Abstract:
:Acute blood-brain barrier (BBB) opening in cerebral ischemia is an often observed but seldom studied phenomenon. Increased permeability has been implicated with several consequences including exacerbating ischemic injury, leading to hemorrhagic transformation (HT) and also predictive of chronic damage and a way of delivering therapeutics to the diseased parts of brain. Very few studies have investigated the 'size' of such acute openings. Herein the blood-brain distribution of fluorescent isothiocyanate (FITC)- labeled red blood cells (RBCs; approximately 5 tm in diameter) and two different sized plasma flow markers in cerebral microvessels was studied by laser scanning confocal microscopy (LSCM) 6 and 24 hours after the onset of a 3 hour period of focal ischemia. At hour 6, Evans blue-tagged albumin [EB-Alb; molecular weight (MW)= 68 kDa, Stokes-Einstein radius=37 A], a marker of both plasma flow and BBB opening, was seen both inside and around microvessels whereas the RBCs were only intravascular. FITC-labeled dextran (FITC-dextran; MW=2000 kDa, Stokes-Einstein radius = approximately 150 A), another plasma flow tracer, had not leaked across the BBB into the tissue at this time. At hour 24, both RBCs and FITC-dextran were found extravascularly along with EB-Alb. We postulate that smaller sized openings in BBB at hour 6 limited the leaking of the two large tracers (RBCs and FITC-dextran) and that such size-dependency was lost by 24 hours with the progression of the ischemic injury.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Nagaraja TN,Keenan KA,Brown SL,Fenstermacher JD,Knight RAdoi
10.1179/174313206X153815subject
Has Abstractpub_date
2007-01-01 00:00:00pages
78-80issue
1eissn
0161-6412issn
1743-1328journal_volume
29pub_type
杂志文章abstract::Predictions from a structured cortical model led us to test the hypothesis that music training enhances young children's spatial-temporal reasoning. Seventy-eight preschool children participated in this study. Thirty-four children received private piano keyboard lessons, 20 children received private computer lessons, ...
journal_title:Neurological research
pub_type: 杂志文章
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abstract::Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP.Methods: A total of 36 male Sprague-Dawley rats were divi...
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journal_title:Neurological research
pub_type: 杂志文章
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journal_title:Neurological research
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doi:10.1080/01616412.1981.11739608
更新日期:1981-01-01 00:00:00
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journal_title:Neurological research
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更新日期:1994-08-01 00:00:00
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doi:10.1080/01616412.2017.1281196
更新日期:2017-04-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172284
更新日期:2007-01-01 00:00:00
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doi:10.1179/016164103101201175
更新日期:2003-03-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2010-07-01 00:00:00
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更新日期:2006-10-01 00:00:00
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doi:10.1179/016164101101198992
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pub_type: 临床试验,杂志文章
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更新日期:2012-12-01 00:00:00
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doi:10.1179/016164107X172167
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1990.11739941
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更新日期:2012-07-01 00:00:00
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/01616412.2000.11740733
更新日期:2000-09-01 00:00:00