Coma of vascular aetiology: evaluation and prognosis.


:The authors have done a revision of 450 patients admitted during the last 3 years to the emergency service of the Hospital de S. José with the diagnosis of CVA. In this retrospective study were included the patients of greater than or equal to 3 degree of the RLS/85 coma scale, the diagnostic being confirmed by CAT, angiography and/or autopsy, and simultaneously evaluated by the Glasgow coma scale. The studied population was grouped into: SAH; ICH with or without ventricular drowning, cerebellar haematoma, brainstem haematoma, ischaemic CVA. The factors of vascular risk: diabetes and hypertension, the age of the patients and coma level were correlated with the degree of cerebral disability of discharge in all patients. The following factors are clearly related with bad prognosis: coma of degree greater than or equal to 4 in the RLS/85 scale; ischaemic aetiology; intraventricular haemorrhage.


Neurol Res


Neurological research


Costa B,Candido J,Girbal A,Afonso L,Ribeiro J,Gonçalves V,Luis V,Antunes J




Has Abstract


1992-01-01 00:00:00




2 Suppl








  • A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm.

    abstract:BACKGROUND:It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Liu MX,Zhong J,Xia L,Dou NN,Li ST

    更新日期:2019-04-01 00:00:00

  • In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system.

    abstract:OBJECTIVES:The purpose of this study was to characterize mouse neural stem cells (NSC) transduced by a multigenic lentiviral vector (LV) and stably express recombinant human nerve growth factor (rhNGF). We obtained NSC-derived cell lines which express human NGF in relevant amount to exploit their ability for therapeuti...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Cenciarelli C,Budoni M,Mercanti D,Fernandez E,Pallini R,Aloe L,Cimino V,Maira G,Casalbore P

    更新日期:2006-07-01 00:00:00

  • Matrix metalloproteinase-9 potentiates early brain injury after subarachnoid hemorrhage.

    abstract:OBJECTIVE:This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury after subarachnoid hemorrhage (SAH). METHOD:Sprague-Dawley male rats (n=36) weighing between 250 and 300 g were used. SAH was produced by injecting autologous arterial blood into the pre-chiasmatic cistern. MMP-9 pro...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo Z,Sun X,He Z,Jiang Y,Zhang X,Zhang JH

    更新日期:2010-09-01 00:00:00

  • Augmentation of endoplasmic reticulum stress in cerebral ischemia/reperfusion injury associated with comorbid type 2 diabetes.

    abstract:OBJECTIVE:Diabetes is one of the major risk factors for ischemic stroke and is reported to aggravate the ischemic brain damage in different experimental models as well as clinical situations. However, the mechanisms underlying the exacerbated ischemia/reperfusion (I/R) brain injury associated with comorbid diabetes ar...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Srinivasan K,Sharma SS

    更新日期:2011-10-01 00:00:00

  • Hypervolemic haemodilution and completed stroke: how important is the application time for its effect?

    abstract::In 75 patients with completed stroke hypervolemic haemodilution was performed for 1 day with 500 ml 6% HES 200.000/0.6-0.66 (Elohäst) to test the acute influence of application time for haemorheological changes. The patients were divided into 3 groups randomly selected: group A received the infusion for 2 hours, group...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Költringer P,Langsteger W,Reisecker F,Eber O

    更新日期:1992-01-01 00:00:00

  • Radiation-induced apoptosis of oligodendrocytes in the adult rat optic chiasm.

    abstract:OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Nagayama K,Kurita H,Nakamura M,Kusuda J,Tonari A,Takayama M,Fujioka Y,Shiokawa Y

    更新日期:2005-06-01 00:00:00

  • Local fibrinolysis and aspiration of intracerebral hematomas in rats. An experimental study using MR monitoring.

    abstract::Serial magnetic resonance (MR) imaging has not yet been validated in the therapy of experimental intracerebral hematomas in a rat model. It is possible to test the effect of local fibrinolysis and aspiration on the clot volume using serial magnetic resonance imaging and different MR-sequences. Experiments were carried...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Deinsberger W,Hartmann M,Vogel J,Jansen O,Kuschinsky W,Sartor K,Böker DK

    更新日期:1998-06-01 00:00:00

  • An endoscopic pedicle probe: preliminary development.

    abstract::Insertion of pedicle screws in the thoracolumbar spine can be challenging. Incorrect placement can lead to a failure of fusion or to significant neurologic morbidity. Recently, techniques utilizing intraoperative monitoring and stereotaxis have been developed to achieve proper screw placement. While these techniques m...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Frank EH,Chamberland DL

    更新日期:1997-12-01 00:00:00

  • COMT Val158Met polymorphism and Parkinson's disease risk: a pooled analysis in different populations.

    abstract:OBJECTIVE:Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in ...

    journal_title:Neurological research

    pub_type: 杂志文章,meta分析


    authors: Wang YC,Zou YB,Xiao J,Pan CD,Jiang SD,Zheng ZJ,Yan ZR,Tang KY,Tan LM,Tang MS

    更新日期:2019-04-01 00:00:00

  • Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging.

    abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Lo EH,Rogowska J,Batchelder KF,Wolf GL

    更新日期:1996-04-01 00:00:00

  • Cerebral density and perfusion measured among heart disease patients with and without stroke.

    abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Obara K,Meyer JS,Muramatsu K,Mortel KF

    更新日期:1995-10-01 00:00:00

  • Endovascular treatment of congenital carotid-cavernous fistulas in infancy.

    abstract::Congenital dural arteriovenous fistulas have been infrequently described in pediatric population and they generally affect the transverse, sigmoid, straight or sagittal sinuses. Congenital carotid-cavernous fistulas in infancy are considered very rare and to our knowledge, only four cases have been reported in literat...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Cohen JE,Gomori JM,Grigoriadis S,Rajz G

    更新日期:2008-07-01 00:00:00

  • Intraoperative on-line monitoring of cerebral pH by microdialysis in neurosurgical procedures.

    abstract::The objective of this study was to improve the ability to detect cerebrovascular complications in patients undergoing complicated neurosurgical procedures using on-line monitoring of cerebral pH with in vivo microdialysis. We employed on-line pH monitoring in patients with a variety of neurosurgical procedures includi...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Mendelowitsch A,Sekhar LN,Caputy AJ,Shuaib A

    更新日期:1998-03-01 00:00:00

  • CCR7 expression on peripheral blood lymphocytes is up-regulated following treatment of multiple sclerosis with interferon-beta.

    abstract::A prospective study of the expression of the chemokine receptor CCR7 was performed in 11 relapsing-remitting multiple sclerosis (MS) patients during 12 months of interferon-beta (IFNbeta) treatment. The results show increased expression of CCR7 on peripheral blood lymphocytes (PBL) of MS patients receiving IFNbeta tre...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Vallittu AM,Saraste M,Airas L

    更新日期:2007-12-01 00:00:00

  • Computer-controlled acupuncture. Quantification and separation of specific effects.

    abstract::The effects of acupuncture have been described and handed down empirically for centuries but there are few reports based on objective data. The aim of this study was to provide selective evidence of a specific effect of acupuncture on the brain and the eye using a Doppler ultrasound technique. A transcranial Doppler s...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Litscher G,Wang L,Yang NH,Schwarz G

    更新日期:1999-09-01 00:00:00

  • Morphometric predictors of posterior circulation aneurysms risk rupture.

    abstract:OBJECTIVES:Intracranial aneurysms (IAs) of the posterior circulation (PC) rupture more frequently and their morbidity and mortality rates are higher compared to anterior circulation. Morphological parameters such as size ratio (SR), inflow angle and parent artery geometry are believed to contribute significantly in det...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Tykocki T,Nauman P,Dow Enko A

    更新日期:2014-08-01 00:00:00

  • Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow.

    abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Tsutsui S,Nanba T,Yoshioka Y,Sasaki M,Fujiwara S,Kobayashi M,Yoshida K,Miyoshi K,Sato S,Ogasawara K

    更新日期:2018-08-01 00:00:00

  • SELDI-TOF analysis of glioblastoma cyst fluid is an approach for assessing cellular protein expression.

    abstract:OBJECTIVES:In about 10% of glioblastoma patients, preoperative MRI discloses the presence of tumor cysts. Whereas the impact of cystic appearance on prognosis has been discussed extensively, only little is known about the tumor cyst fluid. In this study, we tested the feasibility of the surface enhanced laser desorptio...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Hoelscher M,Richter N,Melle C,von Eggeling F,Schaenzer A,Nestler U

    更新日期:2013-12-01 00:00:00

  • Direct ethanol injection for skull metastasis from hepatocellular carcinoma. The techniques and consequences of a therapeutic trial.

    abstract::The frequency of skull metastasis from hepatocellular carcinoma (HCC) is increasing together with the recent progress in the management of the primary lesion. Cases are often complicated with poor general conditions or metastasis to the other organs, and not readily indicated for surgery. A direct injection of ethanol...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Isaka T,Yoshimine T,Fujimoto K,Masuzawa M,Maruno M,Hayakawa T,Nakatani S

    更新日期:1998-12-01 00:00:00

  • Early decrease of P-glycoprotein in the endothelium of the rat brain capillaries after moderate dose of irradiation.

    abstract::In this study, we examined the degree of disruption of blood-brain barrier (BBB) in irradiated rat brains using P-glycoprotein, one of the functional molecules of BBB, as a marker. In the animal experiments, disruption of BBB has been mainly studied at the acute stage of brain edema caused by a lethal dose of irradiat...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Mima T,Toyonaga S,Mori K,Taniguchi T,Ogawa Y

    更新日期:1999-03-01 00:00:00

  • Anti-GQ1b IgG antibody activities related to the severity of Miller Fisher syndrome.

    abstract::The correlation between the activities of anti-GQ1b IgG antibodies in sera of patients with Miller Fisher syndrome and their clinical manifestations was investigated. The clinical severity was analyzed for 16 patients by scoring their symptoms during the peak of the clinical course and 4 weeks after onset. Serum sampl...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Mizoguchi K

    更新日期:1998-10-01 00:00:00

  • Effect of labetalol on cerebral blood flow and middle cerebral arterial flow velocity in healthy volunteers.

    abstract::The effect of labetalol, a combined alpha- and beta-adrenoceptor antagonist, on the cerebral circulation was investigated in 7 normotensive subjects. Cerebral blood flow (CBF) was measured with the intravenous 133Xe method and mean flow velocity (Vmean) in the middle cerebral artery was determined using transcranial D...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Schroeder T,Schierbeck J,Howardy P,Knudsen L,Skafte-Holm P,Gefke K

    更新日期:1991-03-01 00:00:00

  • Effects of cerebral small vessel disease on the outcome of patients with ischemic stroke caused by large artery atherosclerosis.

    abstract:OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Zhu H,Li Z,Lv J,Zhao R

    更新日期:2018-05-01 00:00:00

  • Sepsis associated encephalopathy.

    abstract:INTRODUCTION:Alteration of sensorium or an encephalopathy is a common diagnostic dilemma in critically ill patients and can be caused by a number of conditions. Sepsis associated encephalopathy (SAE) is now the most common encephalopathy encountered among intensive care unit (ICU) patients. DEFINITIONS:SAE is an encep...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Maramattom BV

    更新日期:2007-10-01 00:00:00

  • Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia.

    abstract::Acute blood-brain barrier (BBB) opening in cerebral ischemia is an often observed but seldom studied phenomenon. Increased permeability has been implicated with several consequences including exacerbating ischemic injury, leading to hemorrhagic transformation (HT) and also predictive of chronic damage and a way of del...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Nagaraja TN,Keenan KA,Brown SL,Fenstermacher JD,Knight RA

    更新日期:2007-01-01 00:00:00

  • Positron emission tomographic evaluation of histological malignancy in gliomas using oxygen-15 and fluorine-18-fluorodeoxyglucose.

    abstract::HEADTOME III, a high resolution PET, has been employed using 15O and 18F labelled pharmaceuticals to evaluate histological malignancy of gliomas preoperatively. PET study was applied on eighteen preoperative gliomas including two recurrent cases. Haemocirculatory and metabolic indices of regional cerebral blood flow (...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Mineura K,Yasuda T,Kowada M,Shishido F,Ogawa T,Uemura K

    更新日期:1986-09-01 00:00:00

  • Endothelin receptors A and B are expressed in distinct cellular compartments of rat hippocampus following global ischemia: an immunocytochemical study.

    abstract:OBJECTIVES:The syntheses of endothelin receptors A and B were previously shown to be upregulated in rat dorsal hippocampus after traumatic brain injury. Here we characterize endothelin receptor A and endothelin receptor B cellular distribution in hippocampus after permanent global brain ischemia and their possible asso...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Kreipke CW,Reynolds CA,Schafer PC,Schafer S,Pirooz R,Rafols JA

    更新日期:2011-03-01 00:00:00

  • Diffusion tensor MRI for the assessment of cerebral ischemia/reperfusion injury in the penumbra of non-human primate stroke model.

    abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Guo J,Zheng HB,Duan JC,He L,Chen N,Gong QY,Tang HH,Li HX,Wang L,Cheng JQ

    更新日期:2011-01-01 00:00:00

  • Online assessment of brain tissue oxygen autoregulation in traumatic brain injury and subarachnoid hemorrhage.

    abstract::Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Soehle M,Jaeger M,Meixensberger J

    更新日期:2003-06-01 00:00:00

  • Hyperbaric oxygenation in fluid microembolism.

    abstract::Because clinicians require objectively demonstrable neurological deficits to confirm a diagnosis, the recognition of embolic events in the nervous system is generally restricted to the effects of ischemic necrosis produced by arterial occlusion. However, magnetic resonance imaging (MRI) has shown that lesser degrees o...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: James PB

    更新日期:2007-03-01 00:00:00