Abstract:
OBJECTIVE:In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment. METHODS:Data from 10 patients already on statins at stroke onset (Pre-S group) was compared with data from both 29 patients starting statin treatment right after stroke onset (Post-S group) and with 8 healthy controls. In T-cells isolated from stroke patients, we analyzed the activity of the main cytoskeletal regulator RhoA GTPase and its downstream effectors: rho-associated protein kinase (ROCK), myosin phosphatase targeting protein subunit 1 (pMYPT1), myosin light chain kinase (pMLC) and cofilin. In the blood samples, we further determined levels of 12 key plasma cytokines as well as C-reactive protein (CRP) and kallikrein. RESULTS:Compared to healthy controls, the Post-S group achieved significantly higher RhoA and ROCK activities, while the Pre-S did not differ from controls. Levels of pMYPT1, pMLC and cofilin did not differ from controls in the Pre-S and Post-S groups. At day 90 after stroke, interferon γ and IL-18 were significantly increased in the Post-S group compared to the Pre-S group. We found a positive correlation between CRP and NIHSS, whereas kallikrein levels showed no correlation with NIHSS at any of the days. CONCLUSION:Stroke induces changes in the RhoA-ROCK pathway in T-cells. CRP and NIHSS score correlated positively in the study. Statins may have an anti-inflammatory effect as statin treatment before stroke reduces post-stroke pro-inflammatory levels. RhoA GTPase and its downstream effectors are possibly the key to improve statin treatment in stroke.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Schultz NEØ,Hasseldam H,Rasmussen RS,Vindegaard N,McWilliam O,Iversen HK,Johansen FFdoi
10.1080/01616412.2018.1558000subject
Has Abstractpub_date
2019-04-01 00:00:00pages
289-297issue
4eissn
0161-6412issn
1743-1328journal_volume
41pub_type
杂志文章abstract:OBJECTIVES:Hourly neurologic assessments for traumatic brain injury (TBI) in the critical care setting are common practice but prolonged use may actually be harming patients through sleep deprivation. We reviewed practice patterns at our institution in order to gain insight into the role of frequent neurological assess...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000285
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to characterize mouse neural stem cells (NSC) transduced by a multigenic lentiviral vector (LV) and stably express recombinant human nerve growth factor (rhNGF). We obtained NSC-derived cell lines which express human NGF in relevant amount to exploit their ability for therapeuti...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X115161
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Computed tomographic angiography (CTA) was invented more than 20 years ago, but only gained acceptance recently, thanks to advancements in the computer technology. It can demonstrate areas of arterial stenosis or occlusion with accuracy nearly that of digital subtraction angiography (DSA). It is also able to ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X340969
更新日期:2008-10-01 00:00:00
abstract::Corticotrophin releasing factor has been shown in several models of tissue injury to be an effective treatment for edema. In a previous study we demonstrated this ability in two models of traumatic brain injury (TBI). The aim of this study was to assess whether human corticotrophin releasing factor (hCRF) could additi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740737
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12761752770177
更新日期:2011-01-01 00:00:00
abstract::Acute presentation of Type I Chiari malformation in children is distinctly rare. An 11 year old male suffered a trauma to the right temporal-parietal region in a tobogganing accident resulting in an open depressed skull fracture. Radiographic evaluation included a Computed Tomographic scan which also demonstrated a si...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740599
更新日期:1998-01-01 00:00:00
abstract::Magnetic resonance (MR) is a powerful new imaging modality which has recently become competitive with X-ray computed tomography (CT) for imaging of the central nervous system (CNS). The advantages of MR include lack of ionizing radiation and the necessity to use iodinated contrast. MR is able to image directly in the ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1984.11739671
更新日期:1984-09-01 00:00:00
abstract::Somatosensory-evoked potentials induced by electrical stimulation of the median nerve were recorded in patients with intracerebral lesions and in normal controls and were studied by means of spectral analysis. The results shown that (1) there is a statistically-significant difference between spectral distributions obt...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739571
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172167
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of ne...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1576356
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Transcranial Doppler (TCD) measures blood flow velocities (BFV) and is an indirect method of assessing cerebral blood flow (CBF). Positron emission tomography (PET) is a direct method to measure CBF. This study evaluates the correlations between TCD and PET findings Methods: Nine patients with a symptomatic c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X325191
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To review the historical development and current status of endovascular techniques used in the treatment of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. METHODS:This article summarizes the relevant literature on neurointerventional therapy for vasospasm, namely instillation of intraar...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X152043
更新日期:2006-10-01 00:00:00
abstract::The authors have done a revision of 450 patients admitted during the last 3 years to the emergency service of the Hospital de S. José with the diagnosis of CVA. In this retrospective study were included the patients of greater than or equal to 3 degree of the RLS/85 coma scale, the diagnostic being confirmed by CAT, a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740023
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:We tested whether repetitive magnetic stimulation (rMS) induces an afferent input to the spinocerebral tract in patients with complex regional pain syndrome (CRPS). METHODS:Cortical and spinal motor evoked potentials (cMEP and sMEP), as well as the contra- and ipsilateral silent period (cCSP and iCSP), were...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164105X17224
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Elevated homocysteine level is a risk factor for ischemic stroke and associated with small vessel disease such as confluent leukoaraiosis in white and black population. We investigated the relationship between the total serum homocysteine level and ischemic stroke subtypes in Chinese population. METHODS:Thre...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12445616596445
更新日期:2010-07-01 00:00:00
abstract::Background Transtemporal Doppler (TTD) with middle cerebral artery (MCA) is widely used for right-to-left shunt (RLS) detection. However, an alternative method for patients without suitable temporal bone windows should be established. The present study prospectively evaluated the effectiveness of transorbital Doppler ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1428276
更新日期:2018-03-01 00:00:00
abstract::Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1454092
更新日期:2018-06-01 00:00:00
abstract::Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to reveal severe dyses...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201274
更新日期:2003-03-01 00:00:00
abstract::This study was performed to test whether GYKI 52466, a nonNMDA receptor antagonist, would improve microregional oxygen supply and consumption balance in the focal cerebral ischemic area. Rats were anesthetized with 1.4% isoflurane. For the GYKI Group (n = 8), 10 min before middle cerebral artery (MCA) occlusion, a bol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740935
更新日期:1999-04-01 00:00:00
abstract::We investigated the neuroprotective effects of a novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (pitavastatin) on ischemic neuronal damage in gerbils using immunohistochemistry. The animals were allowed to survive for 14 days after 5 min of ischemia induced by bilateral occlusion of the comm...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225014102
更新日期:2004-09-01 00:00:00
abstract::Huntington's disease is an inherited neurodegenerative disorder, characterized by loss of spiny neurons in the striatum and cortex, which usually happens in the third or fourth decades of life. In advanced form of the disease, progressive striatum atrophy happens and medium spiny neurons, which occupy more than 80% of...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X327955
更新日期:2008-12-01 00:00:00
abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740543
更新日期:1998-07-01 00:00:00
abstract::Objectives: Brain arteriovenous malformations (AVMs) represent high-flow vascular lesions made up of a complex network of feeding arteries and draining veins interposed by a nidus and without a capillary bed. The management of the AVMs represents a challenge, and the optimal treatment should be considered based on the...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1803604
更新日期:2020-12-01 00:00:00
abstract::Objective: Remote limb ischemic postconditioning (RIPostC) protects the brain from damage induced by transient focal ischemia/reperfusion. However, the underlying mechanism remains unclear. Methods: RIPostC induced by 10 min of occlusion and another 10 min releasing of blood flow for three cycles in the hind limbs was...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1523037
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of calcification surrounding the odontoid process (odontoid calcification) with crowned dens syndrome (CDS) and without CDS (non-CDS) and investigate factors that may related to the onset of CDS. METHODS:Retrospective review of consecutive patients visited Sir Run Run Shaw Hospital ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1792700
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X338043
更新日期:2009-06-01 00:00:00
abstract::The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and environmental factors play important roles in its pathogenesis. While demyelination of axons is a hallmark histological feature of MS, axonal and neuronal dysfunction may correlate better with clinical disability. All major immune cell ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X98125
更新日期:2006-04-01 00:00:00
abstract::No marker that predicts accurately the time of occurrence of cerebral vasospasm due to subarachnoid hemorrhage (SAH) has been reported. In the present study, membrane-bound tissue factor (mTF) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) were evaluated as a predictor of the time of occurr...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199225
更新日期:2001-10-01 00:00:00
abstract::Different surgical approaches exist for the treatment of chronic subdural hematoma. None of these approaches is superior to the other, so a minimal-invasive device (a hollow screw) was developed. The system consists of a stable hollow screw of surgical steel with a perforated tip, a hand-drill, screwdriver with guide,...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740897
更新日期:1999-01-01 00:00:00
abstract::Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X25225
更新日期:2005-04-01 00:00:00