasmic inclusions of aggregated proteins (Lewy bodies), and neuroinflammation. The inflammation of neurons causes release of various inflammatory mediators (IFNs,...

journal_title：Neurological research

authors： Pal R,Tiwari PC,Nath R,Pant KK

更新日期：2016-12-01 00:00:00

abstract：:The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological sco...

journal_title：Neurological research

authors： Ruan GP,Han YB,Wang TH,Xing ZG,Zhu XB,Yao X,Ruan GH,Wang JX,Pang RQ,Cai XM,He J,Zhao J,Pan XH

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To explore the primary regularity of cerebral electrical impedance (CEI) change in healthy people, patients with intracerebral hemorrhage (ICH) and patients with cerebral infarction (CI). METHODS:CEI of 200 healthy volunteers, 78 patients with ICH and 51 patients with CI were measured by noninvasive brain-ed...

journal_title：Neurological research

authors： Liu L,Dong W,Ji X,Chen L,Chen L,He W,Jia J

更新日期：2006-01-01 00:00:00

abstract：:Cyclic GMP (cGMP) mediates smooth muscle relaxation in the central nervous system. In subarachnoid hemorrhage (SAH), decreases in intrinsic nitric oxide (NO) cause cerebral vasospasms due to the regulation of cGMP formation by NO-mediated pathways. As phosphodiesterase type V (PDE V) selectively hydrolyzes cGMP, we hy...

journal_title：Neurological research

authors： Inoha S,Inamura T,Ikezaki K,Nakamizo A,Amano T,Fukui M

更新日期：2002-09-01 00:00:00

abstract：:Although neuronal death has been studied in experimental models of ischemia, the precise mechanisms regulating cell death remain unclear. Furthermore, the timing and pattern of neuronal death in human stroke has not been extensively studied. To further our understanding of ischemia-induced neuronal death, we examined ...

journal_title：Neurological research

authors： Guglielmo MA,Chan PT,Cortez S,Stopa EG,McMillan P,Johanson CE,Epstein M,Doberstein CE

更新日期：1998-06-01 00:00:00

abstract：:Twenty-four patients presenting an acute stroke with watershed cerebral infarct on CT scan or MRI were included in this retrospective study. Age was 63 +/- 14 years (mean +/- SD), and sex ratio was 2 men for 1 woman. Main clinical features were: in anterior location, lower limb weakness and frontal syndrome with trans...

journal_title：Neurological research

authors： Evrard S,Woimant F,Le Coz P,Polivka M,Cousin C,Haguenau M

更新日期：1992-01-01 00:00:00

abstract：:We examined whether or not NF-kappaB, a factor that regulates expression of the genes that code for pro-inflammatory cytokines, is activated in cerebrospinal fluid (CSF) cells to investigate the production of pro-inflammatory cytokines by CSF cells in patients with meningitis. Western blotting demonstrated that NF-kap...

journal_title：Neurological research

authors： Ichiyama T,Isumi H,Yoshitomi T,Nishikawa M,Matsubara T,Furukawa S

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:Although magnesium is a well-known treatment for vasospasm following subarachnoid hemorrhage, its mechanism of action for cerebral vascular relaxation is not clear. In addition, it is known that L-type calcium (Ca(2+)) channels play a pivotal role in smooth muscle contraction. To investigate the role of L-t...

journal_title：Neurological research

authors： Sharma N,Cho DH,Kim SY,Bhattarai JP,Hwang PH,Han SK

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of ne...

journal_title：Neurological research

authors： Montes P,Vigueras-Villaseñor RM,Rojas-Castañeda JC,Monfil T,Cervantes M,Moralí G

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:In the present study, we investigated the effects of treadmill exercise on microglial activation and the subsequent release of tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1-beta in the hippocampus in a rat model of type 2 diabetes. METHODS:At 30 weeks of age, diabetic (Zucker diabeti...

journal_title：Neurological research

authors： Yoo DY,Chae J,Jung HY,Yim HS,Kim JW,Nam SM,Kim DW,Choi JH,Seong JK,Yoon YS,Hwang IK

更新日期：2015-08-01 00:00:00

abstract：:We describe the advantages and clarify the technical key points of a microendoscopic, minimally invasive technique to the posterior surgical approach for cervical degenerative disease. The authors studied the microendoscopic posterior approach using the METRx system in both cadaver models and in clinical cases. This n...

journal_title：Neurological research

authors： Yuguchi T,Nishio M,Akiyama C,Ito M,Yoshimine T

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role ...

journal_title：Neurological research

authors： Han DH,Bai GY,Yang TK,Sim BS,Kwak YG,Kim CJ

更新日期：2007-09-01 00:00:00

abstract：:Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...

journal_title：Neurological research

authors： Chun Y,Chen Y,Elsisy M,Sukinik J,Shridhar P,Park JK,Kim YB,Hong CK,Chung J

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...

journal_title：Neurological research

authors： Reed LK,Wen J,Liang B,Wang X,Feng D,Huang JH

更新日期：2020-10-01 00:00:00

abstract：:Although rat models implanted with C6 glioma cells have been widely utilized for the assessment of new therapeutic modalities, a convenient in vivo model is still required. We implanted C6 glioma cells into the brains and the abdominal subcutaneous regions of Wistar rats, and evaluated the volumes of the growing tumor...

journal_title：Neurological research

authors： Watanabe K,Sakamoto M,Somiya M,Amin MR,Kamitani H,Watanabe T

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVES:We attempted to determine whether a functional polymorphism of TRPM6 (rs2274924) is associated with susceptibility to epilepsy following ischemic stroke, and to further explore the effect of this polymorphism on serum levels of Mg2+ in post-stroke patients. METHODS:We carried out a case-control study on 378...

journal_title：Neurological research

authors： Fu CY,Chen SJ,Cai NH,Liu ZH,Zhang M,Wang PC,Zhao JN

更新日期：2019-04-01 00:00:00

abstract：:The decrease in intracellular creatine concentration in Duchenne muscular dystrophy may contribute to the deterioration of intracellular energy homeostasis and may thus be one of the factors aggravating muscle weakness and degeneration. Oral creatine supplementation should have potential in alleviating the clinical sy...

journal_title：Neurological research

authors： Felber S,Skladal D,Wyss M,Kremser C,Koller A,Sperl W

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...

journal_title：Neurological research

authors： Tang LL,Zheng JS

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...

journal_title：Neurological research

authors： Strassner C,Buhl R,Mehdorn HM

更新日期：2009-06-01 00:00:00

abstract：:An approach to aneurysms arising at the bifurcation of the basilar artery and its neighborhood is described. The temporal pole of the nondominant side is retracted posteriorly to provide a wide operative field and a better view of aneurysms. ...

journal_title：Neurological research

authors： Sano K

更新日期：1980-01-01 00:00:00

abstract：:Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimu...

journal_title：Neurological research

authors： Kleim JA,Bruneau R,VandenBerg P,MacDonald E,Mulrooney R,Pocock D

更新日期：2003-12-01 00:00:00

abstract：:A 52-year-old male underwent lumboperitoneal shunting after external decompressive craniectomy. His postoperative course was accompanied by remarkable displacement of the intracranial structures to the opposite side of craniectomy. This phenomenon, probably caused by the siphon effect of cerebrospinal fluid shunting, ...

journal_title：Neurological research

authors： Aoki N

更新日期：1991-06-01 00:00:00

abstract：:The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the rela...

journal_title：Neurological research

authors： Mao X,Wang T,Peng R,Chang X,Li N,Gu Y,Zhao D,Liao Q,Liu M

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To explore the value of dynamically monitored levels of plasma prothrombin fragment(1+2) (F(1+2)) and D-dimer in the process of thrombolysis with urokinase. METHODS:Blood samples were collected at baseline and at hours 1, 2, 3, 6, 12, 24, 48, 72, and 96 after urokinase infusion finished. The levels of plasma...

journal_title：Neurological research

authors： Meng R,Ji X,Li B,Zhou J,Li W,Ding Y

更新日期：2009-05-01 00:00:00

abstract：:We examined antioxidant activity of cabergoline, a dopamine agonist, during the aerobic oxidation of phosphatidylcholine liposomes at 37 degrees C. Cabergoline retarded the oxidation initiated with a lipid-soluble initiator significantly better than that with a water-soluble initiator, suggesting that cabergoline loca...

journal_title：Neurological research

authors： Sohmiya M,Tanaka M,Okamoto K,Fujisawa A,Yamamoto Y

更新日期：2004-06-01 00:00:00