Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.

Abstract:

OBJECTIVES:We attempted to determine whether a functional polymorphism of TRPM6 (rs2274924) is associated with susceptibility to epilepsy following ischemic stroke, and to further explore the effect of this polymorphism on serum levels of Mg2+ in post-stroke patients. METHODS:We carried out a case-control study on 378 post-stroke epilepsy patients and 420 controls (stroke patients without secondary epilepsy). We used DNA sequencing to determine the genotypes of the TRPM6 rs2274924 polymorphism, and used the ion selective electrode method to measure serum levels of Mg2+. RESULTS:The distribution of the CC genotype and the frequency of the C allele were significantly higher in the post-stroke epilepsy patients than in the controls (P < 0.01). With regard to the post-stroke epilepsy patients, the serum levels of Mg2+ decreased significantly in the TRPM6 rs2274924 C allele carriers compared to the rs2274924 T allele carriers. CONCLUSION:The TRPM6 rs2274924 polymorphism may be associated with susceptibility to epilepsy following stroke, and the C allele may be associated with increased risk of post-stroke epilepsy. The TRPM6 rs2274924 polymorphism may also influence serum levels of Mg2+ in post-stroke epilepsy patients.

journal_name

Neurol Res

journal_title

Neurological research

authors

Fu CY,Chen SJ,Cai NH,Liu ZH,Zhang M,Wang PC,Zhao JN

doi

10.1080/01616412.2019.1568755

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

378-383

issue

4

eissn

0161-6412

issn

1743-1328

journal_volume

41

pub_type

杂志文章
  • Distribution of artificial cerebral microemboli in stroke patients with patent foramen ovale.

    abstract:OBJECTIVES:Patent foramen ovale (PFO) is considered as an important risk factor for cerebrovascular diseases. Nevertheless, the relationship between the distribution of high-intensity transient signals (HITS), resulting from injection of air mixed with saline and detected by transcranial Doppler (TCD), and clinical cer...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X18458

    authors: Telman G,Kouperberg E,Sprecher E,Goldsher D,Yarnitsky D

    更新日期:2005-01-01 00:00:00

  • Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle.

    abstract:OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164108X323717

    authors: Oishi A,Tobimatsu S,Ogata K,Taniwaki T,Kinukawa N,Toyoshiba H,Kira J

    更新日期:2008-12-01 00:00:00

  • Bone marrow mesenchymal stem cells can improve the motor function of a Huntington's disease rat model.

    abstract:OBJECTIVES:The purpose of this study was to investigate the ability of bone marrow mesenchymal stem cells (BMSCs) to survive in the striatum and improve motor function in the quinolinic acid (QA) lesion rat model of Huntington's disease (HD). METHODS:One week following QA lesioning of the striatum, rats were transplan...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12816242542571

    authors: Jiang Y,Lv H,Huang S,Tan H,Zhang Y,Li H

    更新日期:2011-04-01 00:00:00

  • Protocol-directed weaning from mechanical ventilation in neurological patients: a randomised controlled trial and subgroup analyses based on consciousness.

    abstract:OBJECTIVES:To assess whether a weaning protocol reduces the mechanical ventilation (MV) duration compared to physician's judgement-based weaning in neurological patients and to determine whether patient consciousness influences this reduction. METHODS:A randomised controlled trial was conducted in a neurological inten...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1743132815Y.0000000092

    authors: Fan L,Su Y,Elmadhoun OA,Zhang Y,Zhang Y,Gao D,Ye H,Chen W

    更新日期:2015-11-01 00:00:00

  • Suboptimal awareness and control of hypertension increases the risk of subarachnoid hemorrhage in the community: results from the ACROSS.

    abstract:BACKGROUND:High blood pressure (BP) is a major risk factor for stroke and all of its pathological subtypes including subarachnoid hemorrhage (SAH). However, there is little evidence demonstrating whether failure to have regular BP measured could result in underestimation of people at risk for SAH. Therefore, we aimed ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132811Y.0000000020

    authors: Shiue I,Hankey GJ,Arima H,Anderson CS

    更新日期:2011-12-01 00:00:00

  • Detection of experimentally induced brain tumors in rats using high resolution computed tomography.

    abstract:OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X18250

    authors: Psarros TG,Mickey B,Giller C

    更新日期:2005-01-01 00:00:00

  • Prognostic value of perfusion-weighted magnetic resonance imaging in acute intracerebral hemorrhage.

    abstract:OBJECTIVE:This study intends to investigate the prognostic value of perfusion-weighted magnetic resonance imaging in acute intracerebral hemorrhage. METHODS:Demographic, clinical and biochemical data between acute intracerebral hemorrhage (AICH) and healthy volunteer groups were assessed in this study, such as rCBV an...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1177932

    authors: Hu X,Bai X,Zai N,Sun X,Zhu L,Li X

    更新日期:2016-07-01 00:00:00

  • Fetal striatal homotransplantation for Huntington's disease: first two case reports.

    abstract::Based on the successful use of fetal striatal brain grafting in the restoration of striatal function in rat and nonhuman primate models of Huntington's disease, as well as on the evidence for the clinical potential of fetal brain grafting in the treatment of Parkinson's disease, homotopic fetal striatal homotransplant...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1995.11740334

    authors: Madrazo I,Franco-Bourland RE,Castrejon H,Cuevas C,Ostrosky-Solis F

    更新日期:1995-08-01 00:00:00

  • Combined preoperative onyx embolization and protective internal carotid artery covered stent placement for treatment of glomus vagale tumor: review of literature and illustrative case.

    abstract:OBJECTIVE:Surgical resection of complex glomus vagale tumors can be complicated by extensive blood loss and might require surgical sacrifice of an encased internal carotid artery. METHODS:A young patient presented with mass effect from glomus valage tumor. Computerized tomography angiography showed an encased interna...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/1743132812Y.0000000036

    authors: Alaraj A,Pytynia K,Carlson AP,Krishna PH,Charbel FT,Amin-Hanjani S,Aletich V

    更新日期:2012-07-01 00:00:00

  • Protective effect of low molecular weight polyethylene glycol on the repair of experimentally damaged neural membranes in rat's spinal cord.

    abstract:OBJECTIVES:Membrane disruption is one of the main factors that cause axonal damage and functional deficits manifested in spinal cord injury (SCI). In this study, we used polyethylene glycol (PEG) to induce immediate membrane sealing and to promote functional recovery after SCI. METHODS:The effects of PEG (200-2000 Da)...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000133

    authors: Kouhzaei S,Rad I,Mousavidoust S,Mobasheri H

    更新日期:2013-05-01 00:00:00

  • Role of the endothelium on extraluminal and intraluminal vasoactive mechanisms in the perfused rabbit basilar artery.

    abstract::In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740128

    authors: Ogawa R,Ohta T,Tsuji M,Mori M

    更新日期:1993-06-01 00:00:00

  • Iodine-125 interstitial irradiation of virally induced dog brain tumours.

    abstract::Brain tumours were induced by intracerebral inoculation of beagle puppies with Avian sarcoma virus (ASV) suspension. The inoculation produced solitary or multiple sarcomas in three dogs and intraventricular anaplastic gliomas in four dogs. At the time of the first tumour positive CT-control Iodine-125 seeds (activity ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1984.11739685

    authors: Ostertag CB,Warnke P,Kleihues P,Bigner DD

    更新日期:1984-12-01 00:00:00

  • Evaluation of the regional cerebral vasodilatory capacity before carotid endarterectomy by the acetazolamide test.

    abstract::To estimate the regional perfusion pressure and possibly the stump pressure during carotid endarterectomy, cerebral blood flow (CBF) measurements including a vasodilatory test were performed preoperatively. CBF was measured by 133Xe inhalation and emission tomography. An intravenous dose of 1g acetazolamide (Diamox) w...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1987.11739765

    authors: Vorstrup S,Boysen G,Brun B,Engell HC

    更新日期:1987-03-01 00:00:00

  • Simultaneous recording of tissue PCO2, interstitial pH and potassium activity in the rat cerebral cortex during anoxia and the subsequent recovery period.

    abstract::Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1989.11739882

    authors: Ohno M,Obrenovitch TP,Hartell N,Barratt S,Bachelard HS,Symon L

    更新日期:1989-09-01 00:00:00

  • Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson's disease subjects.

    abstract:OBJECTIVES:Parkinson's disease (PD) afflicts approximately 1-2% of the population over 50 years of age. No cures or effective modifying treatments exist and clinical diagnosis is currently confounded by a lack of definitive biomarkers. We sought to discover potential biomarkers in the cerebrospinal fluid (CSF) of neuro...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000063

    authors: Maarouf CL,Beach TG,Adler CH,Shill HA,Sabbagh MN,Wu T,Walker DG,Kokjohn TA,Roher AE,Arizona PD Consortium.

    更新日期:2012-09-01 00:00:00

  • Relationship between the states of spinal impact injuries and magnetically evoked EMGs in rats.

    abstract::The relationship between the states of spinal impact injuries and magnetically evoked electromyograms (EMGs) were studied in rats. Impact injuries to the spinal cord were induced at a depth of 0.25-2.0 mm by insertion of a cylinder tip measuring 2 mm in diameter into the lumbar vertebrae L1-L2. Magnetically induced el...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2000.11740747

    authors: Chiba A,Hiruma S,Hashimoto S,Inase M

    更新日期:2000-10-01 00:00:00

  • Effects of tetrahydrobiopterin on cerebral infarction after transient focal ischemia in rats.

    abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12700393823651

    authors: Tang LL,Zheng JS

    更新日期:2011-12-01 00:00:00

  • Induction of PML immunoreactivity in rat brain neurons after transient middle cerebral artery occlusion.

    abstract::Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164101101199162

    authors: Hayashi T,Sasaki C,Iwai M,Sato K,Zhang WR,Warita H,Abe K

    更新日期:2001-10-01 00:00:00

  • Influence of biological factors on changes in mean cerebral blood flow velocity in normal ageing: a transcranial Doppler study.

    abstract::Analysis of the blood flow velocities in the middle cerebral artery by transcranial Doppler ultrasonography was performed in 158 healthy volunteers (aged 14-70 years; 82 men and 76 women). In a subgroup of 38 men and 21 women the end-tidal [CO2] was also measured. The influence of biological factors such as age, sex, ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1990.11739941

    authors: Ackerstaff RG,Keunen RW,van Pelt W,Montauban van Swijndregt AD,Stijnen T

    更新日期:1990-09-01 00:00:00

  • Immunomodulatory effectiveness of azithromycin in prevention of postlaminectomy epidural fibrosis.

    abstract:OBJECTIVE:One of the important causes of failed back surgery is the extensive peridural fibrosis collecting in the surgical field after spinal surgeries. Today we know that inflammatory mechanisms mediated by the immune system of the body plays an important role in generation of fibrosis. Azithromycin, a macrolide anti...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12767786356471

    authors: Emmez H,Börcek AÖ,Durdağ E,Uyar PG,Kaymaz M,Aykol S

    更新日期:2011-05-01 00:00:00

  • Effect of Fluosol-DA and hetastarch on local cerebral blood flow, cortical O2 availability and computerized EEG data during cerebral ischaemia.

    abstract::This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monke...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1990.11739906

    authors: Tranmer BI,Iacobacci R,Feiler S

    更新日期:1990-03-01 00:00:00

  • The nutritional management of patients with head injuries.

    abstract::Severe head injuries tend to be associated with hypermetabolism and hypercatabolism resulting in negative nitrogen balances which may exceed 30 grams day-1. Enteral feeding should begin as soon as the patient is hemodynamically stable, attempting to reach a non-protein caloric intake of at least 30-35 kcal kg-1 day-1 ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164101101198451

    authors: Wilson RF,Dente C,Tyburski JG

    更新日期:2001-03-01 00:00:00

  • The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis.

    abstract::Although neuronal death has been studied in experimental models of ischemia, the precise mechanisms regulating cell death remain unclear. Furthermore, the timing and pattern of neuronal death in human stroke has not been extensively studied. To further our understanding of ischemia-induced neuronal death, we examined ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740520

    authors: Guglielmo MA,Chan PT,Cortez S,Stopa EG,McMillan P,Johanson CE,Epstein M,Doberstein CE

    更新日期:1998-06-01 00:00:00

  • Alteration of aminergic neurotransmitter release after two consecutive transient global ischaemias: an in vivo microdialysis study in rat.

    abstract::This study was designed to evaluate the effects of two consecutive ischaemias on extracellular monoaminergic neurotransmitter concentrations. The data on the neuroamine changes induced by the second ischaemia could be used to assess the delay in aminergic neurotransmission subsequent to the primary injury. Dopamine (D...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740134

    authors: Decombe R,Bentué-Ferrer D,Allain H,Van den Driessche J

    更新日期:1993-06-01 00:00:00

  • Silent cerebral ischemic lesions after carotid artery stenting with distal cerebral protection.

    abstract:OBJECTIVE:To evaluate by MR diffusion weighted image (DWI-MR) the presence of new ischemic cerebral lesions after carotid artery stenting (CAS) and distal cerebral protection, in patients with internal carotid artery (ICA) stenosis >70. METHODS:Sixty-seven CAS were performed under cerebral protection with a distal fil...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X35431

    authors: González A,Piñero P,Martínez E,González-Marcos JR,Rafel E,Mayol A,Gil-Peralta A

    更新日期:2005-01-01 00:00:00

  • Temporo-polar approach to aneurysms of the basilar artery at and around the distal bifurcation: technical note.

    abstract::An approach to aneurysms arising at the bifurcation of the basilar artery and its neighborhood is described. The temporal pole of the nondominant side is retracted posteriorly to provide a wide operative field and a better view of aneurysms. ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1980.11739588

    authors: Sano K

    更新日期:1980-01-01 00:00:00

  • Atherosclerotic plaque burden of middle cerebral artery and extracranial carotid artery characterized by MRI in patients with acute ischemic stroke in China: association and clinical relevance.

    abstract:OBJECTIVES:This study sought to compare the atherosclerotic plaque burden between middle cerebral artery (MCA) and extracranial carotid artery (ECA) in ischemic stroke patients using high-resolution, black-blood (HR BB) MRI and to investigate the relationship between plaque burden found in both arteries and stroke seve...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2017.1281196

    authors: Cao Y,Sun Y,Zhou B,Zhao H,Zhu Y,Xu J,Liu X

    更新日期:2017-04-01 00:00:00

  • Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine-dihydropyridine hybrid molecule.

    abstract:OBJECTIVES:The aim of this study was to investigate the effects of oral administration of a novel benzodiazepine derivative, JM-20, on the neurological behavior of different rodent models, focusing on the GABAergic effect. We have also investigated the acute toxicity of oral administration of JM-20 in mice. METHODS:Mi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000216

    authors: Figueredo YN,Rodríguez EO,Reyes YV,Domínguez CC,Parra AL,Sánchez JR,Hernández RD,Verdecia MP,Pardo Andreu GL

    更新日期:2013-10-01 00:00:00

  • Early decrease of P-glycoprotein in the endothelium of the rat brain capillaries after moderate dose of irradiation.

    abstract::In this study, we examined the degree of disruption of blood-brain barrier (BBB) in irradiated rat brains using P-glycoprotein, one of the functional molecules of BBB, as a marker. In the animal experiments, disruption of BBB has been mainly studied at the acute stage of brain edema caused by a lethal dose of irradiat...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740920

    authors: Mima T,Toyonaga S,Mori K,Taniguchi T,Ogawa Y

    更新日期:1999-03-01 00:00:00

  • Microsurgical approach for symptomatic brain AVMs - single center experience.

    abstract::Objectives: Brain arteriovenous malformations (AVMs) represent high-flow vascular lesions made up of a complex network of feeding arteries and draining veins interposed by a nidus and without a capillary bed. The management of the AVMs represents a challenge, and the optimal treatment should be considered based on the...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1803604

    authors: Gorgan RM,Petrescu GED,Brehar FM

    更新日期:2020-12-01 00:00:00