Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult.

abstract：:Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...

journal_title：Neurological research

authors： Soehle M,Jaeger M,Meixensberger J

更新日期：2003-06-01 00:00:00

abstract：:Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equ...

journal_title：Neurological research

authors： Ohno M,Obrenovitch TP,Hartell N,Barratt S,Bachelard HS,Symon L

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...

journal_title：Neurological research

authors： Hou D,Liu J,Feng R,Gao Y,Wang Y,Wu J

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...

journal_title：Neurological research

authors： Liebetrau M,Burggraf D,Büscher C,Linz W,Hamann GF

更新日期：2005-07-01 00:00:00

abstract：:Spinal cord neuron and dorsal column fiber responses to electrical stimulation of the sciatic nerve in anesthetized cats were recorded before, during, and after periods of repetitive electrical stimulation of the sciatic nerve through an implantable nerve cuff stimulator device of the type and method used in human pat...

journal_title：Neurological research

authors： Ignelzi RJ,Nyquist JK,Tighe WJ Jr

更新日期：1981-01-01 00:00:00

abstract：:The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...

journal_title：Neurological research

authors： Christensen JC

更新日期：1987-09-01 00:00:00

abstract：:Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....

journal_title：Neurological research

authors： Ildan F,Göçer AI,Tuna M,Polat S,Kaya M,Isbir T,Cetinalp E

更新日期：2001-01-01 00:00:00

abstract：:Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...

journal_title：Neurological research

authors： Zunker P,Haase C,Borggrefe M,Georgiadis D,Georgiadis A,Ringelstein EB

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:This study investigated the relationship between traumatic coagulopathy and severe brain swelling (SBS) during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury (TBI). METHODS:A retrospective study was conducted in 96 patients who consecutively ...

journal_title：Neurological research

authors： Wang K,Xue Y,Chen X,Zhou B,Lou M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family. In this family, male patients were moderately to severely affected. METHODS:We performed immunofluorescence to ...

journal_title：Neurological research

authors： Da Y,Wang W,Liu Z,Chen H,Di L,Previch L,Chen Z

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:In about 10% of glioblastoma patients, preoperative MRI discloses the presence of tumor cysts. Whereas the impact of cystic appearance on prognosis has been discussed extensively, only little is known about the tumor cyst fluid. In this study, we tested the feasibility of the surface enhanced laser desorptio...

journal_title：Neurological research

authors： Hoelscher M,Richter N,Melle C,von Eggeling F,Schaenzer A,Nestler U

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Neurovascular ultrasound (nUS) is widely used as a screening and monitoring tool in patients with spontaneous cervical artery dissection (sCAD). The aim of the study was to describe the sonographical course of the affected arteries in patients with a MRI-proven sCAD by repetitive nUS. METHODS:Thirty-seven co...

journal_title：Neurological research

authors： Sengelhoff C,Nebelsieck J,Nassenstein I,Maintz D,Nabavi DG,Kuhlenbaeumer G,Ringelstein EB,Dittrich R

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:Surgical management of tumors in the sacropelvic region is a challenging field of spine surgery because of the region's complex local anatomy and biomechanics. Recent developments in anesthesia and intensive care have allowed us to perform extended surgeries focused on the en bloc resection of sacropelvic tu...

journal_title：Neurological research

authors： Varga PP,Szoverfi Z,Lazary A

更新日期：2014-06-01 00:00:00

abstract：:Following cerebral ischemia, the extracellular concentration of excitatory amino acids increases, and the excitatory cell death may play an important role contributing to ischemic neuronal damage. Although sequential metabolic changes in permanent local cerebral ischemia have been reported, the effect of reperfusion i...

journal_title：Neurological research

authors： Liu Y,Mituska S,Hashizume K,Hosaka T,Nukui H

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production. The present study examined if thrombin modulates vascular endoth...

journal_title：Neurological research

authors： Xu Y,Gu Y,Keep RF,Heth J,Muraszko KM,Xi G,Hua Y

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:The role of inflammation in cognitive alterations in a post-operative setting is still not fully understood. Surgical interventions can cause systemic inflammations which eventually can induce neuroinflammation. However, the main causes of functional changes after surgery are still elusive. In this study, we ...

journal_title：Neurological research

authors： Schnitzler S,Kopitz J,Plaschke K

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METH...

journal_title：Neurological research

authors： Tang J,Li YJ,Mu J,Li Q,Yang DY,Xie P

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Cerebrospinal fluid (CSF) oligoclonal bands (OB) imply intrathecal immunoglobulin synthesis and B-cell immune process. There is scarce evidence of OB having a role in disease prognosis. The objective of the present study was to determine OB's prognostic value regarding disease progression. METHODS:Betwee...

journal_title：Neurological research

authors： Rojas JI,Tizio S,Patrucco L,Cristiano E

更新日期：2012-11-01 00:00:00

abstract：:No marker that predicts accurately the time of occurrence of cerebral vasospasm due to subarachnoid hemorrhage (SAH) has been reported. In the present study, membrane-bound tissue factor (mTF) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) were evaluated as a predictor of the time of occurr...

journal_title：Neurological research

authors： Hirashima Y,Endo S,Nakamura S,Kurimoto M,Takaku A

更新日期：2001-10-01 00:00:00

abstract：:Intraoperative use of somatosensory evoked potentials (SEP's) to monitor intracranial aneurysm surgery and flash visual evoked potentials (F-VEP's) for parasellar surgery have been routinely employed in our clinic. We found that both EP modalities are sensitive to the changing concentration of our standard hypotensive...

journal_title：Neurological research

authors： Wang AD,Costa e Silva I,Symon L,Jewkes D

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:To review the historical development and current status of endovascular techniques used in the treatment of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. METHODS:This article summarizes the relevant literature on neurointerventional therapy for vasospasm, namely instillation of intraar...

journal_title：Neurological research

authors： Brisman JL,Eskridge JM,Newell DW

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To explore the risk factors for stroke-associated pneumonia (SAP). METHODS:A retrospective research study was carried out to investigate the clinical data of 1435 patients admitted to the neurological intensive care unit at our university hospital between 1 January 2000 and 31 December 2009. RESULTS:A multi...

journal_title：Neurological research

authors： Sui R,Zhang L

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:Our objective was to characterize the heat shock response (HSR) in a model of traumatic brain injury (TBI) and to determine the association of HSR to cell death. METHODS:We used immunofluorescent detection of HSP-70 to characterize HSR and TUNEL labeling to determine the pattern of cell death. RESULTS:HSP-...

journal_title：Neurological research

authors： DeGracia DJ,Kreipke CW,Kayali FM,Rafols JA

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...

journal_title：Neurological research

authors： Tang LL,Zheng JS

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...

journal_title：Neurological research

authors： Reed LK,Wen J,Liang B,Wang X,Feng D,Huang JH

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...

journal_title：Neurological research

authors： Balser D,Rodgers SD,Johnson B,Shi C,Tabak E,Samadani U

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The amyloid hypothesis stimulates the discovery of compounds, which promotes beta-amyloid peptide (Aβ) clearance, thereby altering the underlying pathophysiology of Alzheimer's disease (AD). Hence, the present study aims at the evaluation of anti-amyloidogenic potential of Gelidiella acerosa. METHODS:Prevent...

journal_title：Neurological research

authors： Syad AN,Devi KP

更新日期：2015-01-01 00:00:00

abstract：:Aspirin therapy for stroke prophylaxis in low risk patients has paradoxically demonstrated an increased risk of ischemic stroke in several studies. Moreover, the MAST-Italy trial reported a near doubling of mortality with the addition of aspirin to thrombolytics while experimentally, we have noted that aspirin antagon...

journal_title：Neurological research

authors： Bednar MM,Gross CE

更新日期：1999-07-01 00:00:00

abstract：:The potential role of magnetic resonance angiography (MRA) in clinical neurosurgical practice was evaluated in 150 consecutive patients in an attempt to define clinical situations in which it aided in diagnosis, helped guide treatment options, and/or possibly eliminated the need for conventional catheter angiography. ...

journal_title：Neurological research

authors： Awad IA,Mckenzie R,Magdinec M,Masaryk T

更新日期：1992-12-01 00:00:00

abstract：:Nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells can be increased after the treatment with L-threo-3,4-dihydroxyphenylserine (DOPS). Since the increase of NGF is not blocked by the treatment with decarboxylase inhibitor, DOPS may have direct effect to increase the NGF content. ...

journal_title：Neurological research

authors： Lee TH,Abe K,Nakamura M,Kogure K,Itoyama Y

更新日期：1994-06-01 00:00:00