Synergistic inhibition of lipid peroxidation by vitamin E and a dopamine agonist, cabergoline.

Abstract:

:We examined antioxidant activity of cabergoline, a dopamine agonist, during the aerobic oxidation of phosphatidylcholine liposomes at 37 degrees C. Cabergoline retarded the oxidation initiated with a lipid-soluble initiator significantly better than that with a water-soluble initiator, suggesting that cabergoline locates in the lipid layer of liposomal membranes. Cabergoline inhibited the oxidation of liposomal membranes synergistically with endogenous antioxidants such as ascorbic acid, ubiquinol-10 and vitamin E, and vitamin E was the most efficient synergist. These results suggest that cabergoline may have a neuroprotective effect on the substantia nigra of Parkinsonian patients because of its synergistic antioxidant activity with vitamin E as well as its action on dopamine receptor.

journal_name

Neurol Res

journal_title

Neurological research

authors

Sohmiya M,Tanaka M,Okamoto K,Fujisawa A,Yamamoto Y

doi

10.1179/016164104225016029

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

418-21

issue

4

eissn

0161-6412

issn

1743-1328

journal_volume

26

pub_type

杂志文章
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    abstract::Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 1...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:

    authors: Ikeda K,Iwasaki Y,Tagaya N,Shiojima T,Kobayashi T,Kinoshita M

    更新日期:1995-12-01 00:00:00

  • Online assessment of brain tissue oxygen autoregulation in traumatic brain injury and subarachnoid hemorrhage.

    abstract::Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164103101201580

    authors: Soehle M,Jaeger M,Meixensberger J

    更新日期:2003-06-01 00:00:00

  • Temporo-polar approach to aneurysms of the basilar artery at and around the distal bifurcation: technical note.

    abstract::An approach to aneurysms arising at the bifurcation of the basilar artery and its neighborhood is described. The temporal pole of the nondominant side is retracted posteriorly to provide a wide operative field and a better view of aneurysms. ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1980.11739588

    authors: Sano K

    更新日期:1980-01-01 00:00:00

  • Reduction of nerve growth factor receptor immunoreactivity in ischaemic gerbil hippocampal CA1 neurons after treatment with L-threo-3,4-dihydroxyphenylserine (DOPS).

    abstract::Nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells can be increased after the treatment with L-threo-3,4-dihydroxyphenylserine (DOPS). Since the increase of NGF is not blocked by the treatment with decarboxylase inhibitor, DOPS may have direct effect to increase the NGF content. ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740227

    authors: Lee TH,Abe K,Nakamura M,Kogure K,Itoyama Y

    更新日期:1994-06-01 00:00:00

  • Angiogenic capacity of human omental stem cells.

    abstract:OBJECTIVES:The goals of the present study are to obtain, expand and characterize a stem cell population from human omentum and to evaluate its in vivo angiogenic capacities. METHODS:Human omental CD34+ cells were obtained from samples of human omentum by density gradient centrifugation in Ficoll. Proliferative pattern...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X63674

    authors: García-Gómez I,Goldsmith HS,Angulo J,Prados A,López-Hervás P,Cuevas B,Dujovny M,Cuevas P

    更新日期:2005-12-01 00:00:00

  • A comparative study on clinical characterizations between acute myelitis onset of neuromyelitis optica spectrum disease and idiopathic transverse myelitis.

    abstract:BACKGROUND/AIMS:Both of neuromyelitis optica spectrum disease (NMOSDs) and idiopathic transverse myelitis (ITM) could present as acute transverse myelitis. However, long-term immunological treatment and prognosis are different for high recurrence of NMOSDs. In this study, we summarized clinical differences between acut...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1773628

    authors: Liu Z,Xie M,Lu Z,Zhang C,Chen H,Xu Y,Zhang M

    更新日期:2020-07-01 00:00:00

  • Predictors of early vs. late permanent shunt insertion after aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:Numerous studies have identified different predictors for secondary hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH), although predictors regarding timing of the shunt operation have never been reported. Predictors for an early shunt, which was defined as a shunt operation performed ≤30 days after...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1199184

    authors: Shigematsu H,Sorimachi T,Osada T,Aoki R,Srivatanakul K,Oda S,Matsumae M

    更新日期:2016-07-01 00:00:00

  • Posterior microendoscopic surgical approach for the degenerative cervical spine.

    abstract::We describe the advantages and clarify the technical key points of a microendoscopic, minimally invasive technique to the posterior surgical approach for cervical degenerative disease. The authors studied the microendoscopic posterior approach using the METRx system in both cadaver models and in clinical cases. This n...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164103101201058

    authors: Yuguchi T,Nishio M,Akiyama C,Ito M,Yoshimine T

    更新日期:2003-01-01 00:00:00

  • Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow.

    abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1457130

    authors: Tsutsui S,Nanba T,Yoshioka Y,Sasaki M,Fujiwara S,Kobayashi M,Yoshida K,Miyoshi K,Sato S,Ogasawara K

    更新日期:2018-08-01 00:00:00

  • Straight from the horse's mouth: neurological injury in equestrian sports.

    abstract:OBJECTIVES:Equestrian sports can result in a variety of injuries to the nervous system due to many factors. We describe our series of 80 patients with injuries sustained during participation in equestrian sports. METHODS AND RESULTS:All patients seen at the regional trauma center with injuries associated with equestri...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000373

    authors: Srinivasan V,Pierre C,Plog B,Srinivasan K,Petraglia AL,Huang JH

    更新日期:2014-10-01 00:00:00

  • Quantitative analysis of early postoperative cerebral blood flow contributes to the prediction and diagnosis of cerebral hyperperfusion syndrome after revascularization surgery for moyamoya disease.

    abstract:OBJECTIVE:Cerebral hyperperfusion syndrome (HPS) is a potential complication of extracranial-intracranial (EC-IC) bypass for moyamoya disease; however, the pathological threshold of the early cerebral blood flow (CBF) increases after EC-IC bypass has yet to be determined. The purpose of this study is to evaluate the pr...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000432

    authors: Fujimura M,Niizuma K,Endo H,Sato K,Inoue T,Shimizu H,Tominaga T

    更新日期:2015-02-01 00:00:00

  • Differentiation of HT22 neurons induces expression of NMDA receptor that mediates homocysteine cytotoxicity.

    abstract:INTRODUCTION:Neurotoxic homocysteine (Hcy) is thought to be an independent risk factor for neurodegenerative diseases, including Alzheimer's disease. This study is to determine whether HT22 cells, a murine hippocampal neuronal model, can be used as an in vitro model, besides the primary neuronal cultures, to investiga...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132811Y.0000000057

    authors: Zhao Z,Lu R,Zhang B,Shen J,Yang L,Xiao S,Liu J,Suo WZ

    更新日期:2012-01-01 00:00:00

  • Extracellular vesicles isolated from human olfactory ensheathing cells enhance the viability of neural progenitor cells.

    abstract:OBJECTIVE:Acquired neurological diseases such as severe traumatic brain or spinal cord injury (SCI) cause irreversible disability. Olfactory ensheathing cell (OEC) transplantation has been trialed as a promising SCI treatment. Extracellular vesicles (EVs), which regulate cell-cell interactions, have recently garnered e...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1794371

    authors: Tu YK,Hsueh YH

    更新日期:2020-11-01 00:00:00

  • Acute vasoparalysis after subarachnoid haemorrhage and cerebral trauma: general reflex phenomenon?

    abstract::In patients with head trauma and consecutive acute diffuse cerebral swelling the sudden initial rise in intracranial pressure with subsequent impairment of cerebral blood flow is explained by engorgement due to vasoparalysis. How quickly hyperaemic brain swelling can occur is shown by a case report. The review of clin...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740190

    authors: Krasznai L,Grote EH

    更新日期:1994-02-01 00:00:00

  • Spatial and temporal characteristics of visual motion perception involving V5 visual cortex.

    abstract::The anatomical substrates of the perception of motion have not yet been established in a detailed way on an individual level. The aim of this study was to develop a systematic procedure for mapping the visual cortex using Transcranial Magnetic Stimulation (TMS). The results showed that such an individual and detailed ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101199891

    authors: d'Alfonso AA,van Honk J,Schutter DJ,Caffé AR,Postma A,de Haan EH

    更新日期:2002-04-01 00:00:00

  • Sphenoorbital meningiomas: surgical management and outcome.

    abstract:OBJECTIVE:Surgical management of sphenoorbital meningiomas ranges among the most complex of intracranial tumors. We report on our experience of surgical technique, outcome, and tumor recurrence in sphenoorbital meningiomas. METHODS:Between 2003 and 2013, surgical resections for sphenoorbital meningioma were performed ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132814Y.0000000329

    authors: Forster MT,Daneshvar K,Senft C,Seifert V,Marquardt G

    更新日期:2014-08-01 00:00:00

  • Alteration of aminergic neurotransmitter release after two consecutive transient global ischaemias: an in vivo microdialysis study in rat.

    abstract::This study was designed to evaluate the effects of two consecutive ischaemias on extracellular monoaminergic neurotransmitter concentrations. The data on the neuroamine changes induced by the second ischaemia could be used to assess the delay in aminergic neurotransmission subsequent to the primary injury. Dopamine (D...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740134

    authors: Decombe R,Bentué-Ferrer D,Allain H,Van den Driessche J

    更新日期:1993-06-01 00:00:00

  • Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits.

    abstract:OBJECTIVES:Although magnesium is a well-known treatment for vasospasm following subarachnoid hemorrhage, its mechanism of action for cerebral vascular relaxation is not clear. In addition, it is known that L-type calcium (Ca(2+)) channels play a pivotal role in smooth muscle contraction. To investigate the role of L-t...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000016

    authors: Sharma N,Cho DH,Kim SY,Bhattarai JP,Hwang PH,Han SK

    更新日期:2012-04-01 00:00:00

  • Protective effect of low molecular weight polyethylene glycol on the repair of experimentally damaged neural membranes in rat's spinal cord.

    abstract:OBJECTIVES:Membrane disruption is one of the main factors that cause axonal damage and functional deficits manifested in spinal cord injury (SCI). In this study, we used polyethylene glycol (PEG) to induce immediate membrane sealing and to promote functional recovery after SCI. METHODS:The effects of PEG (200-2000 Da)...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000133

    authors: Kouhzaei S,Rad I,Mousavidoust S,Mobasheri H

    更新日期:2013-05-01 00:00:00

  • Can safe and radical resection of all types of parasagittal meningiomas be achievable? -the introduction of a simplified surgical strategy.

    abstract::Background: Surgery of parasagittal meningiomas (PSMs) is still technically challenging, for the balance between radical resection and preservation of venous circulation. In this article, we'd systemically introduce the technical nuances of a simplified strategy for radical resection of all types of PSMs. All the case...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1847530

    authors: Zhang N,Yang T,Hameed F,Zhang X,Yao Y,Li D,Li C,Yu S,Xu Y,Xia C,Fu X

    更新日期:2020-11-11 00:00:00

  • Effects of conditioning peripheral repetitive magnetic stimulation in patients with complex regional pain syndrome.

    abstract:OBJECTIVES:We tested whether repetitive magnetic stimulation (rMS) induces an afferent input to the spinocerebral tract in patients with complex regional pain syndrome (CRPS). METHODS:Cortical and spinal motor evoked potentials (cMEP and sMEP), as well as the contra- and ipsilateral silent period (cCSP and iCSP), were...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1179/016164105X17224

    authors: Krause P,Foerderreuther S,Straube A

    更新日期:2005-06-01 00:00:00

  • Evaluation of cerebral autoregulation following diffuse brain injury in rats.

    abstract::The normal cerebral circulation has the ability to maintain a stable cerebral blood flow over a wide range of cerebral perfusion pressures and this is known as cerebral autoregulation. This autoregulation may be impaired in the injured brain. Closed head injury was induced in 28 Sprague-Dawley rats weighing 400-450 g....

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740832

    authors: Prat R,Markiv V,Dujovny M,Misra M

    更新日期:1997-08-01 00:00:00

  • Head registration techniques for image-guided surgery.

    abstract::Localization of the pathological structures in relation to the surrounding anatomy and understanding of the surgical anatomy are probably the most important keys to successful neurosurgery. Image-guided surgery is an important tool for understanding an individual's anatomy and for precisely locating the lesion. Head r...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740481

    authors: Alp MS,Dujovny M,Misra M,Charbel FT,Ausman JI

    更新日期:1998-01-01 00:00:00

  • N omega-nitro-L-arginine attenuates early ischemic neuronal damage of prolonged focal cerebral ischemia and recirculation in rats.

    abstract::The present study aimed to examine the effects of N omega-nitro-L-arginine (LNA) on the early ischemic neuronal damage (EIND). All the experiments were carried out under general anesthesia, maintaining the blood gases and the body temperature within the physiological ranges. The local CBF, the topographically correspo...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740795

    authors: Matsui T,Nagafuji T,Mori T,Asano T

    更新日期:1997-04-01 00:00:00

  • Odontoid calcification and crowned dens syndrome: data from a Chinese center.

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    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1792700

    authors: Lu PL,Niu ZF,Qiu CW,Hu XY

    更新日期:2020-11-01 00:00:00

  • Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine-dihydropyridine hybrid molecule.

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  • Relation of supersensitivity to cerebral vasospasm induced by oxyhaemoglobin.

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    pub_type: 杂志文章

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    authors: Iwai R,Kamiyama K,Nagahori T,Ohtsuji T,Endo S,Takaku A

    更新日期:1988-09-01 00:00:00

  • Thrombosis and recanalization of symptomatic nongiant saccular aneurysm.

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    authors: Cohen JE,Rajz G,Umansky F,Spektor S

    更新日期:2003-12-01 00:00:00

  • The lack of influence of IVS5-91 G>A polymorphism of the SCN1A gene on efficacy of lamotrigine in patients with focal epilepsy.

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    authors: Markovic I,Pejanovic-Skobic N,Bozina N,Susak Sporis I,Sporis D,Basic S

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