Measurement of regional cerebrovascular haemoglobin oxygen saturation in cats using optical spectroscopy.

Abstract:

:We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio--percentage haemoglobin: oxygen saturation--is quantified. This saturation is the weighted summation of saturation in the cerebrovascular system: arterial, venous, and capillary beds. In a cat model of progressive cerebral hypoxia, a positive linear correlation between this regional measurement of cerebral saturation and actual saturation, calculated from cerebral arterial and mixed venous blood, was noted (n = 20, r = 0.88, p less than 0.01). The spectroscopic measurement rSHbO2 is also used to index cerebral oxygen extraction. During hypoxia spectroscopic indexed oxygen extraction (iOE) and cerebral arterial-venous difference in oxygen content were simultaneously measured. A least-squares positive linear correlation between these two parameters was noted [AVDO2 = iOE (0.05) + 4.4] (n = 40, r = 0.6, s = 1.2). Objective measurement of 'regional cerebrovascular haemoglobin saturation' and an index of cerebral oxygen extraction are possible using optical spectroscopy.

journal_name

Neurol Res

journal_title

Neurological research

authors

McCormick PW,Stewart M,Ray P,Lewis G,Dujovny M,Ausman JI

doi

10.1080/01616412.1991.11739967

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

65-70

issue

1

eissn

0161-6412

issn

1743-1328

journal_volume

13

pub_type

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