Simultaneous recording of tissue PCO2, interstitial pH and potassium activity in the rat cerebral cortex during anoxia and the subsequent recovery period.

Abstract:

:Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equal to 7.2 to pH approximately equal to 6.5, K+e to rise from approximately equal to 2.4 up to a maximum of approximately equal to 39 mmol/l, and PtCO2 to increase from approximately equal to 52 to approximately equal to 80 mmHg. Lactate increased from 2 to 5 mmol/kg tissue weight during anoxia and did not fall significantly after re-oxygenation for 10 min. A marked relationship existed between changes in PtCO2 and H+e. After re-oxygenation, K+e (extracellular potassium ion activity) and PtCO2 returned to the pre-anoxic level in a few minutes, whereas H+e took approximately equal to 30 min to recover. H+e recovered in a biphasic manner; a rapid decrease lasting approximately equal to 1 min preceded a much slower phase. We propose that the biphasic normalization of H+e after anoxia mainly reflects an initial and rapid washout of CO2 from brain tissue and a subsequent slow elimination of lactic acid occurring via metabolism and removal by the circulation.

journal_name

Neurol Res

journal_title

Neurological research

authors

Ohno M,Obrenovitch TP,Hartell N,Barratt S,Bachelard HS,Symon L

doi

10.1080/01616412.1989.11739882

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

153-9

issue

3

eissn

0161-6412

issn

1743-1328

journal_volume

11

pub_type

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