Measurement of regional cerebrovascular haemoglobin oxygen saturation in cats using optical spectroscopy.


:We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio--percentage haemoglobin: oxygen saturation--is quantified. This saturation is the weighted summation of saturation in the cerebrovascular system: arterial, venous, and capillary beds. In a cat model of progressive cerebral hypoxia, a positive linear correlation between this regional measurement of cerebral saturation and actual saturation, calculated from cerebral arterial and mixed venous blood, was noted (n = 20, r = 0.88, p less than 0.01). The spectroscopic measurement rSHbO2 is also used to index cerebral oxygen extraction. During hypoxia spectroscopic indexed oxygen extraction (iOE) and cerebral arterial-venous difference in oxygen content were simultaneously measured. A least-squares positive linear correlation between these two parameters was noted [AVDO2 = iOE (0.05) + 4.4] (n = 40, r = 0.6, s = 1.2). Objective measurement of 'regional cerebrovascular haemoglobin saturation' and an index of cerebral oxygen extraction are possible using optical spectroscopy.


Neurol Res


Neurological research


McCormick PW,Stewart M,Ray P,Lewis G,Dujovny M,Ausman JI




Has Abstract


1991-03-01 00:00:00












  • Assessment of anti-amyloidogenic activity of marine red alga G. acerosa against Alzheimer's beta-amyloid peptide 25-35.

    abstract:OBJECTIVE:The amyloid hypothesis stimulates the discovery of compounds, which promotes beta-amyloid peptide (Aβ) clearance, thereby altering the underlying pathophysiology of Alzheimer's disease (AD). Hence, the present study aims at the evaluation of anti-amyloidogenic potential of Gelidiella acerosa. METHODS:Prevent...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Syad AN,Devi KP

    更新日期:2015-01-01 00:00:00

  • Humoral immune response to influenza vaccine in natalizumab-treated MS patients.

    abstract:OBJECTIVES:Natalizumab is a drug with documented efficacy in relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of natalizumab has immunosuppressive properties and it is not yet investigated if treatment with natalizumab affects the immunological response to vaccination. This study aims to investig...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Vågberg M,Kumlin U,Svenningsson A

    更新日期:2012-09-01 00:00:00

  • Repetitive electrical stimulation of peripheral nerve and spinal cord activity.

    abstract::Spinal cord neuron and dorsal column fiber responses to electrical stimulation of the sciatic nerve in anesthetized cats were recorded before, during, and after periods of repetitive electrical stimulation of the sciatic nerve through an implantable nerve cuff stimulator device of the type and method used in human pat...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Ignelzi RJ,Nyquist JK,Tighe WJ Jr

    更新日期:1981-01-01 00:00:00

  • Effect of midbrain raphe nucleus stimulation on somatosensory evoked potential in cat.

    abstract::Experiments were carried out to clarify the effect of serotonin [5-hydroxytryptamine (5-HT)] upon the somatosensory evoked potential (SEP) elicited by superficial radial nerve stimulation in cat, and the following results were obtained: (i) in untreated (control) animals, a significant reduction occurred in amplitude ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Iwayama K,Mori K,Fukushima M,Yamashiro K

    更新日期:1989-06-01 00:00:00

  • Distribution of artificial cerebral microemboli in stroke patients with patent foramen ovale.

    abstract:OBJECTIVES:Patent foramen ovale (PFO) is considered as an important risk factor for cerebrovascular diseases. Nevertheless, the relationship between the distribution of high-intensity transient signals (HITS), resulting from injection of air mixed with saline and detected by transcranial Doppler (TCD), and clinical cer...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Telman G,Kouperberg E,Sprecher E,Goldsher D,Yarnitsky D

    更新日期:2005-01-01 00:00:00

  • Diffusion tensor MRI for the assessment of cerebral ischemia/reperfusion injury in the penumbra of non-human primate stroke model.

    abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo J,Zheng HB,Duan JC,He L,Chen N,Gong QY,Tang HH,Li HX,Wang L,Cheng JQ

    更新日期:2011-01-01 00:00:00

  • Cell transplantation for Parkinson's disease.

    abstract::Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of the dopamine producing neurons projecting from the substantia nigra into the corpus striatum. Current medical therapy is limited and cannot stop or reverse the degeneration. Over the past 30 years, attempts were m...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Roitberg B,Urbaniak K,Emborg M

    更新日期:2004-06-01 00:00:00

  • Intraluminal suture occlusion of the middle cerebral artery in Spontaneously Hypertensive rats.

    abstract::In models of middle cerebral artery occlusion using intraluminal suture, the size and the distribution of ischemic injury vary considerably among laboratories. In transcranial models of cerebral ischemia, a more consistent cerebral ischemic lesion is seen in Spontaneously Hypertensive rats (SHR). In the present study,...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Dogan A,Başkaya MK,Rao VL,Rao AM,Dempsey RJ

    更新日期:1998-04-01 00:00:00

  • Radiation-induced apoptosis of oligodendrocytes in the adult rat optic chiasm.

    abstract:OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Nagayama K,Kurita H,Nakamura M,Kusuda J,Tonari A,Takayama M,Fujioka Y,Shiokawa Y

    更新日期:2005-06-01 00:00:00

  • Validity, sensitivity and specificity of the mentation, behavior and mood subscale of the UPDRS.

    abstract:OBJECTIVE:The unified Parkinson's disease rating scale (UPDRS) is the most widely used tool to rate the severity and the stage of Parkinson's disease (PD). However, the mentation, behavior and mood (MBM) subscale of the UPDRS has received little investigation regarding its validity and sensitivity. Three items of this ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Holroyd S,Currie LJ,Wooten GF

    更新日期:2008-06-01 00:00:00

  • Music training causes long-term enhancement of preschool children's spatial-temporal reasoning.

    abstract::Predictions from a structured cortical model led us to test the hypothesis that music training enhances young children's spatial-temporal reasoning. Seventy-eight preschool children participated in this study. Thirty-four children received private piano keyboard lessons, 20 children received private computer lessons, ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Rauscher FH,Shaw GL,Levine LJ,Wright EL,Dennis WR,Newcomb RL

    更新日期:1997-02-01 00:00:00

  • Diffusion tensor tractography to visualize axonal outgrowth and regeneration in a 4-cm reverse autograft sciatic nerve rabbit injury model.

    abstract:BACKGROUND:Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical techniqu...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Farinas AF,Pollins AC,Stephanides M,O'Neill D,Al-Kassis S,Esteve IVM,Colazo JM,Keller PR,Rankin T,Wormer BA,Kaoutzanis C,Dortch RD,Thayer WP

    更新日期:2019-03-01 00:00:00

  • The multifunctional role of IGF-1 in peripheral nerve regeneration.

    abstract::The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cel...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Rabinovsky ED

    更新日期:2004-03-01 00:00:00

  • Sphenoorbital meningiomas: surgical management and outcome.

    abstract:OBJECTIVE:Surgical management of sphenoorbital meningiomas ranges among the most complex of intracranial tumors. We report on our experience of surgical technique, outcome, and tumor recurrence in sphenoorbital meningiomas. METHODS:Between 2003 and 2013, surgical resections for sphenoorbital meningioma were performed ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Forster MT,Daneshvar K,Senft C,Seifert V,Marquardt G

    更新日期:2014-08-01 00:00:00

  • Cerebral hemodynamics during induced tachycardia in routine electrophysiologic studies: a transcranial Doppler study.

    abstract::Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zunker P,Haase C,Borggrefe M,Georgiadis D,Georgiadis A,Ringelstein EB

    更新日期:1998-09-01 00:00:00

  • Biomathematical models of schizophrenia.

    abstract::This paper summarizes the work of developing and analyzing a mathematical model of schizophrenia. First the psychological and physiological studies of patients with periodic catatonia made by R. R. Gjessing are briefly described. Then a mathematical model, which is based on Gjessing's work and consists of a set of non...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Cronin J

    更新日期:1979-01-01 00:00:00

  • Music-supported therapy (MST) in improving post-stroke patients' upper-limb motor function: a randomised controlled pilot study.

    abstract:OBJECTIVE:Music-supported therapy (MST) is a new approach for motor rehabilitation of stroke patients. Recently, many studies have demonstrated that MST improved the motor functions of post-stroke patients. However, the underlying mechanism for this effect is still unclear. It may result from repeated practice or repea...

    journal_title:Neurological research

    pub_type: 杂志文章,随机对照试验


    authors: Tong Y,Forreider B,Sun X,Geng X,Zhang W,Du H,Zhang T,Ding Y

    更新日期:2015-05-01 00:00:00

  • The nutritional management of patients with head injuries.

    abstract::Severe head injuries tend to be associated with hypermetabolism and hypercatabolism resulting in negative nitrogen balances which may exceed 30 grams day-1. Enteral feeding should begin as soon as the patient is hemodynamically stable, attempting to reach a non-protein caloric intake of at least 30-35 kcal kg-1 day-1 ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Wilson RF,Dente C,Tyburski JG

    更新日期:2001-03-01 00:00:00

  • Albumin ameliorates tissue plasminogen activator-mediated blood-brain barrier permeability and ischemic brain injury in rats.

    abstract:OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METH...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Tang J,Li YJ,Mu J,Li Q,Yang DY,Xie P

    更新日期:2009-03-01 00:00:00

  • The time course of glucose metabolism in rat cerebral ischemia with middle cerebral artery occlusion-reperfusion model and the effect of MK-801.

    abstract::Following cerebral ischemia, the extracellular concentration of excitatory amino acids increases, and the excitatory cell death may play an important role contributing to ischemic neuronal damage. Although sequential metabolic changes in permanent local cerebral ischemia have been reported, the effect of reperfusion i...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Liu Y,Mituska S,Hashizume K,Hosaka T,Nukui H

    更新日期:1996-12-01 00:00:00

  • Surgical resection and reconstruction after resection of tumors involving the sacropelvic region.

    abstract:OBJECTIVES:Surgical management of tumors in the sacropelvic region is a challenging field of spine surgery because of the region's complex local anatomy and biomechanics. Recent developments in anesthesia and intensive care have allowed us to perform extended surgeries focused on the en bloc resection of sacropelvic tu...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Varga PP,Szoverfi Z,Lazary A

    更新日期:2014-06-01 00:00:00

  • Is mild vascular cognitive impairment reversible? Evidence from a study on the effect of carotid endarterectomy.

    abstract::Mild vascular cognitive impairment (mVCI) is a broader term that is intended to detect cognitive loss before the development of dementia. The identification of preventable risk factors as well as therapeutic strategies of intervention is still unclear. It has been suggested that carotid endarterectomy (CEA) improves c...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Borroni B,Tiberio G,Bonardelli S,Cottini E,Facheris M,Akkawi N,Pezzini A,Cervi E,Giulini SM,Padovani A

    更新日期:2004-07-01 00:00:00

  • The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis.

    abstract::Although neuronal death has been studied in experimental models of ischemia, the precise mechanisms regulating cell death remain unclear. Furthermore, the timing and pattern of neuronal death in human stroke has not been extensively studied. To further our understanding of ischemia-induced neuronal death, we examined ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guglielmo MA,Chan PT,Cortez S,Stopa EG,McMillan P,Johanson CE,Epstein M,Doberstein CE

    更新日期:1998-06-01 00:00:00

  • Field potential recording from rat hippocampus provides a functional evaluation method for assessing demyelination and myelin repair.

    abstract:OBJECTIVES:In multiple sclerosis (MS) demyelination occurs in both white and gray matter. Here we introduce an electrophysiological approach for studying functional demyelination and myelin repair in rat hippocampus, a gray matter structure, which is frequently affected in patients suffering from MS. METHODS:Using a s...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Azin M,Goudarzvand M,Mirnajafi-Zadeh J,Javan M

    更新日期:2013-10-01 00:00:00

  • Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine-dihydropyridine hybrid molecule.

    abstract:OBJECTIVES:The aim of this study was to investigate the effects of oral administration of a novel benzodiazepine derivative, JM-20, on the neurological behavior of different rodent models, focusing on the GABAergic effect. We have also investigated the acute toxicity of oral administration of JM-20 in mice. METHODS:Mi...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Figueredo YN,Rodríguez EO,Reyes YV,Domínguez CC,Parra AL,Sánchez JR,Hernández RD,Verdecia MP,Pardo Andreu GL

    更新日期:2013-10-01 00:00:00

  • Refractory status epilepticus: new insights in presentation, treatment, and outcome.

    abstract::Refractory status epilepticus (RSE), defined as status epilepticus that fails to respond to the acute administration of two antiepileptic medications, occurs in approximately a third of patients with status epilepticus, and is associated with increased hospital length of stay, mortality, and functional disability. Com...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Hocker S,Wijdicks EF,Rabinstein AA

    更新日期:2013-03-01 00:00:00

  • Evolving management of symptomatic chronic subdural hematoma: experience of a single institution and review of the literature.

    abstract:OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Balser D,Rodgers SD,Johnson B,Shi C,Tabak E,Samadani U

    更新日期:2013-04-01 00:00:00

  • Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI mice.

    abstract:OBJECT:The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo® application on brain injury in experimental TBI mice using S...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo D,Li D,Li J,Li Y,Hu X,Guan F,Yang B

    更新日期:2017-09-01 00:00:00

  • Superior protective effects of phenytoin against hypoxia in a pharmacological screening test.

    abstract::The selection of drugs to prevent the development of pathology in cerebral infarction remains an important problem. For the selection of effective drugs from among a large number of possible candidates, widely-used test screening techniques are sufficient for obtaining a good understanding of candidate drug effects. T...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Imaizumi S,Suzuki J,Kinouchi H,Yoshimoto T

    更新日期:1988-03-01 00:00:00

  • The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma.

    abstract:OBJECTIVES:Recent preclinical studies suggest that treating glioblastoma (GBM) with a combination of targeted chemotherapy and radiotherapy may enhance the anti-tumor effects of both therapies. However, the effects of these treatments on glioma growth and progression are poorly understood. METHODS:In this study, we h...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: D'Amico R,Lei L,Kennedy BC,Sisti J,Ebiana V,Crisman C,Christensen JG,Gil O,Rosenfeld SS,Canoll P,Bruce JN

    更新日期:2012-04-01 00:00:00