Simultaneous recording of tissue PCO2, interstitial pH and potassium activity in the rat cerebral cortex during anoxia and the subsequent recovery period.


:Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equal to 7.2 to pH approximately equal to 6.5, K+e to rise from approximately equal to 2.4 up to a maximum of approximately equal to 39 mmol/l, and PtCO2 to increase from approximately equal to 52 to approximately equal to 80 mmHg. Lactate increased from 2 to 5 mmol/kg tissue weight during anoxia and did not fall significantly after re-oxygenation for 10 min. A marked relationship existed between changes in PtCO2 and H+e. After re-oxygenation, K+e (extracellular potassium ion activity) and PtCO2 returned to the pre-anoxic level in a few minutes, whereas H+e took approximately equal to 30 min to recover. H+e recovered in a biphasic manner; a rapid decrease lasting approximately equal to 1 min preceded a much slower phase. We propose that the biphasic normalization of H+e after anoxia mainly reflects an initial and rapid washout of CO2 from brain tissue and a subsequent slow elimination of lactic acid occurring via metabolism and removal by the circulation.


Neurol Res


Neurological research


Ohno M,Obrenovitch TP,Hartell N,Barratt S,Bachelard HS,Symon L




Has Abstract


1989-09-01 00:00:00












  • Reduction of nerve growth factor receptor immunoreactivity in ischaemic gerbil hippocampal CA1 neurons after treatment with L-threo-3,4-dihydroxyphenylserine (DOPS).

    abstract::Nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells can be increased after the treatment with L-threo-3,4-dihydroxyphenylserine (DOPS). Since the increase of NGF is not blocked by the treatment with decarboxylase inhibitor, DOPS may have direct effect to increase the NGF content. ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Lee TH,Abe K,Nakamura M,Kogure K,Itoyama Y

    更新日期:1994-06-01 00:00:00

  • Direct percutaneous carotid artery stenting with distal protection: technical case report.

    abstract::We describe the technique of percutaneous carotid artery stent placement with distal protection in a patient in whom marked innominate artery ectasia prevented transfemoral access to the right common carotid artery. After induction of general anesthesia, ultrasound was used to guide direct puncture of the common carot...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Perez-Arjona EA,DelProsto Z,Fessler RD

    更新日期:2004-04-01 00:00:00

  • Steroid effects on vestibular compensation in human.

    abstract::Vestibular neuritis (VN) rapidly damages unilateral vestibular periphery, inducing severe balance disorders. In most cases, such vestibular imbalance is gradually restored to within the normal level after clinical therapies. This successive clinical recovery occurs due to regeneration of vestibular periphery and/or ac...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kitahara T,Kondoh K,Morihana T,Okumura S,Horii A,Takeda N,Kubo T

    更新日期:2003-04-01 00:00:00

  • The combination of a programmable valve and a subclavicular anti-gravity device in hydrocephalus patients at high risk for hygromas.

    abstract:OBJECTIVES:In order to avoid occurrence of post-operative hygromas in specific hydrocephalus patients being at high risk of overdrainage, a combination of programmable valve and anti-gravity device is widely recommended. We analyzed our series of hydrocephalus patients implanted with such a shunt configuration focusin...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zachenhofer I,Donat M,Roessler K

    更新日期:2012-04-01 00:00:00

  • CART modulates beta-amyloid metabolism-associated enzymes and attenuates memory deficits in APP/PS1 mice.

    abstract:INTRODUCTION:Cocaine- and amphetamine-regulated transcript (CART) peptide has been demonstrated to exert neuroprotective effects in stroke and some neurodegeneration diseases. In current study, we investigated the protective effects and underlying mechanisms of CART in APP/PS1 mice. METHODS:The protein levels of CART,...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Yin K,Jin J,Zhu X,Yu L,Wang S,Qian L,Han L,Xu Y

    更新日期:2017-10-01 00:00:00

  • In vitro and in vivo experiments of a novel intra-arterial neurovascular decompressor for treating neurovascular compression syndromes: a brief report.

    abstract::Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Chun Y,Chen Y,Elsisy M,Sukinik J,Shridhar P,Park JK,Kim YB,Hong CK,Chung J

    更新日期:2019-07-01 00:00:00

  • Transsphenoidal surgery for visual loss in patients with pituitary adenomas.

    abstract::This paper presents the results of transsphenoidal surgery in 41 consecutive patients with visual loss from pituitary adenomas. The most common pattern of loss was bitemporal hemianopia. Transsphenoidal decompression resulted in visual improvement in 78% of patients. If patients with optic atrophy and pre-operative co...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: el-Azouzi M,Black PM,Candia G,Zervas NT,Panagopoulos KP

    更新日期:1990-03-01 00:00:00

  • Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study.

    abstract:BACKGROUND AND PURPOSE:Stroke is a multi-factorial disease influenced by both genetic and environmental factors. The aim of this case-control study was to determine the association between Endothelial Nitric Oxide Synthase G894T (rs1799983) gene polymorphism and susceptibility to ischemic stroke (IS) in North Indian po...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Kumar A,Misra S,Kumar P,Sagar R,Prasad K,Pandit AK,Chakravarty K,Kathuria P,Yadav AK

    更新日期:2016-07-01 00:00:00

  • Protective effect of low molecular weight polyethylene glycol on the repair of experimentally damaged neural membranes in rat's spinal cord.

    abstract:OBJECTIVES:Membrane disruption is one of the main factors that cause axonal damage and functional deficits manifested in spinal cord injury (SCI). In this study, we used polyethylene glycol (PEG) to induce immediate membrane sealing and to promote functional recovery after SCI. METHODS:The effects of PEG (200-2000 Da)...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Kouhzaei S,Rad I,Mousavidoust S,Mobasheri H

    更新日期:2013-05-01 00:00:00

  • Brain volume and perfusion asymmetry in temporal lobe epilepsy with and without hippocampal sclerosis.

    abstract:: Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zhang Y,Dou W,Zuo Z,You H,Lv Y,Hou B,Shi L,Feng F

    更新日期:2020-12-15 00:00:00

  • Humoral immune response to influenza vaccine in natalizumab-treated MS patients.

    abstract:OBJECTIVES:Natalizumab is a drug with documented efficacy in relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of natalizumab has immunosuppressive properties and it is not yet investigated if treatment with natalizumab affects the immunological response to vaccination. This study aims to investig...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Vågberg M,Kumlin U,Svenningsson A

    更新日期:2012-09-01 00:00:00

  • Effects of popliteal illumination on cerebral near-infrared spectroscopy.

    abstract::The endogenous clock of humans can be influenced by light application to the popliteal region. Previously, it had been assumed that light must fall directly into the eye in order to influence the inner circadian clock. This study, published in 1998, has not been reproduced. We investigated the effects of laser light i...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Litscher G

    更新日期:2001-12-01 00:00:00

  • Sleep promoting effects of intravenously administered acidic fibroblast growth factor.

    abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Galan JM,Cuevas B,Dujovny N,Giménez-Gallego G,Cuevas P

    更新日期:1996-12-01 00:00:00

  • Stretching and electrical stimulation regulate the metalloproteinase-2 in rat denervated skeletal muscle.

    abstract:OBJECTIVE:To evaluate the effects of electrical stimulation (ES), stretching and their combined effects in matrix metalloproteinases (MMPs) gene expression and activity during early denervation of rat tibialis anterior (TA) muscle by axonotmesis. METHODS:Thirty adult male Wistar rats were divided into five groups: no...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Peviani SM,Russo TL,Durigan JL,Vieira BS,Pinheiro CM,Galassi MS,Salvini TF

    更新日期:2010-10-01 00:00:00

  • Safely performing neurosurgical procedures during COVID-19 pandemic.

    abstract:INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Reed LK,Wen J,Liang B,Wang X,Feng D,Huang JH

    更新日期:2020-10-01 00:00:00

  • The multifunctional role of IGF-1 in peripheral nerve regeneration.

    abstract::The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cel...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Rabinovsky ED

    更新日期:2004-03-01 00:00:00

  • Is on-admission capillary blood beta-hydroxybutyrate concentration associated with the acute stroke severity and short-term functional outcome?

    abstract:OBJECTIVES:In conditions with reduced glucose levels/inability of glucose utilization, ketone bodies, especially beta-hydroxybutyrate (BHB), become a major energy source in the brain. In animal models, BHB infusion shows acute beneficial effects on the hypoxic brain. The present prospective observational study is the f...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Pikija S,Trkulja V,Simundic AM,Vrcek E,Boskovic K,Bacani S

    更新日期:2013-11-01 00:00:00

  • Role of the endothelium on extraluminal and intraluminal vasoactive mechanisms in the perfused rabbit basilar artery.

    abstract::In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Ogawa R,Ohta T,Tsuji M,Mori M

    更新日期:1993-06-01 00:00:00

  • Epidemiology of traumatic brain injuries: Indian scenario.

    abstract::Traumatic brain injuries (TBIs) are a leading cause of morbidity, mortality, disability and socioeconomic losses in India and other developing countries. Specific topics addressed in this paper include magnitude of the problem, causes, context of injury occurrence, risk factors, severity, outcome and impact of TBIs on...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Gururaj G

    更新日期:2002-01-01 00:00:00

  • Brain tumor demarcation by applying a LAMSTAR neural network to spectroscopy data.

    abstract::The application of optical spectroscopy for intra-operatively delineating brain tumors has been studied in this paper. The classification of tissue as normal, tumor and boundary is done using the LAMSTAR neural network (NN). The objective is to combine both fluorescence and reflectance as attributes to be used for the...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Sivaramakrishnan A,Graupe D

    更新日期:2004-09-01 00:00:00

  • Neuroprotective effect of basic fibroblast growth factor on wobbler mouse motor neuron disease.

    abstract::Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 1...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Ikeda K,Iwasaki Y,Tagaya N,Shiojima T,Kobayashi T,Kinoshita M

    更新日期:1995-12-01 00:00:00

  • Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI mice.

    abstract:OBJECT:The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo® application on brain injury in experimental TBI mice using S...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo D,Li D,Li J,Li Y,Hu X,Guan F,Yang B

    更新日期:2017-09-01 00:00:00

  • The effect of normothermic and hypothermic hypoxia-ischemia on brain hypoxanthine phosphoribosyl transferase activity.

    abstract:OBJECTIVES:Cerebral hypoxia-ischemia leads to the depletion of ATP. Hypoxanthine, a degradation product of ATP, can be salvaged by hypoxanthine phosphoribosyl transferase (HPRT) and used to reform high-energy purines. Hypothermia conserves ATP in hypoxia-ischemia, possibly by preserving HPRT activity. We hypothesized t...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Cherin T,Catbagan M,Treiman S,Mink R

    更新日期:2006-12-01 00:00:00

  • Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status.

    abstract:OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Stark AM,Schem C,Maass N,Hugo HH,Jonat W,Mehdorn HM,Held-Feindt J

    更新日期:2010-04-01 00:00:00

  • Application of magnetic resonance angiography to neurosurgical practice: a critical review of 150 cases.

    abstract::The potential role of magnetic resonance angiography (MRA) in clinical neurosurgical practice was evaluated in 150 consecutive patients in an attempt to define clinical situations in which it aided in diagnosis, helped guide treatment options, and/or possibly eliminated the need for conventional catheter angiography. ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Awad IA,Mckenzie R,Magdinec M,Masaryk T

    更新日期:1992-12-01 00:00:00

  • Diffusion tensor MRI for the assessment of cerebral ischemia/reperfusion injury in the penumbra of non-human primate stroke model.

    abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo J,Zheng HB,Duan JC,He L,Chen N,Gong QY,Tang HH,Li HX,Wang L,Cheng JQ

    更新日期:2011-01-01 00:00:00

  • Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps.

    abstract:BACKGROUND:Mapping of brain perfusion using bolus tracking methods is increasingly used to assess the amount and severity of cerebral ischemia in acute stroke. Using relative perfusion maps, however, it is difficult to identify the tissue at risk-maximum (TARM) of infarction with sufficient reliability and reproducibil...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Nabavi DG,Dittrich R,Kloska SP,Nam EM,Klotz E,Heindel W,Ringelstein EB

    更新日期:2007-04-01 00:00:00

  • Cell proliferation in ependymal/subventricular zone and nNOS expression following focal cerebral ischemia in adult rats.

    abstract::Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in normal developing brain, but the role of nNOS in neurogenesis in the ischemic brain remains unclear. To investigate the temporal and spatial relationship between cell proliferation of the ependymal/subventricular zone (SVZ), a principal neuroproliferative...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zhang P,Liu Y,Li J,Kang Q,Tian Y,Chen X,Shi Q,Song T

    更新日期:2006-01-01 00:00:00

  • Carotid endarterectomy in high risk patients.

    abstract::We elected to compare the clinical outcomes of carotid endarterectomy (CEA) patients who were thought to be at increased risk for peri-operative complications because of advanced age (> 79 years), medical comorbidities and contralateral internal carotid artery occlusion to patients without these risk factors. A prospe...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Harbaugh RE,Magnadottir HB

    更新日期:2002-01-01 00:00:00

  • The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat.

    abstract::Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Ildan F,Göçer AI,Tuna M,Polat S,Kaya M,Isbir T,Cetinalp E

    更新日期:2001-01-01 00:00:00